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Displaying 20 of 43 results for "TGFBR3"
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  1. Crystal structure of betaglycan ZP-C domain PDB

    ID: PDB:3QW9

    Description: Transforming growth factor beta receptor type 3

  2. Transcriptional Profiling of Cultured, Embryonic Epicardial Cells Identifies Novel Genes and Signaling Pathways Regulated by TGFβR3 in vitro BioProject

    ID: PRJNA302322

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: n important role in coronary vessel formation and Tgfbr3-/- mice exhibit failed coronary vessel development associated with decreased epicardial cell invasion. Immortalized Tgfbr3-/- e...
  3. Expression data from TGFBR3 controls and TGFBR3 knockdown of SUM159 3D cultures BioProject

    ID: PRJNA237556

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Outer ECM-attached vs. inner cells of MCF10A acini at day 6 of morphogenesis BioProject

    ID: PRJNA177354

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: rganotypic 3D culture. The first program contains TGFBR3, a high-affinity receptor for transforming growth factor β (TGFβ) and other related ligands. The second program contains the JUND transcription factor together with the basal-like marker, KRT5. By disrupting the TGFBR3 and JUND programs individually, we reveal an important circuit for 3D morphogenesis that is wire...
  5. Outer ECM-attached vs. inner cells of MCF10A acini at day 6 of morphogenesis ArrayExpress

    ID: E-GEOD-41527

    Description: rganotypic 3D culture. The first program contains TGFBR3, a high-affinity receptor for transforming growth factor β (TGFβ) and other related ligands. The second program contains the JUND transcription factor together with the basal-like marker, KRT5. By disrupting the TGFBR3 and JUND programs individually, we reveal an important circuit for 3D morphogenesis that is wire...

  6. Gene expression profiling in true interval breast cancer reveals overactivation of mTOR signalling pathway ArrayExpress

    ID: E-GEOD-47108

    Description: DBC and PTEN (phosphatase and tensin homolog) and TGFBR3 (transforming growth factor beta receptor III), down-regulated in TIBC vs SDBC. Their differential expression was confirmed by RT-qPCR and immunohistochemistry, suggesting mTOR pathway overexpression in TIBC at both mRNA and protein level. Further expanded analysis by immunohistochemistry for mTOR pathway activation, including expression of phosphorylated forms of mTOR, 4E-BP1, eIF-4G, RPS6KB2 and S6, confirmed the upregulation of this pathway in TIBC. Conclusions: TIBC and SDBC shows differential expression profile both at the gene and protein levels. The mTOR signaling is significantly upregulated in TIBC compared with SDBC, suggesting an enhanced aggressiveness of TIBC. Besides, CP may also represent novel immunohistochemical marker helpful in distinguishing between TIBC and SDBC. Further studies with larger sets of patients are guaranteed to verify these findings associated with TIBC. 5 TIBC samples where compared with 5 SDBC...

  7. Expression data from TGFBR3 controls and TGFBR3 knockdown of SUM159 3D cultures ArrayExpress

    ID: E-GEOD-54756

    Description: ge in triple negative cell line upon knockdown of TGFBR3. Genotype specific differences in expression profiles have been evaluated using human HuGene1.0-ST affymetrix array. RNA was extracted from SUM159 controls and SUM159 TGFBR3KD cells cultured in 3-dim...

  8. Gene expression profiling in true interval breast cancer reveals overactivation of mTOR signalling pathway BioProject

    ID: PRJNA203581

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: DBC and PTEN (phosphatase and tensin homolog) and TGFBR3 (transforming growth factor beta receptor III), down-regulated in TIBC vs SDBC. Their differential expression was confirmed by RT-qPCR and immunohistochemistry, suggesting mTOR pathway overexpression in TIBC at both mRNA and protein level. Further expanded analysis by immunohistochemistry for mTOR pathway activation, including expression of phosphorylated forms of mTOR, 4E-BP1, eIF-4G, RPS6KB2 and S6, confirmed the upregulation of this pathway in TIBC. Conclusions: TIBC and SDBC shows differential expression profile both at the gene and protein levels. The mTOR signaling is significantly upregulated in TIBC compared with SDBC, suggesting an enhanced aggressiveness of TIBC. Besides, CP may also represent novel immunohistochemical marker helpful in distinguishing between TIBC and SDBC. Further studies with larger sets of patients are guaranteed to verify these findings associated with TIBC. Overall design: 5 TIBC samples where compared with 5 SDBC...
  9. Structure of mouse ZP-C domain of TGF-Beta-Receptor-3 PDB

    ID: PDB:4AJV

    Description: TRANSFORMING GROWTH FACTOR BETA RECEPTOR TYPE 3

  10. Expression data from TGFBR3 controls and TGFBR3 knockdown of SUM159 3D cultures OmicsDI

    ID: E-GEOD-54756

    Date Released: 06-18-2015

    Description: ge in triple negative cell line upon knockdown of TGFBR3. Genotype specific differences in expression profiles have been evaluated using human HuGene1.0-ST affymetrix array. RNA was extracted from SUM159 controls and SUM159 TGFBR3KD cells cultured in 3-dim...

  11. TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR EXTRACELLULAR DOMAIN PDB

    ID: PDB:1PLO

    Description: TGF-beta receptor type II (E.C.2.7.1.37)

  12. Inhibition of uPA expression by CRISPR-dCas9 DNA methyltransferases BioProject

    ID: PRJNA301943

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ted methylation in three human genes tested: uPA, TGFBR3, and CDKN2A in human HEK293T cells. We also showed that these methyltransferases could mediate gene inhibition. Overall design: five samples co-transfected with five uPA sgRNAs and each of the four dCas9 fusions, or control transfection with pUC19 plasmid...
  13. A single-cell transcriptome atlas of the human pancreas ArrayExpress

    ID: E-GEOD-81076

    Description: using CEL-seq or on cells stained for CD63, CD13, TGFBR3 or CD24 and CD44. The RaceID algorithm was used to identify clusters of cells corresponding to the major pancreatic cell types and to mine for novel cell type-specific genes as well as subpopulations within the known pancreatic cell types....

