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Displaying 13 of 13 results for "SMAD6"
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  1. Epigenetic regulation of Bmp2 and Smad6 in Ras-induced senescence ArrayExpress

    ID: E-GEOD-18125

    Description: and Bmp2, a secreted factor for BMP/SMAD signal. Smad6, specific BMP/SMAD pathway inhibitor, was identified as the only one gene showing de novo H3K27 trimethylation with H3K4me3, resulting in strong repression. Ras-activated cells senesced with SMAD1/5/8 phosphorylation, and they escaped from senescence with decreased SMAD1/5/8 phosphorylation when introducing Smad6 or knocking-down Bmp2. Mouse embryonic fibroblasts were established from 13.5 embryonic day embryos of C57/B6. After cells were passaged twice (MEFp2), cells were ...

  2. Epigenetic regulation of Bmp2 and Smad6 in Ras-induced senescence BioProject

    ID: PRJNA119455

    Keywords: Other

    Access Type: download

  3. Epigenetic regulation of Bmp2 and Smad6 in Ras-induced senescence OmicsDI

    ID: E-GEOD-18125

    Date Released: 05-02-2014

    Description: and Bmp2, a secreted factor for BMP/SMAD signal. Smad6, specific BMP/SMAD pathway inhibitor, was identified as the only one gene showing de novo H3K27 trimethylation with H3K4me3, resulting in strong repression. Ras-activated cells senesced with SMAD1/5/8 phosphorylation, and they escaped from senescence with decreased SMAD1/5/8 phosphorylation when introducing Smad6 or knocking-down Bmp2. Mouse embryonic fibroblasts were established from 13.5 embryonic day embryos of C57/B6. After cells were passaged twice (MEFp2), cells were ...

  4. Biocompatibility and Discovery of the Potential Applications of Magnetite (Fe3O4) Nanoparticles BioProject

    ID: PRJNA116539

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ng including six genes, Id1, Id2, Id3, Caspase-9, Smad6 and SMAD7, important negative regulators of these signaling pathways involved in development and tumorigenesis. Overall design: Total RNA isolated from MNP treated HeLa cells compared to untreated controls....
  5. Transcription profiling by array of spontaneous lung tumors in mice to compare to human non-small cell lung cancer ArrayExpress

    ID: E-GEOD-31013

    Description: Hnf4a, Tcf21, Ptprd, Hpgd, Hopx, Ogn, Id4, Hoxa5, Smad6, Smad7, Zbtb16, Cyr61, Dusp4, and Ifi16. In addition, several genes important in lung development were also differentially expressed, such as Smad6, Hopx, Sox4, Sox9 and Mycn. Conclusion: In this study, we have demonstrated that several cancer genes and signaling pathways relevant for human NSCLC were similarly altered in spontaneous murine lung tumors. Six spontaneous lung tumors and six normal lungs (as controls) from 2-year-old B6C3F1 mice....

  6. Data from: A major gene for bovine ovulation rate Dryad

    DateIssued: 08-07-2015

    Description: his region contains three candidate genes, SMAD3, SMAD6 and IQCH. While candidate gene screening failed to identify the causative polymorphism, three polymorphisms were identified that can be used as a haplotype to track inheritance of the high ovulation rate allele in descendants of the carrier sire....

  7. Gene expression profiling of normal lung tissue adjacent to lung adenocarcinoma (ADCA) ArrayExpress

    ID: E-GEOD-31267

    Description: es in vitro indicated that four of them (SLC14A1, SMAD6, TMEM100, and TXNIP) inhibited colony formation when over-expressed by transfection in lung cancer cell lines, suggesting their potential tumor-suppressor activity. Our findings indicated that individual variations in the transcriptional profile of normal lung tissue may reflect the lung ADCA patients’ predisposition to a specific clinical stage. The 120 RNA samples from normal lung were combined in 24 small pools, with 12 pools constituted by stage I patients and 12 pools by stage >I patients (5 samples per pool)...

