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Displaying 20 of 30 results for "TGM2"
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  1. Transcription profiling by array of human sputum samples from patients with exercise-induced bronchoconstriction ArrayExpress

    ID: E-GEOD-13785

    Description: t two novel mediators trefoil factor 3 (TFF3) and transglutaminase 2 (TGM2) have increased expression in airways cells and secreted product in the airways. In vitro studies indicate that 1) TFF3 induces nitric oxide synthase in airway epithelial cells from asthmatics and 2) TGM2 augments the enzymatic activity of secreted phospholipase A2 (sPLA2) group X, an enzyme recently been implicated in asthma pathogenesis. Since PLA2 serves as the first rate-limiting step leading to eicosanoid generation, these results suggest that TGM2 may be a key initiator of the airway inflammatory cascade in asthma. EIB ...

  2. Global gene expression profile and splicing events of iPS-derived motorneurons from SMA patient, unaffected father and TGC-treated cells ArrayExpress

    ID: E-GEOD-27205

    Description: rting SMN2 into SMN1 with target gene correction (TGC), were used to study gene expression and splicing events linked to pathogenetic mechanisms. Microarray technology was used to assess the global gene expression profile as well as splicing events of iPS-derived motorneurons from SMA patient, unaffected father and TGC-treated cells. The microarray data derived from three different groups: SMA patient, healty father and treated SMA patient's cells. Each population consists of three RNA profiling c...

  3. Transglutaminase2 complexed with GTP PDB

    ID: PDB:4PYG

    Description: Protein-glutamine gamma-glutamyltransferase 2 (E.C.2.3....

  4. Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta ArrayExpress

    ID: E-GEOD-39584

    Description: lectively disrupts specification of this discrete TGC sub-type. Transcriptional profiling experiments identified additional SpA-TGC lineage restricted marker genes that potentially regulate placental morphogenesis. Prdm1BEH/+ (Vincent et al., 2005) animals were intercrossed to generate null placental tissue. Total RNA obtained from 10 Prdm1+/+ and 11 Prdm1-/- E9.5 placenta samples was hybridized to Illumina WG6_V2 beadchips....

  5. Effect of cajanin stilbene acid and its synthetic derivatives on MCF-7 breast cancer cells BioProject

    ID: PRJNA271005

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: nd its synthetic derivatives (CSA6, CSA9, CSA19). TGM2 gene encoding transglutaminase 2 was commonly deregulated after treatment with all four CSA compounds. All compounds revealed strong effects on cell cycle progression and DNA damage response. Promoter motif analysis of the deregulated genes further supported the microarray results emphasizing the relevance of transcrip...
  6. Data from: Enhanced B-cell receptor recognition of the autoantigen transglutaminase 2 by efficient catalytic self-multimerization Dryad

    DateIssued: 08-05-2015

    Description: ase is autoantibody production towards the enzyme transglutaminase 2 (TG2) that catalyzes the formation of covalent protein-protein cross-links. Activation of TG2-specific B cells...

  7. Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease BioProject

    ID: PRJNA126507

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. Differential gene expression in nephron progenitors lacking miR-17~92 BioProject

    ID: PRJNA229148

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: esign: mRNA profiles of control and mutant (=Six2-TGC; miR-17~92 flx/flx) embryonic day 16 kidneys were generated by deep sequencing, in triplicate, using Illumina HiSeq2000...
  9. Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta BioProject

    ID: PRJNA171158

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: lectively disrupts specification of this discrete TGC sub-type. Transcriptional profiling experiments identified additional SpA-TGC lineage restricted marker genes that potentially regulate placental morphogenesis. Overall design: Prdm1BEH/+ (Vincent et al., 2005) animals were intercrossed to generate null placental tissue. Total RNA obtained from 10 Prdm1+/+ and 11 Prdm1-/- E9.5 placenta samples was hybridized to Illumina WG6_V2 beadchips....
  10. Global gene expression profiles of iPSC from SMA patient, unaffected father and iPS 19.9 compared to transcriptomic data obtained by corresponding fib... BioProject

    ID: PRJNA141985

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: rting SMN2 into SMN1 with target gene correction (TGC), were used to study gene expression and splicing events linked to pathogenetic mechanisms. Microarray technology was used to assess global gene expression profiles of iPSC from SMA patient, unaffected father and iPS 19.9 (Prof. J. Thomson's lab) compared to transcriptomic data obtained by corresponding fibroblasts. Overall design: The microarray data derived from three different individuals: SMA patient, healthy father and control iPS cells (19.9). We analyzed iPSC f...
  11. Gene expression profiling of ATRA-differentiated wild-type and TG2 knockout NB4 cells ArrayExpress

    ID: E-GEOD-23702

    Description: One of the most induced genes in APL NB4 cells is transglutaminase 2 (TG2). RNAi-mediated stable silencing of TG2 in NB4 cells (TG2-KD NB4) coupled with whole genome microarray analysis revealed that TG2 is involved in the expression of a large number of ATRA-regulated genes. The affected genes participate in granulocyte functions and their silencing lead to reduced adhesive, migratory and phagocytic capacity of neutrophils and less superoxide production. The expression of genes related to cell cycle control ...

