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Displaying 19 of 19 results for "SOHLH2"
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  1. Transcriptional changes in Sohlh1/Sohlh2 double knockout newborn mouse ovaries BioProject

    ID: PRJNA133643

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Transcriptional changes in Sohlh1 knockout and Sohlh2 knockout mouse newborn ovaries BioProject

    ID: PRJNA133645

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Transcriptional changes in Sohlh1 knockout and Sohlh2 knockout mouse newborn ovaries ArrayExpress

    ID: E-GEOD-24816

    Description: Sohlh1 and Sohlh2 are germ cell-specific basic helix-loop-helix transcription factors critical in early folliculogenesis. We discovered that S...

  4. Regulation of early folliculogenesis by Sohlh1 and Sohlh2 in mouse ovary ArrayExpress

    ID: E-GEOD-24817

    Description: ries: GSE24815: Transcriptional changes in Sohlh1/Sohlh2 double knockout mouse newborn ovaries GSE24816: Transcriptional changes in Sohlh1 knockout and Sohlh2 knockout mouse newborn ovaries Refer to individual Series...

  5. Transcriptional changes in Sohlh1/Sohlh2 double knockout newborn mouse ovaries ArrayExpress

    ID: E-GEOD-24815

    Description: Sohlh1 and Sohlh2 are germ cell-specific basic helix-loop-helix transcription factors critical in early folliculogenesis. Differential genes e...

  6. Transcription profiling by array of testis from Sohlh1 and Sohlh2 knock out mice ArrayExpress

    ID: E-GEOD-21525

    Description: Sohlh1 and Sohlh2 encode a germ cell-specific basic helix-loop-helix transcriptional regulator critical in spermatogonial differentiation. Sev...

  7. Transcriptional changes in Sohlh1 knockout and Sohlh2 knockout mouse newborn ovaries OmicsDI

    ID: E-GEOD-24816

    Date Released: 06-10-2011

    Description: Sohlh1 and Sohlh2 are germ cell-specific basic helix-loop-helix transcription factors critical in early folliculogenesis. We discovered that S...

  8. Transcriptional changes in Sohlh1/Sohlh2 double knockout newborn mouse ovaries OmicsDI

    ID: E-GEOD-24815

    Date Released: 06-10-2011

    Description: Sohlh1 and Sohlh2 are germ cell-specific basic helix-loop-helix transcription factors critical in early folliculogenesis. Differential genes e...

  9. Mus musculus strain:129/B6 mixed : Mus musculus strain:129/B6 mixed Raw sequence reads BioProject

    ID: PRJNA293873

    Keywords: raw sequence reads

    Access Type: download

    dataset.description: SOHLH1 and SOHLH2 are germ cell specific transcriptional factor. here we compare Transcriptome or Gene expression between wild-type, Sohlh1 KO...
  10. Regulation of early folliculogenesis by Sohlh1 and Sohlh2 in mouse ovary OmicsDI

    ID: E-GEOD-24817

    Date Released: 06-10-2011

    Description: ries: GSE24815: Transcriptional changes in Sohlh1/Sohlh2 double knockout mouse newborn ovaries GSE24816: Transcriptional changes in Sohlh1 knockout and Sohlh2 knockout mouse newborn ovaries Refer to individual Series...

  11. Transcription profiling by array of testis from Sohlh1 and Sohlh2 knock out mice OmicsDI

    ID: E-GEOD-21525

    Date Released: 04-30-2015

    Description: Sohlh1 and Sohlh2 encode a germ cell-specific basic helix-loop-helix transcriptional regulator critical in spermatogonial differentiation. Sev...

