TP53I3 | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 16 of 16 results for "TP53I3"
i
  1. Crystal structure of Human P53 inducible oxidoreductase (TP53I3,PIG3) PDB

    ID: PDB:2OBY

    Description: Putative quinone oxidoreductase (E.C.1.-.-.-)

  2. CRYSTAL STRUCTURE OF HUMAN P53 INDUCIBLE OXIDOREDUCTASE (TP53I3,PIG3) PDB

    ID: PDB:2J8Z

    Description: QUINONE OXIDOREDUCTASE (E.C.1.-.-.-)

  3. Pig3 Dryad

    DateIssued: 05-08-2017

    Description: z Column 2: Left Ventricular Volume @200Hz Column 3: Aortic Pressure @200Hz Column 4: Femoral Pressure @200Hz...

  4. Identification of TRIML2, a Novel p53 Target, that Enhances p53-SUMolylation and Regulates the Transactivation of Pro-apoptotic Genes BioProject

    ID: PRJNA260290

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. A large intergenic non-coding RNA induced by p53 mediates global gene repression in the p53 transcriptional response BioProject

    ID: PRJNA127275

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. Transcription profiling of human HCT116 PTEN+/+ cell lines and three independently-derived HCT116 PTEN-/- cell lines ArrayExpress

    ID: E-GEOD-6263

    Description: f PTEN gene-targeted human cancer cells. Numerous p53 effectors were upregulated following PTEN deletion, including p21, GDF15, PIG3, NOXA, and PLK2. Stable depletion of p53 led to reversion of the gene expression program. Western blots revealed that p53 was stabilized in HCT116 PTEN-/- c...

  7. A large intergenic non-coding RNA induced by p53 mediates global gene repression in the p53 transcriptional response ArrayExpress

    ID: E-GEOD-21761

    Description: identification of lincRNAs that are regulated by p53. One of these lincRNAs (lincRNA-p21) serves as a repressor in p53-dependent transcriptional responses. Inhibition of lincRNA-p21 affects the expression of hundreds of gene targets enriched for genes normally repressed by p53. The observed transcriptional repression by lincRNA-p21 is mediated through the physical association ...

  8. The role of mRNA decay in p53-induced gene expression BioProject

    ID: PRJNA308079

    Keywords: Transcriptome or Gene expression

    Access Type: download

  9. K562 leukaemia cell line treated with thalidomide analog BioProject

    ID: PRJNA111991

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Rab10, Rab11, Sec22b, sorting nexin 2, calnexin, protein disulfide isomerase, GRP78, GRP94 among others that are involved in vesicular transport and ER stress response. Amino-trifluoro-phthalimides exerted potent anticancer activities in vitro on different cell lines including melanoma, leukemia, hepatocellular carcinoma, glioblastoma. They are non-toxic to adult animals up-to 1 g/kg but are highly teratogenic to zebrafis...
  10. K562 leukaemia cell line treated with thalidomide analog ArrayExpress

    ID: E-GEOD-14945

    Description: Rab10, Rab11, Sec22b, sorting nexin 2, calnexin, protein disulfide isomerase, GRP78, GRP94 among others that are involved in vesicular transport and ER stress response. Amino-trifluoro-phthalimides exerted potent anticancer activities in vitro on different cell lines including melanoma, leukemia, hepatocellular carcinoma, glioblastoma. They are non-toxic to adult animals up-to 1 g/kg but are highly teratogenic to zebrafis...

  11. Identification of genes whose expression is modulated by the presence or absence of PTEN BioProject

    ID: PRJNA100549

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: f PTEN gene-targeted human cancer cells. Numerous p53 effectors were upregulated following PTEN deletion, including p21, GDF15, PIG3, NOXA, and PLK2. Stable depletion of p53 led to reversion of the gene expression program. Western blots revealed that p53 was stabilized in HCT116 PTEN-/- c...
  12. Myc-dependent purine biosynthesis regulates the expression of oncogenes and tumour suppressors in prostate cancer cells ArrayExpress

