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Displaying 80 of 80 results for " "
  1. Osmotic-Release Methylphenidate (OROS-MPH) for ADHD in Adolescents with Substance Use Disorders

    Keywords: adolescent; adhd; oros-mph

    Description: Research shows a high prevalence of Attention Deficit Hyperactivity Disorder (ADHD) in adolescents with substance abuse disorders and indicates that t...

  2. A Feasibility Study of a Telephone Enhancement Procedure (TELE) to Improve Participation in Continuing Care Activities

    Keywords:

    Description: Relapse rates are frequently high during the first few months after substance abuse treatment, often reversing many of the positive results of treatme...

  3. A Multicenter Safety Trial of Buprenorphine/Naloxone for the Treatment of Opiate Dependence

    Keywords: phase 3; buprenorphine; naloxone; opiate

    Description: This 52-week study is designed to determine the efficacy and safety of a buprenorphine/naloxone sublingual tablet formulation as an office-based thera...

  4. HIV and HCV Risk Reduction Interventions in Drug Detoxification and Treatment Settings

    Keywords: hepatitis c; hiv/aids

    Description: The connection between AIDS and drug injection is well established. Through June 2000, injection drug users accounted for more than a third of all cas...

  5. Screening, Motivational Assessment, Referral, and Treatment in Emergency Departments (SMART-ED)

    Keywords: screening brief intervention and referral to treatment; emergency department

    Description: This was a randomized, controlled trial that enrolled 1285 participants who were identified with problematic substance use during an ED visit. Partici...

  6. Patient Feedback: A Performance Improvement Study in Outpatient Addiction Treatment

    Keywords:

    Description: Although accrediting organizations, funding sources, and other agencies require community treatment providers to monitor performance, there are no stu...

  7. A Pilot Study of Osmotic-Release Methylphenidate in Initiating and Maintaining Abstinence in Smokers with ADHD

    Keywords: adhd; oros-mph; smoking

    Description: Adult ADHD is a common and impairing neuro-psychiatric disorder, affecting approximating seven to eight millions adults in the United States. Substanc...

  8. A Multicenter Clinical Trial of Buprenorphine in Treatment of Opiate Dependence

    Keywords: phase 3; buprenorphine; opiate

    Description: The primary purpose of this 16-week maintenance study is to determine the safety and effectiveness of 8 mg per day sublingual buprenorphine as compare...

  9. Safety Evaluation Of Cocaine Treatment Medication, Modafinil: Interactions With Intravenous Cocaine

    Keywords: cocaine; interaction; modafinil; phase 1b

    Description: The primary objectives of this study are to determine: 1. The safety/tolerability of modafinil as a cocaine treatment medication in cocaine dependent ...

  10. MET to Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse

    Keywords: motivational interviewing

    Description: Early dropout, partial attendance, and early relapse are common occurrences in most substance abuse treatment programs. Because the bulk of attrition ...

  11. Telemetric and Holter ECG Warehouse (THEW): Thorough QT Study #1 ECG Data

    Type: image

    Description: Study Design: The study was a double-blind, randomised, 5-way crossover study. The study consisted of a single cohort of 35 subjects. Each subject was...

  12. Telemetric and Holter ECG Warehouse (THEW): Exercise testing and perfusion imaging ECG Data

    Type: image

    Description: High-Resolution 12-lead continuous ECG from Patients undergoing Bruce protocol and myocardial perfusion imaging Study Design: This database include...

  13. MIT-BIH Arrhythmia Database

    Type: image

    Description: Since 1975, our laboratories at Boston's Beth Israel Hospital (now the Beth Israel Deaconess Medical Center) and at MIT have supported our own researc...

  14. Telemetric and Holter ECG Warehouse (THEW): Quinidine (AZCERT)

    Type: image

    Description: IDENTIFICATION : E-OTH-12-2365-019 The data from this study was conducted by Benton et al and published in 2000 (PDF). The study aimed at determining...

  15. Mito-Tracker Red Fluorescent Labelled Guinea Pig Hearts

    Type: image

    Description: Control guinea pig heart perfused with Mito-Tracker Red to label polarized mitochondria.

  16. Physionet MIMIC II Database

    Type: image

    Description: The MIMIC II Database consists of: 1) The MIMIC II Waveform Database version 3, a collection that includes 23,180 record sets for approximately 13,500...

  17. Cocaine Use Reduction with Buprenorphine (CURB)

    Keywords: naltrexone; cocaine; buprenorphine

    Description: This was a randomized, controlled trial that enrolled 302 cocaine-dependent participants who had either past-year opioid dependence or past-year opioi...

