RBBP5 | bioCADDIE Data Discovery Index
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Displaying 20 of 57 results for "RBBP5"
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  1. Crystal structure of the MLL3-Ash2L-RbBP5 complex PDB

    ID: PDB:5F6K

    Description: one-lysine N-methyltransferase 2C (E.C.2.1.1.43), Retinoblastoma-binding protein 5, peptide ARTKQTARK...

  2. The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L PDB

    ID: PDB:5F6L

    Description: Retinoblastoma-binding protein 5, Set1/Ash2 histone methyltransferase comp...

  3. Crystal structure of Ash2L SPRY domain in complex with RbBP5 PDB

    ID: PDB:4X8P

    Description: Ash2L, Retinoblastoma-binding protein 5

  4. Crystal structure of Ash2L SPRY domain in complex with phosphorylated RbBP5 PDB

    ID: PDB:4X8N

    Description: 2 histone methyltransferase complex subunit ASH2, Retinoblastoma-binding protein 5...

  5. WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE PDB

    ID: PDB:2XL3

    Description: WD REPEAT-CONTAINING PROTEIN 5, RETINOBLASTOMA-BINDING

  6. WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE RECRUITED TO NOVEL SITE PDB

    ID: PDB:2XL2

    Description: WD REPEAT-CONTAINING PROTEIN 5, RETINOBLASTOMA-BINDING

  7. Structural and biochemical insights into MLL1 core complex assembly and regulation. PDB

    ID: PDB:3P4F

    Description: WD repeat-containing protein 5, Retinoblastoma-binding

  8. Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis BioProject

    ID: PRJNA270977

    Keywords: Epigenomics

    Access Type: download

    dataset.description: demonstrated that the inactivation of menin (the protein product of MEN1) results in increased activity of DNA (cytosine-5)-methyltransferase 1 (DNMT1) by retinoblastoma-binding protein 5 (Rbbp5) activation in MEN1 tumor tissues. The increased activity of DNMT1 mediated global DNA hypermethylation, which in turn resulted in aberrant activation of the Wnt/β-catenin signaling pathway through inactivation of Sox regulatory genes. Our study provides impor...
  9. NHGRI Menin ChIP-Chip ArrayExpress

    ID: E-GEOD-5357

    Description: encodes a ubiquitously expressed tumor suppressor protein called menin. Menin was recently shown to interact with several components of a trithorax family histone methyltransferase complex including ASH2, Rbbp5, WDR5, and the leukemia proto-oncoprotein MLL. To elucidate menin's role as a tumor suppressor and gain in...

  10. Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis ArrayExpress

    ID: E-GEOD-64412

    Description: nin results in enhanced activity of DNA (cytosine-5)-methyltransferase 1 (DNMT1) by retinoblastoma-binding protein 5 (Rbbp5) activation in MEN1 tumor tissues. The increased activity of DNMT1 mediated global DNA hypermethylation, which in turn resulted in aberrant activation of the Wnt/β-catenin signaling pathway through inactivation of Sox regulatory genes. Our study provides important insights into the possible regulatory role of menin in DNA methylation and its impact on the pathogenesis of MEN1 tumor development. Global DNA methylation in tissues from patients with MEN1-parathyroid tumors. Thirty-eight human parathyroid specimens were used: 13 sporadic (non-MEN1) parathyroid adenomas, 12 MEN1-parathyroid tumors, 4 par...

  11. NHGRI Menin ChIP-Chip OmicsDI

    ID: E-GEOD-5357

    Date Released: 06-27-2012

    Description: encodes a ubiquitously expressed tumor suppressor protein called menin. Menin was recently shown to interact with several components of a trithorax family histone methyltransferase complex including ASH2, Rbbp5, WDR5, and the leukemia proto-oncoprotein MLL. To elucidate menin's role as a tumor suppressor and gain in...