    ID: E-GEOD-51384

    Description: thway in response to siRNA knockdown of c-Myc and inducible overexpression of c-Myc. In addition c-Myc is recruited to the promoters of genes in the pathway as determined by chromatin immunoprecipitation. Using immunohistochemistry and real-time transcript detection we show that two enzymes (PAICS and IMPDH2) within the pathway are overexpressed in prostate cancers. An inhibitor of IMPDH2 reduces cell proliferation and significantly reduces the levels of guanosine triphosphate within treated cells. This imposes nucleolar stress on cells as determined by significant reductions in the levels of guanine nucleotide binding protein-like 3 (GNL3). In addition the levels of c-Myc, p53 and the androgen receptor are affected and the expression of tumour suppressive microRNA-34b is increased. Combining the IMPDH2 inhibitor with anti-androgens results in a combinatorial in...

  13. The Long-HER Study ArrayExpress

    ID: E-GEOD-44272

    Description: kinase pathway, apoptosis signalling pathway and p53 pathway significantly correlated with response. The PI3K pathway was the most strongly associated with poor response to trastuzumab-based therapy: tumours in the control group usually had four or five alterations in this pathway, whereas tumours in the Long-HER group had two alterations at most. These findings support that trastuzumab may provide a substantial long-term survival benefit in a selected group of patients. Whole genome expression analysis comparing long-term survivors vs. a control group predicted early progression to trastuzumab-based therapy. Multiple alterations in genes related to the PI3K-mTOR pathway seem to be required to confer resistance to this therapy. 53 FFPE samples, which passed the RNA quality control criteria, were analyzed (45 primary tumours and 8 metastases). Among these 53 samples, 35 samples corresponded to long-term responders and 18 to the control group....

  14. Myc-dependent purine biosynthesis regulates the expression of oncogenes and tumour suppressors in prostate cancer cells BioProject

    ID: PRJNA222856

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: thway in response to siRNA knockdown of c-Myc and inducible overexpression of c-Myc. In addition c-Myc is recruited to the promoters of genes in the pathway as determined by chromatin immunoprecipitation. Using immunohistochemistry and real-time transcript detection we show that two enzymes (PAICS and IMPDH2) within the pathway are overexpressed in prostate cancers. An inhibitor of IMPDH2 reduces cell proliferation and significantly reduces the levels of guanosine triphosphate within treated cells. This imposes nucleolar stress on cells as determined by significant reductions in the levels of guanine nucleotide binding protein-like 3 (GNL3). In addition the levels of c-Myc, p53 and the androgen receptor are affected and the expression of tumour suppressive microRNA-34b is increased. Combining the IMPDH2 inhibitor with anti-androgens results in a combinatorial in...
  15. The Long-HER Study BioProject

    ID: PRJNA189275

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: kinase pathway, apoptosis signalling pathway and p53 pathway significantly correlated with response. The PI3K pathway was the most strongly associated with poor response to trastuzumab-based therapy: tumours in the control group usually had four or five alterations in this pathway, whereas tumours in the Long-HER group had two alterations at most. These findings support that trastuzumab may provide a substantial long-term survival benefit in a selected group of patients. Whole genome expression analysis comparing long-term survivors vs. a control group predicted early progression to trastuzumab-based therapy. Multiple alterations in genes related to the PI3K-mTOR pathway seem to be required to confer resistance to this therapy. Overall design: 53 FFPE samples, which passed the RNA quality control criteria, were analyzed (45 primary tumours and 8 metastases). Among these 53 samples, 35 samples corresponded to long-term responders and 18 to the control group....
  16. Transcription profiling of human HCT116 PTEN+/+ cell lines and three independently-derived HCT116 PTEN-/- cell lines OmicsDI

    ID: E-GEOD-6263

    Date Released: 03-27-2012

    Description: f PTEN gene-targeted human cancer cells. Numerous p53 effectors were upregulated following PTEN deletion, including p21, GDF15, PIG3, NOXA, and PLK2. Stable depletion of p53 led to reversion of the gene expression program. Western blots revealed that p53 was stabilized in HCT116 PTEN-/- c...


Displaying 16 of 16 results for "TP53I3"