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Displaying 20 of 29 results for "ROBO1"
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  1. Crystal structure of the third fibronectin domain (Fn3) of human ROBO1 in complex with the Fab fragment of murine monoclonal antibody B2212A. PDB

    ID: PDB:3WIH

    Description: Roundabout homolog 1, anti-human ROBO1 antibody B2212A Fab light chain, an...

  2. Crystal structure of the Fab fragment of B2212A, a murine monoclonal antibody specific for the third fibronectin domain (Fn3) of human ROBO1. PDB

    ID: PDB:3WII

    Description: anti-human ROBO1 antibody B2212A Fab light chain, anti-human ROBO1 antibody B2212A Fab heavy chain

  3. Affymetrix SNP array data for myelodysplastic syndromes (MDS) samples BioProject

    ID: PRJNA295958

    Keywords: Variation

    Access Type: download

    dataset.description: ic syndrome (MDS) remains unknown. We report that ROBO1 and ROBO2 are identified as novel progression-related somatic mutations using whole-exome and targeted sequencing in six of 16 (37.5%) paired MDS patients undergoing d...
  4. Affymetrix SNP array data for myelodysplastic syndromes (MDS) samples OmicsDI

    ID: E-GEOD-73005

    Date Released: 09-20-2015

    Description: ic syndrome (MDS) remains unknown. We report that ROBO1 and ROBO2 are identified as novel progression-related somatic mutations using whole-exome and targeted sequencing in six of 16 (37.5%) paired MDS patients undergoing d...

  5. FIRST AND SECOND IG DOMAINS FROM HUMAN ROBO1 (FORM 2) PDB

    ID: PDB:2V9R

    Description: ROUNDABOUT HOMOLOG 1

  6. FIRST AND SECOND IG DOMAINS FROM HUMAN ROBO1 PDB

    ID: PDB:2V9Q

    Description: ROUNDABOUT HOMOLOG 1

  7. Affymetrix SNP array data for myelodysplastic syndromes (MDS) samples ArrayExpress

    ID: E-GEOD-73005

    Description: ic syndrome (MDS) remains unknown. We report that ROBO1 and ROBO2 are identified as novel progression-related somatic mutations using whole-exome and targeted sequencing in six of 16 (37.5%) paired MDS patients undergoing d...

  8. Complex between the second LRR domain of Slit2 and The first Ig domain from Robo1 PDB

    ID: PDB:2V9T

    Description: ROUNDABOUT HOMOLOG 1, SLIT HOMOLOG 2 PROTEIN N-PRODUCT

  9. Axon Guidance Receptor PDB

    ID: PDB:4HLJ

    Description: Roundabout homolog 1

  10. Canine Cutaneous Peripheral Nerve Sheath Tumours versus Fibrosarcomas can be Differentiated by Neuroectodermal Marker Genes in their Transcriptome ArrayExpress

    ID: E-GEOD-34382

    Description: eripheral nerve sheath tumors: FMN2, KIF1B, GLI1, ROBO1, NMUR2, DOK4 and HMG20B. Furthermore, eight genes associated with carcinogenesis were up-regulated in fibrosarcomas: FHL2, PLAGL1, FNBP1L, BAG2, HK1, CSK and Cox5A. Comparison of the fibrosarcoma and PNST transcriptome therefore identified PNST phenotype-associated genes involved in neuroectodermal differentiation which may be potential PNST markers. Furthermore, the identified fibrosarcoma phenotype-associated genes may be potential markers to differentiate fibrosarcomas from other tumor types and may be involved in their pathogenesis. The aim of the present study was to examine the differences in global gene expression of histologically prototypic fibrosarcomas and PNST. To this end, complete transcriptome microarray analyses were used to quantify differences in gene expression activity in both tumor types....