  12. Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis OmicsDI

    ID: E-GEOD-64412

    Date Released: 12-26-2015

    Description: nin results in enhanced activity of DNA (cytosine-5)-methyltransferase 1 (DNMT1) by retinoblastoma-binding protein 5 (Rbbp5) activation in MEN1 tumor tissues. The increased activity of DNMT1 mediated global DNA hypermethylation, which in turn resulted in aberrant activation of the Wnt/β-catenin signaling pathway through inactivation of Sox regulatory genes. Our study provides important insights into the possible regulatory role of menin in DNA methylation and its impact on the pathogenesis of MEN1 tumor development. Global DNA methylation in tissues from patients with MEN1-parathyroid tumors. Thirty-eight human parathyroid specimens were used: 13 sporadic (non-MEN1) parathyroid adenomas, 12 MEN1-parathyroid tumors, 4 par...

  13. NHGRI Menin ChIP-Chip BioProject

    ID: PRJNA96251

    Keywords: Epigenomics

    Access Type: download

    dataset.description: encodes a ubiquitously expressed tumor suppressor protein called menin. Menin was recently shown to interact with several components of a trithorax family histone methyltransferase complex including ASH2, Rbbp5, WDR5, and the leukemia proto-oncoprotein MLL. To elucidate menin's role as a tumor suppressor and gain in...
  14. Structure of the SPRY domain of human Ash2L PDB

    ID: PDB:3TOJ

    Description: Set1/Ash2 histone methyltransferase complex subunit ASH2

    datasetDistributions.storedIn: Protein Data Bank
  15. MLL and Pol2 Chip-chip in interphase and mitotic arrested cells ArrayExpress

    ID: E-GEOD-19155

    Description: vation following mitotic exit. MLL tethers Menin, RbBP5, and ASH2L to its occupied sites during mitosis, but is dispensable for preserving histone H3K4 methylation. These findings implicate mitotic bookmarking as a component of Trithorax-based gene regulation which may facilitate inheritance of active gene expression states during cell division. anti-MLL ChIP (antibody 456) and anti-pol2 chip (sc-899) in chromatin prepared from interphase and mitotic HeLa cells...

  16. RBBP5_CAEEL UniProt:Swiss-Prot

    ID: Q09309

    Description: Retinoblastoma-binding protein homolog 5 WD 1 WD 2 WD 3...

  17. Rb1+/+ versus Rb1ΔS/ΔS RNA Seq BioProject

    ID: PRJNA263014

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Upon G1-S transition, cyclin-dependent kinases (CDKs) phosphorylate the retinoblastoma tumor suppressor
  18. H2A.Z Facilitates Access of Active and Repressive Complexes to Chromatin in Embryonic Stem Cell Self-renewal and Differentiation ArrayExpress

    ID: E-GEOD-34483

    Description: enewing ESCs, knockdown of H2A.Z compromises OCT4 binding to its target genes and leads to decreased binding of MLL complexes to active genes and of PRC2 complex to repressed genes in self-renewal of ESCs. During differentiation of ESCs, inhibition of H2A.Z also compromises RA-induced RARα binding, activation of differentiation markers and the repression of pluripotency genes. We propose that H2A.Z mediates such contrasting activities by acting as a 'general facilitator' that generates access for a variety of complexes both activating and repressive. ChIP-Seq in murine embryonic stem (mES) cells for H2A.Z and ac...

  19. X-ray structure of WDR5-SETd1b Win motif peptide binary complex PDB

    ID: PDB:4ES0

    Description: WD repeat-containing protein 5, Histone-lysine N-methyltransferase SETD1B (E.C.2.1.1.43)

  20. H2A.Z Facilitates Access of Active and Repressive Complexes to Chromatin in Embryonic Stem Cell Self-renewal and Differentiation BioProject

    ID: PRJNA151337

    Keywords: Epigenomics

    Access Type: download

    dataset.description: enewing ESCs, knockdown of H2A.Z compromises OCT4 binding to its target genes and leads to decreased binding of MLL complexes to active genes and of PRC2 complex to repressed genes in self-renewal of ESCs. During differentiation of ESCs, inhibition of H2A.Z also compromises RA-induced RARα binding, activation of differentiation markers and the repression of pluripotency genes. We propose that H2A.Z mediates such contrasting activities by acting as a 'general facilitator' that generates access for a variety of complexes both activating and repressive. Overall design: ChIP-Seq in murine embryonic stem (mES) cells ...

Displaying 20 of 57 results for "RBBP5"