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Displaying 20 of 68 results for "TRAF5"
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  1. Crystal Structure of the TRAF domain of TRAF5 PDB

    ID: PDB:4GJH

    Description: TNF receptor-associated factor 5

  2. Homo sapiens : CD40 and TANK peptide libraries BioProject

    ID: PRJNA307051

    Keywords: raw sequence reads

    Access Type: download

    dataset.description: Tumor necrosis receptor-associated factors (TRAFs) constitute a family of adapter proteins that act in numerous signaling pathw...
  3. STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A 5-RESIDUE CD40 PEPTIDE PDB

    ID: PDB:1D00

    Description: STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A 5-RE...

  4. Transcription profiling of pig coronary arterial endothelial cells by multiple passaging in vitro ArrayExpress

    ID: E-GEOD-8974

    Description: agen, thrombospondin 1 and 3, transforming growth factor ?) upregulated and nuclear factor kappa B (NF?B)-signaling pathway [IkappaB, TNF receptor-associated factor 1 and 5 (TRAF1 and 5)] activated in senescent cells. The differential gene expression of MnSOD and TRAF5 was confirmed at the protein level by Western blotting and biochemical assay (MnSOD). The basal and stimulated (by tumor necrosis factor-?)?levels of NF?B were augmented as demonstrated by electrophoretic mobility shift assay. In summary, cultured senescent endothelial cells exhibit reduced nitric oxide production, and decreased antioxidative, proliferative capacities, augmented expression of extracellular matrix components and activation of NF?B. These molecular changes do not exactly mimick those occurring...

  5. To study the genomic changes in senescent porcine coronary arterial endothelial cells by multiple passaging in vitro BioProject

    ID: PRJNA102429

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: agen, thrombospondin 1 and 3, transforming growth factor beta) upregulated and nuclear factor kappa B (NFKB)-signaling pathway [IkappaB, TNF receptor-associated factor 1 and 5 (TRAF1 and 5)] activated in senescent cells. The differential gene expression of MnSOD and TRAF5 was confirmed at the protein level by Western blotting and biochemical assay (MnSOD). The basal and stimulated (by tumor necrosis factor-alpha) levels of NFKB were augmented as demonstrated by electrophoretic mobility shift assay. In summary, cultured senescent endothelial cells exhibit reduced nitric oxide production, and decreased antioxidative, proliferative capacities, augmented expression of extracellular matrix components and activation of NFKB. These molecular changes do not exactly mimick those oc...
  6. Microarray Profile of Measles Virus Nucleocapsid Protein (MVNP) Regulated Gene Expression in RANKL and M-CSF stimulated normal human bone marrow deriv... ArrayExpress

    ID: E-GEOD-29106

    Description: activating protein (6.5 fold), OSCAR (5.5 fold), TRAF5 (8.5 fold) mRNA expression compared to empty vector (EV) transduced cells. MVNP also elevated gene expression of cytokines/growth factors such as IL-17 (18 fold), IL-1F7 (10 fold), IL-17R (4.5 fold) and IL-11 (7 fold). Interestingly, MVNP transduced cells demonstrated high level expression of signal regulatory protein beta 1 (SIRPβ1) (353 fold). SIRPβ1 has been shown to interact with DAP 12, an ITAM containing adaptor protein which plays an important role in osteoclast differentiation. Real-time PCR analysis of total RNA isolated from normal human peripheral blood monocytes transduced with MVNP confirmed upregulation of SIRPβ1 mRNA expression in the absence of RANKL stimulation. In contrast, RANKL stimulation did not alter SIRPβ1 expression in these cells. Furthermore, bone marrow mononuclear cells derived from patients with PDB showed high levels of SIRPβ1 mRNA expression compared to normal subjects. Thus, MVNP regula...

  7. DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3 PDB

    ID: PDB:1L0A

    Description: TNF receptor associated factor 3, TRAF family member-associated

  8. Transcription profiling of pig coronary arterial endothelial cells by multiple passaging in vitro OmicsDI

    ID: E-GEOD-8974

    Date Released: 05-02-2014

    Description: agen, thrombospondin 1 and 3, transforming growth factor ?) upregulated and nuclear factor kappa B (NF?B)-signaling pathway [IkappaB, TNF receptor-associated factor 1 and 5 (TRAF1 and 5)] activated in senescent cells. The differential gene expression of MnSOD and TRAF5 was confirmed at the protein level by Western blotting and biochemical assay (MnSOD). The basal and stimulated (by tumor necrosis factor-?)?levels of NF?B were augmented as demonstrated by electrophoretic mobility shift assay. In summary, cultured senescent endothelial cells exhibit reduced nitric oxide production, and decreased antioxidative, proliferative capacities, augmented expression of extracellular matrix components and activation of NF?B. These molecular changes do not exactly mimick those occurring...