  18. Brief Strategic Family Therapy (BSFT) For Adolescent Drug Abusers

    Keywords: adolescent; family therapy

    Description: Adolescent drug abuse continues to be one of the most pressing public health issues in the United States—our nation’s teenagers continue to use il...

  19. A Multicenter Efficacy/Safety Trial of Buprenorphine/Naloxone for the Treatment of Opiate Dependence

    Keywords: phase 3; buprenorphine; naloxone; opiate

    Description: This 52-week study is designed to determine the efficacy and safety of a buprenorphine/naloxone sublingual tablet formulation as an office-based thera...

  20. Phase 2, Double-Blind, Placebo-Controlled Trial Of Reserpine For The Treatment Of Cocaine Dependence

    Keywords: reserpine; phase 2b; cocaine; stimulant

    Description: The primary objective of this study is to assess the efficacy of reserpine in reducing cocaine use in subjects with cocaine dependence (DSM-IV criteri...

  21. A Two-Phase Randomized Controlled Clinical Trial of Buprenorphine/Naloxone Treatment Plus Individual Drug Counseling for Opioid Analgesic Dependence

    Keywords: buprenorphine; naloxone; opiate

    Description: Patients with prescription opioid dependence may be able to benefit from pharmacological treatments shown to be effective in heroin addicts. Clinical ...

  22. Reducing HIV/STD Risk Behaviors: A Research Study for Men in Drug Abuse Treatment

    Keywords: hiv/aids; men; sexually transmitted infections

    Description: Drug treatment, itself, can have a powerful positive effect on HIV drug use risk behavior, especially needle use behaviors. However, sexual risk behav...

  23. Phase 2, Double-Blind, Placebo-Controlled Trial Of Bupropion For Methamphetamine Dependence

    Keywords: phase 2b; methamphetamine; bupropion; stimulant

    Description: The primary objective of this study is to assess the efficacy of bupropion in reducing methamphetamine use in subjects with methamphetamine dependence...

  24. Buprenorphine/Naloxone-Facilitated Rehabilitation for Opioid Dependent Adolescents/Young Adults

    Keywords: adolescent; buprenorphine; heroin; naloxone

    Description: The use of heroin by American adolescents is at its highest level since the 1960s. However, the treatment of young heroin users has not been particula...

  25. Suboxone (Buprenorphine/Naloxone) Taper: A Comparison of Two Schedules

    Keywords: buprenorphine; naloxone; opiate; suboxone

    Description: For decades clinicians have been frustrated by the inability to successfully detoxify opiate addicted patients because opiate-based detoxification, on...

  26. A Randomized Controlled Evaluation of Buspirone for Relapse-Prevention in Adults with Cocaine Dependence (BRAC)

    Keywords: cocaine; buspirone; stimulant

    Description: This was a randomized, controlled pilot trial in which 62 inpatient/residential participants were recruited from six sites to participate in a study c...

  27. Telemetric and Holter ECG Warehouse (THEW): Thorough QT Study #2 ECG Data

    Type: image

    Description: Study Design: This is a single-center, single-dose, randomized, double-blind, double-dummy, placebo-controlled, active-comparator, four-way crossover ...

  28. Telemetric and Holter ECG Warehouse (THEW): Chest Pain (IMMEDIATE HR ECG) ECG Data

    Type: image

    Description: High-Resolution Holter 12-lead ECG from Chest Pain Patients. Study Design: The Ischemia Monitoring and Mapping in the Emergency Department in Appro...

  29. Physionet ANSI/AAMI EC13 Test Waveforms

    Type: image

    Description: The files in this set can be used for testing a variety of devices that monitor the electrocardiogram. The recordings include both synthetic and real ...

  30. Telemetric and Holter ECG Warehouse (THEW): Occluded Artery Trial (Stony Brooke Univ.)

    Type: image

    Description: OAT:Defibrillator in Non-Ischemic Cardiomyopathy Treatment Evaluation Trial IDENTIFICATION : E-OTH-03-0802-018 The database (E-OTH-03-0802-018) ho...

  31. Physionet MGH/MF Multi-Parameter Waveform Database

    Type: image

    Description: The Massachusetts General Hospital/Marquette Foundation (MGH/MF) Waveform Database is a comprehensive collection of electronic recordings of hemodynam...

  32. An Evaluation of Neurocognitive Function, Oxidative Damage, and Their Association With Treatment Outcomes in Methamphetamine and Cocaine Abusers

    Keywords: stimulant

    Description: This was an ancillary study to CTN-0031, a randomized controlled trial of Stimulant Abuser Groups to Engage in 12-Step (STAGE-12). 219 participants fr...

