RAPGEF5 | bioCADDIE Data Discovery Index
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Displaying 20 of 50 results for "RAPGEF5"
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  1. RPGF5_RAT UniProt:Swiss-Prot

    ID: P83900

    Description: Rap guanine nucleotide exchange factor 5

  2. Structure of Epac2 in complex with cyclic-AMP and Rap PDB

    ID: PDB:3CF6

    Description: Rap guanine nucleotide exchange factor (GEF

  3. Data from: Kinetic estimation of GFR improves prediction of dialysis and recovery after kidney transplantation Dryad

    DateIssued: 05-14-2015

    Description: ctive analysis, we investigated kinetic estimated GFR under non-steady-state conditions, KeGFR, in prediction of DGF. KeGFRsCr was calculated at 4h, 8h and 12h in 56 recipients of deceased donor kidneys from initial serum creatinine (sCr) concentrations, estimated creatinine production rate, volume of distribution, and the difference between cons...

  4. A Comparison of GFR by Cockcroft-Gault Equations and Gates method for estimating Glomerular Filtration Rate in Chronic Kidney Disease Patients Figshare

    ID: doi:10.6084/M9.FIGSHARE.1328359

    Release Date: 03-09-2015

    Description:

  5. A Comparison of GFR by Cockcroft-Gault Equations and Gates method for estimating Glomerular Filtration Rate in Chronic Kidney Disease Patients Figshare

    ID: doi:10.6084/M9.FIGSHARE.1328359.V1

    Release Date: 01-19-2016

    Description:

  6. MethylMalonic Acidemia (MMA) is predicted by lipocalin-2 (LCN2) and attenuated by antioxidant therapy ArrayExpress

    ID: E-GEOD-41044

    Description: anifested a decreased glomerular filtration rate (GFR), chronic tubulointerstital nephritis (CTIN) and prominent ultrastructural changes in the proximal tubular mitochondria, replicating precisely the renal manifestations seen in a large MMA patient cohort. To explore the pathophysiological changes that underlie the renal disease of MMA, we compared gene expression profiles of whole kidney mRNA samples between 4 female Mut +/+, Mut +/- and Mut -/- ;TgINS-Alb-Mut mice after they ingested a HP diet for 2 months. Females were used because more survived the dietary challenge, whereas the histology, ultrastructure and GFR effects were identical between sexes...

  7. of Schwartz and CDK-EPI Equations for Estimating GFR in Children, Adolescents, and Adults: a Retrospective Cross-Sectional Study... Dataverse

    Description: y 2014 to a single university hospital to undergo GFR measurement for suspected or established renal dysfunction, renal risk, or before kidney donation. During the study period, some patients could have several GFR measurements but, for the present study, only the ...

    Person: DA SILVA SELISTRE, LUCIANO

    Release Date: 12-15-2015

  8. Transcription profiling of human kidneys from chronic allograft nephropathy patients treated with either cyclosporin or sirolimus immunosuppression re... ArrayExpress

    ID: E-GEOD-1743

    Description: dney transplant survival, comparable increases in 5 and 10-year outcomes have not been achieved. Chronic allograft nephropathy (CAN) is a major cause of late graft loss. Toxic nephropathy and inadequate long-term immunosuppression are possibl...

  9. Targeting proximal tubule mitochondrial dysfunction attenuates the renal disease of methylmalonic acidemia BioProject

    ID: PRJNA175609

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: anifested a decreased glomerular filtration rate (GFR), chronic tubulointerstital nephritis (CTIN) and prominent ultrastructural changes in the proximal tubular mitochondria, replicating precisely the renal manifestations seen in a large MMA patient cohort. Overall design: To explore the pathophysiological changes that underlie the renal disease of MMA, we compared gene expression profiles of whole kidney mRNA samples between 4 female Mut +/+, Mut +/- and Mut -/- ;TgINS-Alb-Mut mice after they ingested a HP diet for 2 months. Females were used because more survived the dietary challenge, whereas the histology, ultrastructure and GFR effects were identical between sexes...
  10. RA domain of guanine nucleotide exchange factor for Rap1 PDB

    ID: PDB:1WGY

    Description: Rap guanine nucleotide exchange factor 5

  11. Data from: Hepcidin-25 in diabetic chronic kidney disease is predictive for mortality and progression to end stage renal disease Dryad

    DateIssued: 04-21-2015

    Description: models. Results: Patients (age 67 yrs, 53% male, GFR 51 ml/min, hemoglobin 131 g/L, EPO 13.5 U/L, hepcidin-25 62.0 ng/ml) were followed for a median time of 4.2 yrs. Forty-nine patients died (19.7%) and forty (16.1%) patients reached the composite endpoint. Elevated hepcidin levels were independently associated with higher ferritin-levels, lower EPO-levels and impaired kidney function (all p<0.05). Hepcidin was related to mortality, along with its interaction with EPO, older age, greater proteinuria and elevated CRP (all p<0.05). Hepcidin was also predictive for progression of CKD, aside from baseline GFR, proteinuria, low albumin- and hemoglobin-levels and a history of CVD (all p<0.05). Conclusions: We found hepcidin-25 to be associated with EPO and impaired kidney function in diabetic CKD. Elevated hepcidin-25 and EPO-levels were independent predictors of mortality, while hepcidin-25 was also predictive for progression of CKD. Both hepcidin-25 and EPO may represent important prognostic factors of clinical outcome and have the potential to further define “high risk” populations in CKD....

