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Displaying 20 of 21 results for "SMAD6"
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  1. Epigenetic regulation of Bmp2 and Smad6 in Ras-induced senescence ArrayExpress

    ID: E-GEOD-18125

    Description: ding p16Ink4a and Bmp2, a secreted factor for BMP/SMAD signal. Smad6, specific BMP/SMAD pathway inhibitor, was identified as the only one gene showing de novo H3K27 trimethylation with H3K4me3, resulting in strong repression. Ras-activated cells senesced with SMAD1/5/8 phosphorylation, and they escaped from senescence with decreased SMAD1/5/8 phosphorylation when introducing Smad6 or knocking-down Bmp2. Mouse embryonic fibroblasts were established from 13.5 embryonic day embryos...

  2. Epigenetic regulation of Bmp2 and Smad6 in Ras-induced senescence BioProject

    ID: PRJNA119455

    Keywords: Other

    Access Type: download

  3. Epigenetic regulation of Bmp2 and Smad6 in Ras-induced senescence OmicsDI

    ID: E-GEOD-18125

    Date Released: 05-02-2014

    Description: ding p16Ink4a and Bmp2, a secreted factor for BMP/SMAD signal. Smad6, specific BMP/SMAD pathway inhibitor, was identified as the only one gene showing de novo H3K27 trimethylation with H3K4me3, resulting in strong repression. Ras-activated cells senesced with SMAD1/5/8 phosphorylation, and they escaped from senescence with decreased SMAD1/5/8 phosphorylation when introducing Smad6 or knocking-down Bmp2. Mouse embryonic fibroblasts were established from 13.5 embryonic day embryos...

  4. Biocompatibility and Discovery of the Potential Applications of Magnetite (Fe3O4) Nanoparticles BioProject

    ID: PRJNA116539

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ng including six genes, Id1, Id2, Id3, Caspase-9, Smad6 and SMAD7, important negative regulators of these signaling pathways involved in development and tumorigenesis. Overall design: Total RNA isolated from MNP treated HeLa cells compared to untreated controls....
  5. Transcription profiling by array of spontaneous lung tumors in mice to compare to human non-small cell lung cancer ArrayExpress

    ID: E-GEOD-31013

    Description: Hnf4a, Tcf21, Ptprd, Hpgd, Hopx, Ogn, Id4, Hoxa5, Smad6, Smad7, Zbtb16, Cyr61, Dusp4, and Ifi16. In addition, several genes important in lung development were also differentially expressed, such as Smad6, Hopx, Sox4, Sox9 and Mycn. Conclusion: In this study, we have demonstrated that several cancer genes and signaling pathways relevant for human NSCLC were similarly altered in spontaneous murine lung tumors. Six spontaneous lung tumors and six normal lungs (as controls) from 2-year-old B6C3F1 mice....

  6. Data from: A major gene for bovine ovulation rate Dryad

    DateIssued: 08-07-2015

    Description: his region contains three candidate genes, SMAD3, SMAD6 and IQCH. While candidate gene screening failed to identify the causative polymorphism, three polymorphisms were identified that can be used as a haplotype to track inheritance of the high ovulation rate allele in descendants of the carrier sire....

  7. Gene expression profiling of normal lung tissue adjacent to lung adenocarcinoma (ADCA) ArrayExpress

    ID: E-GEOD-31267

    Description: statistical association with clinical stage, with 6 genes downregulated in high clinical stage patients, including the TMEM100 gene showing the best statistical association. Five of these 6 genes were also downregulated in lung ADCA tissue as compared to normal tissue. Functional studies in vitro indicated that four of them (SLC14A1, SMAD6, TMEM100, and TXNIP) inhibited colony formation when over-expressed by transfection in lung cancer cell lines, suggesting their potential tumor-suppressor activity. Our findings indicated that individual variations in the transcriptional profile of normal lung tissue may reflect the lung ADCA patients’ predisposition to a specific clinical stage. The 120 RNA samples from normal lung were combined in 24 small pools, with 12 pools constituted by stage I patients and 12 pools by stage ...

  8. Global Differential Gene Expression Analysis of Spontaneous Lung Tumors in B6C3F1 Mice: Comparison to Human Non-Small Cell Lung Cancer BioProject

    ID: PRJNA146331

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Hnf4a, Tcf21, Ptprd, Hpgd, Hopx, Ogn, Id4, Hoxa5, Smad6, Smad7, Zbtb16, Cyr61, Dusp4, and Ifi16. In addition, several genes important in lung development were also differentially expressed, such as Smad6, Hopx, Sox4, Sox9 and Mycn. Conclusion: In this study, we have demonstrated that several cancer genes and signaling pathways relevant for human NSCLC were similarly altered in spontaneous murine lung tumors. Overall design: Six spontaneous lung tumors and six normal lungs (as controls) from 2-year-old B6C3F1 mice....
  9. Gene expression profiling of normal lung tissue adjacent to lung adenocarcinoma (ADCA) BioProject

    ID: PRJNA146131

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: statistical association with clinical stage, with 6 genes downregulated in high clinical stage patients, including the TMEM100 gene showing the best statistical association. Five of these 6 genes were also downregulated in lung ADCA tissue as compared to normal tissue. Functional studies in vitro indicated that four of them (SLC14A1, SMAD6, TMEM100, and TXNIP) inhibited colony formation when over-expressed by transfection in lung cancer cell lines, suggesting their potential tumor-suppressor activity. Our findings indicated that individual variations in the transcriptional profile of normal lung tissue may reflect the lung ADCA patients’ predisposition to a specific clinical stage. Overall design: The 120 RNA samples from normal lung were combined in 24 small pools, with 12 pools constituted by stage I patients and 12...
  10. Identification of AUF1 target mRNAs BioProject