  33. Smoking Cessation Treatment with Transdermal Nicotine Replacement Therapy in Substance Abuse Rehabilitation Programs

    Keywords: nicotine replacement; smoking

    Description: The prevalence of cigarette smoking among substance abusers is high, and substance abusers who smoke have more health problems, higher death rates, an...

  34. Buprenorphine/Naloxone versus Clonidine for Outpatient Opiate Detoxification

    Keywords: buprenorphine; clonidine; naloxone; opiate

    Description: For decades clinicians have been frustrated by the inability to successfully detoxify opiate addicted patients because opiate-based detoxification, on...

  35. Phase 2, Double-Blind, Placebo-Controlled Trial Of Modafinil For The Treatment Of Cocaine Dependence

    Keywords: phase 2b; modafinil; cocaine; stimulant

    Description: The primary objective of this study is to evaluate the efficacy of modafinil relative to placebo in increasing the weekly mean proportion of cocaine n...

  36. Reducing HIV/STD Risk Behaviors: A Research Study for Women in Drug Abuse Treatment

    Keywords: hiv/aids; sexually transmitted infections; women

    Description: Women in drug-using communities are one of the fastest growing groups of people with AIDS in the U.S. Female drug users, even if they are in drug trea...

  37. Long-Term Follow-Up to CTN-0030 (A Two-Phase Randomized Controlled Clinical Trial of Buprenorphine/Naloxone Treatment Plus Individual Drug Counseling ...

    Keywords: buprenorphine; naloxone; opiate

    Description: This was an ancillary study to CTN-0030, a two-phase randomized controlled clinical trial of buprenorphine/naloxone treatment plus individual drug cou...

  38. Women's Treatment for Trauma and Substance Use Disorders

    Keywords: ptsd; women

    Description: Post-traumatic stress disorder (PTSD) is common among drug users, particularly among women. Those who suffer from both of these conditions also strugg...

  39. Project Aware: HIV Rapid Testing & Counseling in STD Clinics in the U.S. – an Adaptation of CTN-0032

    Keywords: hiv/aids; sexually transmitted infections

    Description: This was a randomized, controlled trial in which 5012 participants seeking medical or health services from nine STD clinics were enrolled in a study c...

  40. Phase 2, Double-Blind, Placebo-Controlled Trial Of Modafinil For Methamphetamine Dependence

    Keywords: phase 2b; modafinil; methamphetamine; stimulant

    Description: The primary objective of this study is to assess the efficacy of modafinil in increasing the number of methamphetamine non-use weeks in subjects with ...

  41. Job Seekers Training for Patients with Drug Dependence

    Keywords: job training

    Description: Drug abuse clients who are employed typically do better in their treatment than those who are unemployed. In addition, unemployment is a chronic probl...

  42. Telemetric and Holter ECG Warehouse (THEW): Torsades de Pointes (TdPs) ECG Data

    Type: image

    Description: This database includes six 12-lead recordings (sampling frequency 180Hz) from six individuals who experienced one or multiple episodes of TdPs. These ...

  43. Physionet MIT-BIH Noise Stress Test Database

    Type: image

    Description: This database includes 12 half-hour ECG recordings and 3 half-hour recordings of noise typical in ambulatory ECG recordings. The noise recordings were...

  44. Telemetric and Holter ECG Warehouse (THEW): DEFINITE Study (NorthWestern Univ.)

    Type: image

    Description: DEFINITE: Defibrillator in Non-Ischemic Cardiomyopathy Treatment Evaluation Trial IDENTIFICATION : E-HOL-03-0401-017 ICD therapy to optimal medical ...

  45. Physionet European ST-T Database

    Type: image

    Description: The European ST-T Database is intended to be used for evaluation of algorithms for analysis of ST and T-wave changes. This database consists of 90 ann...

  46. Motivational Incentives for Enhanced Drug Abuse Recovery: Methadone Clinics

    Keywords: methadone; motivational incentives

    Description: To improve treatment outcomes, it is necessary to use interventions that can motivate clients to attend treatment and initiate and sustain abstinence....

  47. Web-delivery of Evidence-Based, Psychosocial Treatment for Substance Use Disorders

    Keywords: web-based therapy; telemedicine; computer-assisted therapy

    Description: This was a randomized, controlled trial in which 507 participants in outpatient treatment for substance use disorders were recruited from ten sites to...

  48. HIV Rapid Testing and Counseling in Drug Abuse Treatment Programs in the U.S.

    Keywords: hiv/aids

    Description: This was a randomized, controlled clinical trial in which 1,281 adults receiving drug abuse treatment were recruited from 12 sites to participate in a...

