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Displaying 20 of 79 results for "SH2B3"
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  1. Compare proB cells from WT, Tp53-/-, Lnk-/-, Tp53-/-Lnk-/- mice and Tp53-/-Lnk-/-B-ALL ArrayExpress

    ID: E-GEOD-76940

    Description: The adaptor protein LNK (SH2B3) has emerged as an important protein

  2. Expression data from Sh2b3 Knock-out NOTCH1-induced leukemias BioProject

    ID: PRJNA188332

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Compare proB cells from WT, Tp53-/-, Lnk-/-, Tp53-/-Lnk-/- mice and Tp53-/-Lnk-/-B-ALL BioProject

    ID: PRJNA309083

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Differential expression between Sh2b3 knockout and wild type mice BioProject

    ID: PRJNA273746

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. Differential expression between Sh2b3 knockout and wild type mice ArrayExpress

    ID: E-GEOD-65348

    Description: To validate the predicted Sh2b3 derived gene regulatory subnetwork using integrative network approach in human population study, we examined the gene expres...

  6. Expression data from Sh2b3 Knock-out NOTCH1-induced leukemias ArrayExpress

    ID: E-GEOD-44025

    Description: formally address the tumor suppressor activity of Sh2b3 in vivo, we tested the interaction between oncogenic NOTCH1 and Sh2b3 loss in a retroviral- transduction bone...

  7. Compare proB cells from WT, Tp53-/-, Lnk-/-, Tp53-/-Lnk-/- mice and Tp53-/-Lnk-/-B-ALL OmicsDI

    ID: E-GEOD-76940

    Date Released: 04-11-2016

    Description: The adaptor protein LNK (SH2B3) has emerged as an important protein

  8. Differential expression between Sh2b3 knockout and wild type mice OmicsDI

    ID: E-GEOD-65348

    Date Released: 06-20-2015

    Description: To validate the predicted Sh2b3 derived gene regulatory subnetwork using integrative network approach in human population study, we examined the gene expres...

  9. Expression data from Sh2b3 Knock-out NOTCH1-induced leukemias OmicsDI

    ID: E-GEOD-44025

    Date Released: 06-02-2014

    Description: formally address the tumor suppressor activity of Sh2b3 in vivo, we tested the interaction between oncogenic NOTCH1 and Sh2b3 loss in a retroviral- transduction bone...

  10. Using human genetic variation to improve red blood cell production from stem cells BioProject

    ID: PRJNA279278

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: genetic variation of blood counts to focus on the SH2B3 gene. By producing loss of function of SH2B3 using targeted knockdown and genome editing approaches in human hematopoietic stem and progenitor cells, as well as human pluripotent stem cells, we are able to significantly improve both the quality and yield of in vitro derived RBCs. We illustrate how insight from human genetic variation can assist in the development of broadly applicable approaches that have tremendous value for regenerative medicine. Overall design: CD34+ cells from G-CSF mobilized peripheral blood was purified by positive magnetic selection using an Ultrapure Microbead Kit (Miltenyi Biotech) according to the manufacturer's protocol following mononuclear cell purification ...
  11. Young and old HSCs from WT and Lnk-/- mice BioProject

    ID: PRJNA171115

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. Young and old HSCs from WT and Lnk-/- mice OmicsDI

    ID: E-GEOD-39553

    Date Released: 10-18-2012

    Description: The adaptor protein Lnk is an important negative regulator of HSC homeostasis and self-renewal. T...

  13. Young and old HSCs from WT and Lnk-/- mice ArrayExpress

    ID: E-GEOD-39553

    Description: The adaptor protein Lnk is an important negative regulator of HSC homeostasis and self-renewal. T...

  14. Transcription profiling by array of Drosophila with Lnk deletion compared to wild type genotype OmicsDI

    ID: E-MTAB-4612

    Date Released: 03-31-2016

    Description: Drosophila Lnk is the single ancestral orthologue of a highly conserved family of structurally-related intracellular adaptor

  15. 5686318 RGD

    Description: ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous ...

    Creators: PhysGen Knockouts

    biologicalEntity.identifiers: SS-Sh2b3em1Mcwi-/-
  16. 5686322 RGD

    Description: ZFN mutant founders were backcrossed with SS/JrHsdMcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous ...

    Creators: PhysGen Knockouts

    biologicalEntity.identifiers: SS-Sh2b3em1Mcwi-/+
  17. Transcription profiling by array of Drosophila with Lnk deletion compared to wild type genotype ArrayExpress

    ID: E-MTAB-4612

    Description: Drosophila Lnk is the single ancestral orthologue of a highly conserved family of structurally-related intracellular adaptor

  18. Long non-coding RNAs and microRNAs involved in integrated co-regulation of neuronal maturation [microRNA expression] ArrayExpress

    ID: E-GEOD-44832

    Description: with Axin2, Cntn1, Ncam1, Negr1, Ntrk2, Nrxn1 and Sh2b3 displayed an inverse expression profile to their mRNA whereas long non-coding RNA -mRNA pairs for Kit, Prkcb and Ralgds displayed similar expression profiles. These genes were also predicted targets of the altered miRNAs, miR-124, -128, -129-5p, -203, -218, -290-5p, -326, -329, -377 and -495. These microRNAs particularly regulate the cell adhesion molecules, Cntn1, Ncam1, Negr1 and Nrxn1 that determine axonogenesis and dendritogenesis, supporting the observed co-regulation of these biological processes by non-coding RNAs. Verification of expression of these long non-coding RNA-mRNA pairs in an in vitro model of ischemic-reperfusion injury showed an inverse expression profile, thus confirming their role(s) in maintenance of the neuronal structure and function. This neuronal transcriptome (mRNAs, lncRNAs, miRNAs) is in turn orchestrated by C/EBPα/β transcription factors and CTCF, thereby governing intricate control of neuronal development. microRNA expression profiling of ...

  19. MU2 ADAPTIN SUBUNIT (AP50) OF AP2 ADAPTOR (SECOND DOMAIN), COMPLEXED WITH CTLA-4 INTERNALIZATION PEPTIDE TTGVYVKMPPT PDB

    ID: PDB:1H6E

    Description: CLATHRIN COAT ASSEMBLY PROTEIN AP50, CYTOTOXIC T-LYMPHOCYTE PROTEIN 4

  20. Long non-coding RNAs and microRNAs involved in integrated co-regulation of neuronal maturation [mRNA and lncRNA expression] ArrayExpress

    ID: E-GEOD-44833

    Description: with Axin2, Cntn1, Ncam1, Negr1, Ntrk2, Nrxn1 and Sh2b3 displayed an inverse expression profile to their mRNA whereas long non-coding RNA -mRNA pairs for Kit, Prkcb and Ralgds displayed similar expression profiles. These genes were also predicted targets of the altered miRNAs, miR-124, -128, -129-5p, -203, -218, -290-5p, -326, -329, -377 and -495. These microRNAs particularly regulate the cell adhesion molecules, Cntn1, Ncam1, Negr1 and Nrxn1 that determine axonogenesis and dendritogenesis, supporting the observed co-regulation of these biological processes by non-coding RNAs. Verification of expression of these long non-coding RNA-mRNA pairs in an in vitro model of ischemic-reperfusion injury showed an inverse expression profile, thus confirming their role(s) in maintenance of the neuronal structure and function. This neuronal transcriptome (mRNAs, lncRNAs, miRNAs) is in turn orchestrated by C/EBPα/β transcription factors and CTCF, thereby governing intricate control of neuronal development. mRNA and long non-coding RNA expr...


Displaying 20 of 79 results for "SH2B3"