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Displaying 20 of 41 results for "TNS2"
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  1. Crystal structure of Phosphotyrosine-binding domain from the Human Tensin-like C1 domain-containing phosphatase (TENC1) PDB

    ID: PDB:3HQC

    Description: Tensin-like C1 domain-containing phosphatase

  2. NMR Solution Structure of SH2 Domain of the Human Tensin Like C1 Domain Containing Phosphatase (TENC1) PDB

    ID: PDB:2KNO

    Description: Tensin-like C1 domain-containing phosphatase

  3. Expression data from renal cortex of ICR-derived Glomerulonephritis (ICGN) mice and ICR mice ArrayExpress

    ID: E-GEOD-45005

    Description: reditary nephrotic syndrome. Deletion mutation of tensin 2 (Tns2), a focal adhesion molecule, has been suggested to be responsible for nephrotic syndrome in ICGN mice, however, existence of other associative factors has been sug...

  4. Expression data from renal cortex of ICR-derived Glomerulonephritis (ICGN) mice and ICR mice BioProject

    ID: PRJNA192820

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: reditary nephrotic syndrome. Deletion mutation of tensin 2 (Tns2), a focal adhesion molecule, has been suggested to be responsible for nephrotic syndrome in ICGN mice, however, existence of other associative factors has been sug...
  5. Solution structure of the PTB domain of KIAA1075 protein from human PDB

    ID: PDB:2DKQ

    Description: KIAA1075 protein

  6. Expression data from renal cortex of ICR-derived Glomerulonephritis (ICGN) mice and ICR mice OmicsDI

    ID: E-GEOD-45005

    Date Released: 05-13-2014

    Description: reditary nephrotic syndrome. Deletion mutation of tensin 2 (Tns2), a focal adhesion molecule, has been suggested to be responsible for nephrotic syndrome in ICGN mice, however, existence of other associative factors has been sug...

  7. TENS4_BOVIN UniProt:Swiss-Prot

    ID: Q32PJ7

    Description: Tensin-4 SH2 Phosphatase tensin-type Ser-rich Phosphoserine

  8. TAG83_CAEEL UniProt:Swiss-Prot

    ID: P91301

    Description: Putative protein phosphatase tag-83 Phosphatase tensin-type C2 tensin-type Phosphocysteine ...

  9. FH18_ARATH UniProt:Swiss-Prot

    ID: Q9SK28

    Description: Formin-like protein 18 Phosphatase tensin-type C2 tensin-type FH2 Pro-rich Phosph...

  10. AUXI_BOVIN UniProt:Swiss-Prot

    ID: Q27974

    Description: Putative tyrosine-protein phosphatase auxilin 1 2 3 Phosphatase tensin-type C2 tensin

  11. elective PI3KBeta Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers... PDB

    ID: PDB:4AJW

    Description: PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (E.C.2.7.1.153)

  12. ne Amide PI3Kbeta Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers... PDB

    ID: PDB:4BFR

    Description: PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC S SUBUNIT BETA ISOFORM (E.C.2.7.1.153)

  13. The novel binding mode of DLC1 and Tensin2 PTB domain PDB

    ID: PDB:2LOZ

    Description: Tensin-like C1 domain-containing phosphatase

  14. Crystal structure of tensin1 PTB domain PDB

    ID: PDB:1WVH

    Description: Tensin

  15. miRNA profiling of gastric epithelium from Pten mutant mouse ArrayExpress

    ID: E-GEOD-27047

    Description: Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor that negatively regulates...

  16. miRNA profiling of gastric epithelium from Pten mutant mouse BioProject

    ID: PRJNA137643

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor that negatively regulates...
  17. Gene expression profiling in true interval breast cancer reveals overactivation of mTOR signalling pathway ArrayExpress

    ID: E-GEOD-47108

    Description: (ribosomal protein S6 kinase, 70kDa, polypeptide 2) both up-regulated in TIBC vs SDBC and PTEN (phosphatase and tensin homolog) and TGFBR3 (transforming growth factor beta receptor III), down-regulated in TIBC vs SDBC. Their differential expression was confirmed by RT-qPCR and immunohistochemistry, suggesting mTOR pathway overexpression in TIBC at both mRNA and protein level. Further expanded analysis by immunohistochemistry for mTOR pathway activation, including expression of phosphorylated forms of mTOR, 4E-BP1, eIF-4G, RPS6KB2 and S6, confirmed the upregulation of this pathway in TIBC. Conclusions: TIBC and SDBC shows differential expression profile both at the gene and protein levels. The mTOR signaling is significantly upregulated in TIBC compared with SDBC, suggesting an enhanced aggressiveness of TIBC. Besides, CP may also represent novel immunohistochemical marker helpful in distinguishing between TIBC and SDBC. Further studies with larger sets of patients are guaranteed to verify these findings associated with TIBC. 5 TIBC samples where compared with 5 SDBC...

  18. Additional file 2: Table S2. of Elevated expression of HSP90 and the antitumor effect of an HSP90 inhibitor via inactivation of the Akt/mTOR pathwa... Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3622340_D2

    Release Date: 12-15-2016

    Description: al; pAkt, phosphorylated protein kinase B; p-ERK1/2, phosphorylated-extracellular signal-regulated kinase1/2; p-4EBP, phosphorylated eukaryotic translation initiation factor 4E-binding protein; p-MEK1/2, phosphorylated mitogen-activated protein kinase1/2

  19. miRNA profiling of gastric epithelium from Pten mutant mouse OmicsDI

    ID: E-GEOD-27047

    Date Released: 06-02-2014

    Description: Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor that negatively regulates...

  20. miR-134/487b/655 Cluster regulates TGF-β-induced epithelial-mesenchymal transition and drug resistance to Gefitinib by targeting MAGI2 in lung adenoc... ArrayExpress

    ID: E-GEOD-51828

    Description: (membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2), a predicted target of these miRNAs and a scaffold protein required for PTEN (phosphatase and tensin homolog), was diminished in A549 cells with EMT after the TGF-β1 stimulation. Overexpression of miR-134 and miR-487b promoted the EMT phenomenon and affected the drug resistance to gefitinib, whereas knockdown of these miRNAs inhibited the EMT process and reversed TGF-β1-induced resistance to gefitinib. Our study demonstrated that the miR-134/487b/655 cluster contributed to the TGF-β1-induced EMT phenomenon and affected the resistance to gefitinib by directly targeting MAGI2, whose suppression subsequently caused loss of PTEN stability in lung cancer cells. The miR-134/miR-487b/miR-655 cluster may be new therapeutic targets in advanced lung adenocarcinoma patients, depending on the EMT phenomenon. miRNA expression profiles before and after TGF-β1 exposure were assessed in the four lung adenocarcinoma cell lines, A549, LC2/ad, PC3, a...


Displaying 20 of 41 results for "TNS2"