    ID: PRJNA271810

    Keywords: Other

    Access Type: download

    dataset.description: of TNFSF11 (known as RANKL), KLF10, HES1, CCNT2, SMAD6, and BCL6. We have mapped some of the instability determinants. HES1 mRNA appeared to have a coding region determinant. Detailed analysis of the RANKL and BCL6 3’UTR revealed for both that full instability required two elements, which are conserved in evolution. In RANKL mRNA both elements are AU-rich and separated by 30 bases, while in BCL6 mRNA one is AU-rich and 60 bases from a non AU-rich element that potentially forms a stem-loop structure. Overall design: We compared mRNAs in RNP-IPs from cell extracts with and without myc-AUF1 p42 induction...
  11. Transcription profiling by array of spontaneous lung tumors in mice to compare to human non-small cell lung cancer OmicsDI

    ID: E-GEOD-31013

    Date Released: 05-01-2015

    Description: Hnf4a, Tcf21, Ptprd, Hpgd, Hopx, Ogn, Id4, Hoxa5, Smad6, Smad7, Zbtb16, Cyr61, Dusp4, and Ifi16. In addition, several genes important in lung development were also differentially expressed, such as Smad6, Hopx, Sox4, Sox9 and Mycn. Conclusion: In this study, we have demonstrated that several cancer genes and signaling pathways relevant for human NSCLC were similarly altered in spontaneous murine lung tumors. Six spontaneous lung tumors and six normal lungs (as controls) from 2-year-old B6C3F1 mice....

  12. Gene expression profile in platelets of mouse regulated by Smad4 gene BioProject

    ID: PRJNA187493

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Mutations of SMAD family member 4 (Smad4) gene caused Hereditary Hemorrhagic Telangiectasia (HHT). It was ...
  13. Gene expression profile in platelets of mouse regulated by Smad4 gene ArrayExpress

    ID: E-GEOD-43814

    Description: Mutations of SMAD family member 4 (Smad4) gene caused Hereditary Hemorrhagic Telangiectasia (HHT). It was ...

  14. Gene expression profile in platelets of mouse regulated by Smad4 gene OmicsDI

    ID: E-GEOD-43814

    Date Released: 06-02-2014

    Description: Mutations of SMAD family member 4 (Smad4) gene caused Hereditary Hemorrhagic Telangiectasia (HHT). It was ...

  15. Transcription profiling of human IMR-90 cells in response to TGF-I?1 OmicsDI

    ID: E-GEOD-17518

    Date Released: 06-10-2011

    Description: Members of the NADPH oxidase (NOX) family of enzymes, which catalyze the reduction of O2 to reactive oxygen species, have increased in number during eukaryotic evolut...

  16. Transcription profiling of human IMR-90 cells in response to TGF-I?1 ArrayExpress

    ID: E-GEOD-17518

    Description: Members of the NADPH oxidase (NOX) family of enzymes, which catalyze the reduction of O2 to reactive oxygen species, have increased in number during eukaryotic evolut...

  17. Gene expression profiling of normal lung tissue adjacent to lung adenocarcinoma (ADCA) OmicsDI

    ID: E-GEOD-31267

    Date Released: 06-02-2014

    Description: statistical association with clinical stage, with 6 genes downregulated in high clinical stage patients, including the TMEM100 gene showing the best statistical association. Five of these 6 genes were also downregulated in lung ADCA tissue as compared to normal tissue. Functional studies in vitro indicated that four of them (SLC14A1, SMAD6, TMEM100, and TXNIP) inhibited colony formation when over-expressed by transfection in lung cancer cell lines, suggesting their potential tumor-suppressor activity. Our findings indicated that individual variations in the transcriptional profile of normal lung tissue may reflect the lung ADCA patients’ predisposition to a specific clinical stage. The 120 RNA samples from normal lung were combined in 24 small pools, with 12 pools constituted by stage I patients and 12 pools by stage ...

  18. Leukemia Inhibitory Factor in C26 Cancer Cachexia ArrayExpress

    ID: E-GEOD-68827

    Description: reporter gene but not reporter genes dependent on SMAD, FOXO, C/EBP, NF-ĸB, or AP-1. Of the gp130 family members IL-11, IL-6, oncostatin M (OSM), and leukemia inhibitory factor (LIF), only OSM and LIF were sufficient to activate the STAT reporter in myotubes. A LIF blocking antibody abolished C26 CM-induced STAT reporter activation STAT3 phosphorylation and myotube atrophy, but blocking antibodies to IL-6 or OSM did not. JAK2 inhibitors also blocked the C26 CM-induced STAT reporter activat...

  19. mRNA expression profile in IMR-90 cells in response to TGF-β1 BioProject

    ID: PRJNA118793

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Members of the NADPH oxidase (NOX) family of enzymes, which catalyze the reduction of O2 to reactive oxygen species, have increased in number during eukaryotic evolut...
  20. Leukemia Inhibitory Factor in C26 Cancer Cachexia BioProject

    ID: PRJNA283877

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: reporter gene but not reporter genes dependent on SMAD, FOXO, C/EBP, NF-ĸB, or AP-1. Of the gp130 family members IL-11, IL-6, oncostatin M (OSM), and leukemia inhibitory factor (LIF), only OSM and LIF were sufficient to activate the STAT reporter in myotubes. A LIF blocking antibody abolished C26 CM-induced STAT reporter activation STAT3 phosphorylation and myotube atrophy, but blocking antibodies to IL-6 or OSM did not. JAK2 inhibitors also blocked the C26 CM-induced STAT reporter activat...

Displaying 20 of 21 results for "SMAD6"