  8. Global Differential Gene Expression Analysis of Spontaneous Lung Tumors in B6C3F1 Mice: Comparison to Human Non-Small Cell Lung Cancer BioProject

    ID: PRJNA146331

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Hnf4a, Tcf21, Ptprd, Hpgd, Hopx, Ogn, Id4, Hoxa5, Smad6, Smad7, Zbtb16, Cyr61, Dusp4, and Ifi16. In addition, several genes important in lung development were also differentially expressed, such as Smad6, Hopx, Sox4, Sox9 and Mycn. Conclusion: In this study, we have demonstrated that several cancer genes and signaling pathways relevant for human NSCLC were similarly altered in spontaneous murine lung tumors. Overall design: Six spontaneous lung tumors and six normal lungs (as controls) from 2-year-old B6C3F1 mice....
  9. Gene expression profiling of normal lung tissue adjacent to lung adenocarcinoma (ADCA) BioProject

    ID: PRJNA146131

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: es in vitro indicated that four of them (SLC14A1, SMAD6, TMEM100, and TXNIP) inhibited colony formation when over-expressed by transfection in lung cancer cell lines, suggesting their potential tumor-suppressor activity. Our findings indicated that individual variations in the transcriptional profile of normal lung tissue may reflect the lung ADCA patients’ predisposition to a specific clinical stage. Overall design: The 120 RNA samples from normal lung were combined in 24 small pools, with 12 pools constituted by stage I patients and 12 pools by stage >I patients (5 samples per pool)...
  10. Identification of AUF1 target mRNAs BioProject

    ID: PRJNA271810

    Keywords: Other

    Access Type: download

    dataset.description: of TNFSF11 (known as RANKL), KLF10, HES1, CCNT2, SMAD6, and BCL6. We have mapped some of the instability determinants. HES1 mRNA appeared to have a coding region determinant. Detailed analysis of the RANKL and BCL6 3’UTR revealed for both that full instability required two elements, which are conserved in evolution. In RANKL mRNA both elements are AU-rich and separated by 30 bases, while in BCL6 mRNA one is AU-rich and 60 bases from a non AU-rich element that potentially forms a stem-loop structure. Overall design: We compared mRNAs in RNP-IPs from cell extracts with and without myc-AUF1 p42 induction...
  11. Transcription profiling by array of spontaneous lung tumors in mice to compare to human non-small cell lung cancer OmicsDI

    ID: E-GEOD-31013

    Date Released: 05-01-2015

    Description: Hnf4a, Tcf21, Ptprd, Hpgd, Hopx, Ogn, Id4, Hoxa5, Smad6, Smad7, Zbtb16, Cyr61, Dusp4, and Ifi16. In addition, several genes important in lung development were also differentially expressed, such as Smad6, Hopx, Sox4, Sox9 and Mycn. Conclusion: In this study, we have demonstrated that several cancer genes and signaling pathways relevant for human NSCLC were similarly altered in spontaneous murine lung tumors. Six spontaneous lung tumors and six normal lungs (as controls) from 2-year-old B6C3F1 mice....

  12. Gene expression profiling of normal lung tissue adjacent to lung adenocarcinoma (ADCA) OmicsDI

    ID: E-GEOD-31267

    Date Released: 06-02-2014

    Description: es in vitro indicated that four of them (SLC14A1, SMAD6, TMEM100, and TXNIP) inhibited colony formation when over-expressed by transfection in lung cancer cell lines, suggesting their potential tumor-suppressor activity. Our findings indicated that individual variations in the transcriptional profile of normal lung tissue may reflect the lung ADCA patients’ predisposition to a specific clinical stage. The 120 RNA samples from normal lung were combined in 24 small pools, with 12 pools constituted by stage I patients and 12 pools by stage >I patients (5 samples per pool)...

  13. Validation Data For Capture-based whole genome promoter bisulfite-seq for 8 pairs of HCC tumor and non-tumor liver (NTL) samples GigaDB

    ID: doi:10.5524/100120

    Release Date: 02-05-2015

    Description: files, we were able to confirm 7 genes, including SMAD6, IFITM1, LRRC4, CHST4, and TBX15 with promoter hypermethylation; and CCL20 and NQO1 with promoter hypomethylation in HCCs....


Displaying 13 of 13 results for "SMAD6"