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Displaying 20 of 86 results for "SLIT1"
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  1. RNA_Seq_of_zebrafish_slit3_mutants BioProject

    ID: PRJEB17675

    Keywords: Other

    Access Type: download

    dataset.description: rozygous and wildtype sibling larvae of zebrafish slit3 mutants. The RNA was DNase treated. Stranded RNAseq libraries were constructed using the Illumina TruSeq Stranded RNA protocol with oligo dT pulldown....
  2. SLIT3-ROBO4 Activation Promotes Vascular Network Formation in Human Engineered Tissue and Angiogenesis in Vivo ArrayExpress

    ID: E-GEOD-48302

    Description: SCs) to generate stable, functional blood vessels.1-5 While there is evidence that the angiogenic effect of MSCs is mediated via the secretion of paracrine signals,6,7 the identity of these signals is unknown. Here, by utilizing two functionally distinct human MSC clones, we found that so-called “pericytic” MSCs secrete the pro-angiogenic neurovascular guidance molecule SLIT3,8 which guides vascular development by directing ROBO4-positive endothelia...

  3. DNMT3B targets in RKO cells by ChIP-on-chip BioProject

    ID: PRJNA121037

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ty of the target genes including P16, DCC, DISC1, SLIT1, CAVEOLIN1, TBX5, TBX18, HOXB13 and some histone variants, that harbor CGI in their promoters, were methylated in multiple colon cancer cell lines but not in normal colon epithelial cells. Further, these genes were reactivated in RKO cells after treatment with 5-aza-2’-deoxycytidine, a DNA hypomethylating agent. COBRA and bisulfite gen...
  4. SLIT3-ROBO4 Activation Promotes Vascular Network Formation in Human Engineered Tissue and Angiogenesis in Vivo BioProject

    ID: PRJNA209636

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. DNMT3B targets in RKO cells by ChIP-on-chip ArrayExpress

    ID: E-GEOD-18929

    Description: ty of the target genes including P16, DCC, DISC1, SLIT1, CAVEOLIN1, TBX5, TBX18, HOXB13 and some histone variants, that harbor CGI in their promoters, were methylated in multiple colon cancer cell lines but not in normal colon epithelial cells. Further, these genes were reactivated in RKO cells after treatment with 5-aza-2’-deoxycytidine, a DNA hypomethylating agent. COBRA and bisulfite gen...

  6. Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure [miRNA-seq] ArrayExpress

    ID: E-GEOD-75600

    Description: ternative promoters embedded within the Slit2 and Slit3 genes by performing RNA sequencing of FACS-isolated motoneurons and a dissected embryonic floor plate cells which served as a control. Next, we performed RNA sequencing of FACS-isolated wild type (WT) motoneurons and motoneurons lacking miR-218 expression (218DKO motoneurons), and find that a large set of genes (named 'TARGET218' genes) with predicted miR-218 binding sites are de-repressed in the absence of miR-218 expression. Finally, we examine the expression of TARGET218 genes in other neuronal subpopulations by FACS-isolating V1, V2a, and V3 interneurons expressing Cre-i...

  7. Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure [RNA-seq] ArrayExpress

    ID: E-GEOD-75599

    Description: ternative promoters embedded within the Slit2 and Slit3 genes by performing RNA sequencing of FACS-isolated motoneurons and a dissected embryonic floor plate cells which served as a control. Next, we performed RNA sequencing of FACS-isolated wild type (WT) motoneurons and motoneurons lacking miR-218 expression (218DKO motoneurons), and find that a large set of genes (named 'TARGET218' genes) with predicted miR-218 binding sites are de-repressed in the absence of miR-218 expression. Finally, we examine the expression of TARGET218 genes in other neuronal subpopulations by FACS-isolating V1, V2a, and V3 interneurons expressing Cre-i...

  8. Data from: Genome-Wide Analyses Suggest Mechanisms Involving Early B-Cell Development in Canine IgA Deficiency Dryad

    DateIssued: 08-24-2015

    Description: as positioned within the first intron of the gene SLIT1. Both KIRREL3 and SLIT1 are highly expressed in the central nervous system and in bone marrow and are potentially important during B-cell development. SERPINA9 expression is restricted to B-cells and peaks at the time-point when B-cells proliferate into antibody-producing plasma cells. The suggestively associated regions were enriched for genes in Gene Ontology gene sets involving inflammation and early immune cell development....

