RGS9-2-controlled adaptations in the striatum determine the onset of action and eficacy of antidepressants in neuropathic pain states

ID: E-GEOD-71527

Date Released: 08-29-2015

Description: The striatal protein Regulator of G protein signaling-2 (

NM_003835.3(RGS9):c.895T>C (p.Trp299Arg) AND Prolonged electroretinal response suppression

Type: Variation

Species: human

NM_003835.3(RGS9):c.1645C>T (p.Arg549Cys) AND not provided

Type: single nucleotide variant

Species: human

NM_003835.3(RGS9):c.1502G>A (p.Arg501His) AND not specified

Type: single nucleotide variant

Species: human

NM_003835.3(RGS9):c.773C>T (p.Ser258Leu) AND not provided

Type: single nucleotide variant

Species: human

NM_003835.3(RGS9):c.704C>T (p.Ala235Val) AND not provided

Type: Variation

Species: human

NM_003835.3(RGS9):c.313_314delACinsGG (p.Thr105Gly) AND not provided

Type: Indel

Species: human

NM_003835.3(RGS9):c.1658T>C (p.Val553Ala) AND not provided

Type: single nucleotide variant

Species: human

Gene profiling studies in postnatal Mfrprd6 mutant eyes reveal differential expression of Prss56, a trypsin-like serine protease, and genes involved i...

ID: E-GEOD-53411

Date Released: 11-01-2014

Description: he expression of RPE-specific visual transduction protein, RPE65, was significantly decreased in Mfrprd6 mutants. As an indirect consequence of the primary RPE cell defect due to the Mfrprd6 mutation, retinal specific transcripts Rgr, Pde6a, GuCa1b, and Rgs9 were also significantly decreased. We also confirmed the significantly elevated levels of Prss56, a gene previously associated with myopia and open angle glaucoma. In the Mfrprd6 mutant, a progressive increase in Prss56 mRNA levels from 14- to 70-fold was observed from P7 to P21, respectively. In situ hybridization and glutamine synthetase staining of mutant eyes indirectly identified Müller glia in the inner nuclear layer of retina as the cell type expressing the Prss56 transcript. This experiment had one model term, a combination of strain and time, which consisted of four levels (B6_P0, B6_P14, Rd6_P0 and Rd6_P14). Three biological replicates were used per term level. A total of 12 Affymetrix Mouse 430v2 Arrays were used in gene expression analysis....

Identification of Differential Gene Expression During Transition of Bovine Corpus Luteum from Early To Mid–Phase.

ID: E-GEOD-10662

Date Released: 05-02-2014

Description: of PGF2alpha receptors; therefore differences in signaling events might be responsible for LS. Hence differential gene expression at two developmental stages, days 4 (D-4) and 10 (D-10) post estrus, might account for differences in signal transduction pathways associated with LS. This possibility was examined in these studies. Microarray analysis (n=3 per stage) identified 167 genes that were differentially expressed (p<0.05). These were categorized into genes involved in cell signaling, steroidogenesis and metabolism, protein degrad...

Effects of knockdown of ROCK1 and ZIPK on gene expression in cultured human vascular smooth muscle cells

ID: E-GEOD-56819

Date Released: 05-25-2015

Description: o-associated kinase (ROCK) and zipper-interacting protein kinase (ZIPK) have been implicated in diverse physiological functions, including smooth muscle contraction, cell proliferatio...