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  1. Comparative analysis of the amorfrutin A and rosiglitazone (Rosi)-dependent hepatic transcriptomes in a mouse model of diet-induced obesity NURSA

    Keywords: whole liver

    Description: Male C57BL/6 mice at 6 weeks of age were fed a HFD (60% of calories as fat) for 12 weeks to induce obesity and insulin resistance. Subsequently mice w...

    ID: 10.1621/Iw9Fidj7Hn

  2. Analysis of the estrogen-related receptor β (ERRβ/ESRRB) and DY131-regulated transcriptome in human DU145 prostate cancer cells NURSA

    Keywords: epithelium DU145 cells

    Description: Human DU145 prostate cancer cells stably transfected with an ERRβ/ESRRB expression vector or an empty vector control were treated for 12 h with 3 µM...

    ID: 10.1621/KhoLDn0eUQ

  3. Chronic time course and dose-dependence analysis of the clofibrate (Clofib)-regulated transcriptome in rat liver NURSA

    Keywords: whole liver

    Description: Livers were isolated from rats treated for 4 - 29 d with or without 30 - 300 mg/kg bw/d Clofib.

    ID: 10.1621/N4Z6Zseri5

  4. Analysis of the 17β-estradiol (17βE2)-regulated transcriptome in rat trigeminal ganglia NURSA

    Keywords: trigeminal ganglia whole

    Description: Cultured trigeminal ganglia from 8 week old random cycling female rats were 17βE2-deprived then treated for 24 h with or without 1 nM 17βE2.

    ID: 10.1621/gWBqfhz6yG

  5. Comparative analysis of the 17β-estradiol (17βE2)-, genistein (Gen)-, and phytoestrogen (S-equol [Sequol] and liquiritigenin [Liquir])-regulated, es... NURSA

    Keywords: epithelium MCF-7 cells

    Description: Human MCF-7 breast cancer cells were infected for 72 h with (i) control adenovirus expressing β-gal; (ii) adenovirus expressing ERβ/ESR2; or (ii) ad...

    ID: 10.1621/0xZtJIMQg2

  6. Analysis of the Ssfa2-dependent transcriptome in mouse liver NURSA

    Keywords: whole liver

    Description: Liver was isolated from 32 week old C57BL6/J male Ssfa2 KO and WT mice fed a normal chow diet.

    ID: 10.1621/NCM4UKSDLs

  7. Analysis of the Bromo Adjacent Homology Domain Containing 1 (Bahd1)-dependent transcriptome in mouse E16.5 placenta and liver NURSA

    Keywords: whole liver

    Description: Placenta and liver tissue was isolated at embryonic day 16.5 from male and female Bahd1 knockout and wild-type mice.

    ID: 10.1621/FPygkhLBsO

  8. Tissue-specific expression patterns of nuclear receptor coregulators NURSA

    Keywords:

    Description: C57/Bl6J and 129x1/SvJ male or female mice (n = 6) at 8-9 weeks of age from each strain were sacrificed at lights-on (ZT0) by halothane inhalation (Ha...

    ID: 10.1621/datasets.04002

  9. Acute time course and dose-dependence analysis of the clofibrate (Clofib)-regulated transcriptome in rat liver NURSA

    Keywords: whole liver

    Description: Livers were isolated from rats treated for 3 - 24 h with or without 30 mg - 300 mg/kg bw/d Clofib.

    ID: 10.1621/39jyLTZloo

  10. Analysis of the GW501516 (GW1516)-regulated transcriptome in primary human macrophages expressing constitutively active AMPK NURSA

    Keywords: myeloid lineage macrophages monocyte-derived

    Description: Primary human macrophages transduced with constitutively active (T172A) AMPK α1 variant were treated for 24 h with or without 100 nM GW1516.

