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Displaying 20 of 57 results for "UBE2C"
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  1. ex (APC15 deletion mutant) in complex with the E2 UBE2C/UBCH10 poised for ubiquitin ligation to substrate (APC/C-CDC20-substrate-UBE2C)... PDB

    ID: PDB:5KHR

    Description: subunit 2, Anaphase-promoting complex subunit 5, Ubiquitin-conjugating enzyme E2 C (E.C.2.3.2.23,2.3.2.24), Cell division cycle protein 20 homolog, HSL1 peptide, Anaphase-promoting complex subunit 7...

  2. omplex/Cyclosome (APC/C-CDH1) with a cross linked Ubiquitin variant-substrate-UBE2C (UBCH10) complex representing key features of multiubiquitination... PDB

    ID: PDB:5L9U

    Description: t 5, Fizzy-related protein homolog, HSL1 peptide, Ubiquitin-conjugating enzyme E2 C (E.C.2.3.2.23,2.3.2.24), Anaphase-promoting complex subunit 7...

  3. CRYSTAL STRUCTURE OF HUMAN MITOTIC-SPECIFIC UBIQUITIN-CONJUGATING ENZYME, UBCH10 PDB

    ID: PDB:1I7K

    Description: UBIQUITIN-CONJUGATING ENZYME E2 H10 (E.C.6.3.2.19)

  4. MELK and UBE2C gene knockdown in prostate cancer cell line PC3 BioProject

    ID: PRJNA146599

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. MELK and UBE2C gene knockdown in prostate cancer cell line PC3 ArrayExpress

    ID: E-GEOD-32873

    Description: In order to address the putative role of MELK and UBE2C in prostate cancer development and progression, we performed functional analysis upon siRNA-based knockdown, and searched for...

  6. MELK and UBE2C gene knockdown in prostate cancer cell line PC3 OmicsDI

    ID: E-GEOD-32873

    Date Released: 10-29-2012

    Description: In order to address the putative role of MELK and UBE2C in prostate cancer development and progression, we performed functional analysis upon siRNA-based knockdown, and searched for...

  7. Structure of an APC2-UBCH10 complex reveals distinctive cullin-RING ligase mechanism for Anaphase-promoting complex/Cyclosome PDB

    ID: PDB:4YII

    Description: molecule, molecule 2

  8. Expression correlates of the full-length androgen receptor and its splicing variants ArrayExpress

    ID: E-GEOD-36549

    Description: eased expression of the AR-driven cell cycle gene UBE2C. In addition, protein expression of AR-V7, but not AR-FL, is positively correlated with UBE2C in clinical CRPC specimens. The cumulative in vitro and in vivo evidence support an adaptive shift toward AR-V-mediated signaling in at least a subset of CRPC tumors as the AR-LBD is rendered inactive, suggesting an important mechanism contributing to drug resistance to CRPC therapies. LNCaP cells lacking AR-V were transfected with AR-V7 with or without androgen stimulation of AR-FL (4 conditions); LNCaP95 cells expressing AR-Vs were treated with control siRNA or siRNA trageting AR-LBD or AR-DBD, with or without androgen stimulation of AR-FL (6 conditions); VCaP cells expressing AR-Vs in the presence of androgen were treated with control siRNA, siRNA trageting AR-LBD, DMSO or MDV3100 to inhibit AR-FL (4 conditions). Total 14 arrays with no replicates....

  9. Modeling lethal prostate cancer variant with small cell carcinoma features [genomic profile] ArrayExpress

    ID: E-GEOD-33053

    Description: and are characterized by a marked upregulation of UBE2C and other M-phase cell cycle genes in the absence of AR, retinoblastoma (RB1) and cyclin D1 (CCND1) expression and confirm these findings in a panel of CRPC patients’ samples. In addition, array comparative genomic hybridization of the xenografts showed that the SCPC/LCNEC tumors display more copy number variations than the adenocarcinoma counterparts and that there is amplification of the UBE2C locus and microdeletions of RB1 in a subset of these, but no AR nor CCND1 deletions. Moreover, the AR, RB1, and CCND1 promoters showed no CpG methylation in the SCPC xenografts. Conclusion: Modeling human prostate cancer with xenografts allows in-depth and detailed studies of its underlying biology. The detailed clinical annotation of the donor tumors enables associations of anticipated relevance to be made. Futures studies in the xenografts will address the functional significance of the findings. Total of 6 samples...

  10. Modeling lethal prostate cancer variant with small cell carcinoma features [expression profile] ArrayExpress

    ID: E-GEOD-32967

    Description: and are characterized by a marked upregulation of UBE2C and other M-phase cell cycle genes in the absence of AR, retinoblastoma (RB1) and cyclin D1 (CCND1) expression and confirm these findings in a panel of CRPC patients’ samples. In addition, array comparative genomic hybridization of the xenografts showed that the SCPC/LCNEC tumors display more copy number variations than the adenocarcinoma counterparts and that there is amplification of the UBE2C locus and microdeletions of RB1 in a subset of these, but no AR nor CCND1 deletions. Moreover, the AR, RB1, and CCND1 promoters showed no CpG methylation in the SCPC xenografts. Conclusion: Modeling human prostate cancer with xenografts allows in-depth and detailed studies of its underlying biology. The detailed clinical annotation of the donor tumors enables associations of anticipated relevance to be made. Futures studies in the xenografts will address the functional significance of the findings. 22 samples were analysed, that included MD...

