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Displaying 20 of 56 results for "TGFBI"
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  1. Protein composition of TGFBI-R124C and TGFBI-R555W associated aggregates suggests multiple mechanisms leading to Lattice and Granular c... OmicsDI

    ID: PXD002236

    Date Released: 11-18-2015

    Description: Transforming Growth Factor Beta-induced (TGFBI)-related dystrophies constitute the most common heritable forms of corneal dystrophy worldwide. However, other than the under...

  2. onus Susceptibility Sequence Variants in VSX1, TGFBI, DOCK9, STK24, and IPO5 Genes in Polish Patients and Novel TGFBI Variant Identification... Figshare

    ID: doi:10.6084/M9.FIGSHARE.1568217

    Release Date: 03-11-2016

    Description:

  3. Gene expression profiles of NIH3T3 cells stably transfected with the plasmids encoding the wild type PreS/S gene or the nonsense mutant gene (sW182*) ... ArrayExpress

    ID: E-GEOD-50180

    Description: ability. The transforming growth factor-induced (TGFBI) gene was downregulated in the sW182* mutant clones, and irresponsive to TGF- treatment. The level of Cyclin D1, a negatively regulated TGFBI target, was highly elevated in sW182* mutant cells. Exogenous expression of TGFBI alleviated the oncogenic activity of sW182* in mouse xenograft study. In human HBV-related HCC cancerous tissue, expression of TGFBI was downregulated in 25 of the 55 (45%) patients. Conclusions: Dysregulation of transforming growth factor-induced (TGFBI) gene is involved in the oncogenic activity of the sW182* mutant of hepatitis B virus S gene. This has never been described before. NIH3T3 cells were...

  4. onus Susceptibility Sequence Variants in VSX1, TGFBI, DOCK9, STK24, and IPO5 Genes in Polish Patients and Novel TGFBI Variant Identification... Figshare

    ID: doi:10.6084/M9.FIGSHARE.1568217.V1

    Release Date: 01-20-2016

    Description:

  5. Gene expression profiles of NIH3T3 cells stably transfected with the plasmids encoding the wild type PreS/S gene or the nonsense mutant gene (sW182*) ... BioProject

    ID: PRJNA216982

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ability. The transforming growth factor-induced (TGFBI) gene was downregulated in the sW182* mutant clones, and irresponsive to TGF- treatment. The level of Cyclin D1, a negatively regulated TGFBI target, was highly elevated in sW182* mutant cells. Exogenous expression of TGFBI alleviated the oncogenic activity of sW182* in mouse xenograft study. In human HBV-related HCC cancerous tissue, expression of TGFBI was downregulated in 25 of the 55 (45%) patients. Conclusions: Dysregulation of transforming growth factor-induced (TGFBI) gene is involved in the oncogenic activity of the sW182* mutant of hepatitis B virus S gene. This has never been described before. Overall design: N...
  6. Gene expression differences in mouse islets after isolation at different time points (0-48hr) OmicsDI

    ID: E-GEOD-27547

    Date Released: 02-28-2011

    Description: TGFbi (transforming growth factor-beta-induced) is a secreted protein and is capable of binding to both extracellular matrix (ECM) ...

  7. Gene expression profiles of NIH3T3 cells stably transfected with the plasmids encoding the wild type PreS/S gene or the nonsense mutant gene (sW182*) ... OmicsDI

    ID: E-GEOD-50180

    Date Released: 08-02-2014

    Description: ability. The transforming growth factor-induced (TGFBI) gene was downregulated in the sW182* mutant clones, and irresponsive to TGF- treatment. The level of Cyclin D1, a negatively regulated TGFBI target, was highly elevated in sW182* mutant cells. Exogenous expression of TGFBI alleviated the oncogenic activity of sW182* in mouse xenograft study. In human HBV-related HCC cancerous tissue, expression of TGFBI was downregulated in 25 of the 55 (45%) patients. Conclusions: Dysregulation of transforming growth factor-induced (TGFBI) gene is involved in the oncogenic activity of the sW182* mutant of hepatitis B virus S gene. This has never been described before. NIH3T3 cells were...

  8. Comparison of two phenotypically distinct lattice corneal dystrophies caused by mutations in the transforming growth factor beta induced (TGFBI) gene OmicsDI

    ID: GPM11210023957

    Date Released:

    Description: pical LCD type 1 due to a A546D/P551Q mutation in TGFBI using laser capture microdissection and a subsequent analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) ... {{/i}}...

  9. Gene expression differences in mouse islets after isolation at different time points (0-48hr) ArrayExpress

    ID: E-GEOD-27547

    Description: TGFbi (transforming growth factor-beta-induced) is a secreted protein and is capable of binding to both extracellular matrix (ECM) ...