  49. Motivational Enhancement Treatment to Improve Treatment Engagement and Outcome for Spanish-Speaking Individuals Seeking Treatment for Substance Abuse

    Keywords: motivational enhancement

    Description: Because Spanish-speaking drug users are often not included in studies of drug abuse treatment, little is known about what works with this population. ...

  50. Buprenorphine/Naloxone versus Clonidine for Inpatient Opiate Detoxification

    Keywords: buprenorphine; clonidine; naloxone; opiate

    Description: For decades clinicians have been frustrated by the inability to successfully detoxify opiate addicted patients because opiate-based detoxification, on...

  51. Double-Blind, Placebo-Controlled Assessment Of Potential Interactions Between Intravenous Methamphetamine And Osmotic-Release Methylphenidate (Oros-Mp...

    Keywords: phase 1b; oral osmotic-release; methylphenidate; methamphetamine; intravenous; stimulant; interaction

    Description: The primary objective of this study is to determine the safety of the OROS-MPH concurrent with i.v. d-methamphetamine infusions of 15 mg and 30 mg. Sa...

  52. MI (Motivational Interviewing) to Improve Treatment Engagement and Outcome in Subjects Seeking Treatment for Substance Abuse

    Keywords: motivational interviewing

    Description: This study aims to evaluate the efficacy of Motivational Interview (MI) techniques, relative to a standard treatment intake interview at participating...

  53. Cocaine-Metyrapone Interaction Study

    Keywords: metyrapone; cocaine; stimulant; interaction; phase 1b

    Description: The primary objectives of this study are: 1. To demonstrate that a 750 mg dose of MRP is safe when used concomitantly with cocaine. 2. To demonstrate ...

  54. Motivational Enhancement Therapy (MET) to Improve Treatment Utilization and Outcome in Pregnant Substance Users

    Keywords: motivational interviewing; women

    Description: About 5% of women use illicit substances during pregnancy, and approximately 22% of these also report using tobacco or alcohol. A number of treatment ...

  55. Stimulant Abuser Groups to Engage in 12-Step (STAGE-12): Evaluation of a Combined Individual-Group Intervention to Reduce Stimulant and Other Drug Use...

    Keywords: stimulant

    Description: This was a randomized, controlled clinical trial in which 471 stimulant abusers were recruited from 10 sites to participate in study comparing 12-Step...

  56. Assessment Of Potential Interactions Between Intravenous Methamphetamine And Oral Selegiline

    Keywords: interaction; methamphetamine; phase 1b; selegiline; stimulant

    Description: The primary objective of this study is to determine the safety of the selegiline concurrent with dmethamphetamine challenges of 15 mg and 30 mg i.v. T...

  57. Telemetric and Holter ECG Warehouse (THEW): Sotalol IV and History of TdPs ECG Data

    Type: image

    Description: Cardiac Patients with and without a History of Drug-induced Torsades de Pointes Study Design: The 34 patients were enrolled after being admitted to...

  58. Telemetric and Holter ECG Warehouse (THEW): Acute Myocardial Infarction ECG Data

    Type: image

    Description: Acute Myocardial Infarction: Patients (N=93) with acute myocardial infarction were identifed based on clinical symptomatic: sudden chest pain (typi...

  59. Telemetric and Holter ECG Warehouse (THEW): FDA1-quinidine, verapamil, ranolazine, dofetilide

    Type: image

    Description: IDENTIFICATION : E-OTH-12-5232-020 Background: This database was shared by the FDA with the THEW in October 2014. The database includes a unique sets...

  60. Physionet Long-Term ST Database

    Type: image

    Description: The Long-Term ST Database contains 86 lengthy ECG recordings of 80 human subjects, chosen to exhibit a variety of events of ST segment changes, includ...

  61. Telemetric and Holter ECG Warehouse (THEW): Chest Pain (IMMEDIATE LR ECG) ECG Data

    Type: image

    Description: Chest Pain Patients from the IMMEDIATE AIM Study Study Design: The Ischemia Monitoring and Mapping in the Emergency Department in Appropriate Triag...

  62. Motivational Incentives for Enhanced Drug Abuse Recovery: Drug Free Clinics

    Keywords: motivational incentives

    Description: To improve treatment outcomes, it is necessary to use interventions that can motivate clients to attend treatment and initiate and sustain abstinence....

  63. A Multicenter Safety Trial of Buprenorphine/Naloxone for the Treatment of Opiate Dependence

    Keywords: phase 3; buprenorphine; naloxone; opiate

    Description: To determine if the 4:1 buprenorphine/naloxone combination tablet can be effectively used to treat patients with opiate dependence in various treatmen...

