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Displaying 20 of 130 results for "TPX2"
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  1. TPX2:importin-alpha complex PDB

    ID: PDB:3KND

    Description: Importin subunit alpha-2, Targeting protein for Xklp2

  2. Crystal structure of Aurora A in complex with VX-680 and TPX2 PDB

    ID: PDB:3E5A

    Description: Serine/threonine-protein kinase 6 (E.C.2.7.11.1), Targeting protein for Xklp2

  3. Additional file 5: of The C-terminal domain of TPX2 is made of alpha-helical tandem repeats Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3610754_D2

    Release Date: 12-14-2016

    Description: Multiple sequence alignment used in Fig. 2. (TXT 2 kb)

  4. Structure of dephosphorylated Aurora A (122-403) bound to TPX2 and AMPPCP PDB

    ID: PDB:4C3P

    Description: AURORA KINASE A (E.C.2.7.11.1), TARGETING PROTEIN FOR XKLP2

  5. STRUCTURE OF AURORA-A 122-403, PHOSPHORYLATED ON THR287, THR288 AND BOUND TO TPX2 1-43 PDB

    ID: PDB:1OL5

    Description: SERINE/THREONINE KINASE 6 (E.C.2.7.1.37), RESTRICTED EXPRESSION PROLIFERATION ASSOCIATED PROTEIN 100

  6. Crystal structure of aurora A in complex with TPX2 and compound 10 PDB

    ID: PDB:3HA6

    Description: Serine/threonine-protein kinase 6 (E.C.2.7.11.1), Targeting protein for Xklp2

  7. Array-based Comparative Genomic Hybridization of Melanoma Cell Lines BioProject

    ID: PRJNA169352

    Keywords: Variation

    Access Type: download

    dataset.description: explored the role of targeting protein for Xklp2 (TPX2), located with 20q11.2, in melanoma pathogenesis, based on initial findings that it was commonly gained and overexpressed.
  8. Crystal structure of Aurora-A bound to a hydrocarbon-stapled proteomimetic of TPX2 PDB

    ID: PDB:5LXM

    Description: Aurora kinase A (E.C.2.7.11.1), Targeting protein for Xklp2

  9. Additional file 6: Table S5. of Genome-wide analysis of the TPX2 family proteins in Eucalyptus grandis Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3602654_D5

    Release Date: 12-14-2016

    Description: d as a reference gene while others are Eucalyptus TPX2 family genes. (XLSX 10 kb)...

  10. Additional file 3: of The C-terminal domain of TPX2 is made of alpha-helical tandem repeats Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3610754_D1

    Release Date: 12-14-2016

    Description: Multiple sequence alignment used in Fig. 1a. (TXT 43 kb)

  11. Additional file 1: of The C-terminal domain of TPX2 is made of alpha-helical tandem repeats Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3610754_D3

    Release Date: 12-14-2016

    Description: FASTA file of sequences used for Fig. 1a. (TXT 21 kb)

  12. Additional file 4: of The C-terminal domain of TPX2 is made of alpha-helical tandem repeats Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3610754_D5

    Release Date: 12-14-2016

    Description: Multiple sequence alignment used in Fig. 1b. (TXT 10 kb)

  13. Additional file 4: Table S3. of Genome-wide analysis of the TPX2 family proteins in Eucalyptus grandis Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3602654_D1

    Release Date: 12-14-2016

    Description: enome-wide analysis of Arabidopsis and Eucalyptus TPX2 genes. Gene name, locus ID and the clade number in the phylogenetic tree (Fig. 1) are shown. (XLSX 10 kb)...

  14. Additional file 3: Table S2. of Genome-wide analysis of the TPX2 family proteins in Eucalyptus grandis Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3602654_D3

    Release Date: 12-14-2016

    Description: Distribution of PFAM plant TPX2 proteins in various clades. A complete list of number of sequences in each clade (clade 1â 6) is presented. (XLSX 17 kb)...

  15. Additional file 2: of The C-terminal domain of TPX2 is made of alpha-helical tandem repeats Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3610754_D4

    Release Date: 12-14-2016

    Description: FASTA file of sequences used for Fig. 1a. (TXT 5 kb)

  16. Additional file 2: Table S1. of Genome-wide analysis of the TPX2 family proteins in Eucalyptus grandis Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3602654_D2

    Release Date: 12-14-2016

    Description: TPX2 proteins in plants (Viridiplantae). 574 of these Plant TPX2 proteins were from 45 different species of plan...

  17. Array-based Comparative Genomic Hybridization of Melanoma Cell Lines ArrayExpress

    ID: E-GEOD-38946

    Description: explored the role of targeting protein for Xklp2 (TPX2), located with 20q11.2, in melanoma pathogenesis, based on initial findings that it was commonly gained and overexpressed.

  18. Chromosome 20q amplification regulates in vitro response to Kinesin-5 inhibitor BioProject

    ID: PRJNA100725

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: enes in this chromosomal region identified AURKA, TPX2 and MYBL2 as genes whose disruption enhances response to Kinesin-5i. Taken together, our results show functional interaction between these genes, and suggest that overexpression of AURKA, TPX2 and MYBL2 is functionally involved in resistance to Kinesin-5i. Furthermore, our results suggest that patients whose tumors overexpress AURKA due to amplifications of 20q will be more likely to resist treatment with Kinesin-5 inhibitor, and that inactivati...
  19. Additional file 5: Table S4. of Genome-wide analysis of the TPX2 family proteins in Eucalyptus grandis Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3602654_D6

    Release Date: 12-14-2016

    Description: s ratios and Evolutionary selection of paralogous TPX2 family proteins. Ks: number of synonymous substitutions per synonymous site; Ka: number of nonsynonymous substitutions per nonsynonymo...

  20. Expression data from serous ovarian carcinomas, serous ovarian borderline tumors and surface epithelium scrapings from normal ovaries ArrayExpress

    ID: E-GEOD-36668

    Description: ated with overall survival (p=0.03). An increased TPX2 (p=0.03) and FOXM1 (p=0.044) expression correlated with optimal normalization of serum CA125 after treatment. Furthermore, we present a common molecular pathway for MD/PD SC, including VEGFA, FOXM1, TPX2, BIRC5 and TOP2A, all significantly upregulated and interacting with TP53. Conclusions: We have identified 21 mRNAs differentially expressed (p<0.01) between MD/PD SC, SBOT and SNO. Thirteen were differentially expressed in MD/PD SC, including VEGFA and ZNF385B, correlating with survival, and FOXM1 and TPX2, correlating with normalization of serum CA125. By the use of oligonucleotid microarrays (Affymetrix U133 Plus 2.0 Arrays) differences in mRNA expression between eleven MD/PD SC, eight SBOT and four SNO samples were analyzed. Differentially expressed mRNAs were selected for validation by RT-qPCR in additional samples totaling 21 MD/PD SC, 13 SBOT and seven samples of SNO. Each mRNA was run in quadruple. The mRNAs differentially expressed in MD/PD SC compared with SNO were correlated with clinical parameters....


Displaying 20 of 130 results for "TPX2"