  9. DOWNSTREAM REGULATOR TANK BINDS TO THE CD40 RECOGNITION SITE ON TRAF3 PDB

    ID: PDB:1KZZ

    Description: TNF receptor associated factor 3, TRAF family member-associated

  10. Microarray Profile of Measles Virus Nucleocapsid Protein (MVNP) Regulated Gene Expression in RANKL and M-CSF stimulated normal human bone marrow deriv... BioProject

    ID: PRJNA140367

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: activating protein (6.5 fold), OSCAR (5.5 fold), TRAF5 (8.5 fold) mRNA expression compared to empty vector (EV) transduced cells. MVNP also elevated gene expression of cytokines/growth factors such as IL-17 (18 fold), IL-1F7 (10 fold), IL-17R (4.5 fold) and IL-11 (7 fold). Interestingly, MVNP transduced cells demonstrated high level expression of signal regulatory protein beta 1 (SIRPβ1) (353 fold). SIRPβ1 has been shown to interact with DAP 12, an ITAM containing adaptor protein which plays an important role in osteoclast differentiation. Real-time PCR analysis of total RNA isolated from normal human peripheral blood monocytes transduced with MVNP confirmed upregulation of SIRPβ1 mRNA expression in the absence of RANKL stimulation. In contrast, RANKL stimulation did not alter SIRPβ1 expression in these cells. Furthermore, bone marrow mononuclear cells derived from patients with PDB showed high levels of SIRPβ1 mRNA expression compared to normal subjects. Thus, MVNP regula...
  11. Structure of mitochondrial Hsp90 (TRAP1) with ADP-BeF3 PDB

    ID: PDB:4J0B

    Description: TNF receptor-associated protein 1

  12. Structure of mitochondrial Hsp90 (TRAP1) with ADP-ALF4- PDB

    ID: PDB:4IYN

    Description: TNF receptor-associated protein 1

  13. Transcription profiling of human frozen tumor biopsies from diffuse large cell lynohoma patients reveals mutations of multiple genes deregulate the NF... ArrayExpress

    ID: E-GEOD-12195

    Description: n that its most aggressive subtype, ABC-DLBCL, is associated with constitutive activation of the NF-kB transcription complex. However, except for a small fraction of cases, it remains unclear whether NF-kB activation in these tumors represents an intrinsic program of the tumor cell of origin or a pathogenetic event. Here we show that >50% of ABC-DLBCL and a smaller fraction of GCB-DLBCL carry somatic mutations at multiple genes, including negative (TNF...

  14. TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma BioProject

    ID: PRJNA116491

    Keywords: Variation

    Access Type: download

    dataset.description: ry infiltrate. Constitutive activation of nuclear factor-kappaB (NF-kappaB) in HRS cells which transcriptionally regulates expression of multiple anti-apoptotic factors and pro-inflammatory cytokines plays a central role in the pathogenesis of cHL (1, 2). In non-stimulated condition, NF-kappaB proteins are rendered inactive by binding to their inhibitors (IkappaB s), which seq...
  15. TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma ArrayExpress

    ID: E-GEOD-15264

    Description: ry infiltrate. Constitutive activation of nuclear factor-kappaB (NF-kappaB) in HRS cells which transcriptionally regulates expression of multiple anti-apoptotic factors and pro-inflammatory cytokines plays a central role in the pathogenesis of cHL (1, 2). In non-stimulated condition, NF-kappaB proteins are rendered inactive by binding to their inhibitors (IkappaB s), which seq...

  16. -seq analysis reveals endogenous aryl hydrocarbon receptor regulation is highly associated with eicosanoid synthesis and tumor necrosis factor act... BioProject

    ID: PRJNA226275

    Keywords: Transcriptome or Gene expression

    Access Type: download

  17. E2AK2_RAT UniProt:Swiss-Prot

    ID: Q63184

    Description: DRBM 1 DRBM 2 Protein kinase ATP Interaction with TRAF5 Ser-rich Proton acceptor ATP N-acetylalanine Phosphoserine Phosphotyrosine; by autocatalysis Phosphotyrosine; by autocatalysis Phosphotyrosine; by autocatalysis Phosphothreonine; by autocatalysis Ph...

  18. Mutations of multiple genes deregulate the NF-kB pathway in diffuse large B cell lymphoma BioProject

    ID: PRJNA113415

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: n that its most aggressive subtype, ABC-DLBCL, is associated with constitutive activation of the NF-kB transcription complex. However, except for a small fraction of cases, it remains unclear whether NF-kB activation in these tumors represents an intrinsic program of the tumor cell of origin or a pathogenetic event. Here we show that >50% of ABC-DLBCL and a smaller fraction of GCB-DLBCL carry somatic mutations at multiple genes, including negative (TNF...
  19. Platelet Activating Factor Receptor and Innate Immunity BioProject

    ID: PRJNA96035

    Keywords: Transcriptome or Gene expression

    Access Type: download

  20. Data from: SNP discovery and gene annotation in the surf clam Mesodesma donacium Dryad

    DateIssued: 04-28-2015

    Description: t shock protein-70 and the translation elongation factor 1-alpha. The Gene Ontology analysis regarding molecular function level revealed that sequences with SNPs were mainly classified to protein and nucleotide binding, as well hydrolase activity, ion binding and oxidoreductase activity. Further, biological processes like cellular and metabolic process, biogenesis, localization and biological regulation were highly annotated. The most expressed genes were related to the mitochondrial electron transport chain, senescence-associated protein, ubiquitin and actin. Interestingly, some relevant genes related to immune response and biomineralization showed a high abundance, such as tumor necrosis factor (TNF)-alpha-receptor-like protein, serine protease inhibitor, heat shock protein, aragonite-...


Displaying 20 of 68 results for "TRAF5"