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Displaying 20 of 81 results for "SOCS6"
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  1. CRYSTAL STRUCTURE OF SOCS6 SH2 DOMAIN IN COMPLEX WITH A C-KIT PHOSPHOPEPTIDE PDB

    ID: PDB:2VIF

    Description: SUPPRESSOR OF CYTOKINE SIGNALLING 6, MAST/STEM CELL GROWTH FACTOR RECEPTOR

  2. SOCS6_PONAB UniProt:Swiss-Prot

    ID: Q5RCM6

    Description: Suppressor of cytokine signaling 6 SH2 SOCS box Poly-Ser

  3. Array-Comparative Genomic Hybridization Reveals Loss of SOCS6 is Associated with Poor Prognosis in Primary Lung Squamous Cell Carcinoma BioProject

    ID: PRJNA147625

    Keywords: Variation

    Access Type: download

  4. Array-Comparative Genomic Hybridization Reveals Loss of SOCS6 is Associated with Poor Prognosis in Primary Lung Squamous Cell Carcinoma ArrayExpress

    ID: E-GEOD-32058

    Description: ce was found for seven genes within 18q22.3, only SOCS6 copy number loss was both technically replicated by qPCR and biologically validated in the test set. DNA copy number profiling using 44K element array comparative genomic hybridization microarrays of 62 primary lung squamous cell carcinomas....

  5. Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide. PDB

    ID: PDB:2HMH

    Description: Suppressor of cytokine signaling 3, Interleukin-6 receptor beta chain

  6. Array-Comparative Genomic Hybridization Reveals Loss of SOCS6 is Associated with Poor Prognosis in Primary Lung Squamous Cell Carcinoma OmicsDI

    ID: E-GEOD-32058

    Date Released: 05-02-2014

    Description: ce was found for seven genes within 18q22.3, only SOCS6 copy number loss was both technically replicated by qPCR and biologically validated in the test set. DNA copy number profiling using 44K element array comparative genomic hybridization microarrays of 62 primary lung squamous cell carcinomas....

  7. IFNg-/- and conditional Socs3-/- mice: cytokine treatments BioProject

    ID: PRJNA84869

    Keywords: Transcriptome or Gene expression

    Access Type: download

  8. ver from mice deficient for IFNg or both IFNg and Suppressor of Cytokine Signalling-1 at 0.5 to 48 hours after INFg treatment... ArrayExpress

    ID: E-GEOD-4232

    Description: lling in mice deficient for IFNg or both IFNg and Suppressor of Cytokine Signalling-1 (SOCS1)....

  9. Regulation of Liver Regeneration and Hepatocarcinogenesis by Suppressor of Cytokine Signaling 3 BioProject

    ID: PRJNA103365

    Keywords: Transcriptome or Gene expression

    Access Type: download

  10. Transcription profiling of mouse liver regeneration in Socs3 h-KO mice, Socs3 fl/fl, Alb-Cre- littermates controls ArrayExpress

    ID: E-GEOD-9549

    Description: Suppressor of cytokine signaling 3 (SOCS3) down-regulates several signaling

  11. Induction of the IL-6/signal transducer and activator of transcription pathway in the lungs of mice exposed to tobacco BioProject

    ID: PRJNA110851

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. Transcription profiling of mouse lung tissue after exposure to mainstream tobacco smoke ArrayExpress

    ID: E-GEOD-12930

    Description: TS). Our results reveal induction of inflammatory cytokine interleukin-6 (IL-6) and its antagonist suppressor of cytokine signalling (SOCS3) mRNA in smoking group. We also show that these changes are transient and are reversed completely after a period of cessation of smoking. Experiment Overall Design...

