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Displaying 11 of 11 results for "SHANK1"
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  1. Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization PDB

    ID: PDB:1Q3P

    Description: Shank1/C-terminal hexapeptide from Guanylate kinase-associated protein

  2. Structural flexibility of Shank PDZ domain is important for its binding to different ligands PDB

    ID: PDB:3QJM

    Description: SH3 and multiple ankyrin repeat domains protein 1, Beta-PIX

    gene.name: Shank1
  3. Structural flexibility of Shank PDZ domain is important for its binding to different ligands PDB

    ID: PDB:3QJN

    Description: SH3 and multiple ankyrin repeat domains protein 1, Beta-PIX

    gene.name: Shank1
  4. SHRPN_BOVIN UniProt:Swiss-Prot

    ID: E1BDF2

    Description: Sharpin Ubiquitin-like RanBP2-type Self-association Interaction with SHANK1 Phosphoserine Phosphoserine

  5. SHRPN_RAT UniProt:Swiss-Prot

    ID: Q9EQL9

    Description: Sharpin Ubiquitin-like RanBP2-type Self-association Interaction with SHANK1 Phosphoserine

  6. On the Relationships in Rhesus Macaques between Chronic Ethanol Consumption and the Brain Transcriptome (Central Nucleus of the Amigdala - CeA) BioProject

    ID: PRJNA328925

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: t. Genes in the latter category included Ctnna2, Shank1, Vamp2, and Syn1. Gene-level expression data were clustered using the Weighted Gene Coexpression Network Analysis (WGCNA) algorithm to identify hub nodes affected by excessive consumption. Key hubs included Nf1, Nkain2, Tmem108 and Penk. The data were also analyzed for alternative exon usage (Iancu et al., 2015). Additional translation and membrane related genes affected by excessive consumption were detected. These included Grm2, Dpysl2 and Kcnc4. Overall, the data illustrate that the effects of excessive ethanol consumption are broad, consistent with the observation that ethanol affects the expression of numerous hub genes. Overall design: 28 samples of Rhesus Macaques that were experimentally naïve at the onset of alc...
  7. SHAN1_MOUSE UniProt:Swiss-Prot

    ID: D3YZU1

    Description: SH3 and multiple ankyrin repeat domains protein 1 ANK 1 ANK 2 ANK 3 ANK 4 ANK 5 ANK 6 SH3 PDZ SAM Pro-rich His-rich Gly-rich Pro-rich Phosphotyrosine ...

    gene.name: Shank1
  8. Crystal Structure of betaPIX Coiled-Coil Domain and Shank PDZ Complex PDB

    ID: PDB:3L4F

    Description: Rho guanine nucleotide exchange factor 7, SH3 and multiple ankyrin repeat domains protein 1

    gene.name: Shank1
  9. Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization PDB

    ID: PDB:1Q3O

    Description: Shank1

  10. Transcriptomic analysis of human iPS cells derived from fragile X syndrome patients during neural differentiation BioProject

    ID: PRJNA307570

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: K9, and KCNT1) and altered temporal regulation of SHANK1 and NNAT in FXS-iPSC derived neurons, indicating impaired neuronal differentiation and function in FXS patients. Furthermore, we found the cholesterol synthesis genes (e.g., SQLE, LSS, and FASN) are up-regulated during the in-vitro neuronal differentiation of FXS-iPSC, which may contribute to the obesity phenotype of FXS patients. In conclusion, we demonstrated that the FMRP deficiency in FXS patients has significant impact on the gene expression patterns during development, and also discovered many potential candidate genes for the cure of FXS symptoms such as neuronal abnormalities and obesity. Overall design: Eight samples at four different time including iPSC, iPSC aggregates, neuroepithelia aggregates, neuron....
  11. De novo genic mutations among a Chinese autism spectrum disorder cohort NIMH

    ID: doi:10.15154/1252218

    Release Date: 01-30-2017

    attributes.description: in ASD (ARHGAP32, NCOR1, PHIP, STXBP1, CDKL5 and SHANK1). Patient follow-up confirms phenotypic features associated with the genetic subtypes and highlights how large global cohorts might be leveraged to identify individually rare mutations in genes that together prove pathogenic significance....

Displaying 11 of 11 results for "SHANK1"