  12. Expression data from testis of day-7 Sohlh1 knock-out mice BioProject

    ID: PRJNA125951

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Sohlh1 and Sohlh2 encode a germ cell-specific basic helix-loop-helix transcriptional regulator critical in spermatogonial differentiation. Sev...
  13. SOLH2_RAT UniProt:Swiss-Prot

    ID: Q3MHT3

    Description: Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 bHLH

    gene.name: Sohlh2
  14. DMRT6 coordinates the transition between mitotic and meiotic developmental programs during mamalian spermatogenesis ArrayExpress

    ID: E-GEOD-60440

    Description: ogonial differentiation factors including SOHLH1, SOHLH2 and DMRT1 and the meiotic initiation factor STRA8 and causing most late spermatogonia to undergo apoptosis. In mice of the 129Sv background, most Dmrt6 mutant spermatogonia can complete differentiation and enter meiosis, but they show defects in chromosome pairing, establishment of the XY body, and processing of recombination foci, and mainly arrest in mid-pachynema. mRNA profiling of Dmrt6 mutant testes together with DMRT6 ChIP-seq suggest that DMRT6 represses genes involved in spermatogonial differentiation and activates genes required for meiotic prophase. Our results indicate that Dmrt6 plays a key role in coordinating the transition in gametogenic programs from spermatogonial differentiation and mitosis to spermatocyte development and meiosis. Six samples for RNA-Seq with three biological replicates in each group. Two samples for ChIP-Seq (one input a...

  15. DMRT6 coordinates the transition between mitotic and meiotic developmental programs during mamalian spermatogenesis BioProject

    ID: PRJNA258272

    Keywords: Other

    Access Type: download

    dataset.description: ogonial differentiation factors including SOHLH1, SOHLH2 and DMRT1 and the meiotic initiation factor STRA8 and causing most late spermatogonia to undergo apoptosis. In mice of the 129Sv background, most Dmrt6 mutant spermatogonia can complete differentiation and enter meiosis, but they show defects in chromosome pairing, establishment of the XY body, and processing of recombination foci, and mainly arrest in mid-pachynema. mRNA profiling of Dmrt6 mutant testes together with DMRT6 ChIP-seq suggest that DMRT6 represses genes involved in spermatogonial differentiation and activates genes required for meiotic prophase. Our results indicate that Dmrt6 plays a key role in coordinating the transition in gametogenic programs from spermatogonial differentiation and mitosis to spermatocyte development and meiosis. Overall design: Six samples for RNA-Seq with three biological replicates in each group. Two samples for ChIP-...
  16. Development of Laser Capture Microdissection to study the gene expression of the sheep early ovarian folliculogenesis ArrayExpress

    ID: E-GEOD-25652

    Description: ation, the expression of 6 oocyte-specific genes (SOHLH2, MAEL, MATER, VASA, GDF9, BMP15) and 3 granulosa cell-specific genes (KITLG, GATA4, AMH) confirmed the purity of the samples and documented their ovine expression profiles. Then, using bovine Affymetrix chip, we identified for the first time, a global gene expression for each follicular compartment during early developmental stages. Particularly the granulosa cell data set is quite unique. 1050 granulosa cell specific transcripts compared to oocyte and 759 oocyte specific transcripts were detected. The analysis of the expression of 2 genes (SIRT7, FST) confirmed this specificity of expression. Finally, the integration of the data stated the 3 main physiological events involved in early folliculogenesis and provided descriptive elements that confirmed the relevance and the potential of the LCM-derived RNAs. Conclusions This method should contribute through an additional genome wide expression profiling to give insights on molecular mechanisms involved in stage transitions and cell type interplays. The 2 ovine follicular compartments (i.e. granulosa cells (G) and oocytes (O) were captured using LCM technology for each early stage (primordial (Pd), primary (Pm), secondary (Sec) follicles. The RNA of each group was extracted using Picopure RNA Isolation kit (Arcturus) and subjected to 2 round T7 amplification (RiboAmp®HS PLUS kit, Arcturus). Ovine microarray experiments were performed using the Affymetrix Bovine Expression Array. First the quality of the cross-species hybridizations was checked by...

