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Displaying 20 of 114 results for "STMN1"
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  1. Murine Embryonic Fibroblasts: Wild-type Stmn1 versus null Stmn1 Cells BioProject

    ID: PRJNA118889

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Murine Embryonic Fibroblasts: Wild-type Stmn1 versus null Stmn1 Cells OmicsDI

    ID: E-GEOD-17432

    Date Released: 06-02-2014

    Description: Background: Stathmin (STMN1) protein functions to regulate assembly of the microtubule cytoskeleton by destabilizing microtubule polymers. Stathmin over-...

  3. Murine Embryonic Fibroblasts: Wild-type Stmn1 versus null Stmn1 Cells ArrayExpress

    ID: E-GEOD-17432

    Description: Background: Stathmin (STMN1) protein functions to regulate assembly of the microtubule cytoskeleton by destabilizing microtubule polymers. Stathmin over-...

  4. Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection ArrayExpress

    ID: E-GEOD-58004

    Description: elial cells promoted proliferation. We identified STMN1 and DIMT1 as miR-210 target genes and demonstrated that inhibition of miR-210 expression augmented cell proliferation by activating STMN1 and DIMT1. Together, our results highlight inflammation-induced epigenetic silencing of miR-210 as a mechanism of induction of chronic gastric diseases, including cancer, during Hp infection. To identify miR-210 targets in gastric cells, whole transcriptome analysis of AGS and MKN45 cells transfected with pre-miR-210 was conducted using Affymetrix GeneChip Human Genome U133 Plus 2.0 Array....

  5. nd expression of ERCC1, BRCA1, TYMS, RRM1, TUBB3, STMN1 and TOP2A in gastric cancer... Figshare

    ID: doi:10.6084/M9.FIGSHARE.C.3659291_D1

    Release Date: 01-06-2017

    Description: Raw data of patients. The general characteristics, gene expressions and polymorphisms of each patient are available. (XLS 54 kb)

  6. Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection OmicsDI

    ID: E-GEOD-58004

    Date Released: 09-05-2014

    Description: elial cells promoted proliferation. We identified STMN1 and DIMT1 as miR-210 target genes and demonstrated that inhibition of miR-210 expression augmented cell proliferation by activating STMN1 and DIMT1. Together, our results highlight inflammation-induced epigenetic silencing of miR-210 as a mechanism of induction of chronic gastric diseases, including cancer, during Hp infection. To identify miR-210 targets in gastric cells, whole transcriptome analysis of AGS and MKN45 cells transfected with pre-miR-210 was conducted using Affymetrix GeneChip Human Genome U133 Plus 2.0 Array....

  7. STMN1_BOVIN UniProt:Swiss-Prot

    ID: Q3T0C7

    Description: Removed Stathmin SLD N-acetylalanine Phosphoserine N6-acetyllysine Phosphoserine Phosphoserine; by CDK1, MAPK1 and MAPK3 Phosphoserine Phosphoserine; ...

    gene.name: STMN1
  8. STMN1_PIG UniProt:Swiss-Prot

    ID: Q6DUB7

    Description: Removed Stathmin SLD N-acetylalanine Phosphoserine N6-acetyllysine Phosphoserine; by PKA Phosphoserine; by CDK1, MAPK1 and MAPK3 Phosphoserine Phospho...

    gene.name: STMN1
  9. STM1B_XENLA UniProt:Swiss-Prot

    ID: Q09005

    Description: Stathmin-1-B SLD

    gene.name: stmn1-b
  10. Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infection BioProject

    ID: PRJNA248682

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: elial cells promoted proliferation. We identified STMN1 and DIMT1 as miR-210 target genes and demonstrated that inhibition of miR-210 expression augmented cell proliferation by activating STMN1 and DIMT1. Together, our results highlight inflammation-induced epigenetic silencing of miR-210 as a mechanism of induction of chronic gastric diseases, including cancer, during Hp infection. Overall design: To identify miR-210 targets in gastric cells, whole transcriptome analysis of AGS and MKN45 cells transfected with pre-miR-210 was conducted using Affymetrix GeneChip Human Genome U133 Plus 2.0 Array....
  11. Expression profile of miR-101 transfection in MCF-7 cells compared with scramble control ArrayExpress

    ID: E-GEOD-31397

    Description: iling, we identified three novel miR-101 targets, STMN1, RAB5A and ATG4D. siRNA-mediated depletion of these genes phenocopied the effect of miR-101 overexpression, demonstrating their importance in autophagy regulation. Importantly, overexpression of STMN1 could partially rescue cells from miR-101-mediated inhibition of autophagy, indicating a functional importance for this target. Finally, we show that miR-101-mediated inhibition of autophagy can sensitize breast cancer cells to 4-hydroxytamoxifen (4-OHT) mediated cell death. Collectively, these data establish a novel link between two highly important and rapidly growing research fields and present a new role for miR-101 as a key regulator of autophagy. MCF-7 cells were seeded in 6-cm plate...

