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Displaying 15 of 15 results for "TIMP4"
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  1. Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2 PDB

    ID: PDB:2E2D

    Description: Matrix metallopeptidase 13 (E.C.3.4.24.-)/Metalloproteinase inhibitor 2

  2. Sternal cartilage microarray (WT vs. TIMPless) ArrayExpress

    ID: E-GEOD-60451

    Description: ily in mammals is unknown. We generated quadruple Timp deficient mice lacking Timp1, Timp2, Timp3 and Timp4 (TIMPless) and found that Timp function is essential for postnatal lifespan, lung form and function and skeletogenesis. TIMPless mice survive embryogenesis but develop pervasive skeletal ab...

  3. Sternal cartilage microarray (WT vs. TIMPless) BioProject

    ID: PRJNA258287

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ily in mammals is unknown. We generated quadruple Timp deficient mice lacking Timp1, Timp2, Timp3 and Timp4 (TIMPless) and found that Timp function is essential for postnatal lifespan, lung form and function and skeletogenesis. TIMPless mice survive embryogenesis but develop pervasive skeletal ab...
  4. TIMP4_RAT UniProt:Swiss-Prot

    ID: P81556

    Description: Metalloproteinase inhibitor 4 NTR Involved in metalloproteinase-binding Involved in metalloproteinase-binding Zinc; via amino nitr...

  5. TIMP4_RABIT UniProt:Swiss-Prot

    ID: O97591

    Description: Metalloproteinase inhibitor 4 NTR Involved in metalloproteinase-binding

  6. Transcription profiling of human Articular chondrocytes from patients with OA undergoing total knee replacement (Mankin Score >3, Ahlb??ck Score >2) a... ArrayExpress

    ID: E-GEOD-16464

    Description: d in matrix synthesis (biglycan, COL9A2, COL11A1, TIMP4, CILP2) was highly induced in 3D cultures of chondrocytes from both donor groups. Genes associated with hypertrophic or OA cartilage (COL10A1, RUNX2, periostin, ALP, PTHR1, MMP13, COL1A1, COL3A1) were not significantly regulated between the two groups of donors. The expression of 661 genes, including COMP, FN1, and SOX9, were differentially regulated between OA and ND chondrocytes cultured in monolayer. During scaffold culture, the differences diminished between the OA and ND chondrocytes, and only 184 genes were differentially regulated. Only few genes were differentially expressed between OA and ND chondrocytes in Hyaff-11 culture. The risk of differentiation into hypertrophic cartilage does not seem to be increased for OA chondrocytes. Our findings suggest that the chondrogenic capacity is not significantly affected by OA and OA chondrocytes fulfill the requirements for matrix-associated ACT. Experiment Overall Design: Gene expression profiles of monolayer cultures (ML; passage 2) and Hyaff-11 scaffold cultures (3D; 14 days in vitro) of chondrocytes from 3 normal donors (ND; underwent ACT treatment) and 3 donors suffering from Osteoarthritis (OA; underwent knee replacement surgery) were determined. Comparative analyses between 3D and ML cultures (3D vs. ML) were performed to assess differentiation capacity of ND and OA chondrocytes. Furthermore, OA-related differences were determined comparing OA and ND monolayer...

  7. CCAAT/Enhancer Binding Proteins (C/EBP)-α and -β are Essential for Ovulation, Luteinization and the Expression of Key Target Genes ArrayExpress

    ID: E-GEOD-23084

    Description: aa3) and novel (Abcb1b, Apln, Igfbp4, Prlr, Ptgfr Timp4) C/EBP target genes including effectors of vascular cell development. Bhmt, a gene controlling methionine metabolism and expressed exclusively in liver and kidney, was high in WT luteal cells but totally absent in Cebpa/b mutant cells. Because numerous genes potentially associated with vascular development were suppressed in the mutant cells, C/EBPa/b appear to dictate the luteinization process by also controlling genes that regulate the formation of the extensive vascular network required to sustain luteal cells. Thus, C/EBPa/b mediate several aspects of granulosa cell differentiation as well as the complex process of luteinization. Five granulosa cell treatments were included: CEBPα/β conditional KO ovary, eCG-treated 48h, hCG 4h wild type ovary, eCG-treated 48h, hCG 8h CEBPα/β conditional KO ovary, eCG-treated 48h, hCG 8h wild type ovary, eCG-treated 48h, hCG 24h CEBPα/β conditional KO ovary, eCG-treated 48h, hCG 24h...

