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Displaying 20 of 24 results for "THOC5"
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  1. THOC5 controls 3´end-processing of immediate early genes via interaction with CPSF100 BioProject

    ID: PRJNA255638

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Genome-wide gene expression analysis in Thoc5- and CFIm68-depleted HeLa cells BioProject

    ID: PRJNA181059

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. molecules of human hepatocellular carcinoma using THOC5, a member of the transcription/export (TREX) complex, depleted system... BioProject

    ID: PRJNA287802

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. molecules of human hepatocellular carcinoma using THOC5, a member of the transcription/export (TREX) complex, depleted system... OmicsDI

    ID: E-GEOD-70178

    Date Released: 12-02-2015

    Description: inhibit these multiple pathways for HCC therapy. THOC5, a member of transcription/export (TREX) complex, that plays a role in less than 1% of mRNA processing in normal cells such as fibroblasts or macrophages, is not required for maintenance of mature hepatocytes. In this study, we have examined the role of THOC5 in human HCC. Enhanced THOC5 expression was not observed in differentiation grading 1 (G1) human HCC, but 78% of G2 and G3 exhibited increased levels of THOC5. Furthermore, the 50% depletion of THOC5

  5. THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation ArrayExpress

    ID: E-GEOD-41170

    Description: THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage dif...

  6. THOC5 controls 3´end-processing of immediate early genes via interaction with CPSF100 OmicsDI

    ID: E-GEOD-59561

    Date Released: 11-08-2014

    Description: signals is tightly regulated at multiple stages. THOC5, a member of the TREX (transcription/export) complex plays a role in expression of only a subset of constitutively active genes. In this report, we show that THOC5 plays a role in the 3´end...

  7. molecules of human hepatocellular carcinoma using THOC5, a member of the transcription/export (TREX) complex, depleted system... ArrayExpress

    ID: E-GEOD-70178

    Description: inhibit these multiple pathways for HCC therapy. THOC5, a member of transcription/export (TREX) complex, that plays a role in less than 1% of mRNA processing in normal cells such as fibroblasts or macrophages, is not required for maintenance of mature hepatocytes. In this study, we have examined the role of THOC5 in human HCC. Enhanced THOC5 expression was not observed in differentiation grading 1 (G1) human HCC, but 78% of G2 and G3 exhibited increased levels of THOC5. Furthermore, the 50% depletion of THOC5

  8. Genome-wide gene expression analysis in Thoc5- and CFIm68-depleted HeLa cells ArrayExpress

    ID: E-GEOD-42327

    Description: polyadenylation site choice, was co-purified with Thoc5, a component of human THO/TREX. Microarray analysis using human HeLa cells reveals knockdown of Thoc5 affects the expression of a subset of non-heat shock genes. Notably, depletion of

  9. THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation BioProject

    ID: PRJNA176023

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage differentiation OmicsDI

    ID: E-GEOD-41170

    Date Released: 05-03-2014

    Description: THOC5, a member of the mRNA export complex, is essential for hematopoiesis in vivo and is required for CSF-1 induced macrophage dif...

  11. THOC5 controls 3´end-processing of immediate early genes via interaction with CPSF100 ArrayExpress

    ID: E-GEOD-59561

    Description: signals is tightly regulated at multiple stages. THOC5, a member of the TREX (transcription/export) complex plays a role in expression of only a subset of constitutively active genes. In this report, we show that THOC5 plays a role in the 3´end...

  12. Genome-wide gene expression analysis in Thoc5- and CFIm68-depleted HeLa cells OmicsDI

    ID: E-GEOD-42327

    Date Released: 06-02-2014

    Description: polyadenylation site choice, was co-purified with Thoc5, a component of human THO/TREX. Microarray analysis using human HeLa cells reveals knockdown of Thoc5 affects the expression of a subset of non-heat shock genes. Notably, depletion of

  13. THOC5_SCHPO UniProt:Swiss-Prot

    ID: Q9USR5

    Description: Uncharacterized THOC5 family protein

  14. The THO complex regulates pluripotency gene mRNA export to control embryonic stem cell self-renewal and somatic cell reprogramming (microarray) ArrayExpress

    ID: E-GEOD-51496

    Description: eracts with pluripotency gene transcripts through Thoc5, and is required for self-renewal at least in part by regulating their export and expression. During differentiation, THO loses its interaction with those transcripts due to reduced Thoc5 expression, leading to decreased expression of pluripotency proteins that facilitates exit from self-renewal. THO is also important for the establishment of pluripotency, as its depletion inhibits somatic cell reprogramming and blastocyst development. Together, our data indicate that THO regulates pluripotency g...

