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Displaying 20 of 31 results for "RBBP5"
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  1. Crystal structure of Ash2L SPRY domain in complex with RbBP5 PDB

    ID: PDB:4X8P

    Description: Ash2L, Retinoblastoma-binding protein 5

  2. Crystal structure of Ash2L SPRY domain in complex with phosphorylated RbBP5 PDB

    ID: PDB:4X8N

    Description: Set1/Ash2 histone methyltransferase complex subunit ASH2, Retinoblastoma-binding protein 5

  3. Crystal structure of the MLL3-Ash2L-RbBP5 complex PDB

    ID: PDB:5F6K

    Description: Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2C (E.C.2.1.1.43), Retinoblastoma-binding protein 5, pept...

  4. WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE RECRUITED TO NOVEL SITE PDB

    ID: PDB:2XL2

    Description: WD REPEAT-CONTAINING PROTEIN 5, RETINOBLASTOMA-BINDING PROTEIN 5

  5. The crystal structure of MLL1 (N3861I/Q3867L) in complex with RbBP5 and Ash2L PDB

    ID: PDB:5F6L

    Description: Retinoblastoma-binding protein 5, Set1/Ash2 histone methyltransferase complex subunit ASH2, Histone-lysine N-methyltransferase 2A (E.C.2.1.1.43)

  6. WDR5 IN COMPLEX WITH AN RBBP5 PEPTIDE AND HISTONE H3 PEPTIDE PDB

    ID: PDB:2XL3

    Description: WD REPEAT-CONTAINING PROTEIN 5, RETINOBLASTOMA-BINDING PROTEIN 5, HISTONE H3.1

  7. NHGRI Menin ChIP-Chip ArrayExpress

    ID: E-GEOD-5357

    Description: histone methyltransferase complex including ASH2, Rbbp5, WDR5, and the leukemia proto-oncoprotein MLL. To elucidate menin's role as a tumor suppressor and gain insights into the endocrine-specific tumor phenotype in MEN1, we mapped the genomic binding sites of menin, MLL1, and Rbbp5, to approximately 20,000 promoters in HeLa S3, HepG2, and pancreatic islet cells using the strategy of chromatin-immunoprecipitation coupled with microarray analysis. We found that menin, ...

  8. NHGRI Menin ChIP-Chip OmicsDI

    ID: E-GEOD-5357

    Date Released: 06-27-2012

    Description: histone methyltransferase complex including ASH2, Rbbp5, WDR5, and the leukemia proto-oncoprotein MLL. To elucidate menin's role as a tumor suppressor and gain insights into the endocrine-specific tumor phenotype in MEN1, we mapped the genomic binding sites of menin, MLL1, and Rbbp5, to approximately 20,000 promoters in HeLa S3, HepG2, and pancreatic islet cells using the strategy of chromatin-immunoprecipitation coupled with microarray analysis. We found that menin, ...

  9. NHGRI Menin ChIP-Chip BioProject

    ID: PRJNA96251

    Keywords: Epigenomics

    Access Type: download

    dataset.description: histone methyltransferase complex including ASH2, Rbbp5, WDR5, and the leukemia proto-oncoprotein MLL. To elucidate menin's role as a tumor suppressor and gain insights into the endocrine-specific tumor phenotype in MEN1, we mapped the genomic binding sites of menin, MLL1, and Rbbp5, to approximately 20,000 promoters in HeLa S3, HepG2, and pancreatic islet cells using the strategy of chromatin-immunoprecipitation coupled with microarray analysis. We found that menin, ...
  10. Structure of the SPRY domain of human Ash2L PDB

    ID: PDB:3TOJ

    Description: Set1/Ash2 histone methyltransferase complex subunit ASH2

    primaryPublication.title: Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30.
  11. MLL and Pol2 Chip-chip in interphase and mitotic arrested cells ArrayExpress

    ID: E-GEOD-19155

    Description: vation following mitotic exit. MLL tethers Menin, RbBP5, and ASH2L to its occupied sites during mitosis, but is dispensable for preserving histone H3K4 methylation. These findings implicate mitotic bookmarking as a component of Trithorax-based gene regulation which may facilitate inheritance of active gene expression states during cell division. anti-MLL ChIP (antibody 456) and anti-pol2 chip (sc-899) in chromatin prepared from interphase and mitotic HeLa cells...

  12. Structural and biochemical insights into MLL1 core complex assembly and regulation. PDB

    ID: PDB:3P4F

    Description: WD repeat-containing protein 5, Retinoblastoma-binding protein 5, Histone-lysine N-methyltransferase MLL (E.C.2.1.1.43)

    dataset.keywords: RbBP5
  13. H2A.Z Facilitates Access of Active and Repressive Complexes to Chromatin in Embryonic Stem Cell Self-renewal and Differentiation ArrayExpress

    ID: E-GEOD-34483

    Description: acetylated H2A.Z. ChIP-Seq of H3K4me3, H3K27me3, RbBP5, SUZ12 and OCT4 for mES cells of both H2A.Z RNAi knockdown and shLuc control. ChIP-Seq of RARalpha in H2A.Z knockdown (withdraw of LIF and exposure to RA for 3h) and control cells. MNase-Seq and chromatin accessibility assay using Benzonase digestion followed by next-generation sequencing for mES cells of both H2A.Z RNAi knockdown and shLuc control. ChIP-Seq of H2A.Z and H3K4me3 for mES cells of both MLL4 RNAi knockdown and shLuc control. RNA-Seq for mES cells of H2A.Z knockdown and shluc control. RNA-Seq for embryonic bodies derived from mES cells (H2A.Z knockdown and shLuc control) at day 3 and day 7....

