SMIM15 | bioCADDIE Data Discovery Index
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Displaying 10 of 10 results for "SMIM15"
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  1. SIM15_MOUSE UniProt:Swiss-Prot

    ID: Q3UTD9

    Description: Small integral membrane protein 15 Helical

  2. SIM15_XENLA UniProt:Swiss-Prot

    ID: A9JTJ0

    Description: Small integral membrane protein 15 Helical

  3. SIM15_PONAB UniProt:Swiss-Prot

    ID: Q5R4D8

    Description: Small integral membrane protein 15 Helical

  4. SIM15_DANRE UniProt:Swiss-Prot

    ID: A3KNM5

    Description: Small integral membrane protein 15 Helical

  5. SIM15_CHICK UniProt:Swiss-Prot

    ID: Q5F409

    Description: Small integral membrane protein 15 Helical

  6. Filoviridae BioProject

    ID: PRJNA16884

    Access Type: download

    dataset.description: capsid, a polymerase complex, and a matrix protein. Virus capsid is enveloped. Virions are filamentous, or pleomorphic, flexible with extensive branching. U- or 6-shaped and circular forms occur particularly after purification. Virions measure about 80 nm in diameter; greatly variable up to 1400 nm in...
  7. Data from: Common internal allosteric network links anesthetic binding sites in a pentameric ligand-gated ion channel Dryad

    DateIssued: 08-15-2016

    Description: known. We examine this issue by way of the model protein Gloeobacter violaceous ligand-gated ion channel (GLIC) using computational molecular dynamics, with a coarse-grained model to enhance sampling. We find that in flooding simulations, both propofol and a generic particle localize to the crystallographic transmembrane anesthetic binding...

  8. Expression of Wnt Receptors in Adult Spiral Ganglion Neurons: Fzd 9 Located at Growth Cones of Regenerating Neurites GEMMA

    ID: 1598

    Keywords: functional genomics

    Description: orin, and slit—in the mature cochlea as late as 15 months. In addition, we observed the expression of all known receptors for the Wnt morphogens, whose neuronal guidance function has only recently been recognized. In situ hybridizations located the mRNAs of the Wnt receptors frizzled 1, 4, 6, 9, and 10 specifically in adult spiral ganglion neurons. Finally, frizzled 9 protein was found in the growth cones of adult spiral ganglion neurons that were regenerating neurites in culture. We conclude from our results that adult spiral ganglion neurons are poised to respond to neurite damage, owing to the constitutive expression of a large and diverse collection of guidance receptors. Wnt signaling, in particular, emerges as a candidate pathway for guiding neurite outgrowth towards a cochlear implant after sensorineural hearing loss. Last Updated (by provider): May 18 2009 Contributers: Young-Jin Kang Richard Kollmar Barbara L Christensen Samit M Shah Albert S Feng...

  9. Expression of Wnt Receptors in Adult Spiral Ganglion Neurons: Fzd 9 Located at Growth Cones of Regenerating Neurites BioProject

    ID: PRJNA111117

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: orin, and slit—in the mature cochlea as late as 15 months. In addition, we observed the expression of all known receptors for the Wnt morphogens, whose neuronal guidance function has only recently been recognized. In situ hybridizations located the mRNAs of the Wnt receptors frizzled 1, 4, 6, 9, and 10 specifically in adult spiral ganglion neurons. Finally, frizzled 9 protein was found in the growth cones of adult spiral ganglion neurons that were regenerating neurites in culture. We conclude from our results that adult spiral ganglion neurons are poised to respond to neurite damage, owing to the constitutive expression of a large and diverse collection of guidance receptors. Wnt signaling, in particular, emerges as a candidate pathway for guiding neurite outgrowth towards a cochlear implant after sensorineural hearing loss. Overall design: To determine which potential guidance receptors were present in the adult cochlea and whether any of them were chronically up- or downregulated after damage, we conducted a mi...
  10. Immunity to Grb10, a signal transduction molecule, inhibits the growth of breast cancer in mice. BioProject

    ID: PRJNA108273

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: se The spontaneous release of 51Cr was less than 15% of the total release in each instance. Enrichment of the vaccine for cells that induce immunity to (SB5b) mammary carcinoma cells. The vaccine was prepared by transfer of a cDNA library derived from SB5b cells into the modified mouse fibroblasts. Since only a small proportion of the transduced cell population was expected to have incorporated cDNAs that included genes specifying tumor antigens (TAA), a unique strategy was used to enrich the vaccine for TAA-positive cells, as described previously (30). In brief, aliquots of the suspension of transduced cells were added to each of ten wells of a 96 well plate. Each pool contained a starting inoculum of 1 x 103 cells. Wells containing higher numbers of TAA-positive cells were detected by comparing the response of C3H/He mice to immunization with cells from the individual pools, as determined by both ELISPOT IFN-? and 51Cr-release cytotoxicity assays. To obtain a sufficient number of cells for immunization, cells from the individual pools were allowed to increase to approximately 5 x 107, through periodic transfers to larger culture plates and eventually cell culture flasks. An aliquot of each of the expanded cell populations was maintained frozen/viable (for later recovery). The remaining portion was used for immunization. Frozen cells derived from the pool that stimulated immunity to the breast cancer cells to the greatest extent (immunohigh), and, for use as a control, from the pool that induced immunity to SB5b cells to the least extent (immunolow), were recovered, reestablished in culture and subjected to additional rounds of positive or negative immune selection (30). (As an additional control, one pool was not subjected to either positive or negative selection (master pool)). After five rounds of selection, microarrays were used to compare the gene expression profiles of cells in the immunohigh and immunolow pools. Microarrays of cellular vaccines enriched for transduced fibroblasts that induced immunity to SB5b cells. cRNA microarrays were used to the compare the gene expression profiles of transduced fibroblasts from the immunohigh and immunolow pools, as described previously (36). RT-PCR of Grb10, a candidate gene specifying a breast cancer antigen, identified by comparing microarrays of the enriched and non enriched vaccines. Grb10 was highly over represented in cells from immunohigh pools. RT-PCR was used to determine if the gene was expressed. Approximately 6 x 106 cells from the immunohigh pool in monolayer culture were disrupted and homogenized. 1 volume of 70% ethanol was added before the extracts were loaded onto RNeasy mini columns. RT-PCR was performed on RNA eluted from the column with a one-step RT-PCR kit (Qiagen, Valencia, CA), according to the manufacturer’s instructions. 1 ug RNA was mixed with buffer containing 1.25 mM MgCl2, 40uM dNTPs, 0.6 µM of each forward and backward primers and 2 µl of a mixture containing reverse transcriptase and Taq polymerase....

Displaying 10 of 10 results for "SMIM15"