TDP2 | bioCADDIE Data Discovery Index
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Displaying 20 of 33 results for "TDP2"
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  1. Crystal structure of D. rerio TDP2 complexed with single strand DNA product PDB

    ID: PDB:4FPV

    Description: Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-)/dna

  2. Crystal structure of TDP2 from Danio rerio complexed with a single strand DNA PDB

    ID: PDB:4F1H

    Description: PROTEIN/DNA Complex

  3. Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Ca2+ complex PDB

    ID: PDB:5INQ

    Description: Tyrosyl-DNA phosphodiesterase 2/DNA Complex

  4. Crystal structure of SeMet TDP2 from Caenorhabditis elegans PDB

    ID: PDB:4F1I

    Description: 5'-tyrosyl-DNA phosphodiesterase (E.C.3.1.4.-)

  5. Mouse Tdp2 reaction product (5'-phosphorylated DNA)-abasic/THF-Mg2+ complex PDB

    ID: PDB:5INK

    Description: Tyrosyl-DNA phosphodiesterase 2/DNA Complex

  6. Mouse Tdp2 D358N protein, apo state with increased disorder amongst variable DNA-binding grasp conformations PDB

    ID: PDB:5INN

    Description: Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-)

  7. Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Mn2+ complex PDB

    ID: PDB:5INP

    Description: Tyrosyl-DNA phosphodiesterase 2/DNA Complex

  8. Human Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex PDB

    ID: PDB:5INO

    Description: Tyrosyl-DNA phosphodiesterase 2/DNA Complex

  9. Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex with deoxyadenosine PDB

    ID: PDB:5INL

    Description: Tyrosyl-DNA phosphodiesterase 2/DNA Complex

  10. Expression data from E16.5 mouse embryonic brain wild-type and knock-out conditions BioProject

    ID: PRJNA237223

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: are differentially expressed as a consequence of Tdp2 absence. Overall design: The data (obtained from three independent pairs of wild type and TDP2D1-3 brains) was normalised using RMA (Robust Multi-Array Average) and genes changing 1.5 fold (corrected p-value cut-off:0.05) between Tdp2+/+ and Tdp2∆1-3...
  11. Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex with 1-N6-etheno-adenine PDB

    ID: PDB:5HT2

    Description: Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-), DNA

  12. Mouse Tdp2 protein, apo state with variable DNA-binding grasp conformations PDB

    ID: PDB:5INM

    Description: Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-)

  13. Mus Musculus Tdp2 reaction product complex with 5'-phosphorylated RNA/DNA, glycerol, and Mg2+ PDB

    ID: PDB:4PUQ

    Description: Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-)

  14. Crystal structure of TDP2 from C. elegans PDB

    ID: PDB:4GEW

    Description: 5'-tyrosyl-DNA phosphodiesterase (E.C.3.1.4.-)

  15. Mus Musculus Tdp2 excluded ssDNA complex PDB

    ID: PDB:4GZ2

    Description: Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-)/dna

  16. Mus Musculus Tdp2 Bound to dAMP and Mg2+ PDB

    ID: PDB:4GYZ

    Description: Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-)

  17. Mus Musculus Tdp2-DNA Substrate Analog (5'-6-aminohexanol) Complex PDB

    ID: PDB:4GZ0

    Description: Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-)/dna

  18. Mus Musculus Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex at 1.5 Angstroms resolution PDB

    ID: PDB:4GZ1

    Description: Tyrosyl-DNA phosphodiesterase 2 (E.C.3.1.4.-)

  19. Mutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-chip] ArrayExpress

    ID: E-GEOD-36751

    Description: ction with this motif. Importantly, we identified TDP2, a 5’-tyrosyl DNA phosphodiesterase involved in the repair of DNA damage caused by etoposide, as a transcriptional target of mtp53. We demonstrate that suppression of TDP2 sensitizes mtp53 expressing cells to etoposide, and that mtp53 and TDP2 are frequently overexpressed in human lung cancer; thus, our analysis identifies a potentially “druggable” component of mtp53’s gain-of-function activity. Comparison of two different transcriptional binding analysis (ChIP-on-ChIP and ChIP-Seq) for the identification of no...

  20. Mutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-Seq] ArrayExpress

    ID: E-GEOD-36749

    Description: ction with this motif. Importantly, we identified TDP2, a 5’-tyrosyl DNA phosphodiesterase involved in the repair of DNA damage caused by etoposide, as a transcriptional target of mtp53. We demonstrate that suppression of TDP2 sensitizes mtp53 expressing cells to etoposide, and that mtp53 and TDP2 are frequently overexpressed in human lung cancer; thus, our analysis identifies a potentially “druggable” component of mtp53’s gain-of-function activity. Comparison of two different transcriptional binding analysis (ChIP-on-ChIP and ChIP-Seq) for the identification of no...


Displaying 20 of 33 results for "TDP2"