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Displaying 9 of 9 results for "PYGO2"
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  1. Expression data from sorted control and Pygo2-null mouse mammary stem/basal cells BioProject

    ID: PRJNA196584

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Expression data from sorted control and Pygo2-null mouse mammary stem/basal cells ArrayExpress

    ID: E-GEOD-45826

    Description: Skin-mammary specific knockout (SSKO) of Pygo2 (K14-cre; Pygo2 flox/-) , a WNT signaling co-activator, results in defective mouse mammary gland developme...

  3. Expression data from sorted control and Pygo2-null mouse mammary stem/basal cells OmicsDI

    ID: E-GEOD-45826

    Date Released: 07-10-2015

    Description: Skin-mammary specific knockout (SSKO) of Pygo2 (K14-cre; Pygo2 flox/-) , a WNT signaling co-activator, results in defective mouse mammary gland developme...

  4. CRYSTAL STRUCTURE OF THE HUMAN PYGO2 PHD FINGER IN COMPLEX WITH THE B9L HD1 DOMAIN PDB

    ID: PDB:2XB1

    Description: PYGOPUS HOMOLOG 2, B-CELL CLL/LYMPHOMA 9-LIKE PROTEIN

  5. Ternary crystal structure of the Pygo2 PHD finger in complex with the B9L HD1 domain and a H3K4me2 peptide PDB

    ID: PDB:4UP0

    Description: PYGOPUS HOMOLOG 2, B-CELL CLL/LYMPHOMA 9-LIKE PROTEIN, HISTONE H3.1

  6. Crystal structure of the Pygo2 PHD finger in complex with the B9L HD1 domain and a chemical fragment PDB

    ID: PDB:4UP5

    Description: PYGOPUS HOMOLOG 2, B-CELL CLL/LYMPHOMA 9-LIKE PROTEIN

  7. LncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [GRO-seq I] BioProject

    ID: PRJNA207829

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: recognition of the H3K4me3 promoter mark by the PHD finger-domain of Pygopus2, recruited by PCGEM1, proves to enhance selective looping of AR-bound enhancers to target gene promoters in these cells, revealing a novel aspect of ligand-induced enhancer-promoter interactions. In “resistant” prostate cancer cells, these overexpressed lncRNAs can interact with, and are required for the robust activation of both truncated and full length AR, causing DHT-independent activation of the AR transcriptional program and cell proliferation. Conditionally-expressed short hairpin RNA (shRNA)-mediated targeting of these lncRNAs in these resistant cancer cell lines strongly suppressed xenograft growth in vivo. Together, these results suggest that these overexpressed lncRNAs can potentially serve as a required component of castration-resistance in prostatic tumors. Overall d...
  8. LncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [GRO-seq I] ArrayExpress

    ID: E-GEOD-47805

    Description: recognition of the H3K4me3 promoter mark by the PHD finger-domain of Pygopus2, recruited by PCGEM1, proves to enhance selective looping of AR-bound enhancers to target gene promoters in these cells, revealing a novel aspect of ligand-induced enhancer-promoter interactions. In “resistant” prostate cancer cells, these overexpressed lncRNAs can interact with, and are required for the robust activation of both truncated and full length AR, causing DHT-independent activation of the AR transcriptional program and cell proliferation. Conditionally-expressed short hairpin RNA (shRNA)-mediated targeting of these lncRNAs in these resistant cancer cell lines strongly suppressed xenograft growth in vivo. Together, these results suggest that these overexpressed lncRNAs can potentially serve as a required component of castration-resistance in prostatic tumors. Global Ru...

  9. LncRNA-dependent mechanisms of androgen receptor-regulated gene activation programs [GRO-seq I] OmicsDI

    ID: E-GEOD-47805

    Date Released: 09-05-2013

    Description: recognition of the H3K4me3 promoter mark by the PHD finger-domain of Pygopus2, recruited by PCGEM1, proves to enhance selective looping of AR-bound enhancers to target gene promoters in these cells, revealing a novel aspect of ligand-induced enhancer-promoter interactions. In “resistant” prostate cancer cells, these overexpressed lncRNAs can interact with, and are required for the robust activation of both truncated and full length AR, causing DHT-independent activation of the AR transcriptional program and cell proliferation. Conditionally-expressed short hairpin RNA (shRNA)-mediated targeting of these lncRNAs in these resistant cancer cell lines strongly suppressed xenograft growth in vivo. Together, these results suggest that these overexpressed lncRNAs can potentially serve as a required component of castration-resistance in prostatic tumors. Global Ru...


Displaying 9 of 9 results for "PYGO2"