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Displaying 20 of 29 results for "PVT1"
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  1. Supplemental Dataset 16. LincRNAs associated with smRNAs Dryad

    DateIssued: 11-13-2012

    dataset.keywords: Noncoding RNA
  2. A renal cancer-associated, renal tubule-specific, HIF-binding enhancer of oncogenic MYC and PVT1 expression BioProject

    ID: PRJNA329187

    Keywords: Other

    Access Type: download

  3. varian cancer cell lines reveals amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer... ArrayExpress

    ID: E-TABM-246

    Description: DNA from 30 cultured ovarian cancer cell lines was extracted with Promega kits and hybridize to arrays. Arrays comprised of 1860 BACs selected to incl...

  4. PRJNA161029 BioProject

    Access Type: download

    dataset.description: pediatric brain tumour is currently treated with non-specific cytotoxic therapies including surgery, whole brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits marked intertumoural heterogeneity, with ...
  5. Unbiased Capture Hi-C reveals the potential targets of breast cancer susceptibility loci ArrayExpress

    ID: E-GEOD-55634

    Description: breast cancer risk. Most of these variants map to non-protein-coding regions; several map to gene deserts, regions of several hundred kb lacking protein-coding genes. We hypothesized that gene deserts h...

  6. miR-1204 promotes tumor development in breast and ovarian cancer cell lines ArrayExpress

    ID: E-GEOD-37185

    Description: he minimal amplified region encodes c-MYC and the non-coding RNA, PVT1 including miR-1204 encoded in exon 1b. Here we analyzed the genomic changes at chromosome 8q24.21 in breast cancer and the functional roles of miR-1204 in breast and ovarian cancer progression. Methods: The genomic changes at chromosome 8q24.21 w...

  7. Molecular profiling of ERBB2-amplified breast cancers ArrayExpress

    ID: E-GEOD-17907

    Description: hway was involved in ER- ERBB2-amplified BCs, and PVT1 and TRPS1 were candidate oncogenes associated with ER+ ERBB2-amplified BCs. The size of the ERBB2-amplicon was different in inflammatory (IBC) and non inflammatory BCs. ERBB2-amplified IBCs were characterized by the downregulated and upregulated mRNA expression of ten and two genes in proportion to CNA, respectively. We have shown that ERBB2 BCs are heterogeneous and identified genomic features that may be useful in the design of therapeutical strategies Tumor tissues were collected from 340 patients with invasive adenocarcinoma who underwent initial surgery at the Institut Paoli-Calmettes (Marseilles, France) between 1987 and 2007 (from a cohort of 2,175 patients with frozen tumor sample) and from a series of 91 Tunisian T4d tumors (TNM, UICC) treated between 1994 and 1998 at the Salah Azaiz Institute (Tunis, Tunisia). Each patient gave informed consent and the study was approved by our institutional review board. Samples were macrodissected and frozen in liquid nitrogen within 30 minutes of removal. Genomic imbalances were determined by aCGH using 244K CGH oligonucleotide microarrays (Hu-244A, Agilent Technologies). Gene expression data of 51 of the 54 BC...

  8. miR-1204 promotes tumor development in breast and ovarian cancer cell lines BioProject

    ID: PRJNA158625

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: he minimal amplified region encodes c-MYC and the non-coding RNA, PVT1 including miR-1204 encoded in exon 1b. Here we analyzed the genomic changes at chromosome 8q24.21 in breast cancer and the functional roles of miR-1204 in breast and ovarian cancer progression. Methods: The genomic changes at chromosome 8q24.21 w...
  9. Unbiased Capture Hi-C reveals the potential targets of breast cancer susceptibility loci BioProject

    ID: PRJNA240252

    Keywords: Epigenomics

    Access Type: download

    dataset.description: breast cancer risk. Most of these variants map to non-protein-coding regions; several map to gene deserts, regions of several hundred kb lacking protein-coding genes. We hypothesized that gene deserts h...
  10. varian cancer cell lines reveals amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer... OmicsDI

    ID: E-TABM-246

    Date Released: 05-02-2014

    Description: DNA from 30 cultured ovarian cancer cell lines was extracted with Promega kits and hybridize to arrays. Arrays comprised of 1860 BACs selected to incl...