    ID: 10.1621/2w9z81daL1

  11. Analysis of the dihydrotestosterone (DHT)-regulated transcriptome in human LNCaP-C4-2B prostate cancer cells NURSA

    Keywords: epithelium LNCaP-C4-2B cells

    Description: Human LNCaP-C4-2B prostate cancer cells were treated with for 16 h with or without 10 nM DHT.

    ID: 10.1621/mpN8PDaTeM

  12. Time course and dose dependence analysis of the bisphenol A (BPA)-regulated transcriptome in Ishikawa cells NURSA

    Keywords: endometrium epithelium Ishikawa cells

    Description: Human Ishikawa endometrial carcinoma cells were treated with or without 1 nM, 100 nM, 10 µM or 100 µM BPA for 8 h, 24 h or 48 h.

    ID: 10.1621/CwEZYldrxg

  13. Time course transcriptomic analysis of rosiglitazone (Rosi)-treated C3H/10T1/2 cells NURSA

    Keywords: WAT adipocytes C3H/10T1/2 cell-derived

    Description: Fully differentiated C3 h/10T1/2 adipocytes were cultured with 1 µM Rosi or vehicle for 1 h.

    ID: 10.1621/hLnw2RmSWG

  14. Mutational analysis of the peroxisome proliferator activated receptor-γ coactivator 1- β (PGC1β/Ppargc1b)-regulated transcriptome in mouse liver an... NURSA

    Keywords: whole liver

    Description: Liver and skeletal muscle were isolated from C5BL/6 wild type mice or mice expressing a mutant form of PGC1β/Ppargc1b lacking two out of the three LX...

    ID: 10.1621/d4Kt4gB72O

  15. Dose dependent analysis of the rosiglitazone (Rosi)-regulated liver and inguinal adipose tissue transcriptomes in the Leprdb null mutant mouse NURSA

    Keywords: whole liver

    Description: Liver or inguinal adipose tissue was collected from male BKS.Cg-m +/+ Leprdb/J mice treated with or without Rosi at a range of doses for 18 days. The...

    ID: 10.1621/9IFwN8xkBn

  16. Analysis of the 17β-estradiol (17βE2) dependent transcriptome in SUM44PE invasive lobular carcinoma breast cancer cell lines NURSA

    Keywords: epithelium SUM44PE cells

    Description: SUM44PE invasive lobular carcinoma breast cancer cell lines were treated with 1 nM 17βE2 or vehicle for 3 h and 24 h.

    ID: 10.1621/6ugTmHZK5X

  17. Transcriptomic analysis of progesterone (P4)-treated mouse ovary NURSA

    Keywords: Female reproductive ovary whole

    Description: Newborn Sprague-Dawley rat ovaries dissected from pups less than 8 h old, were cultured in the presence or absence of 1 µM P4 for 48 h.

    ID: 10.1621/lbPzmF6Pwq

  18. Analysis of the dexamethasone (Dex)- and testosterone (Test)-regulated transcriptomes in rat gastrocnemius muscle NURSA

    Keywords: gastrocnemius whole

    Description: Gastrocnemius muscle was isolated from male Wistar-Hannover rats treated with or without a combination of 0.7 mg/kg/d Dex and 28 mg/kg/d Test for 7 da...

    ID: 10.1621/9MncYfbHNA

  19. Analysis of the androgen receptor (AR) and dihydrotestosterone (DHT)-regulated transcriptomes in normal (LNCaP) and androgen-independent (LNCaP-abl) c... NURSA

    Keywords: epithelium LNCaP cells

    Description: Human LNCaP or LNCaP-abl prostate cancer cells were transfected with AR siRNA or scrambled control siRNA for 72 h. LNCaP-abl cells were also treated w...

    ID: 10.1621/UhiFZHfzQW

  20. Analysis of the Nur77/Nr4a1-regulated transcriptome in pyramidal neurons NURSA

    Keywords: hippocampus pyramidal neurons

    Description: After 10 days in culture, dissociated mouse hippocampal pyramidal neurons were infected with lentivirus expressing Nur77/Nr4a1 or GFP for 6 d.