  12. Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease GEMMA

    ID: 1895

    Keywords: functional genomics

    Description: polyglutamine expansion in the mutant huntingtin protein (mhtt), HD pathogenesis impairs function in the cerebral cortex and in medium spiny neurons of the striatum and involves transcriptional dysregulation of a number of genes. Of these genes, silencing of genes related to mitochondrial fu...

  13. Global gene expression profile and splicing events of iPS-derived motorneurons from SMA patient, unaffected father and TGC-treated cells OmicsDI

    ID: E-GEOD-27205

    Date Released: 01-14-2013

    Description: rting SMN2 into SMN1 with target gene correction (TGC), were used to study gene expression and splicing events linked to pathogenetic mechanisms. Microarray technology was used to assess the global gene expression profile as well as splicing events of iPS-derived motorneurons from SMA patient, unaffected father and TGC-treated cells. The microarray data derived from three different groups: SMA patient, healty father and treated SMA patient's cells. Each population consists of three RNA profiling c...

  14. Trophoblast giant cell underrepresentation (CGH) BioProject

    ID: PRJNA217981

    Keywords: Variation

    Access Type: download

    dataset.description: CNV during various stages of in vivo and in vitro TGC development: e9.5 TGCs vs. embryonic controls, e11.5 TGCs vs. embryonic controls, e13.5 TGCs vs. embryonic controls, e16.5 TGCs vs. embryonic controls, as well as TGCs cultured 3, 5 and 7 days vs. 2N trophoblast stem cells. We also performed the following controls to show that underrepresentation is only found in polypoid trophoblast giant cells and not in either 2N placental cell types nor in other types of polyploid cells: 2N placenta disk vs. embryonic controls...
  15. Hypoxia induces pluripotency in primordial germ cells by HIF1 alpha stabilization and Oct4 deregulation ArrayExpress

    ID: E-GEOD-61472

    Description: by hypoxia likely due to lack of upregulation of c-Myc and Klf4. Gene expression analysis of hypoxia signalling suggests that hiEGLs have not reached the stabilization phase of cell reprogramming. The data suggests that the properties of stemness, pluripotency and selfrenewal, are differentially regulated in primordial germ cell reprogramming induced by hypoxia. 8.5 dpc Oct4-GFP PGCs cultured in hypoxia conditions for 6 days were isolated by FACS. To eliminate the possibility of differences due solely to anaerobic respiration, TGC-10 EGC line was exposed to the hypoxia-mimetic agent Cl2Co at 150 microM for four hours prior to RNA isolation. RNA samples to be analyzed by microarrays were prepared using Qiagen RNeasy columns with on-column DNA digestion. 300 ng of total RNA per sample was used as input into a linear amplification protocol (Tetu-Bio), which involved synthesis of T7-linked double-stranded cDNA and 12 hours of in vitro transcription incorporating biotin-labelled nucleotides. Purif...

  16. Tgl - a bacterial spore coat transglutaminase - cystamine complex PDB

    ID: PDB:4PA5

    Description: Transglutaminase (E.C.2.3.2.13)

  17. Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions change structure for activation PDB

    ID: PDB:1L9N

    Description: Protein-glutamine glutamyltransferase E3 (E.C.2.3.2.13)

  18. Induction of Pathogenic Sets of Genes in Macrophages and Neurons in NeuroAIDS BioProject

    ID: PRJNA91535

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ation, distinct classes of genes were found whose protein products localized to infiltrating macrophages, endothelial cells and resident glia, such as CD163, Glut5, and ISG15. In addition we found proteins induced in cortical neurons (ie, cyclin D3, tissue transglutaminase, 1-antichymotrypsin, and STAT1), which have not previously been described as participating in simian immunodeficiency virus or HIV-related CNS pathology. This molecular phenotyping in the infected brains revealed pathways promoting entry of macrophages into the brain and their subsequent detrimental effects on neurons. These data support the hypothesis that i...
  19. Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions change structure for activation PDB

    ID: PDB:1L9M

    Description: Protein-glutamine glutamyltransferase E3 (E.C.2.3.2.13)

  20. Role of Calcium Ions in the Activation and Activity of the Transglutaminase 3 Enzyme (3 calciums, active form) PDB

    ID: PDB:1NUD

    Description: Protein-glutamine glutamyltransferase E (E.C.2.3.2.13)


Displaying 20 of 30 results for "TGM2"