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Displaying 20 of 39 results for "TOB1"
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  1. Crystal structure of human Tob1 protein PDB

    ID: PDB:2Z15

    Description: Protein Tob1

  2. Crystal structure of human Tob in complex with inhibitor fragment 6 PDB

    ID: PDB:5CI9

    Description: Protein Tob1

  3. Crystal structure of human Tob in complex with inhibitor fragment 1 PDB

    ID: PDB:5CI8

    Description: Protein Tob1

  4. Tob1 is a Constitutively Expressed Repressor of Liver Regeneration BioProject

    ID: PRJNA126919

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. Panicum virgatum strain:TOB | cultivar:TOB : Panicum virgatum TOB Resequencing genome sequencing BioProject

    ID: PRJNA334773

    Keywords: genome sequencing

    Access Type: download

  6. Tob1 is a Constitutively Expressed Repressor of Liver Regeneration OmicsDI

    ID: E-GEOD-21836

    Date Released: 05-02-2014

    Description: e factors repressed after liver injury identified Tob1, a member of the PC3/BTG1 family of mitoinhibitory molecules as a target for further evaluation. Tob1 protein decreases after 2/3 hepatectomy in mice secondary to post-transcriptional mechanisms. Deletion of Tob1 increases hepato...

  7. Tob1 is a Constitutively Expressed Repressor of Liver Regeneration ArrayExpress

    ID: E-GEOD-21836

    Description: e factors repressed after liver injury identified Tob1, a member of the PC3/BTG1 family of mitoinhibitory molecules as a target for further evaluation. Tob1 protein decreases after 2/3 hepatectomy in mice secondary to post-transcriptional mechanisms. Deletion of Tob1 increases hepato...

  8. TOB VS STW populations_text Dryad

    DateIssued: 12-05-2016

    Description: raw dataset with 3980 SNP genotypes for two wild Atlantic salmon populations from the Tobique River and the Stewiacke River in the Bay of Fundy, Canad...

  9. TOB1_RAT UniProt:Swiss-Prot

    ID: Q8R5K6

    Description: Protein Tob1 Important for nuclear localization Bipartite nuclear localization signal Nuclear export signal Poly-Pro Poly-Gln Phosphothreon...

  10. Escherichia coli strain:Tob1 : Escherichia coli strain:Tob1 Genome sequencing and assembly BioProject

    ID: PRJNA341933

    Keywords: Genome sequencing and assembly

    Access Type: download

    dataset.description: Whole genome shotgun sequence of the commensal fecal isolate strain Tob1
  11. Crystal Structure of a Tob-hCaf1 Complex PDB

    ID: PDB:2D5R

    Description: CCR4-NOT transcription complex subunit 7, Tob1 protein

  12. RNA IP Seq analysis of Cnot7 in 4T1 mammary tumor cells ArrayExpress

    ID: E-GEOD-73366

    Description: n by CNOT7 is dependent on contact with CNOT1 and TOB1. We further show TOB1 independently drives metastasis. RNA-immunoprecipitation and integrated transcriptome wide analyses reveal that CNOT7-regulated transcripts are enriched for a tripartite 3’UTR motif bound by RNA-binding proteins known to complex with CNOT7, TOB1, and CNOT1. Collectively, our data support a model of CNOT7, TOB1, CNOT1, and RNA-binding proteins collectively exerting post-transcriptional control on a metastasis suppressive transcriptional program to drive tumor cell metastasis. 48 total samples, 4-5 ...

  13. RNA IP Seq analysis of Cnot7 in 4T1 mammary tumor cells BioProject

    ID: PRJNA296804

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: n by CNOT7 is dependent on contact with CNOT1 and TOB1. We further show TOB1 independently drives metastasis. RNA-immunoprecipitation and integrated transcriptome wide analyses reveal that CNOT7-regulated transcripts are enriched for a tripartite 3’UTR motif bound by RNA-binding proteins known to complex with CNOT7, TOB1, and CNOT1. Collectively, our data support a model of CNOT7, TOB1, CNOT1, and RNA-binding proteins collectively exerting post-transcriptional control on a metastasis suppressive transcriptional program to drive tumor cell metastasis. Overall design: 48 tot...
  14. RNA IP Seq analysis of Cnot7 in 4T1 mammary tumor cells OmicsDI

    ID: E-GEOD-73366

    Date Released: 09-26-2015

    Description: n by CNOT7 is dependent on contact with CNOT1 and TOB1. We further show TOB1 independently drives metastasis. RNA-immunoprecipitation and integrated transcriptome wide analyses reveal that CNOT7-regulated transcripts are enriched for a tripartite 3’UTR motif bound by RNA-binding proteins known to complex with CNOT7, TOB1, and CNOT1. Collectively, our data support a model of CNOT7, TOB1, CNOT1, and RNA-binding proteins collectively exerting post-transcriptional control on a metastasis suppressive transcriptional program to drive tumor cell metastasis. 48 total samples, 4-5 ...

