RPS6KA5 | bioCADDIE Data Discovery Index
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Displaying 20 of 245 results for "RPS6KA5"
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  1. Crystal structure of the C-terminal kinase domain of MSK1 PDB

    ID: PDB:3KN6

    Description: Ribosomal protein S6 kinase alpha-5 (E.C.2.7.11.1)

  2. THE STRUCTURE OF THE N-TERMINAL KINASE DOMAIN OF MSK1 REVEALS A NOVEL AUTOINHIBITORY CONFORMATION FOR A DUAL KINASE PROTEIN PDB

    ID: PDB:1VZO

    Description: RIBOSOMAL PROTEIN S6 KINASE ALPHA 5 (E.C.2.7.1.37)

  3. Comparison of gene expression changes following knockdown of KMT2A and MSK1 in mouse embryonic fibroblasts BioProject

    ID: PRJNA350585

    Keywords: Transcriptome or Gene expression

    Access Type: download

  4. Transcriptional response to stress in serum deprived mouse fibroblasts in the presence of MSK1/2 inhibitor ArrayExpress

    ID: E-GEOD-58746

    Description: anisomycin for 3 or 6 hours to induce the p38/MAP kinase pathway. In order determine transcriptional effects dependent on MSK1/2 kinase activity, H89 inhibitor was used in the study. Serum starved (72 h 0.2% FCS) mouse 3T3 cells were treated with anisomycin (188.5 nM) for 3 h or 6h (in duplicates) either with or without 15-min pre-tr...

  5. Transcriptional response to stress in serum deprived mouse fibroblasts in the presence of MSK1/2 inhibitor. BioProject

    ID: PRJNA253332

    Keywords: Transcriptome or Gene expression

    Access Type: download

  6. Crystal structure of the C-terminal kinase domain of msk1 in complex with AMP-PNP PDB

    ID: PDB:3KN5

    Description: Ribosomal protein S6 kinase alpha-5 (E.C.2.7.11.1)

  7. H2A2B_HUMAN UniProt:Swiss-Prot

    ID: Q8IUE6

    Description: one H2A type 2-B N-acetylserine Phosphoserine; by RPS6KA5 Citrulline; alternate Symmetric dimethylarginine; by PRMT5; alternate N6-crotonyllysine N5-methylglutamine N6-crotonyllysine N6-crotony...

  8. A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation (RNA-seq) ArrayExpress

    ID: E-GEOD-62659

    Description: r silencing as net outcome. Upon differentiation, MSK1-mediated phosphorylation of KAP1 releases the co-repressors from the scaffold, unleashing transcriptional activation by MyoD/Mef2 and their positive cofactors. Thus, our results reveal KAP1 as a previously unappreciated interpreter of cell signaling, which modulates the ability of MyoD to drive myogenesis. Transcriptome profiling of control and Kap1KD in C2C12 during proliferation or at 48hours differentiation stage...

  9. Calactin - a small molecule induces DNA damage and histione modification in leukemia cells ArrayExpress

    ID: E-GEOD-20928

    Description: the histone modification enzymes Aurora B, SET8, MSK1, PCAF, and Gcn5, which result in H3K9, H3K18, and H3K23 acetylation, H3S10 and H3S28 phosphorylation, and H4K20 methylation. Docking results showed that calactin has a tendency to bind the active site of TOP1. This project includes 6 human leukemia K562 cells, 3 for treated 0.15mM calactin for 12hr and the others for control (untreated) samples....

  10. A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation (ChIP-seq) BioProject

    ID: PRJNA264739

    Keywords: Epigenomics

    Access Type: download

    dataset.description: r silencing as net outcome. Upon differentiation, MSK1-mediated phosphorylation of KAP1 releases the co-repressors from the scaffold, unleashing transcriptional activation by MyoD/Mef2 and their positive cofactors. Thus, our results reveal KAP1 as a previously unappreciated interpreter of cell signaling, which modulates the ability of MyoD to drive myogenesis. Overall design: Kap1 and H3K9me3 ChIPseq in proliferating C2C12 cells...
  11. A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation (ChIP-seq) ArrayExpress

    ID: E-GEOD-62660

    Description: r silencing as net outcome. Upon differentiation, MSK1-mediated phosphorylation of KAP1 releases the co-repressors from the scaffold, unleashing transcriptional activation by MyoD/Mef2 and their positive cofactors. Thus, our results reveal KAP1 as a previously unappreciated interpreter of cell signaling, which modulates the ability of MyoD to drive myogenesis. Kap1 and H3K9me3 ChIPseq in proliferating C2C12 cells...

  12. H2A1A_HUMAN UniProt:Swiss-Prot

    ID: Q96QV6

    Description: one H2A type 1-A N-acetylserine Phosphoserine; by RPS6KA5 Citrulline; alternate Symmetric dimethylarginine; by PRMT5; alternate N6-crotonyllysine N5-methylglutamine N6-crotonyllysine N6-crotony...

