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Displaying 20 of 47 results for "RD3"
  1. To study glycobiology-related abnormalities in retinal degeneration, an area that is relatively unexplored

    ID: E-GEOD-31990

    Description: Retinal degeneration is the leading cause of irreversible blindness. Retinitis pigmentosa (RP) is a genetically ...

  2. The alarmin IL-33 amplifies an immune response in the degenerating retina

    ID: E-GEOD-74695

    Description: be expressed in the central nervous system and in retinal Muller cells which imply functions, as yet undescribed, beyond Th2 mediated inflammation. Muller cells support the health of the retina and photoreceptors and are also involved in inflammation in retinal degeneration. It is not known how IL-33/ST2 functions in this capacit...

  3. Transcription profiling of prCAD -/- mouse, a mouse model for retinal degeneration

    ID: E-GEOD-10535

    Description: at exhibit changes in abundance in the context of retinal degeneration by comparing transcript levels in adult wild type and prCAD -/- mouse retinas. Experiment Overall Design: Retinas were dissected from ~4 weeks o...

  4. RNA-seq of ocular (eye) tissues from BC027072 knockout mice (a model for early onset retinal degeneration) and wild type controls

    ID: E-GEOD-63810

    Description: pression changes in a mouse model for early onset retinal degeneration which phenocopies a human form of autosomal recessive retinitis pigmentosa Eye mRNA profiles were generated from 3 week-old C57BL/6J and BC027072 -/- in triplicate and sequenced using the Illumina HiSeq 2500...

  5. RNA-Seq of eye tissues from A/J, BALB/c, and C57BL/6 background mice

    ID: E-GEOD-38359

    Description: 7BL/6 background mice. Examine ocular tissue from 3 different background mice that display varying rates of retinal degeneration....

  6. Gene expression changes during retinal development and rod specification

    ID: E-GEOD-59201

    Description: Photoreceptor disorders are collectively known as retinal degeneration (RD), and include retinitis pigmentosa (RP), cone-rod dystrophy and age related macular

  7. Protective gene expression changes elicited by an inherited defect in photoreceptor structure

    ID: E-GEOD-33134

    Description: nces, we have characterized rod photoreceptor and retinal gene expression changes in response to a defined insult to photoreceptor structure, using the retinal degeneration slow (rds) mouse mod...

  8. small RNAseq analysis of the global retinal transcriptome of rod photoreceptor-specific Dicer1 conditional knockout mice and control littermates

    ID: E-GEOD-55376

    Description: and changes in gene regulation that could lead to retinal degeneration in cKO mice. Examine retinal transcriptome of 3 biological replicates for each genotype from 4-week-old animals with tissue collected between 8:00 - 10:00AM...

  9. Gene expression profile of retina and pineal gland of NeuroD1 conditional knockout mice

    ID: E-GEOD-35396

    Description: he common evolutionary origin of pinealocytes and retinal photoreceptors. Pinealocytes and retinal photoreceptors express a shared set of phototransduction genes and submammalian pinealocytes are photosensitive. In contrast to the retina, the pineal gland is a relatively homogeneous structure, composed 95% of pinealocytes. This makes the pineal gland a particularly useful model for understanding photoreceptor cell biology. The loss of NeuroD1 in th...

  10. RNAseq analysis of the global retinal transcriptome of rod photoreceptor-specific Dicer1 conditional knockout mice and control littermates

    ID: E-GEOD-55377

    Description: and changes in gene regulation that could lead to retinal degeneration in cKO mice. Examine retinal transcriptome of 3 biological replicates for each genotype from 4-week-old animals with tissue collected between 8:00 - 10:00AM...

  11. Gene expression profiling of vasoregression in the retina

    ID: E-GEOD-20967

    Description: opathy model which develops primary photoreceptor degeneration and secondary vasoregression. To improve the understanding of secondary vasoregression in retinal neurodegeneration, we used microarray techniques to compare gene expression profiles in this new model before and after retinal vaso...

  12. Differences in the genomic content of Bordetella pertussis strains before and after vaccine introduction in European countries

    ID: E-GEOD-29579

    Description: yzed have lost three major regions of difference (RD3, 5 and 29). However, difference in frequency of the absent RDs 3, 5 or 29 was observed among the four countries. Of the strains with absent RD5, half had also a duplicated region in the genome. All four RDs (RD22, 23, 24 and 26) absent in Tohama I were present in majority of the tested strains. Results obtained from PFGE analysis correlated well with those of CGH. Recently a novel pertussis toxin promoter allele (ptxP3) was described. Strains with ptxP3 have replaced resident ptxP1 strains. When the recent strains (N=22) selected from the four countries were examined, the ptxP3 allele was found in all countries except Poland. Our result indicates that at least three clusters of B. pertussis circulated in Europe in pre-vaccine era and their genomes were distinct from that of the reference strain Tohama I. Although progressive gene loss occurs in B. pertussis population with time, dif...

  13. Age-related para-inflammation in the neuroretina of the mouse

    ID: E-GEOD-17423

    Description: To understand the age-related retinal gene changes, gene transcription profiles of neural retinal tissues from young adult (3

  14. Oxidative stress induces mitochondrial dysfunction and a protective unfolded protein response in RPE cells

    ID: E-GEOD-49107

    Description: How retinal pigmented epithelial (RPE) cells degenerate from oxidative stress in age-related macular degeneration (A...

  15. Changes in Patients With Wet Age-related Macular Degeneration...

    ID: NCT01810042

    Description: Exudative age-related macular degeneration (ARMD) is complicated by choroidal neovascularization (CNV). Although anti-vascular endothelial growth factor tr...

  16. Molecular Response of Chorioretinal Endothelial Cells to Complement Injury: Implications for Macular Degeneration

    ID: E-GEOD-70806

    Description: Age-related macular degeneration (AMD) is a common, blinding disease of the elderly in which macular photoreceptor cells, retinal pi...

  17. Transcription profiling of rat retina after IONT and IONC - time series

    ID: E-GEOD-9918

    Description: retinal ganglion cells die after optic nerve injury, either crush or transection. The molecular causesunderlying this

  18. Gene regulation in the hyperoxia mouse retina

    ID: E-GEOD-23437

    Description: this toxicity may be important in the progress of retinal dystrophies. This microarray study examines gene expression induced in the C57BL/6J mouse retina by hyperoxia over the 14-day period during which photoreceptors first resist,...

  19. on in Subjects With Exudative Age-Related Macular Degeneration...

    ID: NCT01849692

    Description: d as a microvolume injection or infusion on retinal function and morphology in subjects with exudative age-related macular degeneration (AMD)....

  20. Age-related retinal degeneration study in mice

    ID: E-GEOD-18151

    Description: lain the difference in progression of age-related retinal degeneration (ageRD) between the inbred strains C57BL/6J-c2J (B6a) and BALB/cByJ (C). The specific goal was to find the candidate genes that explain the chromosom...


Displaying 20 of 47 results for "RD3"