  11. Gene expression classifier in papillary thyroid carcinoma: validation and application of a classifier for prognostication ArrayExpress

    ID: E-GEOD-65074

    Description: , FOSL2, GGT5, GPR124, JAM3, LRIG1, NDRG1, PRRX1, ROBO1, SORL1, TCF4, and ZEB1) was identified based on the expression values of these genes in the groups with and without metastasis in the development cohort. The 17 gene classifier for regional and/or distant metastasis identified was tested against the clinical status in the validation cohort. Sensitivity was 51.6% (95% CI 41.2%-61.8) and specificity 61.6 % (95% CI 50.5%-71.9%). Further, the Kaplan-Meyer method was used to estimate whether the classifier was useful as a prognostic marker for recurrences. Log-rank testing failed to identify any significance (p=0.32). Conclusion: A 17 gene classifier for metastatic potential was developed, and the results showed a clear biological difference between groups. However, through validation, the prognostic significance of this classifier could not be shown in identifying metastatic cases or in the ability of dichotomizing patients according to risk of recurrence after primary treatment. 38 patients with papillary thyroid carcinoma from a consecutive cohort of patients, no replicates...

  12. ROBO1_RAT UniProt:Swiss-Prot

    ID: O55005

    Description: Roundabout homolog 1 Extracellular Helical Cytoplasmic Ig-like C2-type 1 I...

  13. Targeted sequencing of 11 candidate genes for dyslexia : Analysis of targeted exons by selector technology enrichment and SOLID sequencing of DNA from... BioProject

    ID: PRJEB4175

    Keywords: Other

    Access Type: download

    dataset.description: 2A, DYX1C1, GCFC2, KIAA0319, MRPL19, PCNT, PRMT2, ROBO1 and S100B) based on previous literature including association analysis and positional cloning, and sequenced exons as well as surrounding intronic regions in 100 unrelated dyslexic individuals from the Finnish population. Subsequent Sequenom genotyping of each individual from the pools validated 92 SNVs. Multiple SNVs in the CYP19A1 gene encoding aromatase showed significant association with dyslexia in the Finnish sample set. This confirms recently published results and further strengthens the role of aromatase in the biology of reading and spelling. Genoty...
  14. Canine Cutaneous Peripheral Nerve Sheath Tumours versus Fibrosarcomas can be Differentiated by Neuroectodermal Marker Genes in their Transcriptome. BioProject

    ID: PRJNA149591

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: eripheral nerve sheath tumors: FMN2, KIF1B, GLI1, ROBO1, NMUR2, DOK4 and HMG20B. Furthermore, eight genes associated with carcinogenesis were up-regulated in fibrosarcomas: FHL2, PLAGL1, FNBP1L, BAG2, HK1, CSK and Cox5A. Comparison of the fibrosarcoma and PNST transcriptome therefore identified PNST phenotype-associated genes involved in neuroectodermal differentiation which may be potential PNST markers. Furthermore, the identified fibrosarcoma phenotype-associated genes may be potential markers to differentiate fibrosarcomas from other tumor types and may be involved in their pathogenesis. Overall design: The aim of the present study was to examine the differences in global gene expression of histologically prototypic fibrosarcomas and PNST. To this end, complete transcriptome microarray analyses were used to quantify differences in gene expression activity in both tumor types....
  15. ICGC Pancreas: Genomewide DNA methylation patterns in pancreatic ductal adenocarcinoma (gene expression of 103 samples) ArrayExpress

