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Displaying 20 of 97 results for "WNT10B"
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  1. Data from: Wnt5a regulates the assembly of human adipose-derived stromal vascular fraction-derived microvasculatures Dryad

    DateIssued: 04-21-2016

    Description: Human adipose-derived stromal vascular fraction (hSVF) cells are an easily accessible, heterogeneous cell system that can spontaneo...

  2. The effect of SubAB treatment on Wnt-High and Wnt-Low sorted human colon cancer stem cells ArrayExpress

    ID: E-GEOD-65879

    Description: -stress and subsequent activation of the unfolded protein response was investigated in colon cancer stem cells and more differentiated colon cancer cells Human colon cancer deriv...

  3. scriptional profiling shows altered expression of wnt pathway- and lipid metabolism-related genes as well as melanogenesis-related genes in melasma.... BioProject

    ID: PRJNA293168

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Crystal structure of the Kelch domain of human KLHL12 PDB

    ID: PDB:2VPJ

    Description: KELCH-LIKE PROTEIN 12

  5. Genome wide screen reveals WNT11, a noncanonical WNT gene, as a target of ETS transcription factor ERG BioProject

    ID: PRJNA126007

    Keywords: Epigenomics

    Access Type: download

  6. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS BioProject

    ID: PRJNA121771

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. Involvement of ERK, Wnt and BMP2 signaling in human articular chondrocyte dedifferentiation in monolayer culture ArrayExpress

    ID: E-GEOD-42235

    Description: es in gene expression during dedifferentiation of human articular chondrocytes to identify underlying mechanisms. Methods: RNA was isolated from monolayer-cultured primary human articular chondrocytes at serial passages. Gene expression was analyzed by microarray. Based on the microarray analysis, relevant genes and pathways were identified. Their functions in chondrocyte dedifferentiation were further investigated in detail. Results: In vitro expanded

  8. Expression profiling of MRC5 senescent fibroblasts BioProject

    ID: PRJNA116923

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: d genes were enriched in three KEGG pathways, the Wingless-type MMTV integration site (WNT) signaling pathway (WNT16, PLCB4, CCND2, SFRP1, WNT5B, RAC2), cytokine-cytokine receptor interaction (TNFRSF10D, TNFRSF10B, TNFRSF10C, IL1R2, IL18, VEGFC), and the p53 signaling pathway (CDKN1A, TNFRSF10B, PERP, STEAP3, ZMAT3). Repressed genes were enriched in three KEGG pathways, cell cycle (PKMYT1, CDC7, CCNE2, MCM4, BUB1, CDC25A, CDKN1B, MCM6, PLK1, CDKN2C, CCNB2, MCM3, BUB1B, CCNA2, CDC2), cytokine-cytokine receptor interaction (KITLG, IL11, TNFSF4, CCL2, PDGFRA, TNFRSF11B, TGFBR1, IL1R1, TNFRSF1...
  9. Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS ArrayExpress

    ID: E-GEOD-19403

    Description: pression during repair and that expression of the Wnt pathway mediator Tcf4 (aka Tcf7l2) within OLPs is specific to lesioned—but not normal—adult white matter. We report that β-catenin signaling is active during oligodendrocyte development and remyelination in vivo. Moreover, we observed similar regulation of Tcf4 in the developing human CNS and lesions of MS. Data mining revealed elevated levels of Wnt pathway mRNA transcripts and proteins within MS lesions, indicating activation of the pathway in this pathological context. We show that dysregulation of Wnt–β-catenin signaling in OLPs results in profound delay of both developmental myelination and remyelination, based on (1) conditional activation of β-catenin in the oligodendrocyte lineage in vivo and (2) findings from APCMin mice, which lack one f...

  10. Expression profiling of desmoid tumors and nodular fasciitis BioProject

    ID: PRJNA93023

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: TX2, EYA2, OAS1, MITF, TCF20), and members of the Wnt signaling pathway (AXIN2, WISP1, SFRP). Remarkably, almost one fourth of the differentially expressed genes encode proteins associated with inflammation and tissue remodeling, including members of the interferon (IFN), tumor necrosis factor (TNF) and transforming growth factor beta (TGF-beta) signaling pathways as well as metalloproteinases (MMP1, 9, 13, 23), urokinase plasminogen activator (PLAU) and cathepsins. Our observations provide the first comparative molecular characterization of desmoid tumors and nodular fasciitis and suggest that selected tyrosine kinases, transcription factors and members of the Wnt, TGF-beta, IFN and TNF signaling pathways may be implicated in influencing and distinguishing their fate. Keywords: comparative genomic hybridization Overall design: 12 desmoid tumors and 6 nodular fasciitis were analyzed using MRC5 as common reference. One duplicate with dye swap was performed (DT1 dye-swap)...
  11. Hong Shan Capsule (HSC) offers radioprotection and modulates acute lethal total-body irradiation-induced alterations of gene expression in rats BioProject

