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Displaying 20 of 220 results for "TBKBP1"
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  1. In vitro responses of fibroblasts from patients with TBK1 deficiency after TLR3 dependent and independent stimuli BioProject

    ID: PRJNA168372

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. In vitro responses of fibroblasts from patients with TBK1 deficiency after TLR3 dependent and independent stimuli ArrayExpress

    ID: E-GEOD-38652

    Description: ferent heterozygous mutations (D50A and G159A) in TBK1, the gene encoding TANK-binding kinase 1, a kinase at the crossroads of multiple IFN-inducing signaling pathways. Both mutant TBK1

  3. esis and regulates levels of the oncogenic kinase Tbk1 and of beta tubulin gene expression in the liver... BioProject

    ID: PRJNA298544

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Profiling of immortalized human lung epithelial cells following oncogenic KRAS expression and TBK1 suppression BioProject

    ID: PRJNA123371

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. In vitro responses of fibroblasts from patients with TBK1 deficiency after TLR3 dependent and independent stimuli OmicsDI

    ID: E-GEOD-38652

    Date Released: 08-06-2012

    Description: ferent heterozygous mutations (D50A and G159A) in TBK1, the gene encoding TANK-binding kinase 1, a kinase at the crossroads of multiple IFN-inducing signaling pathways. Both mutant TBK1

  6. Profiling genes induced by oncogenic KRAS (G12V) and genes regulated by TBK1, a synthetic lethal partner of KRAS BioProject

    ID: PRJNA118473

    Access Type: download

  7. Structure of BX-795 Complexed with Human TBK1 Kinase Domain Phosphorylated on Ser172 PDB

    ID: PDB:4EUU

    Description: Serine/threonine-protein kinase TBK1 (E.C.2.7.11.1)

  8. Genetic Loci that Regulate Ectopic Calcification in Response to Knee Trauma in LG/J by SM/J Advanced Intercross Mice ArrayExpress

    ID: E-GEOD-64793

    Description: 3), and ankylosing-spondylitis (Ank, Pon1, Il1r2, Tbkbp1) indicating that ectopic calcification involves multiple mechanisms. Furthermore, the expression of 11 candidate genes was significantly different between LG/J and SM/J. Correlation analysis showed that Aff3, Fam81a, Syn3, and Ank were correlated with synovial calcification. Our findings of multiple genetic loci affecting the phenotype suggest the involvement of multiple genes contributing to its pathogenesis. We collected tissue lysates from the formalin-fixed paraffin-embedded sections from mouse knee joints and analyzed the expression of several genes by Affymetrix QuantiGene Plex assay....

  9. Transcription profiling by array of liver from Rassf1a homozygous knockout mice, heterozygous deletion of Sav1 and codeletion of Rassf1a and Sav1 ArrayExpress

    ID: E-GEOD-73911

    Description: essor gene RASSF1A (Ras association domain family protein 1A) coding for a microtubule stabilizing protein is epigenetically silenced in most human cancers. As a

  10. The crystal structure of NAP1 in complex with TBK1 PDB

    ID: PDB:5EP6

    Description: 5-azacytidine-induced protein 2, Serine/threonine-protein kinase TBK1 (E.C.2.7.11.1)

  11. Crystal structure and mechanism of activation of TBK1 PDB

    ID: PDB:4IW0

    Description: Serine/threonine-protein kinase TBK1 (E.C.2.7.11.1)

  12. TBK1_XENLA UniProt:Swiss-Prot

    ID: Q6DFJ6

    Description: Serine/threonine-protein kinase TBK1 Protein kinase Ubiquitin-like ATP Proton acceptor ATP

  13. Cyclic-Di-Nucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling BioProject

    ID: PRJNA221579

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: that after autophagy-dependent STING delivery of TBK1 (TANK-binding kinase 1) to endosomal/lysosomal compartments and activation of transcription factors IRF3 (interferon regulatory factors 3) and NF-κB (nuclear factor kappa beta), that STING is subsequently phosphorylated by serine/threonine UNC-51-like kinase (ULK1/ATG1) and IRF3 function is suppressed. ULK1 activation occurred following disassociation from its repressor adenine monophosphate activated protein kinase (AMPK), and was elicited by CDN’S generated by the cGAMP sy...
  14. Profiling of immortalized human lung epithelial cells following infection with oncogenic KRAS (G12V) BioProject

    ID: PRJNA123395

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: KRAS and found that the non-canonical IkB kinase, TBK1, was selectively essential in cells that harbor mutant KRAS. Suppression of TBK1 induced apoptosis specifically in human cancer cell lines that depend on oncogenic KRAS expression. In these cells, TBK1 activated NF- B anti-apoptotic signals involving cREL and BCL-XL that were essential for survival, providing mechanistic insights into this synthetic lethal interaction. These observations identify TBK1 as a potential therapeutic target in KRAS mutant tumors and establish a general approach for the rational identification of co-dependent pathways in cancer. Overall design: Profiling of KRAS activation (mutant), KRAS WT and control in AALE cells (Lundberg et al., Oncogene 2002;21:4577)...
  15. Crystal structure of OPTN NTD and TBK1 CTD complex PDB

    ID: PDB:5EOF

    Description: Optineurin, Serine/threonine-protein kinase TBK1 (E.C.2.7.11.1)

  16. Crystal structure of OPTN E50K mutant and TBK1 complex PDB

    ID: PDB:5EOA

    Description: Optineurin, Serine/threonine-protein kinase TBK1 (E.C.2.7.11.1)

  17. Structure of BX-795 Complexed with Unphosphorylated Human TBK1 Kinase-ULD Domain PDB

    ID: PDB:4EUT

    Description: Serine/threonine-protein kinase TBK1 (E.C.2.7.11.1)

  18. Crystal structure and mechanism of activation of TBK1 PDB

    ID: PDB:4IWP

    Description: Serine/threonine-protein kinase TBK1 (E.C.2.7.11.1)

  19. Transcription profiling of immortalized human lung epithelial cells following oncogenic KRAS expression and TBK1 suppression ArrayExpress

    ID: E-GEOD-17643

    Description: ression of genes induced by KRAS and regulated by TBK1; The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard therapies. Although the identification o...

  20. lial cells ollowing oncogenic KRAS expression and TBK1 suppression or infection with oncogenic KRAS (G12V) - SuperSeries... ArrayExpress

    ID: E-GEOD-17672

    Description: KRAS and found that the non-canonical IkB kinase, TBK1, was selectively essential in cells that harbor mutant KRAS. Suppression of TBK1 induced apoptosis specifically in human cancer cell lines that depend on oncogenic KRAS expression. In these cells, TBK1 activated NF- B anti-apoptotic signals involving cREL and BCL-XL that were essential for survival, providing mechanistic insights into this synthetic lethal interaction. These observations identify TBK1 as a potential therapeutic target in KRAS mutant tumors and establish a general approach for the rational identification of co-dependent pathways in cancer. This SuperSeries is composed of the following subset Series:; GSE17643: Profiling of immortalized human lung epithelia...


Displaying 20 of 220 results for "TBKBP1"