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  1. Differential expression analysis between Microadenoma and Macroadenoma in Cushing's Disease BioProject

    ID: PRJNA294157

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: s differentially expressed, we highlighted CCND2, ZNF676, DAPK1, and TIMP2, and their differential expression was validated through quantitative real-time PCR in another cohort of 15 non-invasive and 3 invasive cortocotrophinomas. We also identified potential biological pathways associated with growth and invasiveness, TGF-β and G protein signaling pathways, DNA damage response pathway, and pathways associated with focal adhesion. Our study revealed a differential pattern of genetic signature in a subgroup of MAC, supporting a genetic influence on corticotrophinomas in patients with CD. Overall design: We analyzed RNA from frozen corticotrophinoma from 12 female subjects with Cushing's Disease using the Affymetrix Human Exon 1.0 ST platform (annotation file: HuEx-1_0-st-v2.na33.1.hg19.transcript.csv). Array data was processed by Affymetrix Expression Console 1.3. No technical replicates were performed....

Displaying 1 of 1 results for "ZNF676"