  12. Tacrolimus in diabetic nephropathy ArrayExpress

    ID: E-GEOD-84908

    Description: nregulated by tacrolimus (e.g. the tumor necrosis factor alpha (TNF), interleukin 4, or interleukin 10). On the other hand, pro-fibrotic stimuli being detrimental to renal function were induced by tacrolimus like the transforming growth factor beta 1 (TGFB1), endothelin 1 (EDN1), or type IV collagen alpha 1 (COL4A1). Conclusion: Patients with DN and elevated TNF levels might benefit from tacrolimus treatment regarding maintaining GFR and reducing inflammation. TGFB1 and EDN1 are proposed as monitoring markers to assess degree of renal damage. Next to this stratification approach, the use of drug combinations consisting of tacrolimus in addition to ACE inhibitors, angiotensin receptor blockers, TGFB1- or EDN1-receptor antagonists might warrant further studies. comparison of gene expression of human mesangial cells after 24h Tacrolimus vs. Ctrl; 4 independent experiments were conducted (4xTacrolimus 24h and 4x ctrl. 24h with Drug solvent (DMSO))...

  13. Renal gene expression in uninephrectomized diabetic OVE26 mice ArrayExpress

    ID: E-GEOD-21448

    Description: pathologies. We showed that albuminuria, reduced GFR and interstitial fibrosis, which normally take 8-9 months to develop, are more advanced in uninephrectomized OVE mice within 10 weeks of surgery, at 4.5 months of age. The accelerated progression of renal damage, especially renal fibro...

  14. Transcription profiling by array of left ventricle biopsies from diabetic and non diabetic patients affected by post-ischemic heart failure against sa... ArrayExpress

    ID: E-GEOD-26887

    Description: habits, Hypertension, Glomerular filtration rate (GFR), Body Mass Index (BMI). Genes expression was assessed by Affymetrix GeneChips Human Gene 1.0 ST array, using total RNA extracted from 7 T2DM HF patients, 12 non-T2DM HF patients and 5 controls....

  15. Renal gene expression in uninephrectomized diabetic OVE26 mice BioProject

    ID: PRJNA126337

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: pathologies. We showed that albuminuria, reduced GFR and interstitial fibrosis, which normally take 8-9 months to develop, are more advanced in uninephrectomized OVE mice within 10 weeks of surgery, at 4.5 months of age. The accelerated progression of renal damage, especially renal fibro...
  16. IPM BioBank GWAS dbGaP

    ID: phs000388.v1.p1

    Description: , progressive CKD is a major and independent risk factor for CVD with an inverse relationship between estimated GFR (eGFR), and risk for mortality and cardiovascular events. This increased risk is only partially explained by the prevalence of cardiovascular risk factors among these patients. We conducted a GWAS of CAD and CKD related phenotypes in IPM Biobank with the primary objective to explore the genetics of overlapping CAD and CKD predominantly in minority populations characterized by increased risk....

    Study Types: Case-Control

  17. De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function BioProject

    ID: PRJNA90605

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: dney transplant survival, comparable increases in 5 and 10-year outcomes have not been achieved. Chronic allograft nephropathy (CAN) is a major cause of late graft loss. Toxic nephropathy and inadequate long-term immunosuppression are possibl...
  18. Transcription profiling of human donor kidneys prior to surgical manipulation vs kidneys removed after laparoscopic donor nephrectomy (LDN) to demonst... ArrayExpress

    ID: E-GEOD-3297

    Description: classification of the 502 genes differentially up-regulated in LDN kidneys identified associations with apoptosis, cell adhesion, cell signaling, regulation of cell growth/proliferation, immune/inflammation, ischemia/stress response and proteolysis/peptidolysis. These data demonstrate an altered renal transcriptome induced by several hours of CO2 pneumoperitoneum and laparoscopic surgery characterized by up-regulation of ischemia and injury associated genes. Experiment Overall Design: Twelve healthy adult kidney donors signed a consent form, and were approved for donation according to the usual evaluation and practice of the Cleveland Clinic Renal Transplant Program. To avoid potentially significant differences in gene expression based on race and/or ethnicity, only white recipients were selected. The patients were divided into two groups; six controls from open donor nephrec...

  19. PowerPoint Slides for: Cystatin C-Creatinine Based Glomerular Filtration Rate Equation in Obese Chronic Kidney Disease Patients: Impact of Deindexatio... Figshare

    ID: doi:10.6084/M9.FIGSHARE.3501626.V1

    Release Date: 07-26-2016

    Description: reatinine to estimate glomerular filtration rate (GFR). However, studies have reported that increased adiposity is associated with a higher level of circulating cystatin C questioning the performance of estimation of GFR using...

  20. Transcriptome analysis of diabetic and non diabetic patients affected by post-ischemic heart failure BioProject

    ID: PRJNA135947

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: habits, Hypertension, Glomerular filtration rate (GFR), Body Mass Index (BMI). Genes expression was assessed by Affymetrix GeneChips Human Gene 1.0 ST array, using total RNA extracted from 7 T2DM HF patients, 12 non-T2DM HF patients and 5 controls....

Displaying 20 of 50 results for "RAPGEF5"