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Displaying 20 of 634 results for "PRKCB"
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  1. Targeting EWSR1-FLI1 oncogene induced protein kinase C beta abolishes Ewing sarcoma growth in vivo BioProject

    ID: PRJNA167796

    Keywords: Transcriptome or Gene expression

    Access Type: download

  2. Targeting EWSR1-FLI1 oncogene induced protein kinase C beta abolishes Ewing sarcoma growth in vivo OmicsDI

    ID: E-GEOD-38392

    Date Released: 07-17-2012

    Description: st Ewing sarcoma. We report the identification of Protein Kinase C Beta (PRKCB) as a protein specifically and highly expressed in Ewing sarcoma as compared to other pediatric canc...

  3. Targeting EWSR1-FLI1 oncogene induced protein kinase C beta abolishes Ewing sarcoma growth in vivo ArrayExpress

    ID: E-GEOD-38392

    Description: st Ewing sarcoma. We report the identification of Protein Kinase C Beta (PRKCB) as a protein specifically and highly expressed in Ewing sarcoma as compared to other pediatric canc...

  4. Identification of protein kinase C beta 2 regulated genes early in dendritic cell differentiation BioProject

    ID: PRJNA236616

    Keywords: Transcriptome or Gene expression

    Access Type: download

  5. Identification of protein kinase C beta 2 regulated genes early in dendritic cell differentiation ArrayExpress

    ID: E-GEOD-54484

    Description: eity. We have found previously that activation of protein kinase C beta 2 (PRKCB2) by cytokines or phorbol esters drives normal human CD34(+) hematopoietic progenitors and myeloid leukemic blasts (KG1, K562 cell lines, and primary patient blasts) to di...

  6. Genome-wide mRNA expression analysis of primary cultured mouse brain microvascular endothelial cells after inhibition of PKC-beta BioProject

    ID: PRJNA210721

    Keywords: Transcriptome or Gene expression

    Access Type: download

  7. Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape [ChIP-seq] BioProject

    ID: PRJNA270358

    Keywords: Epigenomics

    Access Type: download

    dataset.description: Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes b...
  8. Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape [RNA-seq] BioProject

    ID: PRJNA268066

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes b...
  9. Crystal Structure and Allosteric Activation of Protein Kinase C beta II PDB

    ID: PDB:3PFQ

    Description: Protein kinase C beta type (E.C.2.7.11.13)

  10. Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape [RNA-seq] ArrayExpress

    ID: E-GEOD-63497

    Description: Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes b...

  11. Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape [ChIP-seq] ArrayExpress

    ID: E-GEOD-64190

    Description: Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes b...

  12. Genome-wide mRNA expression analysis of primary cultured mouse brain microvascular endothelial cells after inhibition of PKC-beta ArrayExpress

    ID: E-GEOD-48572

    Description: Pharmacological inhibition of protein kinase C beta (PKC-beta) # by the compound LY31...

  13. Gene Expression and DNA methylation profiling in Alzheimer’s Disease patients reveals dysregulated genes associated with site-specific DNA methylati... ArrayExpress

    ID: E-GEOD-84890

    Description: associated with AD (i.e. NOTCH1, LRP5, GFAP, and PRKCB); additionally, several genes could represent novel candidates for participation in AD pathophysiology (i.e. MYT1L, RIMBP2, SNRPN and TMEM132D). 97 RNA samples from middle temporal gyrus of Alzheimer's patients (AD); 98 RNA samples from middle temporal gyrus of age and sex matched non demented controls (ND)...

  14. STAT5 antagonism of B cell enhancer networks drives leukemia and poor patient surviva BioProject

    ID: PRJNA342817

    Keywords: Epigenomics

    Access Type: download

    dataset.description: ts in the pre-BCR signaling components Blnk, Btk, Prkcb, Nfkb1, and Ikzf1 to initiate B-ALL. STAT5 antagonizes NFkB and IKAROS by opposing regulation of shared target genes. STAT5 binding was enriched at super-enhancers, which were associated with an opposing network of transcription factors, including PAX5, EBF1, PU.1, IRF4, and IKAROS. Patients with high ratios of active STAT5 to NF...
  15. Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival BioProject

    ID: PRJNA133897

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: re-BCR signaling components encoded by Blnk, Btk, Prkcb, Nfkb1, and Ikzf1 to initiate B-ALL. STAT5 antagonizes NF-κB and IKAROS by opposing regulation of shared target genes. STAT5 binding was enriched at super-enhancers, which were associated with an opposing network of transcription factors, including PAX5, EBF1, PU.1, IRF4, and IKAROS. Patients with high ratios of active STAT5 to NF-κB or I...
  16. Expression of paraventricular hypothalamus (PVN) from electroconvulsive seizure (ECS) treated C57Bl/6 mice ArrayExpress

    ID: E-GEOD-35259

    Description: depression. Since ECS up-regulates expression of c-Fos in the paraventricular nucleus of hypothalamus (PVN), the function of which is frequently influenced in depression, we hypothesized that ECS modulates functions of the PVN and contributes to its antidepres...