    ID: E-GEOD-50827

    Description: ling, Cell adhesion, Stellate cell activation and Axon guidance. Bisulfite amplicon deep sequencing and qRT-PCR expression analyses of axon guidance pathway genes SLIT2, SLIT3, ROBO1, ROBO3, SRGAP1, and MET suggested epigenetic suppression of SLIT-ROBO signaling and up-regulation of MET expression. Hypo-methylation of MET and ITGA2 correlated with high gene expression, which correlated with poor survival of PDAC patients. These data suggest that aberrant methylation plays an important role in pancreatic carcinogenesis affecting known core signaling pathways with important implications for disease pathophysiology and therapy. This dataset includes gene expression data from 103 primary tumour samples. 86 samples from this dataset have already been deposited into GEO (GSE36924), and has been duplicated here since the data has been processed differently. This data is also available through the International Cancer Genome Consortium (ICGC) Data Portal (), under the project code: Pancreatic Cancer (QCMG, AU). Access to the restricted clinical data must be made through the ICGC Data Access Compliance Office (). This dataset contains gene expression array data from 103 primary pancreatic ductal adenocarcinoma samples. All samples have 1 biological replic...

  16. Solution structure of the fifth ig-like domain from human Roundabout homo1 PDB

    ID: PDB:2EO9

    Description: Roundabout homolog 1

  17. Cyrstal structure of SLIT-ROBO Rho GTPase-activating protein 2 fragment PDB

    ID: PDB:4RTT

    Description: SLIT-ROBO Rho GTPase-activating protein 2

    dataset.keywords: Robo1
  18. Cyrstal structure of SLIT-ROBO Rho GTPase-activating protein 2 fragment PDB

    ID: PDB:4RUG

    Description: SLIT-ROBO Rho GTPase-activating protein 2

    dataset.keywords: Robo1
  19. SAGE Libraries from Highly Purified Mouse Hematopoietic Stem Cells from the E14.5 Fetal Liver and Adult Bone Marrow ArrayExpress

    ID: E-GEOD-13243

    Description: or derived oligos. A suspension of 10,000 lin-Sca-1+CD43+Mac1+ fetal liver (FL) cells (20% pure HSCs as determined by 16-week limiting dilution and single cell transplantation experiments) was obtained from embryonic day 14.5 fetuses. From these cells, we generated a 160,000-tag LongSAGE library containing 7865 tags that map uniquely to the mouse genome (using the RefSeq database through DiscoverySpace; www.bcgsc.ca/DiscoverySpace). A suspension of 3700 CD45midlin-Rho-SP cells (30% pure HSCs) was isolated from adult mouse bone marrow (BM) and then used to generate a 37,000-tag LongSAGE library (956 uniquely mapped tags). Both of these libraries contained tags identifying transcripts that have been previously reported to be associated with HSCs from FL and/or adult BM, including c-kit, pbx-1, tgf-, cul-4a, PrP, c-myc, robo1, sox17, as well as a number of Smarc transcripts, ubiquitin ligase transcripts and TNF-related transcripts. As a first test of the utility of the libraries, we looked for differences in the expression of genes that have been broadly associated with differences in cellular proliferative activity. This comparison identified many such tags in the FL HSC library that were absent from the adult BM HSC library, including multiple cyclins (A2, B2, C, D1...

  20. Systematic analysis of a human renal transcript dataset ArrayExpress

    ID: E-GEOD-21785

    Description: of relevance in glomeruli including among others axon guidance. This finding was further validated by assessing the expression of the axon guidance molecules neuritin (NRN1) and roundabout receptor ROBO1 and -2. Glomerular disease associated differential mRNA regulation of ROBO2 was found in diabetic nephropathy. In summary, using a comparative strategy on microdissected nephrons novel transcripts with predominant expression in the human glomerulus could be identified. A systematic analysis of this glomerulus-specifc gene expression library allows the detection of target molecules and biological processes involved in glomerular biology and renal disease. Sample from kidney biopsies of 6 transplant Living Donors (LD) were microdissected into tubular and glomerular compartment and separately hybridized an Affymetrix HG-U133A microarrays. Background correction and quantile normalization was ferformed using RMAexpress Version 0.3 as part of a dataset of 88 samples for glomeruli and 84 samples for tubuli. All data are reported in log2 scale. A background filter cut-off was defined to lower the count of false positive calls using the highest signal value obtained from non-human Affymet...


Displaying 20 of 29 results for "ROBO1"