    ID: 10.1621/pDfF4bWOiY

  21. Analysis of the GW4604-dependent transcriptome in the intestine of the Cyp27a1 null mutant mouse NURSA

    Keywords: other whole mucosa

    Description: 3-4 month Cyp27a1 knockout mice were treated with or without two doses of 100 mg/kg body weight GW4064 by oral gavage 12 h apart. Mice were sacrifice...

    ID: 10.1621/datasets.04008

  22. Dose-dependent transcriptomic analysis of the diethylhexylphthalate (DEHP)-treated rat neonatal cardiomyocytes NURSA

    Keywords: cardiac muscle cardiomyocytes 1° cells

    Description: Rat neonatal cardiomyocytes isolated from 2-day-old Sprague-Dawley rat pups were treated with or without a range of doses of DEHP for 72 h.

    ID: 10.1621/796eXQYCUb

  23. Comparative analysis of peroxisome proliferator-activated receptor-γ (PPARγ/Pparg)- and GW7845-regulated transcriptomes in rat pancreatic islets NURSA

    Keywords: islets whole

    Description: Rat pancreatic islets isolated from male Wistar rats were transduced with PPARγ/Pparg adenovirus or empty adenovirus for 32 h and treated for 16 h wi...

    ID: 10.1621/VMxZKKVCkB

  24. Analysis of the dihydrotestosterone (DHT)- and RTI 6413-018-dependent transcriptomes in LNCaP prostate cancer cells NURSA

    Keywords: epithelium LNCaP cells

    Description: Human LNCaP prostate cancer cells were treated with 10 nM DHT or 100 nM RTI 6413-018 for 6-24 h.

    ID: 10.1621/PG6srxDzNt

  25. Analysis of the p300/CBP interacting protein (pCIP/Ncoa3) dependent transcriptome in mouse embryonic stem cells NURSA

    Keywords: pluripotent ESCs E14 cells

    Description: Mouse E14 embryonic stem cells were transfected with two pCIP siRNAs or pooled non-specific siRNAs.

    ID: 10.1621/gMh9LUMTKF

  26. Analysis of the thyroid hormone receptor-α (TRα/THRA) and TRβ/THRB-regulated transcriptomes in human HepG2 hepatocellular carcinoma cells NURSA

    Keywords: epithelium HepG2 cells

    Description: Human HepG2 hepatocellular carcinoma cells stably expressing TRα/THRA, TRβ/THRB, or empty vector were treated with or without 100 nM T3 for 6 h.

    ID: 10.1621/OzD9WkdLYj

  27. Analysis of the all-trans retinoic acid (ATRA)-regulated, retinoid X receptor-α (RXRα/Rxra)-dependent transcriptome in mouse liver NURSA

    Keywords: whole liver

    Description: Liver was isolated from male C57BL/6 RXRα/Rxra knockout and wild-type (WT) mice fed a 150 mg/kg ATRA or normal chow diet for 7d.

    ID: 10.1621/VeCAnn9CdU

  28. Time course transcriptomic analysis of 17β-estradiol (17βE2)-treated MCF-7 cells NURSA

    Keywords: epithelium MCF-7 cells

    Description: Human MCF-7 breast carcinoma cells were treated with or without 100 nM 17βE2 for 10 min, 40 min or 160 min.

    ID: 10.1621/wAeixXWJin

  29. Analysis of the hepatocyte nuclear factor 4-α variant 2 (HNF4α/HNF4A-2)-dependent transcriptome in rat pancreatic beta cells NURSA

    Keywords: islets beta cells INS1 cells

    Description: Rat INS-1 pancreatic beta-cells were stably transfected with a vector encoding tetracycline inducible human HNF4α/HNF4A-2 and cultured in the absence...

    ID: 10.1621/fJ25BjavY5

  30. Analysis of the 17β-estradiol (17βE2)-dependent transcriptome in human vagina NURSA

    Keywords: whole vagina

    Description: Vaginal samples were retrieved from women treated with or without 0.05 mg/day 17βE2 for 3 months.

