SREBF1 | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 20 of 177 results for "SREBF1"
i
  1. Folate and vitamin B12 imbalance induces endoplasmic reticulum stress and cholesterol biosynthesis gene expression in human adipocytes ArrayExpress

    ID: E-GEOD-43166

    Description: A methylation showed that the promoter regions of sterol regulatory element-binding transcription factor 1 (SREBF1) and low density lipoprotein receptor (LDLR) were hypomethylated in the low and no B12 conditions. The SREB proteins (SREBP1 and 2) and mRNA expressions (SREBF1 and LDLR) were also increased in the same conditions. Conclusion: The data suggest that low B12 can lead to adipocyte dysfunction by inducing excess cholesterol biosynthesis, homocysteine production and induction of UPR and overall adipocyte dysfunction. Both of these pathways and adipocyte dysfunction play a significant role in the development of cardiovascular diseases. Independent replicate samples of the human adipocyte cell line CHUB-S7 were treated with four different concentrations of B12 and folate....

  2. Microarrays analysis of SREBP-1a and SREBP-1c target genes identify new regulatory pathways. BioProject

    ID: PRJNA107219

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Microarrays analysis of SREBP-1a and SREBP-1c target genes identify new regulatory pathways ArrayExpress

    ID: E-GEOD-10918

    Description: n of human myotubes infected either by SREBP1a or 1C Human myotubes were prepared from 3 different skeletal muscle biopsies. After 7 days of differentiation, myotubes were infected for 48 hours with recombinant adenovirus expressing either Renilla, nuclear SREBP1a or nuclear SREBP1c. Each SREBP1a or SREBP1c infected myotubes culture was compared to Renilla infected myotubes culture. Renilla infected myotubes were considered as the control. Three biolo...

  4. SREBP1c and mock virus expression profiles in AG01518 human fibroblasts BioProject

    ID: PRJNA99079

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Sterol-regulatory element binding proteins (SREBP) cont...
  5. Folate and vitamin B12 imbalance induces endoplasmic reticulum stress and cholesterol biosynthesis gene expression in human adipocytes BioProject

    ID: PRJNA184810

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: A methylation showed that the promoter regions of sterol regulatory element-binding transcription factor 1 (SREBF1) and low density lipoprotein receptor (LDLR) were hypomethylated in the low and no B12 conditions. The SREB proteins (SREBP1 and 2) and mRNA expressions (SREBF1 and LDLR) were also increased in the same conditions. Conclusion: The data suggest that low B12 can lead to adipocyte dysfunction by inducing excess cholesterol biosynthesis, homocysteine production and induction of UPR and overall adipocyte dysfunction. Both of these pathways and adipocyte dysfunction play a significant role in the development of cardiovascular diseases. Overall design: Independent replicate samples of the human adipocyte cell line CHUB-S7 were treated with four different concentrations of B12 and folate....
  6. Gene regulated by Srebp1 and c-Myc during reprogramming BioProject

    ID: PRJNA268836

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. Identification of genes regulated by Rb in wild-type and SREBP1 KO MEFs BioProject

    ID: PRJNA355079

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. The effect of bisphenol A on human preadipocyte differentiation ArrayExpress

    ID: E-GEOD-56085

    Description: e differentiated in the presence of 50 µM BPA or 1 µM dexamethasone (DEX) for 48 hours. Results: Microarray analysis revealed 235 up-regulated and 138 down-regulated genes following BPA treatment, including sterol regulatory element binding factor 1 (SREBF1), a key transcription factor known to regulate many components of lipid metabolism and adipogenesis. For DEX treated preadipocytes, 1136 genes were up-regulated, including the adipogenic marker lipoprotein lipase, while 1031 genes were down-regulated. Ingenu...

  9. The effect of bisphenol A on human preadipocyte differentiation. BioProject

    ID: PRJNA242385

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e differentiated in the presence of 50 µM BPA or 1 µM dexamethasone (DEX) for 48 hours. Results: Microarray analysis revealed 235 up-regulated and 138 down-regulated genes following BPA treatment, including sterol regulatory element binding factor 1 (SREBF1), a key transcription factor known to regulate many components of lipid metabolism and adipogenesis. For DEX treated preadipocytes, 1136 genes were up-regulated, including the adipogenic marker lipoprotein lipase, while 1031 genes were down-regulated. Ingenu...
  10. Folate and vitamin B12 imbalance induces endoplasmic reticulum stress and cholesterol biosynthesis gene expression in human adipocytes OmicsDI

    ID: E-GEOD-43166

    Date Released: 06-02-2014

    Description: A methylation showed that the promoter regions of sterol regulatory element-binding transcription factor 1 (SREBF1) and low density lipoprotein receptor (LDLR) were hypomethylated in the low and no B12 conditions. The SREB proteins (SREBP1 and 2) and mRNA expressions (SREBF1 and LDLR) were also increased in the same conditions. Conclusion: The data suggest that low B12 can lead to adipocyte dysfunction by inducing excess cholesterol biosynthesis, homocysteine production and induction of UPR and overall adipocyte dysfunction. Both of these pathways and adipocyte dysfunction play a significant role in the development of cardiovascular diseases. Independent replicate samples of the human adipocyte cell line CHUB-S7 were treated with four different concentrations of B12 and folate....

