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Displaying 20 of 50 results for "XPO5"
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  1. Re-evaluation of the roles of DROSHA, Exportin 5, and DICER in microRNA biogenesis BioProject

    ID: PRJNA312310

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Re-evaluation of the roles of DROSHA, Exportin 5, and DICER in microRNA biogenesis ArrayExpress

    ID: E-GEOD-77989

    Description: nuclear export of precursor miRNA (pre-miRNA) by Exportin 5 (XPO5), and cytoplasmic processing of pre-miRNA by DICER. To gain a deeper understanding of the contribution of each of these maturation steps, we deleted DROSHA, XPO5, and DICER in the sam...

  3. Re-evaluation of the roles of DROSHA, Exportin 5, and DICER in microRNA biogenesis OmicsDI

    ID: E-GEOD-77989

    Date Released: 03-18-2016

    Description: nuclear export of precursor miRNA (pre-miRNA) by Exportin 5 (XPO5), and cytoplasmic processing of pre-miRNA by DICER. To gain a deeper understanding of the contribution of each of these maturation steps, we deleted DROSHA, XPO5, and DICER in the sam...

  4. Crystal structure of Exportin-5:RanGTP:pre-miRNA complex PDB

    ID: PDB:3A6P

    Description: Exportin-5/13-mer peptide/GTP-binding nuclear protein Ran/RNA

  5. MicroRNA profiling in human colon cancer cell lines ArrayExpress

    ID: E-MTAB-160

    Description: he export of precursor miRNAs into the cytoplasm (XPO5), HCT15 and DLD1. To test the microRNAs involved several comparisons have been performed: DLD1 and HCT15 cell lines have been compared with XPO5 wild-type cell lines (HCT116 and RKO). Furthermore the trans...

  6. MicroRNA profiling in human colon cancer cell lines OmicsDI

    ID: E-MTAB-160

    Date Released: 01-25-2012

    Description: he export of precursor miRNAs into the cytoplasm (XPO5), HCT15 and DLD1. To test the microRNAs involved several comparisons have been performed: DLD1 and HCT15 cell lines have been compared with XPO5 wild-type cell lines (HCT116 and RKO). Furthermore the trans...

  7. Effect of Exportin-5 expression on Mouse fibroblasts in cell cycle re-entry phase BioProject

    ID: PRJNA134635

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. The Lupus autoantigen La prevents mis-channeling of tRNA fragments into the human microRNA pathway [PAR-CLIP] BioProject

    ID: PRJNA311970

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: (miRNA). We demonstrate that fully complementary 5' leader and 3' trailer of the pre-tRNA-Ile form a double-stranded RNA molecule that has low affinity to La. Instead, Exportin 5 (Xpo5) recognizes it as miRNA precursor and transports it into the cytoplasm for Dicer processing and Ago loading. Thus, La functions as gatekeeper to ensure correct tRNA generation and to protect the miRNA pathway from potentially functional tRNA fragments. Overall design: Identification by PAR-CLIP analysis of tRNAs differentially associated with FLAG/HA-Dicer under La knockdown or control knockdown....
  9. The Lupus autoantigen La prevents mis-channeling of tRNA fragments into the human microRNA pathway [miRNA-seq] BioProject

    ID: PRJNA308305

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: (miRNA). We demonstrate that fully complementary 5' leader and 3' trailer of the pre-tRNA-Ile form a double-stranded RNA molecule that has low affinity to La. Instead, Exportin 5 (Xpo5) recognizes it as miRNA precursor and transports it into the cytoplasm for Dicer processing and Ago loading. Thus, La functions as gatekeeper to ensure correct tRNA generation and to protect the miRNA pathway from potentially functional tRNA fragments. Overall design: Identification and characterization of miRNAs and small RNAs derived from pol III transcripts interacting with Ago1-4 isolated by Ago-APP or input samples under La knockdown or control knockdown....
  10. Effect of Exportin-5 expression on Mouse fibroblasts in cell cycle re-entry phase OmicsDI

    ID: E-GEOD-25498

    Date Released: 06-02-2014

    Description: To analyze the effect of Exportin-5 expression on the MEF cells in cell cycle re-entry phase, we have employed whole genome microarray ex...