    ID: 10.1621/HudStqvikW

  31. Analysis of the Am580 and rosiglitazone (Rosi) dependent transcriptomes in human monocyte-derived dendritic cells NURSA

    Keywords: dendritic cells monocyte-derived

    Description: Human monocyte-derived dendritic cells were treated with 100 nM Am580, 2.5 µM Rosi, and 1 µM AGN193109 for 5 days.

    ID: 10.1621/HslyUoSYAs

  32. Analysis of the MEK1/2-regulated transcriptome in R5020-treated human T47D cells NURSA

    Keywords: epithelium T47D cells

    Description: Human T47D breast cancer cells were treated with or without a combination of (1) vehicle or (2) 10 µM U0126 (a MEK 1/2 kinase inhibitor) for 10 minut...

    ID: 10.1621/XGSeVZH1LR

  33. Analysis of the 1,25-dihydroxyvitamin D3 (125DVD3)-dependent transcriptome in human primary bronchial smooth muscle cells NURSA

    Keywords: smooth muscle bronchus 1° cells

    Description: Human primary bronchial smooth muscle cells were treated with or without 100 nM 125DVD3 for 24 h.

    ID: 10.1621/vmOkKoHIoi

  34. Transcriptomic analysis of WY 14,643 and thyroid hormone receptor-β (TRβ/Thrb) Δ337T cross-talk in mouse heart NURSA

    Keywords: whole heart

    Description: 4-6 month old male wild-type mice or mice with cardiomyocyte specific expression of human TRβ/Thrb1 Δ337T dominant negative point mutant were treate...

    ID: 10.1621/iawFmJZiMO

  35. Timecourse analysis of the 17β-estradiol (17βE2) dependent transcriptome in T47D, MCF-7 and BT-474 breast cancer cell lines NURSA

    Keywords: epithelium MCF-7 cells

    Description: Human T47D, MCF-7, and BT-474 breast cancer cells were treated with 10 nM 17βE2 or vehicle for 1-24 h. 

    ID: 10.1621/gKdplxXbTj

  36. Time course analysis of the all-trans retinoic acid (ATRA)-regulated transcriptome in multipotent P19-derived A404 cells NURSA

    Keywords: pluripotent P19 cells

    Description: Multiprotein A404 cells expressing puromycin-N-acetyltransferase under the smooth muscle α-actin promoter, were treated with or without 1 µM ATRA fo...

    ID: 10.1621/olv1cR29xi

  37. Transcriptomic analysis of (1) wild type peroxisome prolferator activated receptor-γ coactivator 1 (PGC1α/PPARGC1); (2) estrogen receptor related re... NURSA

    Keywords: epithelium HepG2 cells

    Description: Human HepG2 liver cancer cells were subjected to adenoviral infection with empty vector or vectors encoding: (1) wild type PGC1; (2) ERRα/Esrra-disru...

    ID: 10.1621/datasets.02004

  38. Analysis of the estrogen receptor-α (ERα/ESR1)-dependent transcriptome in MCF-7 breast cancer cells NURSA

    Keywords: epithelium MCF-7 cells

    Description: Human MCF-7 breast cancer cells were transfected with an ERα/ESR1 shRNA plasmid.

    ID: 10.1621/5F49JYoGXU

  39. Analysis of the 17β-estradiol (17βE2)-regulated transcriptome in mouse hippocampus NURSA

    Keywords: hippocampus whole

    Description: Four month old ovariectomized female C57BL/6 mice were treated with 0.2mg/kg 17βE2 for 1 h prior to removal of hippocampi.

    ID: 10.1621/u8t3ZH9qPV

  40. Time course analysis of the Tamoxifen (Tam)-regulated transcriptome in mouse uterus NURSA

    Keywords: whole uterus

    Description: Ovariectomized female C57BL/6 mice were treated with and without 100 µg/kg body weight Tam for 2 h - 72 h.

