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Displaying 20 of 21 results for "ZC3H12D"
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  1. Transcription profiling of human monocytic cell line, THP-1 cells were stimulated 4 hours with chemokine MIG or CCL2/MCP-1 ArrayExpress

    ID: E-FPMI-5

    Description: monocytic cell line, THP-1 cells were stimulated 4 hours with chemokine MIG or CCL2/MCP-1 (a chemokine that is not positively charged and has no antimicrobial activity). By using a 21,000 oligo-based DNA human microarray we analyzed gene expression profiles induced by MIG and by

  2. ZC12A_RAT UniProt:Swiss-Prot

    ID: A0JPN4

    Description: Endoribonuclease ZC3H12A C3H1-type Ubiquitin association domain Necessary for interaction with TANK RNase RNA binding Necessary for interaction with

  3. Dissection of cancer cell and stromal cell-derived signals in melanoma xenografts following treatment with the stromal-targeting agent DMXAA OmicsDI

    ID: E-GEOD-26308

    Date Released: 05-02-2014

    Description: 5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a tumor vascular disrupting agent, is shown here to have substantial activity as a single agent against huma...

  4. Dissection of cancer cell and stromal cell-derived signals in melanoma xenografts following treatment with the stromal-targeting agent DMXAA ArrayExpress

    ID: E-GEOD-26308

    Description: 5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a tumor vascular disrupting agent, is shown here to have substantial activity as a single agent against huma...

  5. Gene expression profiling defines ATP as a key regulator of human dendritic cell functions BioProject

    ID: PRJNA101679

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: extensively compared the gene expression profiles induced by ATPγS and PGE2 in human MoDCs using microarray technology. At 6 h of stimulation, ATPγS initiated an impressive expression profile compared to that of PGE2 (1125 genes compared to 133 genes respectively) but after 24 h, the number of genes regulated by ATPγS...
  6. Nogo-B protects mice against lipopolysaccharide-induced acute lung injury OmicsDI

    ID: E-GEOD-48787

    Date Released: 06-03-2014

    Description: olar barrier damage and noncardiogenic lung edema induced by excessive inflammation reactions. Nogo-B, a member of the reticulon 4 protein family, plays a critical role in modulating macrophages and neutrophils’ function in inflammation. Its ro...

  7. Dissection of cancer cell and stromal cell-derived signals in melanoma xenografts following treatment with the stromal-targeting agent DMXAA BioProject

    ID: PRJNA136749

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: 5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a tumor vascular disrupting agent, is shown here to have substantial activity as a single agent against huma...
  8. Gulf War Illness Gut Microbiome : Altered gut microbiome in a mouse model of gulf war illness causes neuroinflammation and intestinal injury via leaky... BioProject

    ID: PRJEB19474

    Keywords: Other

    Access Type: download

    dataset.description: ome caused significant decrease in tight junction protein Occludin with a concomitant increase in Claudin-2, a signature of a leaky gut. Resultant leaching of gut caused portal endotoxemia that led to upregulation of toll like receptor 4 (TLR4) activation in the small intestine and the brain. TLR4 knock out mice and mice that had gut decontamination showed significant decrease in tyrosine nitration and inflammatory mediators IL1β and MCP-1 in both the small intestine and frontal cortex. These events signified that gut dysbiosis with simultaneous leaky gut and systemic endotoxemia-induced TLR4 activation contributes to GW chemical-induced neuroinflammation and gastrointestinal disturbances....
  9. Nogo-B protects mice against lipopolysaccharide-induced acute lung injury BioProject

    ID: PRJNA211644

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. The matricellular protein CCN1 activates a pro-inflammatory genetic program in murine macrophages OmicsDI

    ID: E-GEOD-19731

    Date Released: 03-27-2012

    Description: Effects of the matricellular protein CCN1 on macrophage inflammatory gene expression was tested in a macrophage cell line I-13.35. CCN1 (CYR61) is a matricellu...

  11. Nogo-B protects mice against lipopolysaccharide-induced acute lung injury ArrayExpress

    ID: E-GEOD-48787

    Description: olar barrier damage and noncardiogenic lung edema induced by excessive inflammation reactions. Nogo-B, a member of the reticulon 4 protein family, plays a critical role in modulating macrophages and neutrophils’ function in inflammation. Its ro...

  12. The matricellular protein CCN1 activates a pro-inflammatory genetic program in murine macrophages ArrayExpress

    ID: E-GEOD-19731

    Description: Effects of the matricellular protein CCN1 on macrophage inflammatory gene expression was tested in a macrophage cell line I-13.35. CCN1 (CYR61) is a matricellu...