  8. Transcription profiling by array of human bone marrow mesenchymal stem cells after treatment with BMP2 or TGFbeta-3 ArrayExpress

    ID: E-GEOD-10315

    Description: rized by expression of DKK1, APOD/E, SERPINF1 and TIMP4. These data propose new pathways to understand the complexity of MSC differentiation to chondrocytes and new potential targets for cell therapy applied to cartilage repair. Experiment Overall Design: To identify genes involved in TGFbeta03/BMP2-induced chondrogenesis, MSC were isolated from human bone marrow aspirates by adherence to culture dishes and cultivated to passage 3. After induction of chondrogenic differentiation with BMP2 or TGFbeta-3, gene expression was determined by microarray hybridization after 1, 3, 7 and 21 days and compared to the undifferentiated MSC....

  9. Sternal cartilage microarray (WT vs. TIMPless) OmicsDI

    ID: E-GEOD-60451

    Date Released: 09-06-2015

    Description: ily in mammals is unknown. We generated quadruple Timp deficient mice lacking Timp1, Timp2, Timp3 and Timp4 (TIMPless) and found that Timp function is essential for postnatal lifespan, lung form and function and skeletogenesis. TIMPless mice survive embryogenesis but develop pervasive skeletal ab...

  10. CCAAT/Enhancer Binding Proteins (C/EBP)-α and -β are Essential for Ovulation, Luteinization and the Expression of Key Target Genes BioProject

    ID: PRJNA131671

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: aa3) and novel (Abcb1b, Apln, Igfbp4, Prlr, Ptgfr Timp4) C/EBP target genes including effectors of vascular cell development. Bhmt, a gene controlling methionine metabolism and expressed exclusively in liver and kidney, was high in WT luteal cells but totally absent in Cebpa/b mutant cells. Because numerous genes potentially associated with vascular development were suppressed in the mutant cells, C/EBPa/b appear to dictate the luteinization process by also controlling genes that regulate the formation of the extensive vascular network required to sustain luteal cells. Thus, C/EBPa/b mediate several aspects of granulosa cell differentiation as well as the complex process of luteinization. Overall design: Five granulosa cell treatments were included: CEBPα/β conditional KO ovary, eCG-treated 48h, hCG 4h wild type ovary, eCG-treated 48h, hCG 8h CEBPα/β conditional KO ovary, eCG-treated 48h, hCG 8h wild type ovary, eCG-treated 48h, hCG 24h CEBPα/β conditional KO ovary, eCG-treated 48h, hCG 24h...
  11. Multipotent mesenchymal stromal cells: identification of pathways common to TGFβ3/BMP2-induced chondrogenesis BioProject

    ID: PRJNA108545

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: rized by expression of DKK1, APOD/E, SERPINF1 and TIMP4. These data propose new pathways to understand the complexity of MSC differentiation to chondrocytes and new potential targets for cell therapy applied to cartilage repair. Keywords: dose response Overall design: To identify genes involved in TGFβ3/BMP2-induced chondrogenesis, MSC were isolated from human bone marrow aspirates by adherence to culture dishes and cultivated to passage 3. After induction of chondrogenic differentiation with BMP2 or TGFβ3, gene expression was determined by microarray hybridization after 1, 3, 7 and 21 days and compared to the undifferentiated MSC....
  12. Chondrogenic differentiation potential of OA chondrocytes and their use in autologous chondrocyte transplantation BioProject

    ID: PRJNA116043

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: d in matrix synthesis (biglycan, COL9A2, COL11A1, TIMP4, CILP2) was highly induced in 3D cultures of chondrocytes from both donor groups. Genes associated with hypertrophic or OA cartilage (COL10A1, RUNX2, periostin, ALP, PTHR1, MMP13, COL1A1, COL3A1) were not significantly regulated between the two groups of donors. The expression of 661 genes, including COMP, FN1, and SOX9, were differentially regulated between OA and ND chondrocytes cultured in monolayer. During scaffold culture, the differences diminished between the OA and ND chondrocytes, and only 184 genes were differentially regulated. Only few genes were differentially expressed between OA and ND chondrocytes in Hyaff-11 culture. The risk of differentiation into hypertrophic cartilage does not seem to be increased for OA chondrocytes. Our findings suggest that the chondrogenic capacity is not significantly affected by OA and OA chondrocytes fulfill the requirements for matrix-associated ACT. Keywords: time course, cell type comparison, tissue engineered cartilage; osteoarthritis; Hyaff-11 scaffold; human chondrocytes; gene expression profiling; regenerative medicine; differentiation potential Overall design: Gene expression profiles of monolayer cultures (ML; passage 2) and Hyaff-11 scaffold cultures (3D; 14 days in vitro) of chondrocytes from 3 normal donors (ND; underwent ACT treatment) and 3 donors suffering from Osteoarthritis (OA; underwent knee replacement surgery) were determined. Comparative analyses bet...
  13. Transcription profiling by array of human bone marrow mesenchymal stem cells after treatment with BMP2 or TGFbeta-3 OmicsDI

