PRRX1 | bioCADDIE Data Discovery Index
Mountain View
biomedical and healthCAre Data Discovery Index Ecosystem
help Advanced Search
Displaying 20 of 27 results for "PRRX1"
i
  1. d for with non-targeting siRNA or siRNA targeting PRRX1 or both PRRX1 and PPARG... ArrayExpress

    ID: E-MTAB-1906

    Description: r 72h with non-targeting siRNA or siRNA targeting PRRX1 (n=10) or both PRRX1 and PPARG (subset of the subjects, n=4)....

  2. d for with non-targeting siRNA or siRNA targeting PRRX1 or both PRRX1 and PPARG... OmicsDI

    ID: E-MTAB-1906

    Date Released: 06-03-2014

    Description: r 72h with non-targeting siRNA or siRNA targeting PRRX1 (n=10) or both PRRX1 and PPARG (subset of the subjects, n=4)....

  3. DPRX_HUMAN UniProt:Swiss-Prot

    ID: A6NFQ7

    Description: Divergent paired-related homeobox Homeobox

  4. Gene expression in primary chondrocytes derived from Rela-cKO/control mice with/without TNF-α treatment BioProject

    ID: PRJNA315213

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: ct of Rela, we isolated primary chondrocytes from Prrx1-Cre;Relafl/fl and Relafl/fl mice, cultured them with or without 10 ng/mL TNF-α, and compared gene expression profiles by microarray analyses. Overall design: Primary chondrocytes fro...
  5. Fibroblast Major TF KDs BioProject

    ID: PRJNA189487

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: fibroblast specific TF, FOXD1, HOXC4, LHX9, OSR1, PRRX1, TBX3, TWIST2 and NC(negative control siRNA) in fibroblast Overall design: 24 Samples total....
  6. KD of Fibroblast specific TF BioProject

    ID: PRJNA189486

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Combinatorial knock down of LHX9, OSR1, PRRX1, TWIST2, fibroblast specific transcription factors and adipogenic induction by medium change induce transdifferentiation from...
  7. KD of Fibroblast specific TF ArrayExpress

    ID: E-GEOD-44303

    Description: Combinatorial knock down of LHX9, OSR1, PRRX1, TWIST2, fibroblast specific transcription factors and adipogenic induction by medium change induce transdifferentiation from...

  8. Fibroblast Major TF KDs ArrayExpress

    ID: E-GEOD-44305

    Description: fibroblast specific TF, FOXD1, HOXC4, LHX9, OSR1, PRRX1, TBX3, TWIST2 and NC(negative control siRNA) in fibroblast 24 Samples total....

  9. Danio rerio : Danio rerio Raw sequence reads BioProject

    ID: PRJNA294977

    Keywords: raw sequence reads

    Access Type: download

    dataset.description: through antagonism of Jagged-Notch signaling and Prrx1 transcription factors. A genomic analysis of facial skeletal precursors in mutants and overexpression embryos reveals that Jagged-Notch signaling represses genes that are strongly induced as pharyngeal arch neural crest-derived cells begin skeletal differentiation....
  10. Accelerated cartilage differentiation distinguishes the lower from the upper vertebrate face OmicsDI

    ID: E-GEOD-72985

    Date Released: 03-26-2016

    Description: through antagonism of Jagged-Notch signaling and Prrx1 transcription factors. A genomic analysis of facial skeletal precursors in mutants and overexpression embryos reveals that Jagged-Notch signaling represses genes that are strongly induced as pharyngeal arch neural crest-derived cells begin skeletal differentiation. In wild types, initial Jagged-Notch repression dorsally ensures that barx1+ condensations and cartilage differentiation occur first in ventral-intermediate zones of the pharyngeal arches. Red...

  11. Accelerated cartilage differentiation distinguishes the lower from the upper vertebrate face ArrayExpress

    ID: E-GEOD-72985

    Description: through antagonism of Jagged-Notch signaling and Prrx1 transcription factors. A genomic analysis of facial skeletal precursors in mutants and overexpression embryos reveals that Jagged-Notch signaling represses genes that are strongly induced as pharyngeal arch neural crest-derived cells begin skeletal differentiation. In wild types, initial Jagged-Notch repression dorsally ensures that barx1+ condensations and cartilage differentiation occur first in ventral-intermediate zones of the pharyngeal arches. Red...

  12. Accelerated cartilage differentiation distinguishes the lower from the upper vertebrate face BioProject

    ID: PRJNA295533

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: through antagonism of Jagged-Notch signaling and Prrx1 transcription factors. A genomic analysis of facial skeletal precursors in mutants and overexpression embryos reveals that Jagged-Notch signaling represses genes that are strongly induced as pharyngeal arch neural crest-derived cells begin skeletal differentiation. In wild types, initial Jagged-Notch repression dorsally ensures that barx1+ condensations and cartilage differentiation occur first in ventral-intermediate zones of the pharyngeal arches. Red...
  13. KD of Fibroblast specific TF OmicsDI

    ID: E-GEOD-44303

    Date Released: 06-02-2014

    Description: Combinatorial knock down of LHX9, OSR1, PRRX1, TWIST2, fibroblast specific transcription factors and adipogenic induction by medium change induce transdifferentiation from...

  14. Fibroblast Major TF KDs OmicsDI

    ID: E-GEOD-44305

    Date Released: 06-02-2014

    Description: fibroblast specific TF, FOXD1, HOXC4, LHX9, OSR1, PRRX1, TBX3, TWIST2 and NC(negative control siRNA) in fibroblast 24 Samples total....

