PTPN2 | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 20 of 259 results for "PTPN2"
i
  1. PTN2_RAT UniProt:Swiss-Prot

    ID: P35233

    Description: Tyrosine-protein phosphatase non-receptor

  2. PTP2_CAEEL UniProt:Swiss-Prot

    ID: G5EC24

    Description: Tyrosine-protein phosphatase non-receptor

  3. PTN6_RAT UniProt:Swiss-Prot

    ID: P81718

    Description: Tyrosine-protein phosphatase non-receptor

  4. PTN21_HUMAN UniProt:Swiss-Prot

    ID: Q16825

    Description: Tyrosine-protein phosphatase non-receptor

  5. PTN5_RAT UniProt:Swiss-Prot

    ID: P35234

    Description: Tyrosine-protein phosphatase non-receptor

  6. PTN11_CHICK UniProt:Swiss-Prot

    ID: Q90687

    Description: Tyrosine-protein phosphatase non-receptor

  7. Cytoscan HD arrays data for Nodal marginal zone lymphoma (NMZL) BioProject

    ID: PRJNA281882

    Keywords: Variation

    Access Type: download

    dataset.description: l DNA pairs from 18 discovery NMZL identified 557 non-synonymous somatic mutations (average: 30.8/case) affecting 504 genes and 51 copy number abnormalities (CNA) (average: 3.2/case). To further characterize mutation recurrence, the 504 discovered genes were investigated in an independent validation panel of 17 NMZL by targeted sequencing of tumor/normal DNA pairs (MiSeq; target region: 1.6 Mb; mean coverage per sample: 171x-386x). The 17 validation NMZL were also assessed for CNA by high resolution SNP arrays. RNAseq of 11 discovery NMZL did not identify any recurrent gene fusion. By compiling the results of WES and high resolution SNP array, 39 genes were recurrently affected in >3/35 (9%) NMZL by mutations (n=30 genes) or focal CNA (n=9 genes). Among these, MLL2 (34%), PTPRD (20%) and NOTCH2 (20%) were most frequently mutated. Overall, recurrently mutated genes pointed to the molecular deregulation of specific programs in NMZL, namely JAK/STAT, NOTCH, NF-κB and toll-like receptor (TLR) signaling, cell cycle, chromatin remodeling/transcriptional regulation and immune escape (Fig. 1A). JAK/STAT signaling was targeted by mutually exclusive lesions in 43% of NMZL, and the ...
  8. PTPRQ_HUMAN UniProt:Swiss-Prot

    ID: Q9UMZ3

    Description: Phosphatidylinositol phosphatase PTPRQ Extracellular Helical Cytoplasmic Fibronectin type-III 1 Fibronectin type-I...

  9. Expression data from Shp2f/f and SCSKO mice testis BioProject

    ID: PRJNA283875

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ity of Sertoli cells remained largely unexplored. Tyrosine phosphatase protein Shp2 is expressed in germ, Leydig and Sertoli cells of mice testes. But the physiological role of Shp2 in the spermatogenesis was not fully understood. Thus, we conditionally deleted Shp2 gene ...
  10. Expression data from Shp2f/f and SCSKO mice testis ArrayExpress

    ID: E-GEOD-68829

    Description: ity of Sertoli cells remained largely unexplored. Tyrosine phosphatase protein Shp2 is expressed in germ, Leydig and Sertoli cells of mice testes. But the physiological role of Shp2 in the spermatogenesis was not fully understood. Thus, we conditionally deleted Shp2 gene ...

  11. Progression from actinic keratosis to cutaneous squamous cell carcinoma involves miR-204 silencing and a switch towards STAT3 activation BioProject

    ID: PRJNA292560

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ignaling pathway, likely acting through PTPN11, a tyrosine phosphatase that is a direct miR-204 target. We found that activated STAT3, as detected by pY705-STAT3 immunofluorescence, is retained in the membrane and cytoplasm compartment in AK, whereas cSCC displayed STAT3 in the nuclei. Taken together, our data indicates that MiR-204 may act as a “rheostat” that controls the signaling towards the MAPK pathway or the STAT3 pathway. Overall design: 4 samples were analyzed: HaCaT tansduced with control shRNA (n=2) and HaCaT transduced with shRNA against miR-204 (n=2)...
  12. MCF10A-HER2/3 cells grown in 3D cultures in the presence or absence of SHP2 BioProject

    ID: PRJNA156321

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN...
  13. Expression profile of breast cancer cells BT474 grown as xenografts in the presence or absence of SHP2 for 30 days ArrayExpress

    ID: E-GEOD-34523

    Description: The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN...

  14. Transcription profiling by array of human mature naive B cells with different PTPN22 genotypes ArrayExpress

    ID: E-GEOD-24736

    Description: Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene segregates ...

  15. Shp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430A_2 array] ArrayExpress

    ID: E-GEOD-50516

    Description: stry, and genetics to investigate the role of the tyrosine phosphatase Shp2 in tumor cells of MMTV-PyMT mouse mammary glands. Genetic ablation or pharmacological inhibition of Shp2 induces senescence, as determined by the activa...

  16. Crystallographic structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2 at 1.30 Angstroms PDB

    ID: PDB:2QT7

    Description: Receptor-type tyrosine-protein phosphatase-like N

  17. Crystal structure of an abridged form of the mature ectodomain of the Human Receptor-Type Protein Tyrosine Phosphatase ICA512/IA-2 at pH 8.5 PDB

    ID: PDB:3N01

    Description: Receptor-type tyrosine-protein phosphatase-like N

  18. Shp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430_2 array] ArrayExpress

    ID: E-GEOD-50517

    Description: stry, and genetics to investigate the role of the tyrosine phosphatase Shp2 in tumor cells of MMTV-PyMT mouse mammary glands. Genetic ablation or pharmacological inhibition of Shp2 induces senescence, as determined by the activa...

  19. Crystal structure of the PYR1 Abscisic Acid receptor in complex with the HAB1 type 2C phosphatase catalytic domain PDB

    ID: PDB:3QN1

    Description: Abscisic acid receptor PYR1, Protein phosphatase 2C 16 (E.C.3.1.3.16)

  20. MCF10A-HER2/3 cells grown in 3D cultures in the presence or absence of SHP2 ArrayExpress

    ID: E-GEOD-34524

    Description: The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN...


Displaying 20 of 259 results for "PTPN2"