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Displaying 20 of 83 results for "TNFAIP3"
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  1. Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia BioProject

    ID: PRJNA286292

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia ArrayExpress

    ID: E-GEOD-69735

    Description: in T-LGL. Mutations of the tumour suppressor gene TNFAIP3 causing amino-acid exchanges or protein truncations were seen in 3/39 cases (8%). RNA sequencing (Illumina HiSeq 2500) of 5 index patients with paired tumor and non-tumor...

  3. Transcription of Tnfaip3 is regulated by NF-kB and p38 via C/EBPβ in activated macrophages BioProject

    ID: PRJNA203653

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Additional file 3: of MicroRNA-19b-3p regulates nasopharyngeal carcinoma radiosensitivity by targeting TNFAIP3/NF-ÎşB axis Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3622115_D3

    Release Date: 12-15-2016

    Description: Sample ID. (XLSX 26 kb)

  5. Additional file 1: of MicroRNA-19b-3p regulates nasopharyngeal carcinoma radiosensitivity by targeting TNFAIP3/NF-ÎşB axis Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3622115_D1

    Release Date: 12-15-2016

    Description: Sample ID. (XLSX 11 kb)

  6. Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia OmicsDI

    ID: E-GEOD-69735

    Date Released: 06-18-2016

    Description: in T-LGL. Mutations of the tumour suppressor gene TNFAIP3 causing amino-acid exchanges or protein truncations were seen in 3/39 cases (8%). RNA sequencing (Illumina HiSeq 2500) of 5 index patients with paired tumor and non-tumor...

  7. Transcription of Tnfaip3 is regulated by NF-kB and p38 via C/EBPβ in activated macrophages ArrayExpress

    ID: E-GEOD-46361

    Description: n immunoprecipitation assay, we demonstrated that Tnfaip3 is regulated by both NF-kB and p38-dependent C/EBPβ. These results elucidate our understanding of the tight regulation of innate immunity. In order to identify p38-activated transcription factors that cooperate with NF-kB in response to LPS stimulation, microarrays were used to identify genes regulated by both NF-kB and p38 using wild-type, IKK-depleted, and p38 inhibitor-treated mouse bone marrow-derived macrophages (BMDMs). In silico analysis of transcription factor binding sites was used to predict the potential synergistic transcription factors from the co-expressed genes....

  8. Structure of A20 OTU domain bound to ubiquitin PDB

    ID: PDB:5LRX

    Description: Tumor necrosis factor alpha-induced protein 3 (E.C.3.4.19.12,6.3.2.-), Polyubiquitin-B

    gene.name: TNFAIP3, OTUD7C
  9. Transcription of Tnfaip3 is regulated by NF-kB and p38 via C/EBPβ in activated macrophages OmicsDI

    ID: E-GEOD-46361

    Date Released: 05-02-2015

    Description: n immunoprecipitation assay, we demonstrated that Tnfaip3 is regulated by both NF-kB and p38-dependent C/EBPβ. These results elucidate our understanding of the tight regulation of innate immunity. In order to identify p38-activated transcription factors that cooperate with NF-kB in response to LPS stimulation, microarrays were used to identify genes regulated by both NF-kB and p38 using wild-type, IKK-depleted, and p38 inhibitor-treated mouse bone marrow-derived macrophages (BMDMs). In silico analysis of transcription factor binding sites was used to predict the potential synergistic transcription factors from the co-expressed genes....

  10. NF-κB-direct activation of microRNAs with repressive effects on monocyte-specific genes is critical for osteoclast differentiation BioProject

    ID: PRJNA269054

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: monocyte-specific and immunomodulatory genes like TNFAIP3, IGF1R and IL15. Depletion of these miRNAs inhibits osteoclast differentiation and upregulates their targets. These miRNAs are also upregulated in other inflammatory monocytic differentiation processes. Most importantly, we demonstrate for the first time the direct involvement of Nuclear Factor kappa B (NF-κB) in the regulation of these miRNAs, as well as with their...
  11. ASA404 and TNFα treatment in preclinical models of endocrine tumors is associated with differential TNF-R 1 and TLR- 4 –signaling ArrayExpress

    ID: E-GEOD-64250

    Description: ut not in NCI-H295R cells. Finally, we identified TNFAIP3/A20, a member of an inhibitory feedback-loop downstream of both investigated signaling cascades, as overexpressed in the adrenocortical carcinoma tumor model. Subsequent analyses of clinical patient samples confirmed a correlation between tumor TNFAIP3 expression levels and overall survival in patients with ACC. Conclusions: Taken together our findings provide evidence that modulation of TNFα-signaling could be of relevance both for the clinical course of ACC patients and as a marker of treatment response. BON or NCI-H295R tumor cells were treated in-vitro with TNFalpha and compared to unstimulated cells...

  12. Transcription profiling of endotoxin-stimulated human monocytic cells in presence and absence of host defense peptide LL-37 ArrayExpress

    ID: E-FPMI-4

    Description: nflammation, such as TNF-alpha-induced protein 3 (TNFAIP3) and the NF-kappa B inhibitor, NF-kappa BIA, or genes involved in cell movement and recruitment (chemokines). The trends of gene expression were further validated by quantitative real-time PCR. This study implicates that LL-37 plays a role in the delicate balancing act of inflammatory responses....

