Structure of Cobalamin-complexed Bovine Transcobalamin in trigonal crystal form

ID: PDB:2BBC

Description: Transcobalamin II

Structure of Cobalamin-complexed Bovine Transcobalamin in Monoclinic Crystal Form

ID: PDB:2BB6

Description: bovine transcobalamin II

Structure of Human Transcobalamin in complex with Cobalamin

ID: PDB:2BB5

Description: Transcobalamin II

E88 deletion mutant of CD320 in complex with TC2

ID: PDB:4ZRQ

Description: Transcobalamin-2, CD320 antigen

TC:CD320

ID: PDB:4ZRP

Description: Transcobalamin-2, CD320 antigen

Crystal Structure of Haptocorrin in Complex with Cbi

ID: PDB:4KKJ

Description: Transcobalamin-1

Central Role of Th2 and Tc2 Lymphocytes in Multiple Sclerosis Pattern II Demyelinating Lesions

ID: E-GEOD-60914

Date Released: 01-10-2016

Description: gical patterns of MS have been described. Pattern II is characterized by antibody and complement deposition. MS is considered a prototypic T cell-mediated disease, but until now the study of pathogenic T cells has encountered major challenges, most importantly the limited access of brain-infiltrating T cells. Here, we used next generation sequencing to identify clonally expand...

Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice

ID: E-GEOD-57761

Date Released: 04-27-2015

Description: ce. Genetic disruption of autophagy did not cause anemia in wild-type mice but accelerated the decline in mitochondrial respiration and development of macrocytic anemia in mtDNA-mutator mice. These findings highlight a pathological feedback loop that explains how dysfunctional mitochondria can escape autophagy-mediated degradation and propagate in cells predisposed to somatic mtDNA mutations, leading to disease. We used microarrays to identify expression profiles and pathways that are differentially activated or suppressed in Ter119+ bone marrow cells isolated from phlebotomized wildtype or Polg mutant mice...

Transcription profiling of human multiple myeloma patients classified using the TC system to provide a molecular characterization of the TC groups

ID: E-GEOD-2912

Date Released: 03-27-2012

Description: ntified 112 probe sets as characterizing the TC1, TC2, TC4 and TC5 groups, whereas the TC3 samples showed heterogeneous phenotypes and no marker genes. The TC2 group, which showed extra copies of the CCND1 locus and no IGH translocations or the chromosome 13q deletion, was characterized by the overexpression of genes involved in protein biosynthesis at translational level. A meta-analysis of published datasets validated the identified gene expression signatures. CONCLUSIONS. Our data contribute to the understanding of the molecular and biological features of distinct MM subtypes. The identification of a distinctive gene expression pattern in TC2 patients may improve risk stratification and indicate novel therapeutic targets. Experiment Overall Design: This series of microarray experiments contains the gene expression profiles of purified plasma cells (PCs) obtained from 50 newly diagnosed multiple myeloma (MM). PCs were purified from bone marrow specimens, after red blood cell lysis with 0.86% ammonium chloride, using CD138 immunomagnetic microbeads. The pu...

Proteomic analysis of integrin adhesion complex assembly

ID: GPM32310025299

Date Released:

Description: , PXD ID: PXD002159. Experiment: 20101108 JAA FN1 tc2 1-30, file: 20101108_JAA_FN_tc2_AB17.mzml. From ProteomeXchange: {{i}} To explore the dynamics of integrin adhesion complex assembly, isolated adhesion ...

Structure of cobinamide-bound BtuF mutant W66F, the periplasmic vitamin B12 binding protein in E.coli

ID: PDB:5M2Q

Description: Vitamin B12-binding protein

Structure of cobinamide-bound BtuF mutant W66L, the periplasmic vitamin B12 binding protein in E.coli

ID: PDB:5M3B

Description: Vitamin B12-binding protein

Structure of cobinamide-bound BtuF, the periplasmic vitamin B12 binding protein in E.coli

ID: PDB:5M29

Description: Vitamin B12-binding protein

Structure of cobinamide-bound BtuF mutant W66Y, the periplasmic vitamin B12 binding protein in E.coli

ID: PDB:5M34

Description: Vitamin B12-binding protein

Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection.

ID: E-GEOD-3556

Date Released: 10-18-2011

Description: 4) (the cagA 6 hour sample of trial 3 was lost). TC2: Biological replication and expansion of TC1, using more isogenic mutants and timepoints. AGS cells were mock infected, infected with G27, and isogenic mutants in cagN, cagA, cagE, and a deletion of the cag PAI for 0. 1, 3, 6, 12, and 24 hours. Probe synthesis and hybridization was done as in TC1. Note: there may have been a sample mix-up with PAI 12, swapping it with G27 or cagN 12. Groups of assays that are related as part of a time series. Computed...

Transcription profiling of human gastric epithelial (AGS) cells infected with wild type H. pylori (G27) and isogenic mutants in cagA and vacA for 0, 0...

ID: E-SMDB-1661

Date Released: 03-27-2012

Description: 4) (the cagA 6 hour sample of trial 3 was lost). TC2: Biological replication and expansion of TC1, using more isogenic mutants and timepoints. AGS cells were mock infected, infected with G27, and isogenic mutants in cagN, cagA, cagE, and a deletion of the cag PAI for 0. 1, 3, 6, 12, and 24 hours. Probe synthesis and hybridization was done as in TC1. Note: there may have been a sample mix-up with PAI 12, swapping it with G27 or cagN 12....

Transcription profiling by high throughput sequencing of rice grain from from heat-tolerant and -sensitive lines in response to high night temperature...

ID: E-MTAB-4348

Date Released: 02-05-2016

Description: rain samples were harvested, i.e., controls (TC1, TC2 and TC3) and treatments (TT1, TT2 and TT3) of the three biological replicates of the heat-tolerant line, and controls (SC1, SC2 and SC3) and treatments (ST1, ST2 and ST3) of the three biological replicates of the heat-sensitive line....

Growth phase dependent gene expression and motility_3 time courses

ID: E-GEOD-3636

Date Released: 03-27-2012

Description: sion changes over the time course of growth while TC2 refers to the second time course. TC Motility_broth refers to the third time course described in the manuscript used to investigate the concurrent changes in motility and the expression of the genes in the flagellar regulon. Detailed description of the growth of H. pylori for these 3 time courses can be found in the Materials and Methods section of the manuscript along with the exact filtering criteria use...

Small nucleolar RNAs and small Cajal body-specific RNAs show distinct transcriptional profiles in the context of the molecular heterogeneity of multip...

ID: E-GEOD-39683

Date Released: 07-01-2013

Description: ed the only sno/scaRNA characterizing the TC4 MM, TC2 group displayed a distinct sno/scaRNA signature overexpressing members of SNORD115 and SNORD116 families located in a region finely regulated by imprinting mechanism at 15q11. However, the imprinting center resulted overall hypomethylated in MMs independently of the SNORD115 and SNORD116 expression levels. Finally, integrative analyses with available gene expression and genome-wide data revealed the occurrence of significant sno/scaRNAs/host genes co-expression and the putative influence of allelic imbalances on specific snoRNAs expression. Our data extend the current view of sno/scaRNAs deregulation in cancer and add novel information into the bio-molecular complexity of plasma cell dyscrasias. This series of microarray experiments contains the gene expression pro...