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Displaying 20 of 45 results for "RUVBL1"
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  1. 3D STRUCTURE OF THE HUMAN RUVB-LIKE HELICASE RUVBL1 PDB

    ID: PDB:2C9O

    Description: RUVB-LIKE 1 (E.C.3.6.1.-)

  2. mRNA profiling of Pontin depleted ES cells and Oct4 depleted ES cells BioProject

    ID: PRJEB4779

    Keywords: Transcriptome or Gene expression

    Access Type: download

  3. Genome-wide analysis of gene expression perturbed by Pontin shRNA in MCF7 subjected to normoxic and hypoxic conditions BioProject

    ID: PRJNA137927

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. The dodecameric human RuvBL1:RuvBL2 complex with truncated domains II PDB

    ID: PDB:2XSZ

    Description: RUVB-LIKE 1 (E.C.3.6.4.12), RUVB-LIKE 2 (E.C.3.6.4.12)

  5. Genome-wide analysis of gene expression perturbed by Pontin shRNA in MCF7 subjected to normoxic and hypoxic conditions ArrayExpress

    ID: E-GEOD-27813

    Description: In order to investigate the role of Pontin methylation on the expression of hypoxia responsive genes across the whole genome, we performed a microarray analysis from R...

  6. RNA-seq of coding RNA from mouse ES cells with inducible knockout of Pontin, inducible knockout of Oct4, and wild-type controls ArrayExpress

    ID: E-MTAB-1953

    Description: In order to investigate the cooperative roles of Pontin and Oct4 for self-renewal and pluripotency in mouse ES cells, we performed mRNA-sequencing analysis from mRNAs isolated from...

  7. Dodecameric human RuvBL1-RuvBL2 complex (compact conformation) PDBe:EMDB

    Types: Image stored as Reals

    Person: Lopez-Perrote A, Munoz-Hernandez H, Gil D, Llorca O

    Release Date: 09-19-2012

  8. Dodecameric human RuvBL1-RuvBL2 complex (stretched conformation) PDBe:EMDB

    Types: Image stored as Reals

    Person: Lopez-Perrote A, Munoz-Hernandez H, Gil D, Llorca O

    Release Date: 09-19-2012

  9. Pontin functions as an essential coactivator for Oct4 target genes and lincRNAs in embryonic stem cells ArrayExpress

    ID: E-GEOD-58206

    Description: cell identity remain unknown. Here, we find that Pontin chromatin remodeling factor plays an essential role as a coactivator for Oct4 target genes and large intergenic noncoding RNAs (lincRNAs) in ES cells. mRNA- and ChIP-sequencing analyses reveal that Pontin and Oct4 share a substantial set of target genes involved in maintenance of ES cells. Intriguingly, Oct4-dependent coactivator function of Pontin extends to transcription of lincRNAs that are mainly involved in repression of differentiation in ES cells. Together, our findi...

  10. Gene expression profile of micropapillary bladder cancer BioProject

    ID: PRJNA341710

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: of miR-296 and activation of chromatin-remodeling complex RUVBL1. Micropapillary tumors evolve through luminal pathway. Overall design: Total RNA samples obtained from 43 micropapillary bladder tumors and 89 conventional urothelial carcinomas were arrayed...
  11. Data from: Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression Dryad

    DateIssued: 12-11-2015

    Description: Slowly accumulating E2f1 progressively recruits a Pontin/Reptin complex to open the chromatin conformation at E2f target genes and amplifies the E2f transcriptional response. This mechanism enhances the E2f-mediated transactivation of cell cycle genes and initiates the activation of low binding affinity E2f target genes that regulate non-cell cycle functions, such as the Warburg effect. These data indicate that both the physiological and the oncogenic activities of E2f result in distinct transcriptional responses, which could be exploited to target E2f oncogenic activity for therapy....

  12. Expression data from mutant p53 breast cancer cell line SK-BR-3 BioProject

    ID: PRJNA251358

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: in of function. A mutant p53 interacting protein Pontin binds to mutant p53 and promotes its gain of function. This experiment tests whether the interaction of Pontin with mutant p53 regulates the transcriptional activity of mutant p53. We used a breast cancer cell line containing endogenous mutant p53 (SK-BR-3) with or without knockdown of mutant p53 by shRNA to identify genes regulate...
  13. Pontin functions as an essential coactivator for Oct4 target genes and lincRNAs in embryonic stem cells. BioProject

    ID: PRJNA251568

    Keywords: Other

    Access Type: download

  14. Examination of gene expression in wild type and USP49 knockdown cells [RNA-Seq] ArrayExpress

    ID: E-GEOD-38100

    Description: l splicing of a large set of exons. USP49 forms a complex with RVB1 and SUG1, and specifically deubiquitinates histone H2B in vitro and in vivo. USP49 knockdown results in small changes in gene expression, but affects the abundance of over 9,000 isoforms. Exons down-regulated in USP49 knockdown cells show both elevated levels of alternative splicing and a general decrease in splicing efficiency. Importantly, USP49 is relatively enriched at this set of exons. USP49 knockdown increased uH2B levels at these exons as well as upstream 3’ and downstream 5’ intronic splicing elements. Change in H2B ubiquitination level, as modulated by...

  15. RUVB1_XENLA UniProt:Swiss-Prot

    ID: Q9DE26

    Description: RuvB-like 1 ATP

  16. Examination of histone H2B ubiquitination in wild type and USP49 knockdown cells [ChIP-Seq] ArrayExpress

    ID: E-GEOD-38099

    Description: l splicing of a large set of exons. USP49 forms a complex with RVB1 and SUG1, and specifically deubiquitinates histone H2B in vitro and in vivo. USP49 knockdown results in small changes in gene expression, but affects the abundance of over 9,000 isoforms. Exons down-regulated in USP49 knockdown cells show both elevated levels of alternative splicing and a general decrease in splicing efficiency. Importantly, USP49 is relatively enriched at this set of exons. USP49 knockdown increased uH2B levels at these exons as well as upstream 3’ and downstream 5’ intronic splicing elements. Change in H2B ubiquitination level, as modulated by...

  17. Double-heterohexameric rings of full-length Rvb1(ADP)Rvb2(apo) PDB

    ID: PDB:5FM6

    Description: RVB1, RVB2

  18. Pontin functions as an essential coactivator for Oct4 target genes and lincRNAs in embryonic stem cells. OmicsDI

    ID: E-GEOD-58206

    Date Released: 08-19-2015

    Description: cell identity remain unknown. Here, we find that Pontin chromatin remodeling factor plays an essential role as a coactivator for Oct4 target genes and large intergenic noncoding RNAs (lincRNAs) in ES cells. mRNA- and ChIP-sequencing analyses reveal that Pontin and Oct4 share a substantial set of target genes involved in maintenance of ES cells. Intriguingly, Oct4-dependent coactivator function of Pontin extends to transcription of lincRNAs that are mainly involved in repression of differentiation in ES cells. Together, our findi...

  19. Architecture of the yeast pontin-reptin complex PDBe:EMDB

    Types: Image stored as Reals

    Person: Torreira E, Jha S, Lopez-Blanco JR, Arias-Palomo E, Chacon P, Canas C, Ayora S, Dutta A, Llorca O

    Release Date: 09-03-2010

  20. Double-heterohexameric rings of full-length Rvb1(ADP)Rvb2(ADP) PDB

    ID: PDB:5FM7

    Description: RVB1, RVB2


Displaying 20 of 45 results for "RUVBL1"