  13. TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma BioProject

    ID: PRJNA116491

    Keywords: Variation

    Access Type: download

  14. NF-κB-direct activation of microRNAs with repressive effects on monocyte-specific genes is critical for osteoclast differentiation ArrayExpress

    ID: E-GEOD-63773

    Description: monocyte-specific and immunomodulatory genes like TNFAIP3, IGF1R and IL15. Depletion of these miRNAs inhibits osteoclast differentiation and upregulates their targets. These miRNAs are also upregulated in other inflammatory monocytic differentiation processes. Most importantly, we demonstrate for the first time the direct involvement of Nuclear Factor kappa B (NF-κB) in the regulation of these miRNAs, as well as with their...

  15. Affymetrix SNP array data for Marginal Zone Lymphoma samples ArrayExpress

    ID: E-GEOD-24881

    Description: re frequently gains at 3p, 6p, 18p and del(6q23) (TNFAIP3/A20), whilst splenic MZL was associated with del(7q31), del(8p). Nodal MZL did not show statistically significant differences when compared with MALT lymphoma while lacked the splenic MZL-related 7q losses. Gains of 3q and 18q gains were common to all three subtypes. Del(8p) was often present together with del(17p) (TP53). While del(17p) did not determine a worse outcome and del(8p) was only of borderline significance, the presence of both deletions had a highly significant negative impact on the outcome of splenic MZL. Copy number analysis of Affymetrix 250K Nsp SNP arrays was performed for a total of 218 MZL samples were analyzed by high resolution genome wide-DNA profiling: 57 MALT lymphoma, 134 splenic MZL, 25 nodal MZL and two MZ...

  16. A20 IN MARGINAL ZONE LYMPHOMAS ArrayExpress

    ID: E-GEOD-13989

    Description: he tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) gene, a negative regulator of NF-kappa B, were described in ocular adnexal MZL, suggesting a role for A20 as a tumor suppressor in this disease entity. Here, we investigated inactivation of A20 by DNA mutations or deletions in a panel of extranodal (EMZL), nodal (NMZL) and splenic (SMZL) MZLs. Inactivating mutations...

  17. Transcription profiling by array of several human solid tumor cell lines (glioblastoma, breast carcinoma and lung carcinoma) and T-cell leukemia cells... ArrayExpress

    ID: E-MTAB-1900

    Description: ntly up-regulated genes. The increased TNF-alpha, TNFAIP3 and BIRC3 mRNA levels were further confirmed after different treatment durations by real-time quantitative PCR (qPCR). Our results suggest that inhibition of cell proliferation in solid tumor cells essentially occurs through TNF-alpha signaling whereas no conclusion could be drawn concerning the pathways leading to apoptotic cell death in leukemia cells due to the reduced number of differentially expressed genes.ヤ...

  18. Genetic Heterogeneity of DLBCL ArrayExpress

    ID: E-GEOD-43606

    Description: dification (ARID1A and MEF2B), NF-κB (CARD11 and TNFAIP3), PI3 kinase (PIK3CD, PIK3R1, and MTOR), B-cell lineage (IRF8, POU2F2, and GNA13), and WNT signaling (WIF1). We also experimentally validated a mutation in PIK3CD, a gene not previously implicated in lymphomas. The patterns of mutation demonstrated a classic long tail distribution with substantial variation of mutated genes from patient to patient and also between published studies. Thus, our study reveals the tremendous genetic heterogeneity that underlies lymphomas and highlights the need for personalized medicine approaches to treating these patients. 21 DLBCL cell lines and 70 DLBCL patient samples....

  19. Fine Mapping of Eight Psoriasis Susceptibility Loci BioProject

    ID: PRJNA375837

    Access Type: download

    dataset.description: usceptibility regions ( MHC, IL12B, IL23R, IL23A, TNFAIP3, IL13, RNF114, and TNIP1). The custom array also included 5,463 SNPs outside the eight known susceptibility regions, which were selected based on their association p-values in a meta-analysis of HapMap-imputed genotypes of two published GWAS-CASP (Nair et al. 2009) and Kiel, Germany (Ellinghaus et al. 2010). After quality control we analyzed 4,806 samples (2,699 cases and 2,107 controls)....
  20. Fine Mapping of Eight Psoriasis Susceptibility Loci BioProject

    ID: PRJNA375838

    Keywords: Phenotype or Genotype

    Access Type: download

    dataset.description: usceptibility regions ( MHC, IL12B, IL23R, IL23A, TNFAIP3, IL13, RNF114, and TNIP1). The custom array also included 5,463 SNPs outside the eight known susceptibility regions, which were selected based on their association p-values in a meta-analysis of HapMap-imputed genotypes of two published GWAS-CASP (Nair et al. 2009) and Kiel, Germany (Ellinghaus et al. 2010). After quality control we analyzed 4,806 samples (2,699 cases and 2,107 controls)....

Displaying 20 of 83 results for "TNFAIP3"