  11. Leucocyte small nucleolar RNA and microRNA expression data from healthy control subjects of different age BioProject

    ID: PRJNA349990

    Keywords: Transcriptome or Gene expression

    Access Type: download

  12. Molecular profiling of ERBB2-amplified breast cancers BioProject

    ID: PRJNA119979

    Keywords: Other

    Access Type: download

    dataset.description: hway was involved in ER- ERBB2-amplified BCs, and PVT1 and TRPS1 were candidate oncogenes associated with ER+ ERBB2-amplified BCs. The size of the ERBB2-amplicon was different in inflammatory (IBC) and non inflammatory BCs. ERBB2-amplified IBCs were characterized by the downregulated and upregulated mRNA expression of ten and two genes in proportion to CNA, respectively. We have shown that ERBB2 BCs are heterogeneous and identified genomic features that may be useful in the design of therapeutical strategies Overall design: Tumor tissues were collected from 340 patients with invasive adenocarcinoma who underwent initial surgery at the Institut Paoli-Calmettes (Marseilles, France) between 1987 and 2007 (from a cohort of 2,175 patients with frozen tumor sample) and from a series of 91 Tunisian T4d tumors (TNM, UICC) treated between 1994 and 1998 at the Salah Azaiz Institute (Tunis, Tunisia). Each patient gave informed consent and the study was approved by our institutional review board. Samples were macrodissected and frozen in liquid nitrogen within 30 minutes of removal. Genomic imbalances were determined by aCGH using 244K CGH oligonucleotide microarrays (Hu-244A, Agilent Technologies). Gene expression data o...
  13. miR-1204 promotes tumor development in breast and ovarian cancer cell lines OmicsDI

    ID: E-GEOD-37185

    Date Released: 05-11-2012

    Description: he minimal amplified region encodes c-MYC and the non-coding RNA, PVT1 including miR-1204 encoded in exon 1b. Here we analyzed the genomic changes at chromosome 8q24.21 in breast cancer and the functional roles of miR-1204 in breast and ovarian cancer progression. Methods: The genomic changes at chromosome 8q24.21 w...

  14. A small cell lung cancer genome reports complex tobacco exposure signatures OmicsDI

    ID: EGAS00000000051

    Date Released:

    Description: c substitutions were identified, including 132 in coding exons. Multiple mutation signatures testify to the cocktail of carcinogens in tobacco smoke and their proclivities for particular bases and surrounding sequence context. Effects of transcription-coupled repair and a second, more general expression-linked repair pathway were evident. We identified a tandem duplication that duplicates exons 3-8 of CHD7 in-frame, and another two lines carrying PVT1-CHD7 fusion genes, suggesting that CHD7 may be recurrently rearranged in ...

  15. PRJEB4401 BioProject

    Keywords: Other

    Access Type: download

    dataset.description: Background: The regulation of cellular protein levels involves various transcriptional and translational mechanisms. On the translational level one variable is the transi...
  16. Mus musculus strain:C57BL/6 : Whole genome sequencing of Rag2c/c XLF-/- p53-/- B-cell lymphomas BioProject

    ID: PRJNA306227

    Keywords: raw sequence reads

    Access Type: download

    dataset.description: XRCC4-like factor (XLF) functions in classical non-homologous end joining (cNHEJ) but is dispensable for the repair of DNA double strand breaks (DSBs) generated during V(D)J reco...
  17. Unbiased Capture Hi-C reveals the potential targets of breast cancer susceptibility loci OmicsDI

    ID: E-GEOD-55634

    Date Released: 09-06-2014

    Description: breast cancer risk. Most of these variants map to non-protein-coding regions; several map to gene deserts, regions of several hundred kb lacking protein-coding genes. We hypothesized that gene deserts h...

  18. Long-range joining of intra-chromosomal DNA double-strand breaks OmicsDI

    ID: E-GEOD-53755

    Date Released: 01-23-2014

    Description: ISPR/Cas9-generated DSBs 100 kb downstream within Pvt1 in B cells or fibroblasts, respectively. We suggest that CSR exploits a general propensity of intra-chromosomal DSBs separated by several hundred kb to be frequently joined together and discuss relevance of this finding for recurrent interstitial deletions in cancer. Comparison of frequency of long-range joining between I-SceI-induced DSBs at IgH and c-myc loci in different cell types by HTGTS...

  19. Data from: Genome reannotation of the lizard Anolis carolinensis based on 14 adult and embryonic deep transcriptomes Dryad

    DateIssued: 10-05-2015

    Description: , physiology, behavior, and ecology. As the first non-avian reptilian genome sequenced, A. carolinesis is also a prime reptilian model for comparison with other vertebrate genomes. The public databases of Ensembl and NCBI have provided a first generation gene annotation of the anole genome that relies primarily on sequence conservation with related...

  20. Let-7 microRNAs are developmentally regulated in circulating human erythroid cells ArrayExpress

    ID: E-GEOD-17405

    Description: MicroRNA are ~22nt-long small non-coding RNA that negatively regulate protein


Displaying 20 of 29 results for "PVT1"