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Displaying 18 of 18 results for "SULT2A1"
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  1. Crystal structure of human DHEA-ST complexed with androsterone PDB

    ID: PDB:1OV4

    Description: Alcohol sulfotransferase (E.C.2.8.2.2)

  2. Crystal structure of human cytosolic sulfotransferase SULT2A1 in complex with PAP and lithocholic acid PDB

    ID: PDB:3F3Y

    Description: Bile salt sulfotransferase

  3. Identification and Characterization of Two Amino Acids Critical for the Substrate Inhibition of SULT2A1 PDB

    ID: PDB:2QP3

    Description: Bile salt sulfotransferase (E.C.2.8.2.14)

  4. Identification and Characterization of Two Amino Acids Critical for the Substrate Inhibition of SULT2A1 PDB

    ID: PDB:2QP4

    Description: Bile salt sulfotransferase (E.C.2.8.2.14)

  5. Transcription profiling of mouse liver from wild type (WT), RORalphasg/sg, RORgamma-/-, and double knockout animals reveals a regulatory role for RORa... ArrayExpress

    ID: E-GEOD-7564

    Description: and Cyp8b1, and the sulfotransferases Sult1e1 and Sult2a1. Our data show that RORalpha and RORgamma can influence gene expression positively as well as negatively. In addition, our results indicate that RORalpha and RORgamma each affect the expression of a specific set of genes but also exhibit functional redundancy. Our study shows that RORalpha and RORgamma receptors influence the regulation of several metabolic pathways, including those involved in the metabolism of steroids, bile acids, and xenobiotics, suggesting that RORs are important in the control of metabolic homeostasis. Experiment Overall Design: We generated RORalpha and RORgamma double knockout (DKO) mice and compared the gene expression profiles of livers from wild type (WT), RORalphasg/sg, RORgamma-/-, and DKO mice by microarray analysis...

  6. Comparison of global gene expression profiles of microdissected human foetal Leydig cells with their normal and hyperplastic adult equivalents ArrayExpress

    ID: E-MTAB-5453

    Description: his cell type during early development, including SULT2A1, WISP2, HPGD, and IGF2BP1, and their expression changes were validated at the protein level....

  7. Profiling of promoter occupancy by PPARα in human hepatoma cells via ChIP-chip analysis ArrayExpress

    ID: E-GEOD-25547

    Description: s known to be regulated by PPARα, such as ACOX1, SULT2A1, ACADL, CD36, IGFBP1 and G0S2, showed GW7647-induced PPARα binding to their promoter. A GW7647-induced PPARα-binding region was also assigned to SREBP-targets HMGCS1, HMGCR, FDFT1, SC4MOL, and LPIN1, expression of which was induced by GW7647, suggesting cross-talk between PPARα and SREBP signaling. Our data furthermore demonstrate interaction between PPARα and STAT transcription factors in PPARα-mediated transcriptional repression, and suggest interaction between PPARα and TBP and C/EBPα in PPARα-mediated transcriptional activation. Overall, our analysis leads to important new insights into the mechanisms and impact of transcriptional regulation by PPARα in human liver and highlight the importance of cross-talk with other transcription factors. HepG2 cells were gr...

  8. Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of PAP PDB

    ID: PDB:1Q1Z

    Description: sulfotransferase family, cytosolic, 2B, member 1 isofor...

  9. Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of DHEA and PAP PDB

    ID: PDB:1Q22

    Description: sulfotransferase family, cytosolic, 2B, member 1 isofor...

  10. Crystal structure of human pregnenolone sulfotransferase (SULT2B1a) in the presence of PAP PDB

    ID: PDB:1Q1Q

    Description: sulfotransferase family, cytosolic, 2B, member 1 isofor...

  11. Crystal structure of SULT 2A1 LLGG mutant with PAPS PDB

    ID: PDB:4IFB

    Description: Bile salt sulfotransferase (E.C.2.8.2.14)

  12. Crystal Structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of PAP and pregnenolone PDB

    ID: PDB:1Q20

    Description: sulfotransferase family, cytosolic, 2B, member 1 isofor...