  17. DMRT6 coordinates the transition between mitotic and meiotic developmental programs during mamalian spermatogenesis OmicsDI

    ID: E-GEOD-60440

    Date Released: 11-12-2014

    Description: ogonial differentiation factors including SOHLH1, SOHLH2 and DMRT1 and the meiotic initiation factor STRA8 and causing most late spermatogonia to undergo apoptosis. In mice of the 129Sv background, most Dmrt6 mutant spermatogonia can complete differentiation and enter meiosis, but they show defects in chromosome pairing, establishment of the XY body, and processing of recombination foci, and mainly arrest in mid-pachynema. mRNA profiling of Dmrt6 mutant testes together with DMRT6 ChIP-seq suggest that DMRT6 represses genes involved in spermatogonial differentiation and activates genes required for meiotic prophase. Our results indicate that Dmrt6 plays a key role in coordinating the transition in gametogenic programs from spermatogonial differentiation and mitosis to spermatocyte development and meiosis. Six samples for RNA-Seq with three biological replicates in each group. Two samples for ChIP-Seq (one input a...

  18. Development of Laser Capture Microdissection to study the gene expression of the sheep early ovarian folliculogenesis BioProject

    ID: PRJNA133909

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ation, the expression of 6 oocyte-specific genes (SOHLH2, MAEL, MATER, VASA, GDF9, BMP15) and 3 granulosa cell-specific genes (KITLG, GATA4, AMH) confirmed the purity of the samples and documented their ovine expression profiles. Then, using bovine Affymetrix chip, we identified for the first time, a global gene expression for each follicular compartment during early developmental stages. Particularly the granulosa cell data set is quite unique. 1050 granulosa cell specific transcripts compared to oocyte and 759 oocyte specific transcripts were detected. The analysis of the expression of 2 genes (SIRT7, FST) confirmed this specificity of expression. Finally, the integration of the data stated the 3 main physiological events involved in early folliculogenesis and provided descriptive elements that confirmed the relevance and the potential of the LCM-derived RNAs. Conclusions This method should contribute through an additional genome wide expression profiling to give insights on molecular mechanisms involved in stage transitions and cell type interplays. Overall design: The 2 ovine follicular compartments (i.e. granulosa cells (G) and oocytes (O) were captured using LCM technology for each early stage (primordial (Pd), primary (Pm), secondary (Sec) follicles. The RNA of each group was extracted using Picopure RNA Isolation kit (Arcturus) and subjected to 2 round T7 amplification (RiboAmp®HS PLUS kit, Arcturus). Ovine microarray experiments were performed using the Affymetrix Bovine Expression Array. First the quality of the cross-species hybridization...
  19. Development of Laser Capture Microdissection to study the gene expression of the sheep early ovarian folliculogenesis OmicsDI

    ID: E-GEOD-25652

    Date Released: 07-12-2011

    Description: ation, the expression of 6 oocyte-specific genes (SOHLH2, MAEL, MATER, VASA, GDF9, BMP15) and 3 granulosa cell-specific genes (KITLG, GATA4, AMH) confirmed the purity of the samples and documented their ovine expression profiles. Then, using bovine Affymetrix chip, we identified for the first time, a global gene expression for each follicular compartment during early developmental stages. Particularly the granulosa cell data set is quite unique. 1050 granulosa cell specific transcripts compared to oocyte and 759 oocyte specific transcripts were detected. The analysis of the expression of 2 genes (SIRT7, FST) confirmed this specificity of expression. Finally, the integration of the data stated the 3 main physiological events involved in early folliculogenesis and provided descriptive elements that confirmed the relevance and the potential of the LCM-derived RNAs. Conclusions This method should contribute through an additional genome wide expression profiling to give insights on molecular mechanisms involved in stage transitions and cell type interplays. The 2 ovine follicular compartments (i.e. granulosa cells (G) and oocytes (O) were captured using LCM technology for each early stage (primordial (Pd), primary (Pm), secondary (Sec) follicles. The RNA of each group was extracted using Picopure RNA Isolation kit (Arcturus) and subjected to 2 round T7 amplification (RiboAmp®HS PLUS kit, Arcturus). Ovine microarray experiments were performed using the Affymetrix Bovine Expression Array. First the quality of the cross-species hybridizations was checked by...


Displaying 19 of 19 results for "SOHLH2"