  15. Splicing-independent loading of TREX on nascent RNA is required for efficient transcription of dual-strand piRNA clusters in Drosophila BioProject

    ID: PRJNA315501

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: functions is poorly understood. Here we show that Thoc5 and other TREX components are essential for the biogenesis of piRNA, a distinct class of small non-coding RNAs that control expression of transposable elements (TE) in the Drosophila germline. Mutations in TREX lead to defects in piRNA biogenesis resulting in derepression of multiple TE families, gametogenesis defects, and sterility. TREX co...
  16. The THO complex regulates pluripotency gene mRNA export to control embryonic stem cell self-renewal and somatic cell reprogramming (microarray) BioProject

    ID: PRJNA223316

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: eracts with pluripotency gene transcripts through Thoc5, and is required for self-renewal at least in part by regulating their export and expression. During differentiation, THO loses its interaction with those transcripts due to reduced Thoc5 expression, leading to decreased expression of pluripotency proteins that facilitates exit from self-renewal. THO is also important for the establishment of pluripotency, as its depletion inhibits somatic cell reprogramming and blastocyst development. Together, our data indicate that THO regulates pluripotency g...
  17. The THO complex regulates pluripotency gene mRNA export to control embryonic stem cell self-renewal and somatic cell reprogramming (RNA-IP) ArrayExpress

    ID: E-GEOD-48436

    Description: eracts with pluripotency gene transcripts through Thoc5, and is required for self-renewal by regulating their export and expression. During differentiation, THO loses its interaction with those transcripts due to reduced Thoc5 expression, which leads to decreased expression of pluripotency proteins and facilitates differentiation. Finally, THO is also important for the establishment of pluripotency, as its depletion inhibits somatic cell reprogramming and blastocyst development. Together, our data indicates that THO regulates pluripotency gene mRNA e...

  18. Homo sapiens : Illumina sequencing of CFIm68 binding regions in Hela cells BioProject

    ID: PRJDB2593

    Keywords: Other

    Access Type: download

    dataset.description: Genome-wide CFIm68 binding in Hela cells was examined under normal and Thoc5-depleted conditions
  19. The THO complex regulates pluripotency gene mRNA export to control embryonic stem cell self-renewal and somatic cell reprogramming (microarray) OmicsDI

    ID: E-GEOD-51496

    Date Released: 06-03-2014

    Description: eracts with pluripotency gene transcripts through Thoc5, and is required for self-renewal at least in part by regulating their export and expression. During differentiation, THO loses its interaction with those transcripts due to reduced Thoc5 expression, leading to decreased expression of pluripotency proteins that facilitates exit from self-renewal. THO is also important for the establishment of pluripotency, as its depletion inhibits somatic cell reprogramming and blastocyst development. Together, our data indicate that THO regulates pluripotency g...

  20. The THO complex regulates pluripotency gene mRNA export to control embryonic stem cell self-renewal and somatic cell reprogramming (RNA-IP) OmicsDI

    ID: E-GEOD-48436

    Date Released: 06-03-2014

    Description: eracts with pluripotency gene transcripts through Thoc5, and is required for self-renewal by regulating their export and expression. During differentiation, THO loses its interaction with those transcripts due to reduced Thoc5 expression, which leads to decreased expression of pluripotency proteins and facilitates differentiation. Finally, THO is also important for the establishment of pluripotency, as its depletion inhibits somatic cell reprogramming and blastocyst development. Together, our data indicates that THO regulates pluripotency gene mRNA e...


Displaying 20 of 24 results for "THOC5"