    ID: 10.1621/hADB1k9ixl

  41. Analysis of the benzo[a]pyrene (B[a]P)-dependent transcriptome in primary hepatocytes from DNA repair-deficient mice NURSA

    Keywords: hepatocytes 1° cells

    Description: Primary hepatocytes from male wild type or DNA repair-deficient Xpa-/- TP53+/- C57BL/6 mice were cultured with 5 - 60 mM B[a]P or vehicle for 24 h..

    ID: 10.1621/mlrq6A5yRX

  42. Age-dependence and time-course analysis of the 17β-estradiol (17βE2)-regulated transcriptome in mouse hippocampus NURSA

    Keywords: hippocampus whole

    Description: Young (4 months), middle aged (12 months) or aged (18 months) ovariectomized female C57BL/6 mice were treated with and without a single dose of 5 ug 1...

    ID: 10.1621/2xdFWjzGKz

  43. Comparative analysis of hepatotoxicant transcriptomes in murine liver NURSA

    Keywords: whole liver

    Description: Liver was isolated from male and female 7 week old B6C3F1/Crl mice treated for 6 - 72 h with hepatotoxicant activators of: (i) arylhydrocarbon recepto...

    ID: 10.1621/IriKxcGfOe

  44. Chronic time course and dose-dependence analysis of the chlorpromazine (Chlorprom)-regulated transcriptome in rat liver NURSA

    Keywords: whole liver

    Description: Livers were isolated from rats treated for 4 - 29 d with or without 4.5 - 45 mg/kg bw/d Chlorprom.

    ID: 10.1621/cq2ujHYtTF

  45. Analysis of the 17β-estradiol (17βE2)-dependent hepatic transcriptome in the Lep null mutant mouse NURSA

    Keywords: whole liver

    Description: 12 week old female leptin (Lep) null mutant mice (Lep KO) were injected with or without 100 µg/kg body weight 17βE2 once daily for 30 days before li...

    ID: 10.1621/JwGTmrZrDh

  46. Dose analysis of the fenofibrate (Feno)-regulated transcriptome in rat liver NURSA

    Keywords: whole liver

    Description: 7 week old F344/N Slc rats were adminstered (1) ) 0 ppm; (2) 3,000 ppm (8.3 µM); or (3) 6,000 ppm (16.6 µM) Feno for 13 weeks and livers were remove...

    ID: 10.1621/voElhviZ6m

  47. Analysis of the estrogen receptor-related receptor-α (ERRα/Esrra)-regulated transcriptome in mouse kidney NURSA

    Keywords: whole kidney

    Description: Kidneys were isolated from ERRα/Esrra knockout and wild-type male 2-3 month old mice.

    ID: 10.1621/BJrnZDjy7P

  48. Analysis of the 17β-estradiol (17βE2)- and Tamoxifen (Tam)- regulated transcriptomes in Hs587T cells stably expressing estrogen receptor-α (ERα/ES... NURSA

    Keywords: epithelium Hs578T cells

    Description: Human Hs578T breast cancer cells were stably transfected with tetracycline-inducible vectors encoding ERα/ESR1 or ERβ/ESR2 and treated for 24 h with...

    ID: 10.1621/Il8lr1ojs9

  49. Transcriptomic profiling of GW3965-treated differentiated human adipocytes NURSA

    Keywords: WAT adipocytes unspecified 1° cells

    Description: In vitro-differentiated human adipocytes were treated with and without GW3965 for 24 h.

    ID: 10.1621/9JQpRTYs1Y

  50. Analysis of the 17β-estradiol (17βE2)-regulated transcriptome in rat hippocampus NURSA

    Keywords: hippocampus whole

    Description: Ovariectomized female Wistar rats were treated with and without 10 µg/kg body weight 17βE2 for 8 h before hippocampi were removed.

    ID: 10.1621/vbz3DkTCTH


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