  64. Smoking-Cessation and Stimulant Treatment (S-CAST): Evaluation of the Impact of Concurrent Outpatient Smoking-Cessation and Stimulant Treatment on Sti...

    Keywords: bupropion; nicotine replacement; smoking; stimulant

    Description: This was a randomized, controlled trial in which 538 participants were recruited from 12 sites to participate in a study comparing treatment as usual ...

  65. Starting Treatment with Agonist Replacement Therapies (START)

    Keywords: buprenorphine; methadone; opiate

    Description: This was a randomized, open-label, multi-center, Phase 4 study to assess the changes in liver enzymes related to treatment with buprenorphine/naloxone...

  66. Phase 2, Double-Blind, Placebo-Controlled Trial Of Topiramate For The Treatment Of Methamphetamine Dependence

    Keywords: topiramate; phase 2b; methamphetamine; stimulant

    Description: The primary efficacy objective of this study is to determine if topiramate relative to placebo reduces methamphetamine use in subjects with methamphet...

  67. Characteristics of Screening, Evaluation, and Treatment of HIV/AIDS, Hepatitis C Viral Infections, and Sexually Transmitted Infections in Substance Ab...

    Keywords: hepatitis c; hiv/aids; sexually transmitted infections

    Description: Substance abuse is associated with a wide spectrum of medical disorders, including infections due to the human immunodeficiency virus (HIV) and the he...

  68. Stimulant Reduction Intervention using Dosed Exercise (STRIDE)

    Keywords: stimulant

    Description: This was a randomized, controlled trial that enrolled 302 participants diagnosed with stimulant abuse or dependence that began substance use treatment...

  69. Assessment Of Potential Interactions Between Intravenous Cocaine And Tolcapone

    Keywords: cocaine; interaction; phase 1b; stimulant; tolcapone

    Description: The primary objective of this study is to determine the safety of tolcapone treatment, compared to placebo treatment, concurrent with i.v. cocaine inf...

  70. Assessment of the National Drug Abuse Clinical Trials Network: A Baseline for Investigating Diffusion of Innovation

    Keywords: community treatment programs

    Description: The "Baseline Study" is designed to help us better understand the community treatment programs participating in the NIDA Clinical Trials Network (CTN)...

  71. Double-Blind, Placebo-Controlled Trial Of Ondansetron For The Treatment Of Cocaine Dependence

    Keywords: cocaine; ondansetron; phase 1b; stimulant

    Description: The primary objective of this study is to conduct a preliminary assessment of the possible efficacy of ondansetron to reduce cocaine use in outpatient...

  72. Telemetric and Holter ECG Warehouse (THEW): AF and cardioversion ECG Data

    Type: image

    Description: Cardiac Patients with Atrial Fibrillation This database includes 12-lead continuous recordings (from 73 ECGs from patients with persistent AF refer...

  73. Telemetric and Holter ECG Warehouse (THEW): Healthy Patients ECG Data

    Type: image

    Description: The study population consists of 203 healthy subjects from the Intercity Digital Electrocardiogram Alliance (IDEAL) database. Twenty-four hour Holter ...

  74. Telemetric and Holter ECG Warehouse (THEW): ESRD patients during and after hemodialysis ECG Data

    Type: image

    Description: High-Resolution 12-lead 48-hours continuous ECG from end-stage renal disease Patients: during and after hemodialysis session. Study Design: The go...

  75. High Spatial Resolution Mouse Heart Data Sets

    Type: image

  76. Physionet PTB Diagnostic ECG Database

    Type: image

    Description: This database of 549 high-resolution 15-lead ECGs (12 standard leads together with Frank XYZ leads) includes clinical summaries for each record. From ...

  77. Telemetric and Holter ECG Warehouse (THEW): Coronary Artery Patients

    Type: image

    Description: Study Population:This group of cardiac patients is from the Intercity Digital Electrocardiogram Alliance (IDEAL) database. These coronary artery disea...

  78. Axon Instruments Voltage Clamp Protocols

    Type: image

    Description: These are Axon Instruments Voltage Clamp files (.abf and .pro) with the following information: 13509000 - Basel...

  79. Physionet MIMIC Database

    Type: image

    Description: The PhysioBank archives contain 72 complete records from this database, together with periodic measurements ("numerics") for all 121 records of the da...

  80. Telemetric and Holter ECG Warehouse (THEW): Genotyped Long QT syndrome ECG Data

    Type: image

    Description: Congential Long QT syndrome In the mid eighties, Philippe Coumel initiated the systematic recording of Holter ECGs in patients with a prolonged ven...


Displaying 80 of 80 results for " "