  10. Supplementary Material for: A Case of Transforming Growth Factor-β-Induced Gene-Related Oculorenal Syndrome: Granular Corneal Dystrophy Type II with ... Figshare

    ID: doi:10.6084/M9.FIGSHARE.3840732

    Release Date: 09-20-2016

    Description: transforming growth factor-β-induced (TGFBI) gene. The patient was referred to us because of the presence of mild proteinuria without hematuria that was subsequently suggested to be granular corneal dystrophy type II. A kidney biopsy revealed various glomerular and tubular basement membrane changes and widening of the subendothelial space of the glomerular basement membrane by electron microscopy. However, next-generation sequencing revealed that she had no mutation in a gene that is known to be associated with monogenic kidney diseases. Conversely, real-time polymerase chain reaction, using a simple buccal swab, revealed TGFBI

  11. Gene expression differences in mouse islets after isolation at different time points (0-48hr) BioProject

    ID: PRJNA137097

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: TGFbi (transforming growth factor-beta-induced) is a secreted protein and is capable of binding to both extracellular matrix (ECM) ...
  12. Supplementary Material for: A Case of Transforming Growth Factor-β-Induced Gene-Related Oculorenal Syndrome: Granular Corneal Dystrophy Type II with ... Figshare

    ID: doi:10.6084/M9.FIGSHARE.3840732.V1

    Release Date: 09-20-2016

    Description: transforming growth factor-β-induced (TGFBI) gene. The patient was referred to us because of the presence of mild proteinuria without hematuria that was subsequently suggested to be granular corneal dystrophy type II. A kidney biopsy revealed various glomerular and tubular basement membrane changes and widening of the subendothelial space of the glomerular basement membrane by electron microscopy. However, next-generation sequencing revealed that she had no mutation in a gene that is known to be associated with monogenic kidney diseases. Conversely, real-time polymerase chain reaction, using a simple buccal swab, revealed TGFBI

  13. BGH3_RABIT UniProt:Swiss-Prot

    ID: Q95215

    Description: Transforming growth factor-beta-induced protein ig-h3 EMI FAS1 1 FAS1 2 FAS1 3 FAS1 4 Cell attachment site Phosphoserine

    gene.name: TGFBI
  14. Protein composition of TGFBI-R124C and TGFBI-R555W associated aggregates suggests multiple mechanisms leading to Lattice and Granular c... ProteomeXchange

    ID: PXD002236

    Instrument: TripleTOF 5600

    Date Released: 11-18-2015

  15. LCD1-overexpression synthetic lethality BioProject

    ID: PRJNA90515

    Keywords: Transcriptome or Gene expression

    Access Type: download

  16. Identification of TWIST1 transcriptoinal targets in the cranial mesoderm [WNT1 vs. MESP1] BioProject

    ID: PRJNA318628

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: anscriptional targets of TWIST1: Ddr2, Pcolce and Tgfbi. Our findings show that the mesenchymal properties of the cranial mesoderm is likely to be regulated by a network of TWIST1 targets genes that influence the extracellular matrix and cell-matrix interactions, and collectively they are required for the morphogenesis of the craniofacial structures. Overall design: Cranial neural crest and cranial mesoderm cells were isolated by flow sorting of GFP reporter-labelled cells collected from heads of E9.5 mouse embryos. Three replicates were independently isolated and hybridized to Illumina mouse WG v 2.0 chips...
  17. Identification of TWIST1 transcriptoinal targets in the cranial mesoderm [WNT1 vs. MESP1] ArrayExpress

    ID: E-GEOD-80335

    Description: anscriptional targets of TWIST1: Ddr2, Pcolce and Tgfbi. Our findings show that the mesenchymal properties of the cranial mesoderm is likely to be regulated by a network of TWIST1 targets genes that influence the extracellular matrix and cell-matrix interactions, and collectively they are required for the morphogenesis of the craniofacial structures. Cranial neural crest and cranial mesoderm cells were isolated by flow sorting of GFP reporter-labelled cells collected from heads of E9.5 mouse embryos. Three replicates were independently isolated and hybridized to Illumina mouse WG v 2.0 chips...

  18. BGH3_PIG UniProt:Swiss-Prot

    ID: O11780

    Description: Transforming growth factor-beta-induced protein ig-h3 EMI FAS1 1 FAS1 2 FAS1 3 FAS1 4 Cell attachment site Phosphoserine

    gene.name: TGFBI
  19. Identification of TWIST1 transcriptional targets in the cranial mesoderm [ChIP-Seq] ArrayExpress

    ID: E-GEOD-80662

    Description: anscriptional targets of TWIST1: Ddr2, Pcolce and Tgfbi. Our findings show that the mesenchymal properties of the cranial mesoderm is likely to be regulated by a network of TWIST1 targets genes that influence the extracellular matrix and cell-matrix interactions, and collectively they are required for the morphogenesis of the craniofacial structures. Chromatin extracts were subject to chromatin immunoprecipitation with anti TWIST1 monoclonal antibody (ChIP-seq). Input chromatin, not subject to ChIP was used as the negative control. Two independent replicate experiments were performed. Purified, immunoprecipitated DNA was sequenced at Australian Genome Research facility....

  20. Transcription profiling of mouse mutant abcb4 (-/-) ArrayExpress

    ID: E-GEOD-4603

    Description: Mmp12, Mmp15, Spp1, Loxl2, Pdgfa, Pdgfrb, Sparc, Tgfbi, Tgfbr2. Conclusions: During early phases of chronic cholangitis in abcb4 (-/-) mice, hepatic downregulation of serpina3 genes and enhanced transcription of genes sustaining inflammatory processes contribute to fashioning the portal tract pathology. Later, enhanced transcription of genes governing tissue repair consolidate the portal tract pathology. Experiment Overall Design: A time-series where 5 male mice were sacrificed at time-points 3,6,9 and 20 weeks, both sick knockouts and healthy controls. Including one dye-swap there were a total of 6 arrays at each time-point....


Displaying 20 of 56 results for "TGFBI"