RB1 Gene Inactivation by Chromothripsis in Human Retinoblastoma OmicsDI

ID: EGAS00001000598

Date Released:

Description: Retinoblastoma is a rare childhood cancer of the developing retina. Most retinoblastomas initiate with biallelic inactivation of th...

Comparative genomic hybridization by array of retinoblastoma samples against control DNA from healthy individuals to evaluate aCGH and NGS methods in genetic diagnosis of the di... ArrayExpress

ID: E-MTAB-3492

Description: Background: Retinoblastoma (RB) is the most common malignant childhood tumor of the eye and results from inactivation of bot...

RNA-seq of retinoblastoma samples to evaluate aCGH and NGS methods in genetic diagnosis of the disease ArrayExpress

ID: E-MTAB-3515

Description: Retinoblastoma (RB, OMIM:180200) is the most common malignant childhood tumor of the eye with an estimated incid...

Expression data from murine fetal liver cells in culture, time course, combinations of RB1 and p107 knockouts BioProject

ID: PRJNA279400

Keywords: Transcriptome or Gene expression

Access Type: download

Comparative genomic hybridization by array of retinoblastoma samples against control DNA from healthy individuals to evaluate aCGH and NGS methods in genetic diagnosis of the di... OmicsDI

ID: E-MTAB-3492

Date Released: 04-15-2015

Description: Background: Retinoblastoma (RB) is the most common malignant childhood tumor of the eye and results from inactivation of bot...

Expression data from murine fetal liver cells, combinations of RB1 family knockouts BioProject

ID: PRJNA279399

Keywords: Transcriptome or Gene expression

Access Type: download

Next Generation Sequencing targeted approach for the molecular diagnosis of Retinoblastoma. BioProject

ID: PRJEB9126

Keywords: Other

Access Type: download

Expression data from Pou4f3-Rb1 cKO and control inner ear ArrayExpress

ID: E-GEOD-25732

Description: Retinoblastoma gene (Rb1) is required for proper cell cycle exit in the developing mouse inner ear and its delet...

Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer PDB

ID: PDB:2AZE

Description: Transcription factor Dp-1, Transcription factor E2F1, Retinoblastoma-associated protein...

Retinoblastoma : Advantages of a Next Generation Sequencing targeted approach for the molecular diagnosis of Retinoblastoma. BioProject

ID: PRJEB9050

Keywords: Other

Access Type: download

RNA-seq of retinoblastoma samples to evaluate aCGH and NGS methods in genetic diagnosis of the disease OmicsDI

ID: E-MTAB-3515

Date Released: 04-17-2015

Description: Retinoblastoma (RB, OMIM:180200) is the most common malignant childhood tumor of the eye with an estimated incid...

Murine Prostate Tissue: Rb1 null vs. Rb1 E2F binding deficient mutant BioProject

ID: PRJNA133957

Keywords: Transcriptome or Gene expression

Access Type: download

Haploinsufficiency of an RB-E2F1-Condensin II complex causes replication stress and contributes to mesenchymal cancers [CAP-D3 localization] ArrayExpress

ID: E-GEOD-55040

Description: tudy we demonstrate that a complex containing the retinoblastoma protein, E2F1, and Condensin II localizes to major satellite repeats at pericentromeres. In the absence of this complex, this genomic region fails to properly replicate and H2AX phosphorylation at pericentromeric repeats is increased. Our da...

Haploinsufficiency of an RB-E2F1-Condensin II complex causes replication stress and contributes to mesenchymal cancers [γH2AX localization] ArrayExpress

ID: E-GEOD-51558

Description: tudy we demonstrate that a complex containing the retinoblastoma protein, E2F1, and Condensin II localizes to major satellite repeats at pericentromeres. In the absence of this complex, this genomic region fails to properly replicate and H2AX phosphorylation at pericentromeric repeats is increased. Our da...

Myogeneic differentiation in Rb1 or Kdm5a/Jarid1a/Rbp2 deficient mouse embryonic fibroblasts ArrayExpress

ID: E-GEOD-53528

Description: Cells lacking Rb1 are deficient in differentiation. Loss of Kdm5a rescues myogenic differentiation, as judged by appearance of morphologically no...

Gene expression analysis of RB1 knockdown in bone in response to radiation ArrayExpress

ID: E-GEOD-50532

Description: The role of RB1 in response to radiation was examined in human osteoblasts. We demonstrate that RB1 induced SASP genes, a r...

RNA-seq analysis of acute Rb1 deletion in adult mouse tissues ArrayExpress

ID: E-GEOD-71924

Description: Abstract:The pRb tumor suppressor protein associates with chromatin and regulates gene expression. Numerous studies have identified Rb-dependent R...

Expression data from MCF-7 breast cancer cells treated with CNTs, ginsenosides (Rb1 and Rg1) and conjugates (Rb-CNTs and Rg-CNTs) BioProject

ID: PRJNA304617

Keywords: Transcriptome or Gene expression

Access Type: download

Additional file 1: Table S1. of De novo mutational profile in RB1 clarified using a mutation rate modeling algorithm Figshare

ID: doi:10.6084/M9.FIGSHARE.C.3690623_D3

Release Date: 02-14-2017

Description: All de novo germline variants in RB1 gene of patients with RB. “gDNA position” is the nucleotide position in the GENBANK accession number L11...

Modeling Trilateral Retinoblastoma using Human Embryonic Stem Cells BioProject

ID: PRJNA329518

Keywords: Transcriptome or Gene expression

Access Type: download