  11. A systems biology-based approach to deciphering the etiology of steatosis employing patient-derived dermal fibroblasts and iPS cells BioProject

    ID: PRJNA162687

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: s. Transcriptome data enabled the generation of a regulatory network based on the transcription factor SREBF1, linked to a metabolic network of glycerolipid and fatty acid biosynthesis including the downstream transcriptional targets of SREBF1 which include LIPIN1 (LPIN) and low density lipoprotein receptor (LDLR). Glutathione metabolism was among the pathways enriched in steatosis patients in comparison to healthy controls. By using a model of the glutathione pathway we predict a significant increase in the flux through glutathione synthesis as both gamma-glutamylcysteine synthetase and glutathione synthetase have an increased flux...
  12. Dynamics of SREBP1 binding to DNA in mouse liver ArrayExpress

    ID: E-GEOD-48375

    Description: the nutrient-driven rhythm integrate to regulate SREBP1 activity, we evaluated genome-wide the binding of SREBP1 to its targets along the day in wild-type (WT) C57BL/6mice. The recruitment of

  13. Transcription profiling of mouse LXRalpha null, LXRbeta null mutants reveals liver X receptor beta is the dominant LXR subtype in skeletal muscle ArrayExpress

    ID: E-MTAB-61

    Description: increased mRNA levels of LXR target genes such as sterol regulatory element-binding transcription factor 1 (SREBF1), fatty acid synthase (FASN), stearoyl-CoA desaturase 1 (SCD1) and ATP-binding cassette transporter A1 (ABCA1) in myotubes established from WT and LXRalpha KO mice. However, only minor changes in expression level were observed for these genes after treatment with T0901317 in myotubes from LXRbeta KO mice. Gene expression analysis using Affymetrix NuGO Genechip arrays showed that few other genes than the classical, well known LXR target genes were regulated by LXR in skeletal muscle. Furthermore, fu...

  14. Liver X receptor beta is the dominant LXR subtype in skeletal muscle ArrayExpress

    ID: E-GEOD-13192

    Description: increased mRNA levels of LXR target genes such as sterol regulatory element-binding transcription factor 1 (SREBF1), fatty acid synthase (FASN), stearoyl-CoA desaturase 1 (SCD1) and ATP-binding cassette transporter A1 (ABCA1) in myotubes established from WT and LXRα KO mice. However, only minor changes in expression level were observed for these genes after treatment with T0901317 in myotubes from LXRβ KO mice. Gene expression analysis using Affymetrix NuGO Genechip arrays showed that few other genes than the classical, well known LXR target genes were regulated by LXR in skeletal mu...

  15. HUMAN SREBP-1A BOUND TO LDL RECEPTOR PROMOTER PDB

    ID: PDB:1AM9

    Description: STEROL REGULATORY ELEMENT BINDING(STRE)/DNA COMPLEX

  16. Transcription profiling of rat and mouse granulosa cells infected with adenoviral vectors expressing two FOXO1 mutants reveals FSH ... ArrayExpress

    ID: E-GEOD-15727

    Description: The forkhead box transcription factor FOXO1 is highly expressed in granulosa cells of growing follicles but is down-regulated by ...

  17. Increases in Insulin Sensitivity among Obese Youth are Associated with Gene Expression Changes in Whole Blood ArrayExpress

    ID: E-GEOD-50800

    Description: Pase, H+ transporting V0 subunit e2 (ATPV0E), and sterol regulatory element binding transcription factor 1 (SREBF1), and endothelial cell adhesion molecule (ESAM). There were 8 pathways identified that met the criteria for significance, including insulin signaling, type 1 diabetes, and glycerophospholipid metabolism. Participants that increased insulin sensitivity exhibited five times the number of significant genes altered compared to non-responders (1,144 vs. 230). These findings offer insight into the molecular mechanisms underlying health improvements among high-risk Latino youth. Lifestyle interventions may contribute to improved insulin sensitivity through pathways related to insulin signaling and immune response. Further, genetic factors may mediate response to lifestyle intervention. Fifteen (7M/8F) overweight/obese Latino Youth Whole blood RNA samples evaluated pre and post intervention....

  18. Dynamics of SREBP1 binding to DNA in mouse liver BioProject

    ID: PRJNA209935

    Keywords: Epigenomics

    Access Type: download

  19. Liver X receptor beta is the dominant LXR subtype in skeletal muscle BioProject

    ID: PRJNA109483

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: increased mRNA levels of LXR target genes such as sterol regulatory element-binding transcription factor 1 (SREBF1), fatty acid synthase (FASN), stearoyl-CoA desaturase 1 (SCD1) and ATP-binding cassette transporter A1 (ABCA1) in myotubes established from WT and LXRα KO mice. However, only minor changes in expression level were observed for these genes after treatment with T0901317 in myotubes from LXRβ KO mice. Gene expression analysis using Affymetrix NuGO Genechip arrays showed that few other genes than the classical, well known LXR target genes were regulated by LXR in skeletal mu...
  20. HNF1-alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP1 & ChREBP activation BioProject

    ID: PRJNA100277

    Keywords: Transcriptome or Gene expression

    Access Type: download


Displaying 20 of 177 results for "SREBF1"