  13. CRYSTAL STRUCTURE OF HUMAN DEHYDROEPIANDROSTERONE SULFOTRANSFERASE IN COMPLEX WITH SUBSTRATE PDB

    ID: PDB:1J99

    Description: ALCOHOL SULFOTRANSFERASE (E.C.2.8.2.2)

  14. Gene expression profiling reveals a regulatory role for RORalpha and RORgamma in Phase I and Phase II Metabolism BioProject

    ID: PRJNA100331

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: and Cyp8b1, and the sulfotransferases Sult1e1 and Sult2a1. Our data show that RORalpha and RORgamma can influence gene expression positively as well as negatively. In addition, our results indicate that RORalpha and RORgamma each affect the expression of a specific set of genes but also exhibit functional redundancy. Our study shows that RORalpha and RORgamma receptors influence the regulation of several metabolic pathways, including those involved in the metabolism of steroids, bile acids, and xenobiotics, suggesting that RORs are important in the control of metabolic homeostasis. Keywords: knockout comparison Overall design: We generated RORalpha and RORgamma double knockout (DKO) mice and compared the gene expression profiles of livers from wild type (WT), RORalphasg/sg, RORgamma-/-, and DKO mice by microarray analysis...
  15. Profiling of promoter occupancy by PPARα in human hepatoma cells via ChIP-chip analysis BioProject

    ID: PRJNA134025

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: s known to be regulated by PPARα, such as ACOX1, SULT2A1, ACADL, CD36, IGFBP1 and G0S2, showed GW7647-induced PPARα binding to their promoter. A GW7647-induced PPARα-binding region was also assigned to SREBP-targets HMGCS1, HMGCR, FDFT1, SC4MOL, and LPIN1, expression of which was induced by GW7647, suggesting cross-talk between PPARα and SREBP signaling. Our data furthermore demonstrate interaction between PPARα and STAT transcription factors in PPARα-mediated transcriptional repression, and suggest interaction between PPARα and TBP and C/EBPα in PPARα-mediated transcriptional activation. Overall, our analysis leads to important new insights into the mechanisms and impact of transcriptional regulation by PPARα in human liver and highlight the importance of cross-talk with other transcription factors. Overall design: Hep...
  16. Transcription profiling of mouse liver from wild type (WT), RORalphasg/sg, RORgamma-/-, and double knockout animals reveals a regulatory role for RORa... OmicsDI

    ID: E-GEOD-7564

    Date Released: 05-02-2014

    Description: and Cyp8b1, and the sulfotransferases Sult1e1 and Sult2a1. Our data show that RORalpha and RORgamma can influence gene expression positively as well as negatively. In addition, our results indicate that RORalpha and RORgamma each affect the expression of a specific set of genes but also exhibit functional redundancy. Our study shows that RORalpha and RORgamma receptors influence the regulation of several metabolic pathways, including those involved in the metabolism of steroids, bile acids, and xenobiotics, suggesting that RORs are important in the control of metabolic homeostasis. Experiment Overall Design: We generated RORalpha and RORgamma double knockout (DKO) mice and compared the gene expression profiles of livers from wild type (WT), RORalphasg/sg, RORgamma-/-, and DKO mice by microarray analysis...

  17. Profiling of promoter occupancy by PPARα in human hepatoma cells via ChIP-chip analysis OmicsDI

    ID: E-GEOD-25547

    Date Released: 06-26-2012

    Description: s known to be regulated by PPARα, such as ACOX1, SULT2A1, ACADL, CD36, IGFBP1 and G0S2, showed GW7647-induced PPARα binding to their promoter. A GW7647-induced PPARα-binding region was also assigned to SREBP-targets HMGCS1, HMGCR, FDFT1, SC4MOL, and LPIN1, expression of which was induced by GW7647, suggesting cross-talk between PPARα and SREBP signaling. Our data furthermore demonstrate interaction between PPARα and STAT transcription factors in PPARα-mediated transcriptional repression, and suggest interaction between PPARα and TBP and C/EBPα in PPARα-mediated transcriptional activation. Overall, our analysis leads to important new insights into the mechanisms and impact of transcriptional regulation by PPARα in human liver and highlight the importance of cross-talk with other transcription factors. HepG2 cells were gr...

  18. Identification of a transcriptional fingerprint of estrogen exposure in rainbow trout liver BioProject

    ID: PRJNA101151

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: l + tamoxifen (E2+TAM), diethylstilbestrol (DES), dehydroepiandrosterone (DHEA), dihydrotestosterone (DHT) and cortisol (CORT). Estrogen exposure altered the expression of up to 49 genes involved in reproduction, immune response, cell growth, transcriptional regulation, protein synthesis and modification, drug metabolism, redox regulation and signal transduction. E2, DES and DHEA regulated 18 genes in common, mostly those associated with vitellogenesis, cell proliferation and signal transduction. Interestingly, DHEA uniquely regulated several complement component genes of importance to immune response. While the effect of TAM on E2-induced changes in gene exp...

Displaying 18 of 18 results for "SULT2A1"