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Displaying 3 of 3 results for "TIMM8A"
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  1. Transcription profiling of Baboon (Papio anubis) cerebral cortex from neonates consuming long-chain polyunsaturated fatty acid formulas ArrayExpress

    ID: E-GEOD-6519

    Description: d in L3/C. Genes involved in neural development, TIMM8A, NRG1, SEMA3D and NUMB, were upregulated while HES1 and SIM1 showed decreased expression. LUM, EML2, TIMP3 and TTC8 which have roles in visual perception were upregulated and TIA1, a silencer of COX2 gene translation is upregulated in L3/C. Ingenuity network analysis identified a top network associated with nervous system development and function with EGFR as the outstanding interaction partner. In this network EGFR interacts with genes involved in neural or visual perception, TIMP3, NRG1, ADAM17, EDG7 and FGF7. Quantitative real time-PCR analysis on selected genes confirmed the array results. The L and L3 groups have DHA and ARA content within the ranges observed in human and baboon breastmilk, and thus these data indicate that LCPUFA concentrations within the normal range of human breastmilk induce global changes in gene expression across numerous functions including transcripts involved in neural development, visual perception, etc. Experiment Overall Design: Twelve baboon neonates born spontaneously around 182 days gestation were randomized into 3 groups (n=4 per group). They were fed for 12 weeks on one of three formulas: C: Control (no DHA-ARA); L: 1× LCPUFA (0.33%DHA-0.67%ARA); L3: 3× LCPUFA (1.00%DHA-0.67%ARA)....

  2. Microarray Analysis of Baboon neonates consuming long-chain polyunsaturated fatty acid formula BioProject

    ID: PRJNA98791

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: d in L3/C. Genes involved in neural development, TIMM8A, NRG1, SEMA3D and NUMB, were upregulated while HES1 and SIM1 showed decreased expression. LUM, EML2, TIMP3 and TTC8 which have roles in visual perception were upregulated and TIA1, a silencer of COX2 gene translation is upregulated in L3/C. Ingenuity network analysis identified a top network associated with nervous system development and function with EGFR as the outstanding interaction partner. In this network EGFR interacts with genes involved in neural or visual perception, TIMP3, NRG1, ADAM17, EDG7 and FGF7. Quantitative real time-PCR analysis on selected genes confirmed the array results. The L and L3 groups have DHA and ARA content within the ranges observed in human and baboon breastmilk, and thus these data indicate that LCPUFA concentrations within the normal range of human breastmilk induce global changes in gene expression across numerous functions including transcripts involved in neural development, visual perception, etc. Keywords: dietary dose response Overall design: Twelve baboon neonates born spontaneously around 182 days gestation were randomized into 3 groups (n=4 per group). They were fed for 12 weeks on one of three formulas: C: Control (no DHA-ARA); L: 1× LCPUFA (0.33%DHA-0.67%ARA); L3: 3× LCPUFA (1.00%DHA-0.67%ARA)....
  3. Transcription profiling of Baboon (Papio anubis) cerebral cortex from neonates consuming long-chain polyunsaturated fatty acid formulas OmicsDI

    ID: E-GEOD-6519

    Date Released: 03-27-2012

    Description: d in L3/C. Genes involved in neural development, TIMM8A, NRG1, SEMA3D and NUMB, were upregulated while HES1 and SIM1 showed decreased expression. LUM, EML2, TIMP3 and TTC8 which have roles in visual perception were upregulated and TIA1, a silencer of COX2 gene translation is upregulated in L3/C. Ingenuity network analysis identified a top network associated with nervous system development and function with EGFR as the outstanding interaction partner. In this network EGFR interacts with genes involved in neural or visual perception, TIMP3, NRG1, ADAM17, EDG7 and FGF7. Quantitative real time-PCR analysis on selected genes confirmed the array results. The L and L3 groups have DHA and ARA content within the ranges observed in human and baboon breastmilk, and thus these data indicate that LCPUFA concentrations within the normal range of human breastmilk induce global changes in gene expression across numerous functions including transcripts involved in neural development, visual perception, etc. Experiment Overall Design: Twelve baboon neonates born spontaneously around 182 days gestation were randomized into 3 groups (n=4 per group). They were fed for 12 weeks on one of three formulas: C: Control (no DHA-ARA); L: 1× LCPUFA (0.33%DHA-0.67%ARA); L3: 3× LCPUFA (1.00%DHA-0.67%ARA)....


Displaying 3 of 3 results for "TIMM8A"