  13. Negative feedback enables oncogenic signaling in pre-B cells and represents a therapeutic target in acute lymphoblastic leukemia BioProject

    ID: PRJNA253306

    Keywords: Variation

    Access Type: download

  14. Regulation of onco and tumor suppressor miRNA by mTORC1 inhibitor PRP-1 in human chondrosarcoma BioProject

    ID: PRJNA214223

    Keywords: Other

    Access Type: download

  15. Regulation of onco and tumor suppressor miRNA by mTORC1 inhibitor PRP-1 in human chondrosarcoma ArrayExpress

    ID: E-GEOD-49545

    Description: tatistically significant miRNAs(3 upregulated and 6 downregulated) fitting P<0.05 by Benjamini Hochberg were detected when comparing chondrosarcoma cell line treted to not treated control using human Exiqon arrays with biological triplicates.: miR192, regulating cell cycle checkpoinrts was upregulated in treated samples 4 fold, miR125b, known as tumor suppressor in sarcomas was upregulated 4.87 fold. miR20a was upregulated 5.29 , known to form complexes with Argonaute proteins-part of RNA induced silencing complex (RISC) Downregulated miRNas included miR509-3p (12.88 fold), its targets Yap, Rac1 and Yes1 known to be associated with Src kinase activity; miR589 was downregulated 7.46 fold , targets Src adaptors'. miR 302c was downregulated6.46 fold and miR199a=5p -5.66 fold , that acted as oncogenes in sarcomas. miR584 involved on cell migration and TGFbeta ...

  16. Transcription profiling by array of mouse Peroxisome proliferator-activated receptor g (PPARg) null CD4+ T cells after treatment with dextran-sodium s... ArrayExpress

    ID: E-GEOD-20523

    Description: or PPAR g flfl; CD4 Cre+ (CD4cre) mice in a C57BL/6 background were challenged with 2.5% DSS in their drinking water for 0, 2, or 7 days. Mice were scored on disease severity both clinically and histopathologically. Flow cytometry was used to assess lymphocyte and macrophage populations in the blood, spleen, and mesenteric lymph nodes (MLN). Global gene expression in colonic mucosa was profiled using Affymetrix microarrays. RESULTS: Both disease severity and inflammation-related body weight loss were accelerated by the deficiency of PPAR g in T cells. Examination of colon histopathology revealed significantly greater epithelial erosion, le...

  17. Immunoregulatory actions of T cell PPAR g at the colonic mucosa BioProject

    ID: PRJNA125133

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: or PPAR g flfl; CD4 Cre+ (CD4cre) mice in a C57BL/6 background were challenged with 2.5% DSS in their drinking water for 0, 2, or 7 days. Mice were scored on disease severity both clinically and histopathologically. Flow cytometry was used to assess lymphocyte and macrophage populations in the blood, spleen, and mesenteric lymph nodes (MLN). Global gene expression in colonic mucosa was profiled using Affymetrix microarrays. RESULTS: Both disease severity and inflammation-related body weight loss were accelerated by the deficiency of PPAR g in T cells. Examination of colon histopathology revealed significantly greater epithelial erosion, le...
  18. Negative regulation of the IFN/STAT signaling pathway by the Trim24 tumor suppressor protein through Rara inhibition BioProject

    ID: PRJNA122499

    Keywords: Transcriptome or Gene expression

    Access Type: download

  19. Negative regulation of the IFN/STAT signaling pathway by the Trim24 tumor suppressor protein through Rara inhibition ArrayExpress

    ID: E-GEOD-19675

    Description: e that Trim24-mediated repression of the IFN/STAT signaling through Rara inhibition may play a critical role in preventing liver cancer. Generation of Trim24-/- mice has been described previously (Khetchoumian et al., 2007) by gene disruption. To generate compound mutant mice with a single allele of Rara deleted in the Trim24 -/- mutant background, we crossed Trim24 -/- mice with Rara+/- mice. The resulting Trim24+/- Rara+/- mice were generated in the hybrid (C57BL/6 (60%), 129/Sv (40%)) genetic background. These double heterozygous Trim24+/- Rara+/- mice were intercrossed to generate Trim24 -/-, Trim24 -/- Rara+/- and wild-type mice. Transcriptional profiling of mice at 5-weeks and 14-weeks of age....

  20. CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN IN COMPLEX WITH AN IRREVERSIBLE INHIBITOR 13-JAB PDB

    ID: PDB:2J5E

    Description: EPIDERMAL GROWTH FACTOR RECEPTOR (E.C.2.7.10.1)

    material.name: S-{3-[(4-ANILINOQUINAZOLIN-6-YL)AMINO]-3-OXOPROPYL}-L-CYSTEINE

Displaying 20 of 81 results for "SOCS6"