  12. Integrated genomic profiling of endometrial carcinoma BioProject

    ID: PRJNA112025

    Keywords: Other

    Access Type: download

    dataset.description: igh protein expression of the PI3K pathway member STMN1, and an aggressive phenotype in test and validation datasets. However, mutations of PTEN or PIK3CA were not associated with the same expression profile or aggressive phenotype. STMN1 expression had independent prognostic value. The results affirm the utility of systematic characterization of the cancer genome in clinically annotated specimens and suggest the particular importance of the PI3K pathway in patients who have aggressive endometrial cancer. Overall design: 84 endometrial cancers (including 9 cell lines) were subject to 100K SNP analysis. 57 endometrial cancers were subject to expression analysis....
  13. Effect of Leptin on Mouse Trophoblast Giant Cells ArrayExpress

    ID: E-GEOD-10297

    Description: some genes associated with cell motility, such as Stmn1. In addition, leptin appeared to inhibit changes in gene expression associated with terminal differentiation of trophoblast giant cells, including inhibition of members of the TGFß signaling pathway and of genes associated with endoreduplication. However, feulgen staining revealed a loss of cells with low ploidy. We conclude that leptin may be promoting trophoblast invasion by maintaining cells in an intermediate stage of differentiation. Keywords: time course, response to hormone treatment, primary cell culture The experiments were performed on primary cultures of mouse trophoblast cells which were isolated from placentas on day 10 of pregnancy. There were two treatments: control (serum-free medium) and recombinant mouse leptin (50 ng/mL). RNA was collected at two time points, 1 hour and 24 hours, for the controls. RNA was collected at...

  14. Integrated genomic profiling of endometrial carcinoma ArrayExpress

    ID: E-GEOD-14860

    Description: igh protein expression of the PI3K pathway member STMN1, and an aggressive phenotype in test and validation datasets. However, mutations of PTEN or PIK3CA were not associated with the same expression profile or aggressive phenotype. STMN1 expression had independent prognostic value. The results affirm the utility of systematic characterization of the cancer genome in clinically annotated specimens and suggest the particular importance of the PI3K pathway in patients who have aggressive endometrial cancer. 84 endometrial cancers (including 9 cell lines) were subject to 100K SNP analysis. 57 endometrial cancers were subject to expression analysis....

  15. Expression profile of miR-101 transfection in MCF-7 cells compared with scramble control OmicsDI

    ID: E-GEOD-31397

    Date Released: 03-02-2012

    Description: iling, we identified three novel miR-101 targets, STMN1, RAB5A and ATG4D. siRNA-mediated depletion of these genes phenocopied the effect of miR-101 overexpression, demonstrating their importance in autophagy regulation. Importantly, overexpression of STMN1 could partially rescue cells from miR-101-mediated inhibition of autophagy, indicating a functional importance for this target. Finally, we show that miR-101-mediated inhibition of autophagy can sensitize breast cancer cells to 4-hydroxytamoxifen (4-OHT) mediated cell death. Collectively, these data establish a novel link between two highly important and rapidly growing research fields and present a new role for miR-101 as a key regulator of autophagy. MCF-7 cells were seeded in 6-cm plate...

  16. Exchange Rate and Balance of Payment: An Autoregressive Distributed Lag (Ardl) Econometric Investigation on Nigeria Figshare

    ID: doi:10.6084/M9.FIGSHARE.1236642

    Release Date: 11-12-2014

    Description:

  17. Integrated genomic profiling of endometrial carcinoma OmicsDI

    ID: E-GEOD-14860

    Date Released: 05-04-2014

    Description: igh protein expression of the PI3K pathway member STMN1, and an aggressive phenotype in test and validation datasets. However, mutations of PTEN or PIK3CA were not associated with the same expression profile or aggressive phenotype. STMN1 expression had independent prognostic value. The results affirm the utility of systematic characterization of the cancer genome in clinically annotated specimens and suggest the particular importance of the PI3K pathway in patients who have aggressive endometrial cancer. 84 endometrial cancers (including 9 cell lines) were subject to 100K SNP analysis. 57 endometrial cancers were subject to expression analysis....

  18. Audit Firm Rotation and Audit Report Lag in Nigeria Figshare

    ID: doi:10.6084/M9.FIGSHARE.1125856

    Release Date: 08-04-2014

    Description:

  19. Expression profile of miR-101 transfection in MCF-7 cells compared with scramble control BioProject

    ID: PRJNA145871

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: iling, we identified three novel miR-101 targets, STMN1, RAB5A and ATG4D. siRNA-mediated depletion of these genes phenocopied the effect of miR-101 overexpression, demonstrating their importance in autophagy regulation. Importantly, overexpression of STMN1 could partially rescue cells from miR-101-mediated inhibition of autophagy, indicating a functional importance for this target. Finally, we show that miR-101-mediated inhibition of autophagy can sensitize breast cancer cells to 4-hydroxytamoxifen (4-OHT) mediated cell death. Collectively, these data establish a novel link between two highly important and rapidly growing research fields and present a new role for miR-101 as a key regulator of autophagy. Overall design: MCF-7 cells were seed...
  20. Effect of Leptin on Mouse Trophoblast Giant Cells BioProject

    ID: PRJNA108511

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: some genes associated with cell motility, such as Stmn1. In addition, leptin appeared to inhibit changes in gene expression associated with terminal differentiation of trophoblast giant cells, including inhibition of members of the TGFß signaling pathway and of genes associated with endoreduplication. However, feulgen staining revealed a loss of cells with low ploidy. We conclude that leptin may be promoting trophoblast invasion by maintaining cells in an intermediate stage of differentiation. Keywords: time course, response to hormone treatment, primary cell culture Overall design: The experiments were performed on primary cultures of mouse trophoblast cells which were isolated from placentas on day 10 of pregnancy. There were two treatments: control (serum-free medium) and recombinant mouse leptin (50 ng/mL). RNA was collected at two time points, 1 hour and 24 hours, for the controls. RNA ...

Displaying 20 of 114 results for "STMN1"