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Displaying 4 of 4 results for "SPNS2"
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  1. Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts ArrayExpress

    ID: E-GEOD-60761

    Description: negatively regulates the osteoclast expression of Spns2 gene, which encodes a transporter for the signaling lipid sphingosine 1-phosphate (S1P). CTR-deficient mice show increased S1P levels, and their skeletal phenotype is normalized by deletion of the S1P receptor S1P3. Finally, pharmacologic treatment with the non-selective S1P receptor agonist FTY720 causes increased bone formation in wildtype, but not in S1P3-deficient mice. This study redefines the role of CT in skeletal biology, confirms that S1P acts as an osteoanabolic molecule in vivo, and provides evidence for a pharmacologic...

  2. SPNS2_XENTR UniProt:Swiss-Prot

    ID: B0JZE1

    Description: Protein spinster homolog 2 Helical Helical Helical Helical Helical Helical Helical Helical Helical He...

  3. Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts BioProject

    ID: PRJNA259503

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: negatively regulates the osteoclast expression of Spns2 gene, which encodes a transporter for the signaling lipid sphingosine 1-phosphate (S1P). CTR-deficient mice show increased S1P levels, and their skeletal phenotype is normalized by deletion of the S1P receptor S1P3. Finally, pharmacologic treatment with the non-selective S1P receptor agonist FTY720 causes increased bone formation in wildtype, but not in S1P3-deficient mice. This study redefines the role of CT in skeletal biology, confirms that S1P acts as an osteoanabolic molecule in vivo, and provides evidence for a pharmacologic...
  4. Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts OmicsDI

    ID: E-GEOD-60761

    Date Released: 10-25-2014

    Description: negatively regulates the osteoclast expression of Spns2 gene, which encodes a transporter for the signaling lipid sphingosine 1-phosphate (S1P). CTR-deficient mice show increased S1P levels, and their skeletal phenotype is normalized by deletion of the S1P receptor S1P3. Finally, pharmacologic treatment with the non-selective S1P receptor agonist FTY720 causes increased bone formation in wildtype, but not in S1P3-deficient mice. This study redefines the role of CT in skeletal biology, confirms that S1P acts as an osteoanabolic molecule in vivo, and provides evidence for a pharmacologic...


Displaying 4 of 4 results for "SPNS2"