    ID: PRJNA247730

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: -cytokine receptor interaction, mitogen-activated protein kinase (MAPK) signaling pathway, peroxisomal proliferator-activated receptor (PPAR)signaling pathway, gonadotropin-releasing hormone (GnRH) signaling pathway, Wnt signaling pathway, janus kinase-signal transducers and activators of transcription (Jak-STAT) signaling pathway, Notch signaling pathway.Our analysis indicated that the pretreatment of rats with HSC attenuated radiation-induced these pathways, such as multiple MAPK pathways, suggesting that the protective effect of HSC acts mainly through the attenuation of these pathways. Overall design: The rats were randomly assigned to one of the three following treatment groups (10-12 animals per group): normal control, radiation and...
  12. CXCL12 Mediated T-Cell Migration Via Activation of Wnt5A GEMMA

    ID: 2602

    Keywords: functional genomics

    Description: is on CXCL12- treated T-cells, and found that the Wnt family of proteins was significantly upregulated during CXCL12 treatment. Confirmation of these results by real-time PCR and Western analysis indicated that the non-canonical Wnt pathway was specifically upregulated during CXCL12 treatment. In vitro and in vivo knockdown studies confirm that b-catenin (the key mediator of canonical

  13. A novel way for enriching human melanoma precursor cells to identify cellular targets for antineoplastic therapy BioProject

    ID: PRJNA125015

    Keywords: Transcriptome or Gene expression

    Access Type: download

  14. C-terminal splice variants of Gprc5b are expressed in maturing neurons and influence neurite outgrowth BioProject

    ID: PRJNA111239

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Gprc5b, a retinoic acid-inducible orphan G protein–coupled receptor, is a member of the group C metabotropic glutamate receptor family...
  15. RNA-Seq of Single Prostate CTCs Implicates Non-Canonical Wnt Signaling in Antiandrogen Resistance BioProject

    ID: PRJNA281419

    Keywords: Transcriptome or Gene expression

    Access Type: download

  16. Data from: QTL linkage mapping of wing length in zebra finch using genome-wide single nucleotide polymorphisms markers Dryad

    DateIssued: 01-25-2012

    Description: erestingly, all of the QTL signals co-locate with Wnt growth factors and closely interacting genes (Wnt3a, Wnt5a, Wnt6, Wnt7a, Wnt9a, RhoU and RhoV). Our findings therefore suggest that standing genetic variation in the Wnt genes might be linked to avian wing morphology, although there are many other genes that also fall within the confidence regions....

  17. Tobacco Smoke Induces Polycomb-mediated Repression of Dickkopf-1 in Lung Cancer Cells GEMMA

    ID: 2645

    Keywords: functional genomics

    Description: Polycomb-mediated repression of Dkk-1 activates Wnt signaling and enhances tumorigenic potential of lung cancer cells following tobacco smoke exposure Last Updated (by provider):...

  18. Concerted involvement of Cdx/Hox genes and Wnt signalling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone.... BioProject

    ID: PRJNA143903

    Keywords: Variation

    Access Type: download

  19. RNA-Seq of Single Prostate CTCs Implicates Non-Canonical Wnt Signaling in Antiandrogen Resistance ArrayExpress

    ID: E-GEOD-67980

    Description: reated cases indicates activation of noncanonical Wnt signaling (P=0.0064). Ectopic expression of Wnt5a in prostate cancer cells attenuates the antiproliferative effect of AR inhibition, while its suppression in drug-resistant cells restores partial sensitivity, a correlation also evident in an established mouse model. Thus, single cell analysis of prostate CTCs reveals heterogeneity in signaling pathways that could contribute to treatment failure. A total of 221 single candidate prostate CTCs were isolated from 18 patients with metastatic prostate cancer and 4 patients with localized prostate cancer. Of these, 133 cells (60%) had RNA of sufficient quality for amplification and next generation RNA sequencing, and 122 (55%) had >100,000 uniquely aligned sequencing reads. In addition to candidate CTCs, we also obtained comprehens...

  20. Gene expression analyses of primary tumors and metastases, using p53 mouse models BioProject

    ID: PRJNA185264

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: cle homolog 2 (NKD2), a negative regulator of the Wnt signaling pathway, to be significantly downregulated in metastatic OS. An assessment of human OS tumors revealed downregulation of NKD2 in metastatic and recurrent OS. We determined that downregulation was secondary to methylation of the NKD2 promoter region for both mouse and human tumors. Furthermore, in vivo investigations indicate that NKD2 overexpression significant...

Displaying 20 of 97 results for "WNT10B"