  11. Effect of Exportin-5 expression on Mouse fibroblasts in cell cycle re-entry phase ArrayExpress

    ID: E-GEOD-25498

    Description: To analyze the effect of Exportin-5 expression on the MEF cells in cell cycle re-entry phase, we have employed whole genome microarray ex...

  12. WilmsMutationInDROSHA : Recurrent somatic mutation in DROSHA is a frequent event in Wilms tumor and induces microRNA profile changes BioProject

    ID: PRJEB6113

    Keywords: Other

    Access Type: download

    dataset.description: ons in other genes of this pathway (DGCR8, DICER, XPO5 and TARBP2). By assessing the miRNA expression pattern of the recurrent DROSHA-E1147K mutated tumors and cell lines expressing this mutated protein, we determined that the E1147K mutation leads to a predominant down-regulation of a subset of mature miRNAs. We confirmed that the down-regulation occurred exclusively in mature miRNAs and not primary miRNA transcripts, suggesting that the DROSHA E1147K mutation affects correct processing of primary miRNAs. Our data underscore the pivotal role of the miRNA biogenesis pathway in WT tumorigenesis, particularly the major miRNA processing gene DROSHA....
  13. Human immunodeficiency virus 1 : RNA-Seq of RNAs encapsidated by Human Immunodeficiency Virus 1 BioProject

    ID: PRJNA320293

    Keywords: raw sequence reads

    Access Type: download

    dataset.description: f a pre-tRNA requires the nuclear export receptor Exportin 5, indicating that HIV-1 recruits at least some newly made ncRNAs in the cytoplasm. Together, our work identifies the set of RNAs packaged by HIV-1 and reveals that early steps in HIV-1 assembly intersect with host cell ncRNA biogenesis pathways....
  14. XPO1_MOUSE UniProt:Swiss-Prot

    ID: Q6P5F9

    Description: Exportin-1 Importin N-terminal HEAT 1 HEAT 2 HEAT 3 HEAT 4 HEAT 5 HEAT 6 HEAT 7 HEAT 8 HEAT 9 HEAT 10 Necessary ...

  15. XPO1_RAT UniProt:Swiss-Prot

    ID: Q80U96

    Description: Exportin-1 Importin N-terminal HEAT 1 HEAT 2 HEAT 3 HEAT 4 HEAT 5 HEAT 6 HEAT 7 HEAT 8 HEAT 9 HEAT 10 Necessary ...

  16. Crystal structure of RanGTP-Exportin 4-eIF5A complex PDB

    ID: PDB:5DLQ

    Description: Exportin-4, GTP-binding nuclear protein Ran, Eukaryotic translation initiation factor 5A-1

  17. Quantitative polyadenylation map of mouse embryonic epidermal lineages OmicsDI

    ID: E-GEOD-37641

    Date Released: 05-03-2014

    Description: nts of the miRNA pathway, including Dicer, Dgcr8, Xpo5 and Ago2, show dynamic 3' UTR formation patterns, indicating a self-regulatory mechanism. Together, our quantitative analysis reveals a dynamic picture of mRNA 3' end formation in closely related somatic stem cell lineages. Perform 3SEQ in E14 epidermal basal cells and E14 epidermal suprabasal cells....

  18. Quantitative polyadenylation map of mouse embryonic epidermal lineages ArrayExpress

    ID: E-GEOD-37641

    Description: nts of the miRNA pathway, including Dicer, Dgcr8, Xpo5 and Ago2, show dynamic 3' UTR formation patterns, indicating a self-regulatory mechanism. Together, our quantitative analysis reveals a dynamic picture of mRNA 3' end formation in closely related somatic stem cell lineages. Perform 3SEQ in E14 epidermal basal cells and E14 epidermal suprabasal cells....

  19. Crystal structure of yeast CRM1 (Xpo1p) in complex with yeast RanBP1 (Yrb1p) and yeast RanGTP (Gsp1pGTP) PDB

    ID: PDB:3M1I

    Description: GTP-binding nuclear protein GSP1/CNR1, Ran-specific GTPase-activating protein 1, Exportin-1

  20. Karyopherin nuclear state PDB

    ID: PDB:3ICQ

    Description: Exportin-T, GTP-binding nuclear protein GSP1/CNR1/RNA Complex


Displaying 20 of 50 results for "XPO5"