    ID: E-GEOD-10315

    Date Released: 08-27-2015

    Description: rized by expression of DKK1, APOD/E, SERPINF1 and TIMP4. These data propose new pathways to understand the complexity of MSC differentiation to chondrocytes and new potential targets for cell therapy applied to cartilage repair. Experiment Overall Design: To identify genes involved in TGFbeta03/BMP2-induced chondrogenesis, MSC were isolated from human bone marrow aspirates by adherence to culture dishes and cultivated to passage 3. After induction of chondrogenic differentiation with BMP2 or TGFbeta-3, gene expression was determined by microarray hybridization after 1, 3, 7 and 21 days and compared to the undifferentiated MSC....

  14. CCAAT/Enhancer Binding Proteins (C/EBP)-α and -β are Essential for Ovulation, Luteinization and the Expression of Key Target Genes OmicsDI

    ID: E-GEOD-23084

    Date Released: 06-02-2014

    Description: aa3) and novel (Abcb1b, Apln, Igfbp4, Prlr, Ptgfr Timp4) C/EBP target genes including effectors of vascular cell development. Bhmt, a gene controlling methionine metabolism and expressed exclusively in liver and kidney, was high in WT luteal cells but totally absent in Cebpa/b mutant cells. Because numerous genes potentially associated with vascular development were suppressed in the mutant cells, C/EBPa/b appear to dictate the luteinization process by also controlling genes that regulate the formation of the extensive vascular network required to sustain luteal cells. Thus, C/EBPa/b mediate several aspects of granulosa cell differentiation as well as the complex process of luteinization. Five granulosa cell treatments were included: CEBPα/β conditional KO ovary, eCG-treated 48h, hCG 4h wild type ovary, eCG-treated 48h, hCG 8h CEBPα/β conditional KO ovary, eCG-treated 48h, hCG 8h wild type ovary, eCG-treated 48h, hCG 24h CEBPα/β conditional KO ovary, eCG-treated 48h, hCG 24h...

  15. Transcription profiling of human Articular chondrocytes from patients with OA undergoing total knee replacement (Mankin Score >3, Ahlb??ck Score >2) a... OmicsDI

    ID: E-GEOD-16464

    Date Released: 05-01-2014

    Description: d in matrix synthesis (biglycan, COL9A2, COL11A1, TIMP4, CILP2) was highly induced in 3D cultures of chondrocytes from both donor groups. Genes associated with hypertrophic or OA cartilage (COL10A1, RUNX2, periostin, ALP, PTHR1, MMP13, COL1A1, COL3A1) were not significantly regulated between the two groups of donors. The expression of 661 genes, including COMP, FN1, and SOX9, were differentially regulated between OA and ND chondrocytes cultured in monolayer. During scaffold culture, the differences diminished between the OA and ND chondrocytes, and only 184 genes were differentially regulated. Only few genes were differentially expressed between OA and ND chondrocytes in Hyaff-11 culture. The risk of differentiation into hypertrophic cartilage does not seem to be increased for OA chondrocytes. Our findings suggest that the chondrogenic capacity is not significantly affected by OA and OA chondrocytes fulfill the requirements for matrix-associated ACT. Experiment Overall Design: Gene expression profiles of monolayer cultures (ML; passage 2) and Hyaff-11 scaffold cultures (3D; 14 days in vitro) of chondrocytes from 3 normal donors (ND; underwent ACT treatment) and 3 donors suffering from Osteoarthritis (OA; underwent knee replacement surgery) were determined. Comparative analyses between 3D and ML cultures (3D vs. ML) were performed to assess differentiation capacity of ND and OA chondrocytes. Furthermore, OA-related differences were determined comparing OA and ND monolayer...


Displaying 15 of 15 results for "TIMP4"