  15. Gene expression classifier in papillary thyroid carcinoma: validation and application of a classifier for prognostication ArrayExpress

    ID: E-GEOD-65074

    Description: , FBLN2, FOSL2, GGT5, GPR124, JAM3, LRIG1, NDRG1, PRRX1, ROBO1, SORL1, TCF4, and ZEB1) was identified based on the expression values of these genes in the groups with and without metastasis in the development cohort. The 17 gene classifier for regional and/or distant metastasis identified was tested against the clinical status in the validation cohort. Sensitivity was 51.6% (95% CI 41.2%-61.8) and specificity 61.6 % (95% CI 50.5%-71.9%). Further, the Kaplan-Meyer method was used to estimate whether the classifier was useful as a prognostic marker for recurrences. Log-rank testing failed to identify any significance (p=0.32). Conclusion: A 17 gene classifier for metastatic potential was developed, and the results showed a clear biological difference between groups. However, through validation, the prognostic significance of this classifier could not be shown in identifying metastatic cases or in the ability of dichotomizing patients according to risk of recurrence after primary treatment. 38 patients with papillary thyroid carcinoma from a consecutive cohort of patients, no replicates...

  16. Proteomic characterization of the role of Snail1 in the differentiation of 3T3-L1 fibroblasts OmicsDI

    ID: PXD001529

    Date Released: 01-06-2015

    Description: ferentiation of the 3T3-L1 and MSCs as Nr2F6, ASC-1, Prrx1 or Cbx6. These candidates are down regulated due to the overexpression of Snail1 in 3T3-L1 cells. We next investigated the potential binding of Snail1 to promoter of these candidates. In silico analysis with MatInspector program revealed various putative E-box consensus motifs for Snail1. We performed ChIP and Luciferase assay to validate Snail1 binds to different E-box motifs of our candidates. Additionally, we analyzed the ability to prevent the differentiation to adipocytes of the 3T3-L1 cells using siRNAs. This work provided insight into novel proteins with potential roles in the regulation of differentiation to adipocytes of the 3T3-L1 and mMSC cells as Nr2F6, ASC-1, Prrx1 or Cbx6 controlled by Snail1....

  17. Gene expression classifier in papillary thyroid carcinoma: validation and application of a classifier for prognostication BioProject

    ID: PRJNA272877

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: , FBLN2, FOSL2, GGT5, GPR124, JAM3, LRIG1, NDRG1, PRRX1, ROBO1, SORL1, TCF4, and ZEB1) was identified based on the expression values of these genes in the groups with and without metastasis in the development cohort. The 17 gene classifier for regional and/or distant metastasis identified was tested against the clinical status in the validation cohort. Sensitivity was 51.6% (95% CI 41.2%-61.8) and specificity 61.6 % (95% CI 50.5%-71.9%). Further, the Kaplan-Meyer method was used to estimate whether the classifier was useful as a prognostic marker for recurrences. Log-rank testing failed to identify any significance (p=0.32). Conclusion: A 17 gene classifier for metastatic potential was developed, and the results showed a clear biological difference between groups. However, through validation, the prognostic significance of this classifier could not be shown in identifying metastatic cases or in the ability of dichotomizing patients according to risk of recurrence after primary treatment. Overall design: 38 patients with papillary thyroid carcinoma from a consecutive cohort of patients, no replicates...
  18. Region-specific gene expression profiles in left atria of patients with valvular atrial fibrillation ArrayExpress

    ID: E-GEOD-41177

    Description: ) between LA-PV junction and LAA, including genes related to arrhythmia, cell death, fibrosis, hypertrophy, and inflammation. Microarray and q-PCR produced parallel results in analyzing the expression of particular genes. The expression of paired like homeodomain-2 (PITX2) and its target ...

  19. Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2 BioProject

    ID: PRJNA296055

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: e concomitant with increased production of a bone-related mineralizing extra-cellular matrix. Overall design: Expression of genes of interest, including Ezh2, was assessed during osteogenic differentiation of human adipose-derived mesenchymal (AMSCs) on plastic (2D) and on porous-sintered titanium discs (3D). We also assessed gene expression when AMSCs were differen...
  20. Gene expression classifier in papillary thyroid carcinoma: validation and application of a classifier for prognostication OmicsDI

    ID: E-GEOD-65074

    Date Released: 01-27-2015

    Description: , FBLN2, FOSL2, GGT5, GPR124, JAM3, LRIG1, NDRG1, PRRX1, ROBO1, SORL1, TCF4, and ZEB1) was identified based on the expression values of these genes in the groups with and without metastasis in the development cohort. The 17 gene classifier for regional and/or distant metastasis identified was tested against the clinical status in the validation cohort. Sensitivity was 51.6% (95% CI 41.2%-61.8) and specificity 61.6 % (95% CI 50.5%-71.9%). Further, the Kaplan-Meyer method was used to estimate whether the classifier was useful as a prognostic marker for recurrences. Log-rank testing failed to identify any significance (p=0.32). Conclusion: A 17 gene classifier for metastatic potential was developed, and the results showed a clear biological difference between groups. However, through validation, the prognostic significance of this classifier could not be shown in identifying metastatic cases or in the ability of dichotomizing patients according to risk of recurrence after primary treatment. 38 patients with papillary thyroid carcinoma from a consecutive cohort of patients, no replicates...


Displaying 20 of 27 results for "PRRX1"