PPP2R2A | bioCADDIE Data Discovery Index
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Displaying 20 of 23 results for "PPP2R2A"
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  1. Structural Basis of PP2A and Sgo interaction PDB

    ID: PDB:3FGA

    Description: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha

  2. 2AAA_BOVIN UniProt:Swiss-Prot

    ID: Q32PI5

    Description: Removed Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha

  3. 2ABA_MOUSE UniProt:Swiss-Prot

    ID: Q6P1F6

    Description: Removed Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B

  4. 2ABA_PIG UniProt:Swiss-Prot

    ID: Q29090

    Description: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B

  5. Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation PDB

    ID: PDB:4I5N

    Description: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha

  6. Human PTPA in complex with peptide PDB

    ID: PDB:4NY3

    Description: Serine/threonine-protein phosphatase 2A activator (E.C.5.2.1.8), Serine/threonine-protein ph

  7. Structure of a Protein Phosphatase 2A Holoenzyme with B55 subunit PDB

    ID: PDB:3DW8

    Description: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha

  8. 2ABA_ORYSJ UniProt:Swiss-Prot

    ID: Q5Z8Z7

    Description: Serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B

  9. 2AB2A_ARATH UniProt:Swiss-Prot

    ID: Q9XGR4

    Description: Serine/threonine protein phosphatase 2A regulatory subunit B''<

  10. 2ABA_MACFA UniProt:Swiss-Prot

    ID: Q4R7Z4

    Description: Removed Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B

  11. PP2A PR70 Holoenzyme model3_diCa_rcsb.pdb bppnat5_extend.mtz PDB

    ID: PDB:4I5K

    Description: Serine/threonine-protein phosphatase 2A regulatory subunit B''

  12. PP2A PR70 Holoenzyme PDB

    ID: PDB:4I5J

    Description: Serine/threonine-protein phosphatase 2A regulatory subunit B''

  13. Protein phosphatase 2A core complex bound to dinophysistoxin-1 PDB

    ID: PDB:3K7V

    Description: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha

  14. Protein phosphatase 2A core complex bound to dinophysistoxin-2 PDB

    ID: PDB:3K7W

    Description: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha

  15. The crystal structure of ternary PP1G-PPP1R15B and G-actin complex PDB

    ID: PDB:4V0U

    Description: ACTIN, ALPHA SKELETAL MUSCLE, SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC

  16. Structural mechanism of trimeric PP2A holoenzyme involving PR70: insight for Cdc6 dephosphorylation PDB

    ID: PDB:4I5L

    Description: PP2A A alpha subunit (9-589) , PP2A PR70 B"

  17. Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with transcriptional Profile alterations (Copy number) ArrayExpress

    ID: E-GEOD-39380

    Description: 2 encompassing the putative tumor suppressor gene PPP2R2A that was significantly down-regulated in deleted cases. Mutations of TP53 were identified in 4 cases all but one associated with a monoallelic deletion of the gene, whereas activating mutations of BRAF occurred in one case and were absent for N- and K-RAS. To evaluate the influence of allelic imbalances in transcriptional expression we performed an integrated genomic analysis with GEP data, showing a significant dosage effect of genes involved in transcription, translation, methyltransferases activity, apoptosis as well as Wnt and NF-kB signaling pathways. Overall, we provide a compendium of genomic alterations in a prospective series of pPCLs which may contribute to our understanding of this particular form of plasma cell dyscrasia and to better elucidate the mechanisms of tumor progression in MM. This series of microarray experiments contains the genome-wide profiles of 17 primary...

  18. Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with transcriptional Profile alterations (Expression) ArrayExpress

    ID: E-GEOD-39381

    Description: 2 encompassing the putative tumor suppressor gene PPP2R2A that was significantly down-regulated in deleted cases. Mutations of TP53 were identified in 4 cases all but one associated with a monoallelic deletion of the gene, whereas activating mutations of BRAF occurred in one case and were absent for N- and K-RAS. To evaluate the influence of allelic imbalances in transcriptional expression we performed an integrated genomic analysis with GEP data, showing a significant dosage effect of genes involved in transcription, translation, methyltransferases activity, apoptosis as well as Wnt and NF-kB signaling pathways. Overall, we provide a compendium of genomic alterations in a prospective series of pPCLs which may contribute to our understanding of this particular form of plasma cell dyscrasia and to better elucidate the mechanisms of tumor progression in MM. This series of microarray experiments contains the gene expression profiles of purifi...

  19. Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with transcriptional Profile alterations (Copy number) BioProject

    ID: PRJNA171400

    Keywords: Variation

    Access Type: download

    dataset.description: 2 encompassing the putative tumor suppressor gene PPP2R2A that was significantly down-regulated in deleted cases. Mutations of TP53 were identified in 4 cases all but one associated with a monoallelic deletion of the gene, whereas activating mutations of BRAF occurred in one case and were absent for N- and K-RAS. To evaluate the influence of allelic imbalances in transcriptional expression we performed an integrated genomic analysis with GEP data, showing a significant dosage effect of genes involved in transcription, translation, methyltransferases activity, apoptosis as well as Wnt and NF-kB signaling pathways. Overall, we provide a compendium of genomic alterations in a prospective series of pPCLs which may contribute to our understanding of this particular form of plasma cell dyscrasia and to better elucidate the mechanisms of tumor progression in MM. Overall design: This series of microarray experiments contains the genome-wide profil...
  20. METABRIC OmicsDI

    ID: EGAS00000000083

    Date Released:

    Description: fiedputative cancer genes, including deletions in PPP2R2A, MTAP, and MAP2K4.Unsupervised analysis of paired DNA/RNA profiles revealed novel subgroupswith distinct clinical outcomes, which reproduced in the validation cohort.These include a high-risk, ER-positive 11q13/14 cis-acting subgroup and afavourable prognosis subgroup devoid of CNAs. Trans-acting aberration0152hotspots were found to modulate subgroup-specific gene networks, includinga TCR deletion-mediated adaptive immune response in the 0152CNA-devoidsub-group and a Basal-specific chromosome 5 deletion-driven mitotic network.Our results provide a novel molecular stratification of the breast cancerpopulation, derived from the impact of somatic copy number aberrations onthe transcriptome....


Displaying 20 of 23 results for "PPP2R2A"