ZNF383 | bioCADDIE Data Discovery Index
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Displaying 2 of 2 results for "ZNF383"
  1. ZN383_MACFA UniProt:Swiss-Prot

    ID: Q4R6C2

    Description: Zinc finger protein 383 KRAB C2H2-type 1 C2H2-type 2 C2H2-type 3 C2H2-type...

  2. Epigenetic minicircuitry of AML1-ETO/THAP10/MIR383 contributes t(8;21) AML leukemogenesis BioProject

    ID: PRJNA319156

    Keywords: Epigenomics

    Access Type: download

    dataset.description: e study demonstrated that a novel hypermethylated zinc finger containing protein-THAP10 is a target gene and can be epigenetic silenced by AML1-ETO at transcriptional level in t(8;21) AML and silencing of THAP10 by AML1-ETO predicts a poor clinical outcome. Our findings also identified that THAP10 is a bona fide target of miR-383 which can be epigenetic activated by AML1-ETO. In this study, we provided evidence that epigenetic silencing of THAP10 is the mechanistic link between AML1-ETO fusion proteins and tyrosine kinase cascades. In addition, we showed that THAP10 is a nuclear protein which inhibits myeloid proliferation inhibition and promotes differentiation both in vitro and in vivo. Altogether, our results revealed an unexpected and important link between fusion protein ...

Displaying 2 of 2 results for "ZNF383"