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  1. Homo sapiens : Whole exome sequencing in a case of sporadic multiple meningiomas BioProject

    ID: PRJNA268172

    Keywords: exome

    Access Type: download

    dataset.description: t 3 common mutational events (at NF2, FAM109B and TPRXL genes) were detected in the tumors’ DNA when they were compared to the control tissue. Additionally, an array of unique mutations was detected in each tumor, including SMARCB1 in two of the samples, a gene whose alteration leads to the development of meningioma and schwannoma. Moreover, other genes such as IRS4, GULP1, NHSL1 or C10orf53, accounted for one alteration in each sample. Our data suggests a monoclonal origin of the meningiomas in this patient, although the numerous alterations contained in each tumor denoted multiple secondary variable changes in each tumor nodule. Whether the alterations described in this work are driver of tumorgenesis or simply passenger, requires further study....

Displaying 1 of 1 results for "TPRXL"