  9. ICGC Pancreas: Genomewide DNA methylation patterns in pancreatic ductal adenocarcinoma (gene expression of 103 samples) ArrayExpress

    ID: E-GEOD-50827

    Description: on analyses of axon guidance pathway genes SLIT2, SLIT3, ROBO1, ROBO3, SRGAP1, and MET suggested epigenetic suppression of SLIT-ROBO signaling and up-regulation of MET expression. Hypo-methylation of MET and ITGA2 correlated with high gene expression, which correlated with poor survival of PDAC patients. These data suggest that aberrant methylation plays an important role in pancreatic carcinogenesis affecting known core signaling pathways with important implications for disease pathophysiology and therapy. This dataset includes gene expression data from 103 primary tumour samples. 86 samples from this dataset have already been deposited into GEO (GSE36924), and has been duplicated here since the data has been processed differently. This data is also available through the International Cancer Genome Consortium (ICGC) Data Portal (), under the project code: Pancreatic Cancer (QCMG, AU). Access to the restricted clinical data must be made through the ICGC Data Access Compliance Office (). This dataset contains gene expression array data from 103 primary pancreatic ductal adenocarcinoma samples. All samples have 1 biological replicate. These data have corresponding methylation 450K array data (GSE49149)....

  10. DNMT3B targets in RKO cells by ChIP-on-chip OmicsDI

    ID: E-GEOD-18929

    Date Released: 06-10-2011

    Description: ty of the target genes including P16, DCC, DISC1, SLIT1, CAVEOLIN1, TBX5, TBX18, HOXB13 and some histone variants, that harbor CGI in their promoters, were methylated in multiple colon cancer cell lines but not in normal colon epithelial cells. Further, these genes were reactivated in RKO cells after treatment with 5-aza-2’-deoxycytidine, a DNA hypomethylating agent. COBRA and bisulfite gen...

  11. Complex between the second LRR domain of Slit2 and The first Ig domain from Robo1 PDB

    ID: PDB:2V9T

    Description: ROUNDABOUT HOMOLOG 1, SLIT HOMOLOG 2 PROTEIN N-PRODUCT

  12. GREM1_RAT UniProt:Swiss-Prot

    ID: O35793

    Description: Gremlin-1 CTCK N-linked (GlcNAc...) N-linked (GlcNAc...) No interaction with SLIT1

  13. Second LRR domain of human Slit2 PDB

    ID: PDB:2V9S

    Description: SLIT HOMOLOG 2 PROTEIN N-PRODUCT

  14. Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure [RNA-seq] BioProject

    ID: PRJNA304986

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ternative promoters embedded within the Slit2 and Slit3 genes by performing RNA sequencing of FACS-isolated motoneurons and a dissected embryonic floor plate cells which served as a control. Next, we performed RNA sequencing of FACS-isolated wild type (WT) motoneurons and motoneurons lacking miR-218 expression (218DKO motoneurons), and find that a large set of genes (named 'TARGET218' genes) with predicted miR-218 binding sites are de-repressed in the absence of miR-218 expression. Finally, we examine the expression of TARGET218 genes in other neuronal subpopulations by FACS-isolating V1, V2a, and V3 interneurons expressing Cre-i...
  15. SLIT3-ROBO4 Activation Promotes Vascular Network Formation in Human Engineered Tissue and Angiogenesis in Vivo OmicsDI

    ID: E-GEOD-48302

    Date Released: 06-03-2014

    Description: SCs) to generate stable, functional blood vessels.1-5 While there is evidence that the angiogenic effect of MSCs is mediated via the secretion of paracrine signals,6,7 the identity of these signals is unknown. Here, by utilizing two functionally distinct human MSC clones, we found that so-called “pericytic” MSCs secrete the pro-angiogenic neurovascular guidance molecule SLIT3,8 which guides vascular development by directing ROBO4-positive endothelia...

  16. Loss of motoneuron-specific microRNA-218 causes systemic neuromuscular failure [miRNA-seq] BioProject

    ID: PRJNA304985

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ternative promoters embedded within the Slit2 and Slit3 genes by performing RNA sequencing of FACS-isolated motoneurons and a dissected embryonic floor plate cells which served as a control. Next, we performed RNA sequencing of FACS-isolated wild type (WT) motoneurons and motoneurons lacking miR-218 expression (218DKO motoneurons), and find that a large set of genes (named 'TARGET218' genes) with predicted miR-218 binding sites are de-repressed in the absence of miR-218 expression. Finally, we examine the expression of TARGET218 genes in other neuronal subpopulations by FACS-isolating V1, V2a, and V3 interneurons expressing Cre-i...
  17. THE HUMAN SLIT 2 DIMERIZATION DOMAIN D4 PDB

    ID: PDB:2WFH

    Description: SLIT HOMOLOG 2 PROTEIN C-PRODUCT

  18. SRG2B_HUMAN UniProt:Swiss-Prot

    ID: P0DMP2

    Description: SLIT-ROBO Rho GTPase-activating protein 2B F-BAR

  19. SLIK1_PONAB UniProt:Swiss-Prot

    ID: Q5RAC4

    Description: SLIT and NTRK-like protein 1 Extracellular Helical Cytoplasmic LRRNT 1 LRR 1

  20. SRGP2_RAT UniProt:Swiss-Prot

    ID: D4A208

    Description: SLIT-ROBO Rho GTPase-activating protein 2 F-BAR Rho-GAP SH3 Phosphoserine Phosphoserine Phosphoserine Phosphoserine Phosphoserine P...


Displaying 20 of 86 results for "SLIT1"