  11. Affymetrix Oncoscan array data for aggressive variant prostate cancer (AVPC) samples BioProject

    ID: PRJNA298365

    Keywords: Variation

    Access Type: download

    dataset.description: re stained for RB, p53, AR, NKX3-1, ASCL1, AURKA, UBE2C and Ki67. We determined copy number alterations (CNA) by Oncoscan® using DNA from 36 of the 59 samples and 8 PDX lines....
  12. UBE3D_BOVIN UniProt:Swiss-Prot

    ID: Q1JQA1

    Description: Removed E3 ubiquitin-protein ligase E3D Interaction with UBE2C HECT-like N-acetylalanine

  13. UBE3D_PONAB UniProt:Swiss-Prot

    ID: Q5RFG8

    Description: Removed E3 ubiquitin-protein ligase E3D Interaction with UBE2C HECT-like N-acetylalanine

  14. Expression correlates of the full-length androgen receptor and its splicing variants BioProject

    ID: PRJNA153421

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: eased expression of the AR-driven cell cycle gene UBE2C. In addition, protein expression of AR-V7, but not AR-FL, is positively correlated with UBE2C in clinical CRPC specimens. The cumulative in vitro and in vivo evidence support an adaptive shift toward AR-V-mediated signaling in at least a subset of CRPC tumors as the AR-LBD is rendered inactive, suggesting an important mechanism contributing to drug resistance to CRPC therapies. Overall design: LNCaP cells lacking AR-V were transfected with AR-V7 with or without androgen stimulation of AR-FL (4 conditions); LNCaP95 cells expressing AR-Vs were treated with control siRNA or siRNA trageting AR-LBD or AR-DBD, with or without androgen stimulation of AR-FL (6 conditions); VCaP cells expressing AR-Vs in the presence of androgen were treated with control siRNA, siRNA trageting AR-LBD, DMSO or MDV3100 to inhibit AR-FL (4 conditions). Total 14 arrays with no replicates....
  15. DNA microarray analysis for HepG2 cells exposed to arsenic trioxide ArrayExpress

    ID: E-GEOD-48441

    Description: urthermore, three cell cycle genes (i.e., CDC25B, UBE2C, and PTTG1) were proposed as marker genes of inorganic arsenic exposure. Those results indicated the potential pro-carcinogenic actions of inorganic arsenic occur in environmentally relevant exposures (as low as 0.07 µM). In this study, we examined the gene expression alteration in HepG2 cells exposed to arsenic trioxide (5 nM to 40 µM as As2O3 for 48 hours) by DNA microarray with 8795 human genes. HepG2 cells were also exposed to ε-caprolactam as a reference of non carcinogen since it is the only chemical categorized in IARC’s group 4 (Probably Not Carcinogenic). MQ water was used as control. For replicate, three dishes were prepared for each sample and individually treated in parallel....

  16. Nr4a1 and Nr4a3 upregulate cell cycle genes upregulated in the Nkx6.1 beta-cell proliferation pathway ArrayExpress

    ID: E-GEOD-55078

    Description: ents of the anaphase-promoting complex, including Ube2c. We set up a microarray using primary rat islets that were left untreated or transduced with adenoviruses overexpressing GFP, Nr4a1 or Nr4a3 for 48 h....

  17. UBE3D_MOUSE UniProt:Swiss-Prot

    ID: Q8BX13

    Description: Removed E3 ubiquitin-protein ligase E3D Interaction with UBE2C HECT-like N-acetylalanine

  18. UBE3D_RAT UniProt:Swiss-Prot

    ID: Q3T1H6

    Description: Removed E3 ubiquitin-protein ligase E3D Interaction with UBE2C HECT-like N-acetylalanine

  19. Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR1 as prognostic biomarkers independent of WHO grade ArrayExpress

    ID: E-GEOD-74385

    Description: ve R+M tumors was af rmed for PTTG1, AURKB, ECT2, UBE2C and PRC1, while MN1 and LEPR discriminated between NR and R+M WHO grade II tumors. Univariate survival analysis revealed a significant association with progression-free survival for PTTG1, LEPR, MN1, ECT2, PRC1, COX10, UBE2C expression, while multivariate analysis identified a prediction for PTTG1 and LEPR mRNA expression independent of gender, WHO grade and extent of resection. Finally, stainings of PTTG1 and LEPR confirmed malignancy-associated protein expression changes. In conclusion, based on the so far largest study sample of WHO grade III and recurrent meningiomas we report a comprehensive transcriptional landscape and two prognostic markers. Comparative transcriptomic analysis of 62 low- and high-grade meningiomas...

  20. Modeling lethal prostate cancer variant with small cell carcinoma features [genomic profile] OmicsDI

    ID: E-GEOD-33053

    Date Released: 05-04-2014

    Description: and are characterized by a marked upregulation of UBE2C and other M-phase cell cycle genes in the absence of AR, retinoblastoma (RB1) and cyclin D1 (CCND1) expression and confirm these findings in a panel of CRPC patients’ samples. In addition, array comparative genomic hybridization of the xenografts showed that the SCPC/LCNEC tumors display more copy number variations than the adenocarcinoma counterparts and that there is amplification of the UBE2C locus and microdeletions of RB1 in a subset of these, but no AR nor CCND1 deletions. Moreover, the AR, RB1, and CCND1 promoters showed no CpG methylation in the SCPC xenografts. Conclusion: Modeling human prostate cancer with xenografts allows in-depth and detailed studies of its underlying biology. The detailed clinical annotation of the donor tumors enables associations of anticipated relevance to be made. Futures studies in the xenografts will address the functional significance of the findings. Total of 6 samples...


Displaying 20 of 57 results for "UBE2C"