  14. Inhibition of uPA expression by CRISPR-dCas9 DNA methyltransferases ArrayExpress

    ID: E-GEOD-74935

    Description: ted methylation in three human genes tested: uPA, TGFBR3, and CDKN2A in human HEK293T cells. We also showed that these methyltransferases could mediate gene inhibition. five samples co-transfected with five uPA sgRNAs and each of the four dCas9 fusions, or control transfection with pUC19 plasmid...

  15. Outer ECM-attached vs. inner cells of MCF10A acini at day 6 of morphogenesis OmicsDI

    ID: E-GEOD-41527

    Date Released: 06-13-2015

    Description: rganotypic 3D culture. The first program contains TGFBR3, a high-affinity receptor for transforming growth factor β (TGFβ) and other related ligands. The second program contains the JUND transcription factor together with the basal-like marker, KRT5. By disrupting the TGFBR3 and JUND programs individually, we reveal an important circuit for 3D morphogenesis that is wire...

  16. Dynamically regulated miRNA-mRNA networks revealed by exercise ArrayExpress

    ID: E-GEOD-46075

    Description: me. The data suggest that hsa-miR-21-5p regulated TGFBR3, PDGFD and PPM1L mRNAs. Hsa-miR-24-2-5p was likely to be responsible for MYC and KCNJ2 genes and hsa-miR-27a-5p for ST3GAL6. The targets of hsa-miR-181a-5p included ROPN1L and SLC37A3. All these mRNAs are involved in processes highly relevant to exercise response, including immune function, apoptosis, membrane traffic of proteins and transcription regulation. We have identified four miRNA-mRNA networks dynamically regulated following exercise. This work is the first study to monitor miRNAs and mRNAs in parallel into recovery period. The results provide a novel insight into the regulatory role of miRNAs in stress adaptation. Each subject performed a treadmill test with an incremental step protocol until exhaustion. Blood samples were taken from the antecubital vein using indwelling catheter before (T1), immediately after ramp test to exaustion (T2) and after 30 min of recovery (T3). Two weeks later, athletes ...

  17. TWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis ArrayExpress

    ID: E-GEOD-54505

    Description: reases motility, decreases adhesion and induces a growth arrest, changes associated with a complete EMT. Patient microRNA-424 levels positively associate with TWIST1/2 and EMT-like gene signatures and is increased in primary tumors versus matched normal breast. However, microRNA-424 is down-regulated in metastases versus matched primary tumors. Correspondingly, microRNA-424 decreases tumor initiation and is post-transcriptionally down-regulated in macrometastases in mice. RNA-seq identified microRNA-424 regulates numerous genes associated with EMT and breast cancer stemness including the novel miR-424 target, TGFBR3, which regulates mesenchymal phenotypes without influencing miR-424 effects on tumor-initiating phenotypes; instead, we show that ERK signal...

  18. A single-cell transcriptome atlas of the human pancreas BioProject

    ID: PRJNA320424

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: using CEL-seq or on cells stained for CD63, CD13, TGFBR3 or CD24 and CD44. The RaceID algorithm was used to identify clusters of cells corresponding to the major pancreatic cell types and to mine for novel cell type-specific genes as well as subpopulations within the known pancreatic cell types....
  19. DNA copy number analysis of myxoinflammatory fibroblastic sarcoma, and morphologically similar lesions ArrayExpress

    ID: E-GEOD-12593

    Description: m the centromere of chromosome 1 to the 5'-end of TGFBR3. Homozygous deletion was found in one case (case 6) affecting the region 21.08-22.15 Mb on chromosome arm 9p harboring the CDKN2A and CDKN2B genes. DNA copy numbers in cases 1 and 6-8 were analyzed using tiling microarrays containing more than 32 000 partly overlapping BAC clones, generating complete coverage of the human genome (Jönsson et al., 2007, Genes Chromosomes Cancer 46: 543-58.). The arrays were produced at the Swegene DNA Microarray Resource Center, Department of Oncology, Lund University (), as previousl...

  20. Gene expression profiling in true interval breast cancer reveals overactivation of mTOR signalling pathway OmicsDI

    ID: E-GEOD-47108

    Date Released: 01-13-2014

    Description: DBC and PTEN (phosphatase and tensin homolog) and TGFBR3 (transforming growth factor beta receptor III), down-regulated in TIBC vs SDBC. Their differential expression was confirmed by RT-qPCR and immunohistochemistry, suggesting mTOR pathway overexpression in TIBC at both mRNA and protein level. Further expanded analysis by immunohistochemistry for mTOR pathway activation, including expression of phosphorylated forms of mTOR, 4E-BP1, eIF-4G, RPS6KB2 and S6, confirmed the upregulation of this pathway in TIBC. Conclusions: TIBC and SDBC shows differential expression profile both at the gene and protein levels. The mTOR signaling is significantly upregulated in TIBC compared with SDBC, suggesting an enhanced aggressiveness of TIBC. Besides, CP may also represent novel immunohistochemical marker helpful in distinguishing between TIBC and SDBC. Further studies with larger sets of patients are guaranteed to verify these findings associated with TIBC. 5 TIBC samples where compared with 5 SDBC...


Displaying 20 of 43 results for "TGFBR3"