  14. Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis ArrayExpress

    ID: E-GEOD-64412

    Description: se 1 (DNMT1) by retinoblastoma-binding protein 5 (Rbbp5) activation in MEN1 tumor tissues. The increased activity of DNMT1 mediated global DNA hypermethylation, which in turn resulted in aberrant activation of the Wnt/β-catenin signaling pathway through inactivation of Sox regulatory genes. Our study provides important insights into the possible regulatory role of menin in DNA methylation and its impact on the pathogenesis of MEN1 tumor development. Global DNA methylation in tissues from patients with MEN1-parathyroid tumors. Thirty-eight human parathyroid specimens were used: 13 sporadic (non-MEN1) parathyroid adenomas, 12 MEN1-parathyroid tumors, 4 parathyroid carcinomas, and 9 normal parathyroids....

  15. Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis BioProject

    ID: PRJNA270977

    Keywords: Epigenomics

    Access Type: download

    dataset.description: se 1 (DNMT1) by retinoblastoma-binding protein 5 (Rbbp5) activation in MEN1 tumor tissues. The increased activity of DNMT1 mediated global DNA hypermethylation, which in turn resulted in aberrant activation of the Wnt/β-catenin signaling pathway through inactivation of Sox regulatory genes. Our study provides important insights into the possible regulatory role of menin in DNA methylation and its impact on the pathogenesis of MEN1 tumor development. Overall design: Global DNA methylation in tissues from patients with MEN1-parathyroid tumors. Thirty-eight human parathyroid specimens were used: 13 sporadic (non-MEN1) parathyroid adenomas, 12 MEN1-parathyroid tumors, 4 parathyroid carcinomas, and 9 norma...
  16. X-ray structure of WDR5-SETd1b Win motif peptide binary complex PDB

    ID: PDB:4ES0

    Description: WD repeat-containing protein 5, Histone-lysine N-methyltransferase SETD1B (E.C.2.1.1.43)

    dataset.keywords: RbBP5
  17. H2A.Z Facilitates Access of Active and Repressive Complexes to Chromatin in Embryonic Stem Cell Self-renewal and Differentiation BioProject

    ID: PRJNA151337

    Keywords: Epigenomics

    Access Type: download

    dataset.description: acetylated H2A.Z. ChIP-Seq of H3K4me3, H3K27me3, RbBP5, SUZ12 and OCT4 for mES cells of both H2A.Z RNAi knockdown and shLuc control. ChIP-Seq of RARalpha in H2A.Z knockdown (withdraw of LIF and exposure to RA for 3h) and control cells. MNase-Seq and chromatin accessibility assay using Benzonase digestion followed by next-generation sequencing for mES cells of both H2A.Z RNAi knockdown and shLuc control. ChIP-Seq of H2A.Z and H3K4me3 for mES cells of both MLL4 RNAi knockdown and shLuc control. RNA-Seq for mES cells of H2A.Z knockdown and shluc control. RNA-Seq for embryonic bodies derived from mES cells (H2A.Z knockdown and shLuc control) at day 3 and day 7....
  18. MLL and Pol2 Chip-chip in interphase and mitotic arrested cells BioProject

    ID: PRJNA120709

    Keywords: Epigenomics

    Access Type: download

    dataset.description: vation following mitotic exit. MLL tethers Menin, RbBP5, and ASH2L to its occupied sites during mitosis, but is dispensable for preserving histone H3K4 methylation. These findings implicate mitotic bookmarking as a component of Trithorax-based gene regulation which may facilitate inheritance of active gene expression states during cell division. Overall design: anti-MLL ChIP (antibody 456) and anti-pol2 chip (sc-899) in chromatin prepared from interphase and mitotic HeLa cells...
  19. X-ray structure of WDR5-MLL3 Win motif peptide binary complex PDB

    ID: PDB:4ERY

    Description: WD repeat-containing protein 5, Histone-lysine N-methyltransferase MLL3 (E.C.2.1.1.43)

    dataset.keywords: RbBP5
  20. Crystal structure of DPY-30 dimerization/docking domain in complex with Ash2L Sdc1-DPY-30 Interacting region (SDI) PDB

    ID: PDB:4RIQ

    Description: Protein dpy-30 homolog, Set1/Ash2 histone methyltransferase complex subunit ASH2

    dataset.keywords: RbBP5

Displaying 20 of 31 results for "RBBP5"