  17. Transcriptional Profile Analysis of RPGRORF15 frameshift mutation ArrayExpress

    ID: E-GEOD-19124

    Description: processes were altered at 7 weeks (CAMK2G, NTRK2, PRKCB, RALA, RBBP6, RNF41, SEPT5, SMYD3, SPP1, and TUBB2C) and 16 weeks (SLC25A5 and NKAP). Furthermore, DE genes at 7 weeks (ELOVL6, GLOD4, NDUFS4, and REEP1) and 16 weeks (SLC25A5 and TARS2) are related to mitochondrial functions. Real-time PCR of 11 genes confirmed the microarray results and showed differential expression for additional genes not on the array, such as GFAP, RHO, OPN1SW, CNGB3 and the mutated RPGR. Western blotting and IHC analysis also confirmed the high reliability of the presented transcriptomic data. Conclusions: A list of mutated genes in RPGRORF15 diseased retinas, which are likely candidates to further study their role in age-related photoreceptor degeneration diseases, is reported at different crucial ages. The results indicate that at 7 weeks a combination of non-classical anti- and pro-apoptotic genes appears to be involved in photoreceptor degeneration, whereas at both 7 and 16 weeks expression of mitochondria related genes indicates they may play a relevant role in the disease process. 3 biological replicates each for normal and XLPRA2 affected retinas were analyzed at 7 and 16 weeks of age. Each individual sample was hybridized in a reference design using a custom-made retinal cDNA microarray against brain pool to enable cross comparison between gr...

  18. Long non-coding RNAs and microRNAs involved in integrated co-regulation of neuronal maturation [microRNA expression] ArrayExpress

    ID: E-GEOD-44832

    Description: whereas long non-coding RNA -mRNA pairs for Kit, Prkcb and Ralgds displayed similar expression profiles. These genes were also predicted targets of the altered miRNAs, miR-124, -128, -129-5p, -203, -218, -290-5p, -326, -329, -377 and -495. These microRNAs particularly regulate the cell adhesion molecules, Cntn1, Ncam1, Negr1 and Nrxn1 that determine axonogenesis and dendritogenesis, supporting the observed co-regulation of these biological processes by non-coding RNAs. Verification of expression of these long non-coding RNA-mRNA pairs in an in vitro model of ischemic-reperfusion injury showed an inverse expression profile, thus confirming their role(s) in maintenance of the neuronal structure and function. This neuronal transcriptome (mRNAs, lncRNAs, miRNAs) is in turn orchestrated by C/EBPα/β transcription factors and CTCF, thereby governing intricate control of neuronal development. microRNA expression profiling of maturing primary cortical neurons from E15 mouse embryos. Maturing neurons were harvested on Days 2, 4, 6 and 8....

  19. Long non-coding RNAs and microRNAs involved in integrated co-regulation of neuronal maturation [mRNA and lncRNA expression] ArrayExpress

    ID: E-GEOD-44833

    Description: whereas long non-coding RNA -mRNA pairs for Kit, Prkcb and Ralgds displayed similar expression profiles. These genes were also predicted targets of the altered miRNAs, miR-124, -128, -129-5p, -203, -218, -290-5p, -326, -329, -377 and -495. These microRNAs particularly regulate the cell adhesion molecules, Cntn1, Ncam1, Negr1 and Nrxn1 that determine axonogenesis and dendritogenesis, supporting the observed co-regulation of these biological processes by non-coding RNAs. Verification of expression of these long non-coding RNA-mRNA pairs in an in vitro model of ischemic-reperfusion injury showed an inverse expression profile, thus confirming their role(s) in maintenance of the neuronal structure and function. This neuronal transcriptome (mRNAs, lncRNAs, miRNAs) is in turn orchestrated by C/EBPα/β transcription factors and CTCF, thereby governing intricate control of neuronal development. mRNA and long non-coding RNA expression profiling of maturing primary cortical neurons from E15 mouse embryos and neurons subjected to oxygen-glucose deprivation. Maturing neurons were harvested on Days 2, 4, 6 and 8. Neurons on Day...

  20. Long non-coding RNAs and microRNAs involved in integrated co-regulation of neuronal maturation [mRNA and lncRNA expression] BioProject

    ID: PRJNA192570

    Keywords: Transcriptome or Gene expression

    Access Type: download

    dataset.description: whereas long non-coding RNA -mRNA pairs for Kit, Prkcb and Ralgds displayed similar expression profiles. These genes were also predicted targets of the altered miRNAs, miR-124, -128, -129-5p, -203, -218, -290-5p, -326, -329, -377 and -495. These microRNAs particularly regulate the cell adhesion molecules, Cntn1, Ncam1, Negr1 and Nrxn1 that determine axonogenesis and dendritogenesis, supporting the observed co-regulation of these biological processes by non-coding RNAs. Verification of expression of these long non-coding RNA-mRNA pairs in an in vitro model of ischemic-reperfusion injury showed an inverse expression profile, thus confirming their role(s) in maintenance of the neuronal structure and function. This neuronal transcriptome (mRNAs, lncRNAs, miRNAs) is in turn orchestrated by C/EBPα/β transcription factors and CTCF, thereby governing intricate control of neuronal development. Overall design: mRNA and long non-coding RNA expression profiling of maturing primary cortical neurons from E15 mouse embryos and neurons subjected to oxygen-glucose deprivation. Maturing neurons were harvested on Days 2, 4, 6 and 8...

Displaying 20 of 634 results for "PRKCB"