  15. Transcription profiling of human naive CD4+ T cells from CIS early manifestation multiple sclerosis samples, case-control, time-series study ArrayExpress

    ID: E-GEOD-13732

    Description: r discriminated patients from one of these (group#1) from other CIS patients. Remarkably, 92% of patients from group #1 converted to CDMS within 9 months. Consistent downregulation of TOB1, a critical regulator of cell proliferation, was characteristic of group #1 patients. Decreased TOB1 expression at the RNA and protein levels was also confirmed in experimental autoimmune encephalomyelitis (EAE). Finally, a genetic association was observed between TOB1 variation and MS progression in an independent cohort. These results indicate that CIS patients at high risk of conversion have impaired regulation of T cell quiescence resulting in earlier activation of pathogenic CD4+ cells. Experiment Overall Design: Expression data was taken...

  16. Transcription profiling of human naive CD4+ T cells from CIS early manifestation multiple sclerosis samples, case-control, time-series study OmicsDI

    ID: E-GEOD-13732

    Date Released: 06-10-2011

    Description: r discriminated patients from one of these (group#1) from other CIS patients. Remarkably, 92% of patients from group #1 converted to CDMS within 9 months. Consistent downregulation of TOB1, a critical regulator of cell proliferation, was characteristic of group #1 patients. Decreased TOB1 expression at the RNA and protein levels was also confirmed in experimental autoimmune encephalomyelitis (EAE). Finally, a genetic association was observed between TOB1 variation and MS progression in an independent cohort. These results indicate that CIS patients at high risk of conversion have impaired regulation of T cell quiescence resulting in earlier activation of pathogenic CD4+ cells. Experiment Overall Design: Expression data was taken...

  17. CIS (multiple sclerosis) (case-control) (time-series) BioProject

    ID: PRJNA110795

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: r discriminated patients from one of these (group#1) from other CIS patients. Remarkably, 92% of patients from group #1 converted to CDMS within 9 months. Consistent downregulation of TOB1, a critical regulator of cell proliferation, was characteristic of group #1 patients. Decreased TOB1 expression at the RNA and protein levels was also confirmed in experimental autoimmune encephalomyelitis (EAE). Finally, a genetic association was observed between TOB1 variation and MS progression in an independent cohort. These results indicate that CIS patients at high risk of conversion have impaired regulation of T cell quiescence resulting in earlier activation of pathogenic CD4+ cells. Keywords: Disease state: CIS (Clinically Isolated Sy...
  18. CIS (multiple sclerosis) (case-control) (time-series) GEMMA

    ID: 1588

    Keywords: functional genomics

    Description: r discriminated patients from one of these (group#1) from other CIS patients. Remarkably, 92% of patients from group #1 converted to CDMS within 9 months. Consistent downregulation of TOB1, a critical regulator of cell proliferation, was characteristic of group #1 patients. Decreased TOB1 expression at the RNA and protein levels was also confirmed in experimental autoimmune encephalomyelitis (EAE). Finally, a genetic association was observed between TOB1 variation and MS progression in an independent cohort. These results indicate that CIS patients at high risk of conversion have impaired regulation of T cell quiescence resulting in earlier activation of pathogenic CD4+ cells. Last Updated (by provider): Feb 25 2009 Contribute...

  19. Progression Free Survival in Ovarian Cancer is Reflected in Epigenetic DNA-Methylation Profiles ArrayExpress

    ID: E-GEOD-25033

    Description: ation at specific CpG sites (e.g. GREB1, TGIF and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C). Gene ontology analysis revealed that differentially methylated genes were significantly overrepresented in the categories telomere organization, mesoderm development and immune regulation. Conclusion: Epigenetic modifications at specific CpG sites correlate with PFI in ovarian cancer. Therefore, such analysis might be of prognostic value. Bisulphite converted DNA from the 20 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip...

  20. Progression Free Survival in Ovarian Cancer is Reflected in Epigenetic DNA-Methylation Profiles BioProject

    ID: PRJNA134767

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ation at specific CpG sites (e.g. GREB1, TGIF and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C). Gene ontology analysis revealed that differentially methylated genes were significantly overrepresented in the categories telomere organization, mesoderm development and immune regulation. Conclusion: Epigenetic modifications at specific CpG sites correlate with PFI in ovarian cancer. Therefore, such analysis might be of prognostic value. Overall design: Bisulphite converted DNA from the 20 samples were hybridised to the Illumina Infinium 27k Human Methylation Beadchip...

Displaying 20 of 39 results for "TOB1"