VPS35 | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 19 of 19 results for "VPS35"
i
  1. Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on alpha-synuclein BioProject

    ID: PRJNA270712

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on alpha-synuclein OmicsDI

    ID: E-GEOD-64304

    Date Released: 01-03-2015

    Description: xpected genetic interaction between two PD genes, VPS35 and EIF4G1. We provide evidence that EIF4G1 upregulation causes defects associated with protein misfolding. Expression of a sortilin protein rescues these defects, downstream of VPS35, suggesting a potential role for sortilins in PD. We also show interactions between VPS35, EIF4G1 and alpha-synuclein, a protein with a key role in the pathogenesis of both sporadic and familial PD. We extend our findings from yeast to an anima...

  3. Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on alpha-synuclein ArrayExpress

    ID: E-GEOD-64304

    Description: xpected genetic interaction between two PD genes, VPS35 and EIF4G1. We provide evidence that EIF4G1 upregulation causes defects associated with protein misfolding. Expression of a sortilin protein rescues these defects, downstream of VPS35, suggesting a potential role for sortilins in PD. We also show interactions between VPS35, EIF4G1 and alpha-synuclein, a protein with a key role in the pathogenesis of both sporadic and familial PD. We extend our findings from yeast to an anima...

  4. Structure of retromer VPS26-VPS35 subunits bound to SNX3 PDB

    ID: PDB:5F0J

    Description: Vacuolar protein sorting-associated protein 35, Vacuolar protein sorting-associated protein 26A, Sorting nexin-3

  5. Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 PDB

    ID: PDB:5F0L

    Description: Vacuolar protein sorting-associated protein 35, Vacuolar protein sorting-associated protein 26A, Sorting nexin-3, Natural resistance-associated macrop...

  6. Structure of VPS35 N terminal region PDB

    ID: PDB:5F0K

    Description: Vacuolar protein sorting-associated protein 35

  7. Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 (SeMet labeled) PDB

    ID: PDB:5F0M

    Description: Vacuolar protein sorting-associated protein 35, Vacuolar protein sorting-associated protein 26A, Sorting nexin-3, Natural resistance-associated macrop...

  8. Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1(L557M) (SeMet labeled) PDB

    ID: PDB:5F0P

    Description: Vacuolar protein sorting-associated protein 35, Vacuolar protein sorting-associated protein 26A, Sorting nexin-3, Divalent cation transporter II

  9. VPS35_BOVIN UniProt:Swiss-Prot

    ID: Q2HJG5

    Description: Vacuolar protein sorting-associated protein 35 Interaction with SNX3 Interaction with SNX3 Interaction with SLC11A2 Interaction with IGF2R cytoplasmic...

    gene.name: VPS35
  10. FAM21_PONAB UniProt:Swiss-Prot

    ID: Q5RDC1

    Description: ient for interaction with CCDC93 Interaction with VPS35 Interaction with phospholipids Required for interaction with F-actin-capping protein subunit alpha (CAPZA1 or CAPZA2 or CAPZA3) LFa 1 LFa 2 LFa 3 LFa 4 LFa 5 LFa 6 LFa 7 LFa 8 LFa 9 LFa 10 LFa 11 LFa 12 LFa 13 LFa 14 LFa 15 LFa 16 LFa 17 LFa 18 LFa 19 LFa 20 LFa 21 Glu-rich...

  11. FAM21_CRIGR UniProt:Swiss-Prot

    ID: Q91Y25

    Description: ient for interaction with CCDC93 Interaction with VPS35 Interaction with phospholipids Required for interaction with F-actin-capping protein subunit alpha (CAPZA1 or CAPZA2 or CAPZA3) LFa 1 LFa 2 LFa 3 LFa 4 LFa 5 LFa 6 LFa 7 LFa 8 LFa 9 LFa 10 LFa 11 LFa 12 LFa 13 LFa 14 LFa 15 LFa 16 LFa 17 LFa 18 Poly-Glu Poly-Asp Poly-Asp Ph...

  12. FAM21_RAT UniProt:Swiss-Prot

    ID: Q80X08

    Description: ient for interaction with CCDC93 Interaction with VPS35 Interaction with phospholipids Required for interaction with F-actin-capping protein subunit alpha (CAPZA1 or CAPZA2 or CAPZA3) LFa 1 LFa 2 LFa 3 LFa 4 LFa 5 LFa 6 LFa 7 LFa 8 LFa 9 LFa 10 LFa 11 LFa 12 LFa 13 LFa 14 LFa 15 LFa 16 LFa 17 Poly-Glu Poly-Asp Poly-Asp Poly-Ser ...

  13. Crystal structure of mouse VPS29 complexed with Mn2+ PDB

    ID: PDB:3PSN

    Description: Vacuolar protein sorting-associated protein 29 (E.C.3.1.3.3)

    dataset.keywords: VPS35
  14. Functional architecture of the retromer cargo-recognition complex PDB

    ID: PDB:2R17

    Description: Functional architecture of the retromer cargo-recognition complex

    gene.name: VPS35, MEM3
  15. Crystal structure of mouse VPS29 complexed with Zn2+ PDB

    ID: PDB:3PSO

    Description: Vacuolar protein sorting-associated protein 29

    dataset.keywords: VPS35
  16. High coverage target resequencing of coding and regulatory regions of 38 Parkinson's disease genes associated either to the Mendelian or the sporadic ... OmicsDI

    ID: EGAS00001000973

    Date Released:

    Description: , MAPT, RIT2, GIGYF2, HTRA2, EIF4G1, SNCA, LRRK2, VPS35, PINK1, DJ1, ATP13A2, UCHL1, PARK2, FBXO7, and PLA2G6). Sequencing was performed on 249 Parkinson's idiopathic cases and 145 unrelated controls of Spanish origin. All sequencing data was generated with an Illumina Hiseq2000 instrument after enrichment with a custom NimbleGen array. Raw reads were mapped to human reference genome hg19/GRCh37 using BWA aligner....

  17. Unconventional Endosome-Like Compartment and Retromer Complex (Sangare et al., 2016) OmicsDI

    ID: PXD004390

    Date Released: 06-20-2016

    Description: typified by a singular architecture with a trimer Vps35-Vps26-Vps29 core complex that serves as a hub for the known endosome-like compartment (ELC) and parasite-specific proteins. Conditional ablation of TgVps35 revealed that the retromer complex is not only crucial for the biogenesis of secretory organelles, but also for maintaining parasite architecture. The aim of this quantitative experiment was to determine the stoichiometry...

  18. Crystal structure of human vps26 PDB

    ID: PDB:2FAU

    Description: Vacuolar protein sorting 26

    primaryPublication.title: The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain.
  19. Toxoplasma gondii LC-MS/MS OmicsDI

    ID: PXD003603

    Date Released: 04-12-2016

    Description: logues of the core retromer components, Vps26 and Vps35, which are known to regulate retrograde transport from endosomes to the trans-Golgi Network (TGN) in yeast and mammals. Here, we report that a singular architecture with a trimer Vps35-Vps26-Vps29 core complex acts as the major cargo endosomal recycling machinery and is required for parasite integrity and more specifically for secretory organelle biogenesis and maintenance of a multiple ligand-binding transporter at the T. gondii membrane. Our findings provide strong evidence that the unconventional TgSORTLR-containing endosome-like compartment is involved in distinct mechanisms for the delivery of major retromer-dependent cargo. In this current work, we demonstrate a definitive role for the endocytic recycling pathway in T. gondii pathogenesis....


Displaying 19 of 19 results for "VPS35"