  13. H2A1H_HUMAN UniProt:Swiss-Prot

    ID: Q96KK5

    Description: one H2A type 1-H N-acetylserine Phosphoserine; by RPS6KA5 Citrulline; alternate Symmetric dimethylarginine; by PRMT5; alternate N6-crotonyllysine N5-methylglutamine N6-crotonyllysine N6-crotony...

  14. Specific phosphorylation of histone demethylase KDM3A determines target gene expression in response to heat shock BioProject

    ID: PRJNA263810

    Keywords: Epigenomics

    Access Type: download

    dataset.description: e demonstrated that mitogen- and stress-activated protein kinase 1 (MSK1) specifically phosphorylates KDM3A at Ser264 (pKDM3A), which is enriched in the regulatory regions of gene loci in the human genome under heat shock conditions. p-KDM3A directly interacts with and is recruited by the transcription factor Stat1 to activate KDM3A target genes. The demethylation of H3K9me2 at the Stat1 binding site specifically depends on the co-expression of p-KDM3A under heat shock conditions. In contrast to heat shock treatment, IFN-γ treatment does not phosphorylate KDM3A via MSK1, thereby abrogating its downstream effects. To our knowledge, this is the first evidence that a KDM can be modified via phosphorylation to determine its specific binding to target genes in response to cellular stress. Overall design: 3 ChIP samples and two input as controls...
  15. Specific phosphorylation of histone demethylase KDM3A determines target gene expression in response to heat shock ArrayExpress

    ID: E-GEOD-62309

    Description: e demonstrated that mitogen- and stress-activated protein kinase 1 (MSK1) specifically phosphorylates KDM3A at Ser264 (pKDM3A), which is enriched in the regulatory regions of gene loci in the human genome under heat shock conditions. p-KDM3A directly interacts with and is recruited by the transcription factor Stat1 to activate KDM3A target genes. The demethylation of H3K9me2 at the Stat1 binding site specifically depends on the co-expression of p-KDM3A under heat shock conditions. In contrast to heat shock treatment, IFN-γ treatment does not phosphorylate KDM3A via MSK1, thereby abrogating its downstream effects. To our knowledge, this is the first evidence that a KDM can be modified via phosphorylation to determine its specific binding to target genes in response to cellular stress. 3 ChIP samples and two input as controls...

  16. A KAP1 phosphorylation switch controls MyoD function during skeletal muscle differentiation (RNA-seq) BioProject

    ID: PRJNA264734

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: r silencing as net outcome. Upon differentiation, MSK1-mediated phosphorylation of KAP1 releases the co-repressors from the scaffold, unleashing transcriptional activation by MyoD/Mef2 and their positive cofactors. Thus, our results reveal KAP1 as a previously unappreciated interpreter of cell signaling, which modulates the ability of MyoD to drive myogenesis. Overall design: Transcriptome profiling of control and Kap1KD in C2C12 during proliferation or at 48hours differentiation stage...
  17. ETV1_BOVIN UniProt:Swiss-Prot

    ID: Q2KIC2

    Description: 1 ETS Phosphoserine Phosphoserine; by RPS6KA1 and RPS6KA5 Phosphoserine; by RPS6KA1 and RPS6KA5 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)...

  18. Calactin - a small molecule induces DNA damage and histione modification in leukemia cells BioProject

    ID: PRJNA124367

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: the histone modification enzymes Aurora B, SET8, MSK1, PCAF, and Gcn5, which result in H3K9, H3K18, and H3K23 acetylation, H3S10 and H3S28 phosphorylation, and H4K20 methylation. Docking results showed that calactin has a tendency to bind the active site of TOP1. Overall design: This project includes 6 human leukemia K562 cells, 3 for treated 0.15mM calactin for 12hr and the others for control (untreated) samples....
  19. ETV1_MOUSE UniProt:Swiss-Prot

    ID: P41164

    Description: 1 ETS Phosphoserine Phosphoserine; by RPS6KA1 and RPS6KA5 Phosphoserine; by RPS6KA1 and RPS6KA5 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)...

  20. H32_XENTR UniProt:Swiss-Prot

    ID: Q28D37

    Description: sphoserine; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 Phosphothreonine; by PKC N6-acetyllysine Asymmetric dimethylarginine N6-acetyllysine; alternate N6-methylated lysine; alternate N6-acetyllysine N6-acetyllysine; alternate N6-methylated lysine; alternate Phosphoserine; by AURKB, AURKC and RPS6KA5 N6-acetyllysine; alternate N6-methylated lysine; alternate Phosphotyrosine Phosphoserine N6-methylated lysine N6-methylated lysine Pho...


Displaying 20 of 245 results for "RPS6KA5"