  13. The matricellular protein CCN1 activates a pro-inflammatory genetic program in murine macrophages BioProject

    ID: PRJNA122187

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. Reversible and irreversible differentiation of cardiac fibroblasts OmicsDI

    ID: E-GEOD-51824

    Date Released: 01-20-2014

    Description: own by stress fiber absence, low levels of α-SMA protein expression, and high levels of proliferation (32-fold increase after 12 days). Fb seeded in collagen matrices induced no contraction, whereas p-MyoFb and non-p-MyoFb induced 2.5- and 4-fold contraction. Fb produced low levels of collagen and secreted high levels of IL-10. Non-p-MyoFb showed high collagen production and high MCP-1 and TIMP-1 secretion. Transcriptome analysis indicated differential gene expression between all phenotypes. Dedifferentiation of p-MyoFb, but not of non-p-MyoFb, was induced by SD-208 despite maintained stress, shown by stress fiber de-polymerization in 30% of p-MyoFb vs in 8% of non-p-MyoFb. Stress fiber de-polymerization could be induced by mechanical strain release in p-MyoFb and non-p-MyoFb (2 day culture in unrestrained 3-D collagen matrices). Only p-MyoFb showed true dedifferentiat...

  15. Reversible and irreversible differentiation of cardiac fibroblasts ArrayExpress

    ID: E-GEOD-51824

    Description: own by stress fiber absence, low levels of α-SMA protein expression, and high levels of proliferation (32-fold increase after 12 days). Fb seeded in collagen matrices induced no contraction, whereas p-MyoFb and non-p-MyoFb induced 2.5- and 4-fold contraction. Fb produced low levels of collagen and secreted high levels of IL-10. Non-p-MyoFb showed high collagen production and high MCP-1 and TIMP-1 secretion. Transcriptome analysis indicated differential gene expression between all phenotypes. Dedifferentiation of p-MyoFb, but not of non-p-MyoFb, was induced by SD-208 despite maintained stress, shown by stress fiber de-polymerization in 30% of p-MyoFb vs in 8% of non-p-MyoFb. Stress fiber de-polymerization could be induced by mechanical strain release in p-MyoFb and non-p-MyoFb (2 day culture in unrestrained 3-D collagen matrices). Only p-MyoFb showed true dedifferentiat...

  16. LV-Induced Dendritic Cells for AML Immunotherapy ArrayExpress

    ID: E-GEOD-37231

    Description: 1 (lacking the DNA-binding domain), GM-CSF and IL-4 was used to transduce human monocytes. The overnight transduction procedure induced the self-differentiation of monocytes into highly viable and immunophenotypically stable “SmartDC/tWT1” (GM-CSF+, IL-4+, WT1+, IL-6+, IL-8+, TNF-?+, MCP-1+, HLA-DR+, CD86+, CCR2+, CCR5+). RNA expression pattern analyses revealed up...

  17. LV-Induced Dendritic Cells for AML Immunotherapy BioProject

    ID: PRJNA158959

    Keywords: Transcriptome or Gene expression

    Access Type: download

  18. Reversible and irreversible differentiation of cardiac fibroblasts BioProject

    ID: PRJNA225508

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: own by stress fiber absence, low levels of α-SMA protein expression, and high levels of proliferation (32-fold increase after 12 days). Fb seeded in collagen matrices induced no contraction, whereas p-MyoFb and non-p-MyoFb induced 2.5- and 4-fold contraction. Fb produced low levels of collagen and secreted high levels of IL-10. Non-p-MyoFb showed high collagen production and high MCP-1 and TIMP-1 secretion. Transcriptome analysis indicated differential gene expression between all phenotypes. Dedifferentiation of p-MyoFb, but not of non-p-MyoFb, was induced by SD-208 despite maintained stress, shown by stress fiber de-polymerization in 30% of p-MyoFb vs in 8% of non-p-MyoFb. Stress fiber de-polymerization could be induced by mechanical strain release in p-MyoFb and non-p-MyoFb (2 day culture in unrestrained 3-D collagen matrices). Only p-MyoFb showed true dedifferentiat...
  19. Transcription profiling of liver from from spontaneously hypertensive rats expressing human C-reactive protein treated with salsalate ArrayExpress

    ID: E-MTAB-5079

    Description: rats that transgenically express human C-reactive protein (SHR-CRP). We treated 15-month-old male transgenic SHR-CRP rats with salsalate (200 mg/kg/day) mixed as part of a standard diet for 4 weeks. A corresponding untreated control group of male transgenic SHR-CRP rats were fed a standard diet without salsalate. In a similar fashion, we studied a group of nontransgenic SHR treated with salsalate and an untreated group of nontransgenic SHR controls. Parameters of inflammation and glucose and lipid metabolism were measured using standard methods. Statistical significance was evaluated by two-way ANOVA. In t...

  20. Serotonin stimulation of alveolar macrophages from wild type and 5-HT2C deficient animals BioProject

    ID: PRJNA120831

    Keywords: Transcriptome or Gene expression

    Access Type: download


Displaying 20 of 21 results for "ZC3H12D"